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ONTOLOGY REPORT - ANNOTATIONS

Term:cellular response to interleukin-6
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Accession:GO:0071354 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-6 stimulus.
Synonyms:exact_synonym: cellular response to IL-6


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cellular response to interleukin-6 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07054614.1 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107
G Abcc2 ATP binding cassette subfamily C member 2 IEP RGD PMID:20702406 RGD:11081005 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Aqp4 aquaporin 4 IEP RGD PMID:22449442 RGD:8695996 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856 		JBrowse link
G Camp cathelicidin antimicrobial peptide IEP RGD PMID:19879657 RGD:2316237 NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 IEP RGD PMID:8921263 RGD:8549522 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Cfi complement factor I IEP RGD PMID:11530941 RGD:8662322 NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561 		JBrowse link
G Cfl1 cofilin 1 IDA RGD PMID:24760020 RGD:11570414 NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587 		JBrowse link
G Cripto cripto, EGF-CFC family member involved_in ISO (PMID:17720976) RGD PMID:17720976 NCBI chr 8:110,924,774...110,938,545
Ensembl chr 8:110,925,024...110,930,308 		JBrowse link
G Crp C-reactive protein IEP RGD PMID:20100497 RGD:9586010 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Entpd2 ectonucleoside triphosphate diphosphohydrolase 2 IMP RGD PMID:18202114 RGD:9685526 NCBI chr 3:8,213,575...8,219,094
Ensembl chr 3:8,213,663...8,226,866 		JBrowse link
G Fcar Fc alpha receptor involved_in ISO (PMID:25339672) RGD PMID:25339672 NCBI chr 1:69,626,458...69,660,558 JBrowse link
G Fga fibrinogen alpha chain IEP RGD PMID:9488469 RGD:9685026 NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528 		JBrowse link
G Fgf23 fibroblast growth factor 23 IEP RGD PMID:23263654 RGD:10044209 NCBI chr 4:159,914,267...159,923,821
Ensembl chr 4:159,914,272...159,923,821 		JBrowse link
G Fgg fibrinogen gamma chain IEP RGD PMID:11071643 RGD:731198 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322 		JBrowse link
G Ghrh growth hormone releasing hormone IEP RGD PMID:19239705 RGD:5687170 NCBI chr 3:145,992,762...146,012,528
Ensembl chr 3:145,992,763...146,011,889 		JBrowse link
G Hamp hepcidin antimicrobial peptide IEP RGD PMID:23506423 RGD:11041627 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891 		JBrowse link
G Icam1 intercellular adhesion molecule 1 IEP RGD PMID:7865494 RGD:11520781 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Lcn2 lipocalin 2 IEP RGD PMID:22249220 RGD:126781756 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase IEP RGD PMID:8853431 RGD:70321 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mir125a microRNA 125a IEP RGD PMID:29700287 RGD:26884455 NCBI chr 1:58,677,626...58,677,710
Ensembl chr 1:58,677,626...58,677,710 		JBrowse link
G Mir125b1 microRNA 125b-1 involved_in ISO (PMID:20347935) RGD PMID:20347935 NCBI chr 8:41,952,966...41,953,052
Ensembl chr 8:41,952,966...41,953,052 		JBrowse link
G Mir125b2 microRNA 125b-2 involved_in ISO (PMID:20347935) RGD PMID:20347935 NCBI chr11:16,245,620...16,245,707 JBrowse link
G Mir155 microRNA 155 acts_upstream_of_or_within ISO (PMID:24391219) RGD PMID:24391219 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir21 microRNA 21 acts_upstream_of_or_within ISO (PMID:24391219) RGD PMID:24391219 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Myb MYB proto-oncogene, transcription factor acts_upstream_of_or_within ISO (PMID:16162816) RGD PMID:16162816 NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 involved_in ISO
IEA		 (PMID:22357537)
GO_REF:0000107		 RGD
Ensembl		 PMID:22357537 GO_REF:0000107 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Phb1 prohibitin 1 involved_in ISO (PMID:17324931) RGD PMID:17324931 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042 		JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 involved_in ISO (MGI:5308004|PMID:19894142) RGD PMID:19894142 MGI:5308004 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha IEP RGD PMID:23692924 RGD:10059632 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ptgis prostaglandin I2 synthase involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:8185632)		 UniProt
