Bcl2l11 (BCL2 like 11) - Rat Genome Database

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Pathways
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Gene: Bcl2l11 (BCL2 like 11) Heterocephalus glaber
Analyze
Symbol: Bcl2l11
Name: BCL2 like 11
RGD ID: 18917884
Description: ENCODES a protein that exhibits microtubule binding (ortholog); protein kinase binding (ortholog); INVOLVED IN apoptotic process involved in embryonic digit morphogenesis (ortholog); B cell homeostasis (ortholog); cell-matrix adhesion (ortholog); PARTICIPATES IN intrinsic apoptotic pathway; ASSOCIATED WITH Familial Prostate Cancer (ortholog); glomerulonephritis (ortholog); sclerosing cholangitis (ortholog); FOUND IN Bcl-2 family protein complex (ortholog); BIM-BCL-2 complex (ortholog); BIM-BCL-xl complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Bcl-2-like protein 11
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247491,091,096 - 1,125,341 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247491,033,824 - 1,130,099 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process involved in embryonic digit morphogenesis  (ISO)
B cell homeostasis  (ISO)
cell-matrix adhesion  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
developmental pigmentation  (ISO)
ear development  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
in utero embryonic development  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
kidney development  (ISO)
leukocyte homeostasis  (ISO)
lymphocyte apoptotic process  (ISO)
lymphocyte homeostasis  (ISO)
male gonad development  (ISO)
mammary gland development  (ISO)
meiosis I  (IEA)
myeloid cell homeostasis  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of autophagy in response to ER overload  (ISO)
positive regulation of cell cycle  (ISO)
positive regulation of fibroblast apoptotic process  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of lymphocyte apoptotic process  (ISO)
positive regulation of mitochondrial membrane permeability involved in apoptotic process  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of release of cytochrome c from mitochondria  (ISO)
positive regulation of T cell apoptotic process  (ISO)
post-embryonic development  (ISO)
regulation of apoptotic process  (ISO)
regulation of developmental pigmentation  (ISO)
regulation of organ growth  (ISO)
response to endoplasmic reticulum stress  (ISO)
spermatogenesis  (ISO)
spleen development  (ISO)
T cell apoptotic process  (ISO)
T cell homeostasis  (ISO)
thymocyte apoptotic process  (ISO)
thymus development  (ISO)
tube formation  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Bcl2l11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247491,091,096 - 1,125,341 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247491,033,824 - 1,130,099 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
BCL2L11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382111,120,914 - 111,168,445 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2111,119,378 - 111,168,444 (+)EnsemblGRCh38hg38GRCh38
GRCh372111,878,491 - 111,926,022 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362111,594,962 - 111,642,493 (+)NCBINCBI36Build 36hg18NCBI36
Build 342111,597,540 - 111,640,814NCBI
Celera2105,529,086 - 105,576,607 (+)NCBICelera
Cytogenetic Map2q13NCBI
HuRef2104,757,646 - 104,805,166 (+)NCBIHuRef
CHM1_12111,882,732 - 111,930,286 (+)NCBICHM1_1
T2T-CHM13v2.02111,543,978 - 111,591,507 (+)NCBIT2T-CHM13v2.0
Bcl2l11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392127,967,958 - 128,004,467 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2127,967,958 - 128,004,467 (+)EnsemblGRCm39 Ensembl
GRCm382128,126,038 - 128,162,547 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2128,126,038 - 128,162,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv372127,951,774 - 127,988,283 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362127,817,479 - 127,853,613 (+)NCBIMGSCv36mm8
Celera2129,356,352 - 129,393,704 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.23NCBI
Bcl2l11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83135,820,042 - 135,857,330 (+)NCBIGRCr8
mRatBN7.23115,366,783 - 115,404,068 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3115,366,646 - 115,404,068 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3119,256,253 - 119,293,586 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03127,851,801 - 127,889,132 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03125,512,142 - 125,549,477 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03120,726,906 - 120,764,192 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3120,726,906 - 120,764,192 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03126,567,484 - 126,604,461 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43115,692,323 - 115,722,701 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13115,597,895 - 115,628,274 (+)NCBI
