Dnm1l (dynamin 1 like) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Dnm1l (dynamin 1 like) Heterocephalus glaber
Analyze
Symbol: Dnm1l
Name: dynamin 1 like
RGD ID: 18921420
Description: ENCODES a protein that exhibits BH2 domain binding (ortholog); clathrin binding (ortholog); GTP-dependent protein binding (ortholog); INVOLVED IN calcium ion transport (ortholog); cellular response to hypoxia (ortholog); cellular response to lipid (ortholog); PARTICIPATES IN mitochondria fission pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); arrhythmogenic right ventricular dysplasia 9 (ortholog); Charcot-Marie-Tooth disease type 4 (ortholog); FOUND IN brush border (ortholog); clathrin coat of trans-Golgi network vesicle (ortholog); endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dynamin-1-like protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247783,391,690 - 3,475,548 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium ion transport  (ISO)
cellular response to hypoxia  (ISO)
cellular response to lipid  (ISO)
endoplasmic reticulum organization  (ISO)
heart contraction  (ISO)
intracellular distribution of mitochondria  (ISO)
membrane fusion  (ISO)
mitochondrial fission  (IEA,ISO)
mitochondrial fragmentation involved in apoptotic process  (IEA,ISO)
mitochondrial membrane fission  (ISO)
mitochondrion organization  (ISO)
mitocytosis  (ISO)
necroptotic process  (ISO)
negative regulation of mitochondrial fusion  (ISO)
peroxisome fission  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of dendritic spine morphogenesis  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of mitochondrial fission  (ISO)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of release of cytochrome c from mitochondria  (ISO)
positive regulation of synaptic vesicle endocytosis  (ISO)
positive regulation of synaptic vesicle exocytosis  (ISO)
protein complex oligomerization  (ISO)
protein localization to mitochondrion  (ISO)
protein-containing complex assembly  (ISO)
regulation of ATP metabolic process  (ISO)
regulation of gene expression  (ISO)
regulation of mitochondrion organization  (ISO)
regulation of mitophagy  (ISO)
regulation of peroxisome organization  (ISO)
release of cytochrome c from mitochondria  (ISO)
response to endoplasmic reticulum stress  (ISO)
response to flavonoid  (ISO)
response to hypobaric hypoxia  (ISO)
rhythmic process  (IEA)
synaptic vesicle endocytosis  (ISO)
synaptic vesicle recycling via endosome  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Dnm1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247783,391,690 - 3,475,548 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
DNM1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381232,679,301 - 32,745,650 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1232,679,200 - 32,745,650 (+)EnsemblGRCh38hg38GRCh38
GRCh371232,832,235 - 32,898,584 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361232,723,491 - 32,788,621 (+)NCBINCBI36Build 36hg18NCBI36
Build 341232,723,490 - 32,787,810NCBI
Celera1212,653,086 - 12,719,281 (+)NCBICelera
Cytogenetic Map12p11.21NCBI
HuRef1232,584,423 - 32,651,060 (+)NCBIHuRef
CHM1_11232,798,646 - 32,865,086 (+)NCBICHM1_1
T2T-CHM13v2.01232,555,588 - 32,621,929 (+)NCBIT2T-CHM13v2.0
Dnm1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391616,130,092 - 16,176,863 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1616,130,094 - 16,176,823 (-)EnsemblGRCm39 Ensembl
GRCm381616,312,228 - 16,359,038 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1616,312,230 - 16,358,959 (-)EnsemblGRCm38mm10GRCm38
MGSCv371616,312,326 - 16,359,123 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361616,225,811 - 16,272,608 (-)NCBIMGSCv36mm8
Celera1616,883,274 - 16,930,064 (-)NCBICelera
Cytogenetic Map16A2NCBI
cM Map1610.12NCBI
Dnm1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81198,084,049 - 98,135,663 (+)NCBIGRCr8
mRatBN7.21184,581,216 - 84,632,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1184,581,216 - 84,631,482 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1193,314,036 - 93,362,103 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01185,975,178 - 86,023,244 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01185,028,777 - 85,076,843 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,830,968 - 88,882,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,830,957 - 88,880,198 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,885,295 - 91,936,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,617,236 - 86,665,861 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,657,172 - 86,706,365 (-)NCBI
Celera1183,326,642 - 83,375,373 (+)NCBICelera
Cytogenetic Map11q23NCBI
Dnm1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555053,023,018 - 3,081,680 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555053,025,742 - 3,081,491 (-)NCBIChiLan1.0ChiLan1.0