Ensembl
RGD		 PMID:8185632 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451 		JBrowse link
G Ptprt protein tyrosine phosphatase, receptor type, T involved_in ISO (PMID:17360477) RGD PMID:17360477 NCBI chr 3:150,189,343...151,288,145
Ensembl chr 3:150,194,859...151,288,124 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit involved_in ISO (PMID:22357537) RGD PMID:22357537 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Sbno2 strawberry notch homolog 2 involved_in ISO
IBA		 (PMID:25903009)
GO_REF:0000033
(MGI:5660440|PMID:25903009)		 RGD
GO_Central		 PMID:25903009 GO_REF:0000033 MGI:5660440 NCBI chr 7:9,605,572...9,649,529
Ensembl chr 7:9,605,627...9,649,527 		JBrowse link
G Selplg selectin P ligand acts_upstream_of_or_within ISO (PMID:9486531) RGD PMID:9486531 NCBI chr12:42,796,690...42,809,908
Ensembl chr12:42,796,580...42,812,585 		JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N IEP RGD PMID:8611141 RGD:5147422 NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433 		JBrowse link
G St3gal6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:17944600)		 UniProt
Ensembl
RGD		 PMID:17944600 GO_REF:0000024 GO_REF:0000107 NCBI chr11:42,061,282...42,121,801
Ensembl chr11:42,077,621...42,121,776 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 IEP RGD PMID:25484256 RGD:151893491 NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839 		JBrowse link
G Traf7 TNF receptor associated factor 7 acts_upstream_of_or_within ISO (PMID:16162816) RGD PMID:16162816 NCBI chr10:13,533,570...13,552,290
Ensembl chr10:13,533,570...13,552,203 		JBrowse link
interleukin-6-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cebpa CCAAT/enhancer binding protein alpha involved_in ISO (PMID:24429361) RGD PMID:24429361 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Ctr9 CTR9 homolog, Paf1/RNA polymerase II complex component involved_in ISO (MGI:5319608|PMID:17911113) RGD PMID:17911113 MGI:5319608 NCBI chr 1:165,137,277...165,167,303
Ensembl chr 1:165,137,215...165,167,303 		JBrowse link
G Fer FER tyrosine kinase involved_in ISO (PMID:19147545) RGD PMID:19147545 NCBI chr 9:103,520,452...103,827,364
Ensembl chr 9:103,520,493...103,821,451 		JBrowse link
G Gab1 GRB2-associated binding protein 1 acts_upstream_of_or_within ISO MGI:1926435 (PMID:10779359) RGD PMID:10779359 NCBI chr19:27,131,262...27,239,236
Ensembl chr19:27,131,262...27,239,236 		JBrowse link
G Il6 interleukin 6 involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
(PMID:1312474)
(PMID:12552091), (PMID:12829785), (PMID:16946298), (PMID:30670152), (PMID:31145836)
(MGI:3769957|PMID:16330325), (MGI:6142555|PMID:27893700), (MGI:84432|PMID:8910279)		 UniProt
RGD		 PMID:1312474 PMID:8910279 PMID:12552091 PMID:12829785 PMID:16330325 More... GO_REF:0000024 MGI:3769957 MGI:6142555 MGI:84432 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il6r interleukin 6 receptor involved_in
acts_upstream_of_or_within		 ISS
ISO
IBA
IEA		 GO_REF:0000024
(PMID:1312474)
GO_REF:0000033
(PMID:31145836)
(PMID:12829785)
GO_REF:0000107
(MGI:6142555|PMID:27893700)
(PMID:12643274)		 UniProt
RGD
GO_Central
Ensembl		 PMID:1312474 PMID:12643274 PMID:12829785 PMID:27893700 PMID:31145836 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:6142555 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536 		JBrowse link
G Il6st interleukin 6 cytokine family signal transducer involved_in IMP
ISO
IEA		 (PMID:12643274), (PMID:12829785), (PMID:2261637), (PMID:25731159)
GO_REF:0000107
(MGI:5629863|PMID:25731159)		 RGD
Ensembl		 PMID:2261637 PMID:12643274 PMID:12829785 PMID:25731159 PMID:18280048 GO_REF:0000107 MGI:5629863, RGD:5686900 NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936 		JBrowse link
G Jak1 Janus kinase 1 involved_in ISO (PMID:8272873) RGD PMID:8272873 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926 		JBrowse link
G Smad4 SMAD family member 4 involved_in ISO
IEA		 (MGI:3769957|PMID:16330325)
GO_REF:0000107		 RGD
Ensembl		 PMID:16330325 GO_REF:0000107 MGI:3769957 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Spi1 Spi-1 proto-oncogene involved_in ISO
IEA		 (PMID:24429361)
GO_REF:0000107		 RGD
Ensembl		 PMID:24429361 GO_REF:0000107 NCBI chr 3:77,059,744...77,093,730