Celera3114,200,283 - 114,237,903 (+)NCBICelera
Cytogenetic Map3q36NCBI
Bcl2l11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554702,740,682 - 2,780,225 (-)NCBIChiLan1.0ChiLan1.0
BCL2L11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,914,260 - 16,961,753 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A16,917,024 - 16,964,367 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A90,862,070 - 90,909,833 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A112,337,927 - 112,385,079 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A112,337,927 - 112,385,079 (+)Ensemblpanpan1.1panPan2
BCL2L11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11735,619,804 - 35,665,782 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1735,619,582 - 35,664,587 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1735,391,228 - 35,441,388 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01736,397,661 - 36,447,779 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1736,397,342 - 36,445,321 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11735,515,071 - 35,565,168 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01735,589,049 - 35,639,236 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01735,800,089 - 35,850,247 (+)NCBIUU_Cfam_GSD_1.0
Bcl2l11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629281,122,091 - 81,156,497 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493678318,194 - 50,983 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493678315,493 - 50,959 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCL2L11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl345,160,155 - 45,201,186 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1345,156,791 - 45,202,996 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2347,180,506 - 47,223,992 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BCL2L11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11414,178,159 - 14,205,337 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660805,463,438 - 5,508,960 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004844321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013072106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013072114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021257971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021257972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021257973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021257974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021257975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021257976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021257977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021257978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021257979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021257980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021257981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021257982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021257983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021257984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021257985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021257986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021257987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01028917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01028918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01028919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GEBF01003172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JH171425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSHGLT00000011936   ⟹   ENSHGLP00000011807
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247491,091,096 - 1,125,341 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000011937   ⟹   ENSHGLP00000011808
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247491,091,096 - 1,125,341 (-)Ensembl
RefSeq Acc Id: ENSHGLT00000011938   ⟹   ENSHGLP00000011809
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247491,124,374 - 1,125,328 (-)Ensembl
RefSeq Acc Id: XM_004844321   ⟹   XP_004844378
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247491,083,947 - 1,128,020 (-)NCBI
RefSeq Acc Id: XM_013072106   ⟹   XP_012927560
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247491,083,947 - 1,130,099 (-)NCBI
RefSeq Acc Id: XM_013072114   ⟹   XP_012927568
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247491,083,947 - 1,126,462 (-)NCBI
