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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:toll-like receptor 3 signaling pathway
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Accession:GO:0034138 term browser browse the term
Definition:The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 3.
Synonyms:exact_synonym: TLR3 signaling pathway;   toll-like receptor 3 signalling pathway


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toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD86 CD86 molecule involved_in ISO (MGI:5645190|PMID:25158758) UniProt PMID:25158758 MGI:5645190 NCBI chr13:138,427,573...138,504,307
Ensembl chr13:138,427,533...138,504,310 		JBrowse link
G COLEC12 collectin subfamily member 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:105,808,157...106,000,197
Ensembl chr 6:105,808,221...106,007,730 		JBrowse link
G HAVCR2 hepatitis A virus cellular receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:66,138,157...66,160,568
Ensembl chr16:66,139,535...66,160,538 		JBrowse link
G LGALS9 galectin 9 involved_in ISO PMID:25158758 UniProt PMID:25158758 RGD:10054077 NCBI chr12:44,155,079...44,173,634 JBrowse link
G OAS1 2'-5'-oligoadenylate synthetase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:38,851,083...38,867,427
Ensembl chr14:38,851,918...38,859,409 		JBrowse link
G RFTN1 raftlin, lipid raft linker 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:21266579) MGI
Ensembl		 PMID:21266579 GO_REF:0000107 NCBI chr13:3,454,448...3,675,072
Ensembl chr13:3,454,454...3,674,998 		JBrowse link
G SCARA3 scavenger receptor class A member 3 NOT|involved_in ISO (PMID:25204797) UniProt PMID:25204797 NCBI chr14:11,367,402...11,403,173
Ensembl chr14:11,367,427...11,410,978 		JBrowse link
G SCIMP SLP adaptor and CSK interacting membrane protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:51,772,635...51,794,107
Ensembl chr12:51,773,448...51,794,104 		JBrowse link
G TICAM1 TIR domain containing adaptor molecule 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:74,004,566...74,021,100
Ensembl chr 2:74,004,308...74,021,873 		JBrowse link
G TLR3 toll like receptor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:46,966,262...46,977,774
Ensembl chr15:46,969,006...46,979,291 		JBrowse link
G TNF tumor necrosis factor involved_in ISO PMID:25158758 UniProt PMID:25158758 RGD:10054077 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
G TNIP2 TNFAIP3 interacting protein 2 involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 8:1,530,534...1,554,677
Ensembl chr 8:1,533,429...1,554,683 		JBrowse link
G UNC93B1 unc-93 homolog B1, TLR signaling regulator involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:4,898,414...4,909,833
Ensembl chr 2:4,898,409...4,909,856 		JBrowse link
negative regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2RL1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:85,732,082...85,747,552
Ensembl chr 2:85,732,189...85,750,858 		JBrowse link
G RNF170 ring finger protein 170 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:11,777,942...11,817,920
Ensembl chr17:11,780,129...11,816,049 		JBrowse link
G TNFAIP3 TNF alpha induced protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:26,474,158...26,489,771
Ensembl chr 1:26,473,938...26,489,822 		JBrowse link
G UBQLN1 ubiquilin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:31,275,916...31,317,521
Ensembl chr10:31,275,868...31,317,516 		JBrowse link
positive regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV1 caveolin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465 		JBrowse link
G F2RL1 F2R like trypsin receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:85,732,082...85,747,552
Ensembl chr 2:85,732,189...85,750,858 		JBrowse link
G FLOT1 flotillin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:23,253,157...23,265,165
Ensembl chr 7:23,253,162...23,265,106 		JBrowse link
G PELI1 pellino E3 ubiquitin protein ligase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19734906) Ensembl
MGI		 PMID:19734906 GO_REF:0000107 NCBI chr 3:77,740,460...77,796,911
Ensembl chr 3:77,713,489...77,796,914 		JBrowse link
G PTPN22 protein tyrosine phosphatase non-receptor type 22 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:106,692,102...106,758,101
Ensembl chr 4:106,686,604...106,758,099 		JBrowse link
G TIRAP TIR domain containing adaptor protein involved_in ISO (MGI:4943396|PMID:17322885) BHF-UCL PMID:17322885 MGI:4943396 NCBI chr 9:53,374,559...53,394,172
Ensembl chr 9:53,375,644...53,394,165 		JBrowse link
G TRIM3 tripartite motif containing 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:3,256,915...3,281,846
Ensembl chr 9:3,272,798...3,282,366 		JBrowse link
G WDFY1 WD repeat and FYVE domain containing 1 involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr15:125,674,142...125,720,187
Ensembl chr15:125,669,842...125,720,158 		JBrowse link
regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FLOT2 flotillin 2 NOT|involved_in ISO (PMID:25204797) UniProt PMID:25204797 NCBI chr12:45,102,205...45,120,503
Ensembl chr12:45,101,531...45,120,455 		JBrowse link
G HCFC2 host cell factor C2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:28970238) Ensembl
MGI		 PMID:28970238 GO_REF:0000107 NCBI chr 5:80,366,826...80,409,798
Ensembl chr 5:80,368,240...80,409,775 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:40,470,970...40,524,862
Ensembl chr17:40,471,009...40,524,860 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17805
    cellular process 16826
      signal transduction 6963
        intracellular receptor signaling pathway 372
          cytoplasmic pattern recognition receptor signaling pathway 167
            endolysosomal toll-like receptor signaling pathway 48
              toll-like receptor 3 signaling pathway 27
                negative regulation of toll-like receptor 3 signaling pathway 4
                positive regulation of toll-like receptor 3 signaling pathway 8
                regulation of toll-like receptor 3 signaling pathway + 14
Path 2
Term Annotations click to browse term
  biological_process 17805
    response to stimulus 10056
      response to biotic stimulus 1716
        response to external biotic stimulus 1673
          response to other organism 1669
            defense response to other organism 1151
              defense response to symbiont 1034
                innate immune response 837
                  regulation of innate immune response 425
                    positive regulation of innate immune response 351
                      activation of innate immune response 287
                        innate immune response-activating signaling pathway 266
                          pattern recognition receptor signaling pathway 256
                            cytoplasmic pattern recognition receptor signaling pathway 167
                              endolysosomal toll-like receptor signaling pathway 48
                                toll-like receptor 3 signaling pathway 27
                                  negative regulation of toll-like receptor 3 signaling pathway 4
                                  positive regulation of toll-like receptor 3 signaling pathway 8
                                  regulation of toll-like receptor 3 signaling pathway + 14
paths to the root