Dnm1l (dynamin 1 like) - Rat Genome Database

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Pathways
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Gene: Dnm1l (dynamin 1 like) Chinchilla lanigera
Analyze
Symbol: Dnm1l
Name: dynamin 1 like
RGD ID: 8848820
Description: ENCODES a protein that exhibits BH2 domain binding (ortholog); clathrin binding (ortholog); GTP-dependent protein binding (ortholog); INVOLVED IN calcium ion transport (ortholog); cellular response to hypoxia (ortholog); cellular response to lipid (ortholog); PARTICIPATES IN mitochondria fission pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); arrhythmogenic right ventricular dysplasia 9 (ortholog); Charcot-Marie-Tooth disease type 4 (ortholog); FOUND IN brush border (ortholog); clathrin coat of trans-Golgi network vesicle (ortholog); clathrin-coated pit (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dynamin 1-like
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555053,023,018 - 3,081,680 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555053,025,742 - 3,081,491 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium ion transport  (ISO)
cellular response to hypoxia  (ISO)
cellular response to lipid  (ISO)
endoplasmic reticulum organization  (ISO)
heart contraction  (ISO)
intracellular distribution of mitochondria  (ISO)
membrane fusion  (ISO)
mitochondrial fission  (ISO)
mitochondrial fragmentation involved in apoptotic process  (ISO)
mitochondrial membrane fission  (ISO)
mitochondrion organization  (ISO)
mitocytosis  (ISO)
necroptotic process  (ISO)
negative regulation of mitochondrial fusion  (ISO)
peroxisome fission  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of dendritic spine morphogenesis  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of mitochondrial fission  (ISO)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of protein secretion  (ISO)
positive regulation of release of cytochrome c from mitochondria  (ISO)
positive regulation of synaptic vesicle endocytosis  (ISO)
positive regulation of synaptic vesicle exocytosis  (ISO)
protein complex oligomerization  (ISO)
protein localization to mitochondrion  (ISO)
protein-containing complex assembly  (ISO)
regulation of ATP metabolic process  (ISO)
regulation of gene expression  (ISO)
regulation of mitochondrion organization  (ISO)
regulation of mitophagy  (ISO)
regulation of peroxisome organization  (ISO)
release of cytochrome c from mitochondria  (ISO)
response to endoplasmic reticulum stress  (ISO)
response to flavonoid  (ISO)
response to hypobaric hypoxia  (ISO)
synaptic vesicle endocytosis  (ISO)
synaptic vesicle recycling via endosome  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Dnm1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555053,023,018 - 3,081,680 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555053,025,742 - 3,081,491 (-)NCBIChiLan1.0ChiLan1.0
DNM1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381232,679,301 - 32,745,650 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1232,679,200 - 32,745,650 (+)EnsemblGRCh38hg38GRCh38
GRCh371232,832,235 - 32,898,584 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361232,723,491 - 32,788,621 (+)NCBINCBI36Build 36hg18NCBI36
Build 341232,723,490 - 32,787,810NCBI
Celera1212,653,086 - 12,719,281 (+)NCBICelera
Cytogenetic Map12p11.21NCBI
HuRef1232,584,423 - 32,651,060 (+)NCBIHuRef
CHM1_11232,798,646 - 32,865,086 (+)NCBICHM1_1
T2T-CHM13v2.01232,555,588 - 32,621,929 (+)NCBIT2T-CHM13v2.0
Dnm1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391616,130,092 - 16,176,863 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1616,130,094 - 16,176,823 (-)EnsemblGRCm39 Ensembl
GRCm381616,312,228 - 16,359,038 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1616,312,230 - 16,358,959 (-)EnsemblGRCm38mm10GRCm38
MGSCv371616,312,326 - 16,359,123 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361616,225,811 - 16,272,608 (-)NCBIMGSCv36mm8
Celera1616,883,274 - 16,930,064 (-)NCBICelera
Cytogenetic Map16A2NCBI
cM Map1610.12NCBI
Dnm1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81198,084,049 - 98,135,663 (+)NCBIGRCr8
mRatBN7.21184,581,216 - 84,632,382 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1184,581,216 - 84,631,482 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1193,314,036 - 93,362,103 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01185,975,178 - 86,023,244 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01185,028,777 - 85,076,843 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01188,830,968 - 88,882,271 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1188,830,957 - 88,880,198 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01191,885,295 - 91,936,512 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41186,617,236 - 86,665,861 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11186,657,172 - 86,706,365 (-)NCBI
Celera1183,326,642 - 83,375,373 (+)NCBICelera
Cytogenetic Map11q23NCBI
DNM1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21064,005,917 - 64,070,389 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11264,000,313 - 64,066,785 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01253,476,553 - 53,541,421 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11256,077,504 - 56,142,376 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1256,077,504 - 56,142,376 (-)Ensemblpanpan1.1panPan2
DNM1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12716,161,855 - 16,211,983 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2716,163,357 - 16,211,957 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2730,213,206 - 30,264,757 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02716,342,630 - 16,394,291 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2716,341,228 - 16,394,252 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12716,151,140 - 16,202,287 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02716,183,766 - 16,235,121 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02730,361,257 - 30,412,627 (+)NCBIUU_Cfam_GSD_1.0