RefSeq Acc Id: XM_021257971   ⟹   XP_021113630
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247491,083,947 - 1,128,957 (-)NCBI
RefSeq Acc Id: XM_021257972   ⟹   XP_021113631
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247491,094,606 - 1,129,313 (-)NCBI
RefSeq Acc Id: XM_021257973   ⟹   XP_021113632
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247491,094,606 - 1,129,312 (-)NCBI
RefSeq Acc Id: XM_021257974   ⟹   XP_021113633
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247491,083,947 - 1,128,207 (-)NCBI
RefSeq Acc Id: XM_021257975   ⟹   XP_021113634
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247491,033,824 - 1,128,999 (-)NCBI
RefSeq Acc Id: XM_021257976   ⟹   XP_021113635
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247491,090,781 - 1,128,217 (-)NCBI
RefSeq Acc Id: XM_021257977   ⟹   XP_021113636
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247491,083,947 - 1,128,235 (-)NCBI
RefSeq Acc Id: XM_021257978   ⟹   XP_021113637
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247491,083,947 - 1,128,960 (-)NCBI
RefSeq Acc Id: XM_021257979   ⟹   XP_021113638
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247491,085,212 - 1,128,962 (-)NCBI
RefSeq Acc Id: XM_021257980   ⟹   XP_021113639
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247491,094,606 - 1,129,320 (-)NCBI
RefSeq Acc Id: XM_021257981   ⟹   XP_021113640
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247491,090,781 - 1,128,193 (-)NCBI
RefSeq Acc Id: XM_021257982   ⟹   XP_021113641
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247491,083,947 - 1,125,983 (-)NCBI
RefSeq Acc Id: XM_021257983   ⟹   XP_021113642
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247491,090,781 - 1,128,205 (-)NCBI
RefSeq Acc Id: XM_021257984   ⟹   XP_021113643
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247491,083,947 - 1,125,756 (-)NCBI
RefSeq Acc Id: XM_021257985   ⟹   XP_021113644
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247491,083,947 - 1,128,020 (-)NCBI
RefSeq Acc Id: XM_021257986   ⟹   XP_021113645
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247491,083,947 - 1,125,756 (-)NCBI
RefSeq Acc Id: XM_021257987   ⟹   XP_021113646
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247491,083,947 - 1,128,020 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_021113634   ⟸   XM_021257975
- Peptide Label: isoform X5
RefSeq Acc Id: XP_012927560   ⟸   XM_013072106
- Peptide Label: isoform X15
RefSeq Acc Id: XP_021113637   ⟸   XM_021257978
- Peptide Label: isoform X8
RefSeq Acc Id: XP_021113630   ⟸   XM_021257971
- Peptide Label: isoform X1
RefSeq Acc Id: XP_021113636   ⟸   XM_021257977
- Peptide Label: isoform X7
RefSeq Acc Id: XP_021113633   ⟸   XM_021257974
- Peptide Label: isoform X4
RefSeq Acc Id: XP_021113646   ⟸   XM_021257987
- Peptide Label: isoform X17
RefSeq Acc Id: XP_021113644   ⟸   XM_021257985
- Peptide Label: isoform X16
RefSeq Acc Id: XP_004844378   ⟸   XM_004844321
- Peptide Label: isoform X15
RefSeq Acc Id: XP_012927568   ⟸   XM_013072114
- Peptide Label: isoform X12
RefSeq Acc Id: XP_021113641   ⟸   XM_021257982
- Peptide Label: isoform X13
RefSeq Acc Id: XP_021113645   ⟸   XM_021257986
- Peptide Label: isoform X16
RefSeq Acc Id: XP_021113643   ⟸   XM_021257984
- Peptide Label: isoform X15
RefSeq Acc Id: XP_021113638   ⟸   XM_021257979
- Peptide Label: isoform X9
RefSeq Acc Id: XP_021113635   ⟸   XM_021257976
- Peptide Label: isoform X6
- UniProtKB: G5BQZ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021113642   ⟸   XM_021257983
- Peptide Label: isoform X14
RefSeq Acc Id: XP_021113640   ⟸   XM_021257981
- Peptide Label: isoform X11
RefSeq Acc Id: XP_021113639   ⟸   XM_021257980
- Peptide Label: isoform X10
RefSeq Acc Id: XP_021113631   ⟸   XM_021257972
- Peptide Label: isoform X2
RefSeq Acc Id: XP_021113632   ⟸   XM_021257973
- Peptide Label: isoform X3
RefSeq Acc Id: ENSHGLP00000011809   ⟸   ENSHGLT00000011938
RefSeq Acc Id: ENSHGLP00000011807   ⟸   ENSHGLT00000011936
RefSeq Acc Id: ENSHGLP00000011808   ⟸   ENSHGLT00000011937


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000008457 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000011937 ENTREZGENE
  ENSHGLT00000084305 UniProtKB/TrEMBL
InterPro Apoptosis_Bim_N UniProtKB/TrEMBL
  Bcl-2-like_11 UniProtKB/TrEMBL
  Bcl-x_interacting_BH3_dom UniProtKB/TrEMBL
NCBI Gene Bcl2l11 ENTREZGENE
PANTHER BCL-2-LIKE PROTEIN 11 UniProtKB/TrEMBL
  BCL2 INTERACTING MEDIATOR OF CELL DEATH UniProtKB/TrEMBL
Pfam Bclx_interact UniProtKB/TrEMBL
  Bim_N UniProtKB/TrEMBL
PIRSF Bcl-2-like_p11 UniProtKB/TrEMBL
UniProt A0A0P6J9X4_HETGA UniProtKB/TrEMBL
  G5BQZ0 ENTREZGENE, UniProtKB/TrEMBL