DNM1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21064,005,917 - 64,070,389 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11264,000,313 - 64,066,785 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01253,476,553 - 53,541,421 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11256,077,504 - 56,142,376 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1256,077,504 - 56,142,376 (-)Ensemblpanpan1.1panPan2
DNM1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12716,161,855 - 16,211,983 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2716,163,357 - 16,211,957 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2730,213,206 - 30,264,757 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02716,342,630 - 16,394,291 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2716,341,228 - 16,394,252 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12716,151,140 - 16,202,287 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02716,183,766 - 16,235,121 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02730,361,257 - 30,412,627 (+)NCBIUU_Cfam_GSD_1.0
Dnm1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494576,743,024 - 76,799,054 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366073,576,392 - 3,632,554 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366073,576,357 - 3,632,423 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl541,570,282 - 41,636,028 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1541,571,054 - 41,636,058 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2544,756,967 - 44,785,760 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DNM1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11132,114,642 - 32,178,330 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1132,114,675 - 32,177,661 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660692,716,938 - 2,783,519 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_021236534   ⟹   XP_021092193
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247783,391,690 - 3,475,548 (-)NCBI
RefSeq Acc Id: XM_021236535   ⟹   XP_021092194
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247783,391,690 - 3,475,548 (-)NCBI
RefSeq Acc Id: XM_021236536   ⟹   XP_021092195
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247783,391,690 - 3,475,548 (-)NCBI
RefSeq Acc Id: XM_021236537   ⟹   XP_021092196
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247783,391,690 - 3,475,548 (-)NCBI
RefSeq Acc Id: XM_021236538   ⟹   XP_021092197
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247783,391,690 - 3,475,548 (-)NCBI
RefSeq Acc Id: XM_021236539   ⟹   XP_021092198
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247783,391,690 - 3,475,548 (-)NCBI
RefSeq Acc Id: XM_021236540   ⟹   XP_021092199
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247783,391,690 - 3,475,547 (-)NCBI
RefSeq Acc Id: XM_021236541   ⟹   XP_021092200
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247783,391,690 - 3,475,547 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_021092194   ⟸   XM_021236535
- Peptide Label: isoform X2
- UniProtKB: G5BSI1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021092197   ⟸   XM_021236538
- Peptide Label: isoform X5
- UniProtKB: G5BSI1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021092195   ⟸   XM_021236536
- Peptide Label: isoform X3
- UniProtKB: A0A0P6K3Q2 (UniProtKB/TrEMBL),   G5BSI1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021092198   ⟸   XM_021236539
- Peptide Label: isoform X6
- UniProtKB: G5BSI1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021092196   ⟸   XM_021236537
- Peptide Label: isoform X4
- UniProtKB: G5BSI1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021092193   ⟸   XM_021236534
- Peptide Label: isoform X1
- UniProtKB: G5BSI1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021092200   ⟸   XM_021236541
- Peptide Label: isoform X8
- UniProtKB: G5BSI1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021092199   ⟸   XM_021236540
- Peptide Label: isoform X7
- UniProtKB: G5BSI1 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000018513 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000026230 ENTREZGENE
  ENSHGLT00000026231 ENTREZGENE
  ENSHGLT00000052631 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  Dynamin, middle domain UniProtKB/TrEMBL
InterPro Dynamin_GTPase UniProtKB/TrEMBL
  Dynamin_GTPase_CS UniProtKB/TrEMBL
  Dynamin_N UniProtKB/TrEMBL
  Dynamin_SF UniProtKB/TrEMBL
  Dynamin_stalk UniProtKB/TrEMBL
  G_DYNAMIN_dom UniProtKB/TrEMBL
  GED UniProtKB/TrEMBL
  GED_dom UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene Dnm1l ENTREZGENE
PANTHER PTHR11566 UniProtKB/TrEMBL
  PTHR11566:SF39 UniProtKB/TrEMBL
Pfam Dynamin_M UniProtKB/TrEMBL
  Dynamin_N UniProtKB/TrEMBL
  GED UniProtKB/TrEMBL
PRINTS DYNAMIN UniProtKB/TrEMBL
PROSITE G_DYNAMIN_1 UniProtKB/TrEMBL
  G_DYNAMIN_2 UniProtKB/TrEMBL
  GED UniProtKB/TrEMBL
SMART DYNc UniProtKB/TrEMBL
  GED UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A0P6K3Q2 ENTREZGENE, UniProtKB/TrEMBL
  G5BSI1 ENTREZGENE, UniProtKB/TrEMBL