Dnm1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494576,743,024 - 76,799,054 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366073,576,392 - 3,632,554 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366073,576,357 - 3,632,423 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl541,570,282 - 41,636,028 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1541,571,054 - 41,636,058 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2544,756,967 - 44,785,760 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DNM1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11132,114,642 - 32,178,330 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1132,114,675 - 32,177,661 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660692,716,938 - 2,783,519 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnm1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247783,391,690 - 3,475,548 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000003644   ⟹   ENSCLAP00000003570
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555053,023,018 - 3,081,680 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000003645   ⟹   ENSCLAP00000003571
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555053,023,018 - 3,081,680 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000003646   ⟹   ENSCLAP00000003572
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555053,023,018 - 3,081,680 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000003647   ⟹   ENSCLAP00000003573
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555053,023,018 - 3,081,680 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000003648   ⟹   ENSCLAP00000003574
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555053,027,582 - 3,081,391 (-)Ensembl
RefSeq Acc Id: XM_005407112   ⟹   XP_005407169
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555053,025,742 - 3,081,491 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005407113   ⟹   XP_005407170
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555053,025,742 - 3,081,491 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005407114   ⟹   XP_005407171
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555053,025,742 - 3,081,482 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005407116   ⟹   XP_005407173
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555053,025,742 - 3,081,482 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005407117   ⟹   XP_005407174
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555053,025,742 - 3,081,482 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005407118   ⟹   XP_005407175
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555053,025,742 - 3,081,482 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005407119   ⟹   XP_005407176
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555053,025,742 - 3,081,482 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005407121   ⟹   XP_005407178
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555053,025,742 - 3,081,482 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013505924   ⟹   XP_013361378
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555053,025,742 - 3,081,482 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013505925   ⟹   XP_013361379
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555053,025,742 - 3,059,317 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_005407178   ⟸   XM_005407121
- Peptide Label: isoform X7
- UniProtKB: A0A8C2UQA7 (UniProtKB/TrEMBL),   A0A8C2YJM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005407176   ⟸   XM_005407119
- Peptide Label: isoform X6
- UniProtKB: A0A8C2YJM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005407173   ⟸   XM_005407116
- Peptide Label: isoform X3
- UniProtKB: A0A8C2YJM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005407171   ⟸   XM_005407114
- Peptide Label: isoform X2
- UniProtKB: A0A8C2UNN6 (UniProtKB/TrEMBL),   A0A8C2YJM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005407170   ⟸   XM_005407113
- Peptide Label: isoform X10
- UniProtKB: A0A8C2YJM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005407169   ⟸   XM_005407112
- Peptide Label: isoform X9
- UniProtKB: A0A8C2UTQ6 (UniProtKB/TrEMBL),   A0A8C2YJM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005407175   ⟸   XM_005407118
- Peptide Label: isoform X5
- UniProtKB: A0A8C2YJM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005407174   ⟸   XM_005407117
- Peptide Label: isoform X4
- UniProtKB: A0A8C2UNP3 (UniProtKB/TrEMBL),   A0A8C2YJM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013361378   ⟸   XM_013505924
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YJM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013361379   ⟸   XM_013505925
- Peptide Label: isoform X8
- UniProtKB: A0A8C2YJM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000003573   ⟸   ENSCLAT00000003647
RefSeq Acc Id: ENSCLAP00000003574   ⟸   ENSCLAT00000003648
RefSeq Acc Id: ENSCLAP00000003571   ⟸   ENSCLAT00000003645
RefSeq Acc Id: ENSCLAP00000003572   ⟸   ENSCLAT00000003646
RefSeq Acc Id: ENSCLAP00000003570   ⟸   ENSCLAT00000003644
Protein Domains
Dynamin-type G   GED


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000002548 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000003644 ENTREZGENE
  ENSCLAT00000003644.1 UniProtKB/TrEMBL
  ENSCLAT00000003645 ENTREZGENE
  ENSCLAT00000003645.1 UniProtKB/TrEMBL
  ENSCLAT00000003646 ENTREZGENE
  ENSCLAT00000003646.1 UniProtKB/TrEMBL
  ENSCLAT00000003647 ENTREZGENE
  ENSCLAT00000003647.1 UniProtKB/TrEMBL
  ENSCLAT00000003648 ENTREZGENE
  ENSCLAT00000003648.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  Dynamin, middle domain UniProtKB/TrEMBL
InterPro Dynamin UniProtKB/TrEMBL
  Dynamin_GTPase UniProtKB/TrEMBL
  Dynamin_GTPase_CS UniProtKB/TrEMBL
  Dynamin_N UniProtKB/TrEMBL
  Dynamin_stalk UniProtKB/TrEMBL
  G_DYNAMIN_dom UniProtKB/TrEMBL
  GED UniProtKB/TrEMBL
  GED_dom UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene Dnm1l ENTREZGENE
PANTHER PTHR11566 UniProtKB/TrEMBL
  PTHR11566:SF39 UniProtKB/TrEMBL
Pfam Dynamin_M UniProtKB/TrEMBL
  Dynamin_N UniProtKB/TrEMBL
  GED UniProtKB/TrEMBL
PRINTS DYNAMIN UniProtKB/TrEMBL
PROSITE G_DYNAMIN_1 UniProtKB/TrEMBL
  G_DYNAMIN_2 UniProtKB/TrEMBL
  GED UniProtKB/TrEMBL
SMART DYNc UniProtKB/TrEMBL
  GED UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8C2UNN6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2UNP3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2UQA7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2UTQ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YJM9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-26 Dnm1l  dynamin 1 like    dynamin 1-like  Symbol and/or name change 5135510 APPROVED