Bcl2l11 (BCL2 like 11) - Rat Genome Database

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Gene: Bcl2l11 (BCL2 like 11) Chinchilla lanigera
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Symbol: Bcl2l11
Name: BCL2 like 11
RGD ID: 8759575
Description: ENCODES a protein that exhibits microtubule binding (ortholog); protein kinase binding (ortholog); INVOLVED IN apoptotic process involved in embryonic digit morphogenesis (ortholog); B cell homeostasis (ortholog); cell-matrix adhesion (ortholog); PARTICIPATES IN intrinsic apoptotic pathway; ASSOCIATED WITH Familial Prostate Cancer (ortholog); glomerulonephritis (ortholog); sclerosing cholangitis (ortholog); FOUND IN Bcl-2 family protein complex (ortholog); BIM-BCL-2 complex (ortholog); BIM-BCL-xl complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: bcl-2-like protein 11; BCL2-like 11 (apoptosis facilitator)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554702,740,682 - 2,780,225 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process involved in embryonic digit morphogenesis  (ISO)
B cell homeostasis  (ISO)
cell-matrix adhesion  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to estradiol stimulus  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
developmental pigmentation  (ISO)
ear development  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
in utero embryonic development  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (ISO)
kidney development  (ISO)
leukocyte homeostasis  (ISO)
lymphocyte apoptotic process  (ISO)
lymphocyte homeostasis  (ISO)
male gonad development  (ISO)
mammary gland development  (ISO)
myeloid cell homeostasis  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of autophagy in response to ER overload  (ISO)
positive regulation of cell cycle  (ISO)
positive regulation of fibroblast apoptotic process  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of lymphocyte apoptotic process  (ISO)
positive regulation of mitochondrial membrane permeability involved in apoptotic process  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of release of cytochrome c from mitochondria  (ISO)
positive regulation of T cell apoptotic process  (ISO)
post-embryonic development  (ISO)
regulation of apoptotic process  (ISO)
regulation of developmental pigmentation  (ISO)
regulation of organ growth  (ISO)
response to endoplasmic reticulum stress  (ISO)
spermatogenesis  (ISO)
spleen development  (ISO)
T cell apoptotic process  (ISO)
T cell homeostasis  (ISO)
thymocyte apoptotic process  (ISO)
thymus development  (ISO)
tube formation  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Bcl2l11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554702,740,682 - 2,780,225 (-)NCBIChiLan1.0ChiLan1.0
BCL2L11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382111,120,914 - 111,168,445 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2111,119,378 - 111,168,444 (+)EnsemblGRCh38hg38GRCh38
GRCh372111,878,491 - 111,926,022 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362111,594,962 - 111,642,493 (+)NCBINCBI36Build 36hg18NCBI36
Build 342111,597,540 - 111,640,814NCBI
Celera2105,529,086 - 105,576,607 (+)NCBICelera
Cytogenetic Map2q13NCBI
HuRef2104,757,646 - 104,805,166 (+)NCBIHuRef
CHM1_12111,882,732 - 111,930,286 (+)NCBICHM1_1
T2T-CHM13v2.02111,543,978 - 111,591,507 (+)NCBIT2T-CHM13v2.0
Bcl2l11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392127,967,958 - 128,004,467 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2127,967,958 - 128,004,467 (+)EnsemblGRCm39 Ensembl
GRCm382128,126,038 - 128,162,547 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2128,126,038 - 128,162,547 (+)EnsemblGRCm38mm10GRCm38
MGSCv372127,951,774 - 127,988,283 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362127,817,479 - 127,853,613 (+)NCBIMGSCv36mm8
Celera2129,356,352 - 129,393,704 (+)NCBICelera
Cytogenetic Map2F1NCBI
cM Map262.23NCBI
Bcl2l11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83135,820,042 - 135,857,330 (+)NCBIGRCr8
mRatBN7.23115,366,783 - 115,404,068 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3115,366,646 - 115,404,068 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3119,256,253 - 119,293,586 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03127,851,801 - 127,889,132 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03125,512,142 - 125,549,477 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03120,726,906 - 120,764,192 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3120,726,906 - 120,764,192 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03126,567,484 - 126,604,461 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43115,692,323 - 115,722,701 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13115,597,895 - 115,628,274 (+)NCBI
Celera3114,200,283 - 114,237,903 (+)NCBICelera
Cytogenetic Map3q36NCBI
BCL2L11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21216,914,260 - 16,961,753 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A16,917,024 - 16,964,367 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A90,862,070 - 90,909,833 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A112,337,927 - 112,385,079 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A112,337,927 - 112,385,079 (+)Ensemblpanpan1.1panPan2
BCL2L11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11735,619,804 - 35,665,782 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1735,619,582 - 35,664,587 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1735,391,228 - 35,441,388 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01736,397,661 - 36,447,779 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1736,397,342 - 36,445,321 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11735,515,071 - 35,565,168 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01735,589,049 - 35,639,236 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01735,800,089 - 35,850,247 (+)NCBIUU_Cfam_GSD_1.0
Bcl2l11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629281,122,091 - 81,156,497 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493678318,194 - 50,983 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493678315,493 - 50,959 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCL2L11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl345,160,155 - 45,201,186 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1345,156,791 - 45,202,996 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2347,180,506 - 47,223,992 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BCL2L11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11414,178,159 - 14,205,337 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660805,463,438 - 5,508,960 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcl2l11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247491,091,096 - 1,125,341 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247491,033,824 - 1,130,099 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: XM_013522758   ⟹   XP_013378212
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554702,770,337 - 2,780,225 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013522760   ⟹   XP_013378214
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554702,759,198 - 2,780,225 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013522761   ⟹   XP_013378215
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554702,740,682 - 2,780,225 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013522762   ⟹   XP_013378216
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554702,740,682 - 2,780,225 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013378212 (Get FASTA)   NCBI Sequence Viewer  
  XP_013378214 (Get FASTA)   NCBI Sequence Viewer  
  XP_013378215 (Get FASTA)   NCBI Sequence Viewer  
  XP_013378216 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000006627.1
  ENSCLAP00000006628.1
  ENSCLAP00000006629.1
RefSeq Acc Id: XP_013378216   ⟸   XM_013522762
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_013378215   ⟸   XM_013522761
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013378214   ⟸   XM_013522760
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013378212   ⟸   XM_013522758
- Peptide Label: isoform X1
- Sequence:

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000004675 UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000006737.1 UniProtKB/TrEMBL
  ENSCLAT00000006738.1 UniProtKB/TrEMBL
  ENSCLAT00000006739.1 UniProtKB/TrEMBL
InterPro Apoptosis_Bim_N UniProtKB/TrEMBL
  Bcl-x_interacting_BH3_dom UniProtKB/TrEMBL
NCBI Gene Bcl2l11 ENTREZGENE
PANTHER BCL-2-LIKE PROTEIN 11 UniProtKB/TrEMBL
  BCL2 INTERACTING MEDIATOR OF CELL DEATH UniProtKB/TrEMBL
Pfam Bclx_interact UniProtKB/TrEMBL
  Bim_N UniProtKB/TrEMBL
UniProt A0A8C2UYE1_CHILA UniProtKB/TrEMBL
  A0A8C2UZN9_CHILA UniProtKB/TrEMBL
  A0A8C2V242_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Bcl2l11  BCL2 like 11    BCL2-like 11 (apoptosis facilitator)  Symbol and/or name change 5135510 APPROVED