Ensembl chr 3:77,073,012...77,092,393 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO (PMID:25731159)
(MGI:5629863|PMID:25731159)		 RGD PMID:25731159 MGI:5629863 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G St18 ST18 C2H2C-type zinc finger transcription factor involved_in ISO
IEA		 (PMID:18676404)
GO_REF:0000107		 RGD
Ensembl		 PMID:18676404 GO_REF:0000107 NCBI chr 5:12,582,493...12,914,221
Ensembl chr 5:12,584,110...12,671,790 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:12359225), (PMID:12552091), (PMID:16285960), (PMID:16835372), (PMID:16946298), (PMID:17324931), (PMID:24429361)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:12359225 PMID:12552091 PMID:16285960 PMID:16835372 PMID:16946298 More... GO_REF:0000024 GO_REF:0000107 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tut4 terminal uridylyl transferase 4 involved_in ISO (MGI:4365679|PMID:19701194) RGD PMID:19701194 MGI:4365679 NCBI chr 5:123,201,723...123,306,582
Ensembl chr 5:123,203,003...123,306,465 		JBrowse link
G Yap1 Yes1 associated transcriptional regulator involved_in ISO
IEA		 (MGI:5629863|PMID:25731159)
GO_REF:0000107		 RGD
Ensembl		 PMID:25731159 GO_REF:0000107 MGI:5629863 NCBI chr 8:5,095,705...5,166,808
Ensembl chr 8:5,095,722...5,167,010 		JBrowse link
negative regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6st interleukin 6 cytokine family signal transducer involved_in ISO (PMID:8353278) RGD PMID:8353278 NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936 		JBrowse link
G Mir125a microRNA 125a acts_upstream_of_or_within ISO UniProtKB:P05231 (PMID:30670152) RGD PMID:30670152 NCBI chr 1:58,677,626...58,677,710
Ensembl chr 1:58,677,626...58,677,710 		JBrowse link
G Mir125b1 microRNA 125b-1 involved_in ISO (PMID:26455324) RGD PMID:26455324 NCBI chr 8:41,952,966...41,953,052
Ensembl chr 8:41,952,966...41,953,052 		JBrowse link
G Mir125b2 microRNA 125b-2 involved_in ISO (PMID:26455324) RGD PMID:26455324 NCBI chr11:16,245,620...16,245,707 JBrowse link
G Mir26a microRNA 26a involved_in ISO (PMID:23389848) RGD PMID:23389848 NCBI chr 8:118,755,289...118,755,378
Ensembl chr 8:118,755,289...118,755,378 		JBrowse link
G Mir98 microRNA 98 involved_in ISO UniProtKB:P05231 (PMID:26587789), (PMID:31886314) RGD PMID:26587789 PMID:31886314 NCBI chr  X:20,981,235...20,981,342
Ensembl chr  X:20,981,235...20,981,342 		JBrowse link
G Mir99a microRNA 99a involved_in ISO (PMID:26455324) RGD PMID:26455324 NCBI chr11:16,200,443...16,200,523
Ensembl chr11:16,200,443...16,200,523 		JBrowse link
G Mirlet7a1 microRNA let-7a-1 involved_in ISO (PMID:19878981) RGD PMID:19878981 NCBI chr17:16,113,766...16,113,859
Ensembl chr17:16,113,768...16,113,867 		JBrowse link
G Mirlet7c1 microRNA let-7c-1 involved_in ISO (PMID:26455324) RGD PMID:26455324 NCBI chr11:16,201,163...16,201,256
Ensembl chr11:16,201,158...16,201,265 		JBrowse link
G Mirlet7c2 microRNA let7c-2 involved_in ISO (PMID:19878981) RGD PMID:19878981 NCBI chr 7:116,803,771...116,803,865
Ensembl chr 7:116,803,771...116,803,865 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in ISO
IEA
ISS		 (PMID:12359225)
GO_REF:0000107
(MGI:4941441|PMID:20484139)
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:12359225 PMID:20484139 GO_REF:0000024 GO_REF:0000107 MGI:4941441 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627 		JBrowse link
positive regulation of interleukin-6-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qtnf4 C1q and TNF related 4 involved_in ISO (PMID:21658842) RGD PMID:21658842 NCBI chr 3:76,854,368...76,872,991
Ensembl chr 3:76,857,735...76,874,139 		JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor involved_in ISO
IEA		 (PMID:11060035)
GO_REF:0000107		 RGD
Ensembl		 PMID:11060035 GO_REF:0000107 NCBI chr14:2,040,576...2,056,874
Ensembl chr14:2,042,434...2,051,814 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISO (PMID:31827280)
(MGI:6401044|PMID:31827281)		 RGD PMID:31827280 PMID:31827281 MGI:6401044 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    response to stimulus 10511
      response to chemical 5851
        response to peptide 1236
          response to cytokine 1212
            cellular response to cytokine stimulus 1076
              cellular response to interleukin-6 63
                interleukin-6-mediated signaling pathway + 28
paths to the root