Pmaip1 (phorbol-12-myristate-13-acetate-induced protein 1) - Rat Genome Database

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Pathways
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Gene: Pmaip1 (phorbol-12-myristate-13-acetate-induced protein 1) Heterocephalus glaber
Analyze
Symbol: Pmaip1
Name: phorbol-12-myristate-13-acetate-induced protein 1
RGD ID: 18926408
Description: INVOLVED IN apoptotic process (ortholog); cellular response to glucose starvation (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN intrinsic apoptotic pathway; ASSOCIATED WITH B-Cell Chronic Lymphocytic Leukemia (ortholog); COVID-19 (ortholog); immunodeficiency 12 (ortholog); FOUND IN Bcl-2 family protein complex (ortholog); cytosol (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247925,330,289 - 5,338,067 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA,ISO)
cellular response to glucose starvation  (ISO)
cellular response to hypoxia  (ISO)
defense response to virus  (ISO)
DNA damage response  (IEA,ISO)
fibroblast apoptotic process  (ISO)
intrinsic apoptotic signaling pathway  (ISO)
intrinsic apoptotic signaling pathway by p53 class mediator  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of mitochondrial membrane potential  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of DNA damage response, signal transduction by p53 class mediator  (ISO)
positive regulation of establishment of protein localization to mitochondrion  (ISO)
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
positive regulation of fibroblast apoptotic process  (ISO)
positive regulation of glucose metabolic process  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of release of cytochrome c from mitochondria  (ISO)
proteasomal protein catabolic process  (ISO)
reactive oxygen species metabolic process  (ISO)
regulation of mitochondrial membrane permeability  (ISO)
release of cytochrome c from mitochondria  (IEA,ISO)
response to dsRNA  (ISO)
response to UV  (ISO)
response to X-ray  (ISO)
T cell homeostasis  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Pmaip1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247925,330,289 - 5,338,067 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PMAIP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381859,899,996 - 59,904,305 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1859,899,996 - 59,904,305 (+)EnsemblGRCh38hg38GRCh38
GRCh371857,567,228 - 57,571,537 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361855,718,172 - 55,722,518 (+)NCBINCBI36Build 36hg18NCBI36
Build 341855,718,216 - 55,722,517NCBI
Celera1854,285,254 - 54,289,600 (+)NCBICelera
Cytogenetic Map18q21.32NCBI
HuRef1854,276,682 - 54,281,028 (+)NCBIHuRef
CHM1_11857,562,830 - 57,567,176 (+)NCBICHM1_1
T2T-CHM13v2.01860,102,671 - 60,106,980 (+)NCBIT2T-CHM13v2.0
Pmaip1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391866,591,675 - 66,598,629 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1866,591,604 - 66,598,636 (+)EnsemblGRCm39 Ensembl
GRCm381866,458,604 - 66,465,558 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1866,458,533 - 66,465,565 (+)EnsemblGRCm38mm10GRCm38
MGSCv371866,618,258 - 66,625,212 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361866,583,973 - 66,590,927 (+)NCBIMGSCv36mm8
Celera1867,745,077 - 67,752,031 (+)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1839.52NCBI
Pmaip1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81862,255,970 - 62,262,384 (+)NCBIGRCr8
mRatBN7.21859,986,020 - 59,992,434 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1859,986,017 - 59,992,429 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1862,070,712 - 62,074,695 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01862,769,423 - 62,773,407 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01860,619,311 - 60,623,296 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01862,159,128 - 62,179,635 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1862,174,670 - 62,181,102 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01861,365,056 - 61,369,043 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41862,914,845 - 62,918,832 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11862,988,045 - 62,992,033 (+)NCBI
Celera1858,105,912 - 58,109,899 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
Pmaip1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540244,005,517 - 44,010,722 (+)NCBIChiLan1.0ChiLan1.0
LOC100979315
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21777,437,419 - 77,441,738 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11863,130,031 - 63,134,350 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01853,286,590 - 53,290,913 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11856,611,098 - 56,615,449 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1856,611,098 - 56,615,449 (+)Ensemblpanpan1.1panPan2
PMAIP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1116,469,793 - 16,472,910 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl116,469,793 - 16,472,910 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha117,446,017 - 17,449,325 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0116,340,520 - 16,344,361 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl116,340,520 - 16,344,361 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1116,376,897 - 16,380,246 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0116,303,869 - 16,307,124 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0116,558,934 - 16,562,268 (-)NCBIUU_Cfam_GSD_1.0
Pmaip1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494429,746,960 - 29,747,884 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049364974,985,995 - 4,986,720 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PMAIP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1161,182,887 - 161,188,164 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11161,184,458 - 161,188,138 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21178,853,630 - 178,857,420 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PMAIP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11819,861,182 - 19,865,628 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1819,862,743 - 19,865,250 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660605,737,434 - 5,741,800 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_013077231   ⟹   XP_012932685
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247925,330,289 - 5,338,067 (+)NCBI
RefSeq Acc Id: XM_021239267   ⟹   XP_021094926
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247925,330,289 - 5,338,067 (+)NCBI
Protein Sequences
Protein RefSeqs XP_012932685 (Get FASTA)   NCBI Sequence Viewer  
  XP_021094926 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000026136
  ENSHGLP00000047061
  ENSHGLP00100059647
GenBank Protein JAO02101 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_021094926   ⟸   XM_021239267
- Peptide Label: isoform X1
RefSeq Acc Id: XP_012932685   ⟸   XM_013077231
- Peptide Label: isoform X2
- UniProtKB: A0A0P6JCI5 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000018603 ENTREZGENE
  ENSHGLG00000050640 UniProtKB/TrEMBL
  ENSHGLG00100033803 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000026368 ENTREZGENE
  ENSHGLT00000043771 UniProtKB/TrEMBL
  ENSHGLT00100082946 UniProtKB/TrEMBL
InterPro Noxa UniProtKB/TrEMBL
KEGG Report hgl:106010564 UniProtKB/TrEMBL
NCBI Gene Pmaip1 ENTREZGENE
PANTHER PHORBOL-12-MYRISTATE-13-ACETATE-INDUCED PROTEIN 1 UniProtKB/TrEMBL
  PTHR14299 UniProtKB/TrEMBL
Pfam PMAIP1 UniProtKB/TrEMBL
UniProt A0A0P6JCI5 ENTREZGENE, UniProtKB/TrEMBL