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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:toll-like receptor 3 signaling pathway
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Accession:GO:0034138 term browser browse the term
Definition:The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 3.
Synonyms:exact_synonym: TLR3 signaling pathway;   toll-like receptor 3 signalling pathway


show annotations for term's descendants           Sort by:
toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd86 CD86 antigen involved_in IMP (MGI:5645190|PMID:25158758) UniProt PMID:25158758 MGI:5645190 NCBI chr16:36,389,318...36,486,439
Ensembl chr16:36,424,231...36,486,443 		JBrowse link
G Colec12 collectin sub-family member 12 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr18:9,707,648...9,877,995
Ensembl chr18:9,707,595...9,882,644 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 involved_in IMP (MGI:5437532|PMID:22842346) UniProt PMID:22842346 MGI:5437532 NCBI chr11:46,345,758...46,372,082
Ensembl chr11:46,345,762...46,372,082 		JBrowse link
G Irf1 interferon regulatory factor 1 acts_upstream_of_or_within ISO (PMID:28970238) MGI PMID:28970238 NCBI chr11:53,660,841...53,669,200
Ensembl chr11:53,660,841...53,669,200 		JBrowse link
G Irf2 interferon regulatory factor 2 acts_upstream_of_or_within ISO (PMID:28970238) MGI PMID:28970238 NCBI chr 8:47,192,751...47,300,493
Ensembl chr 8:47,192,767...47,300,493 		JBrowse link
G Lgals9 lectin, galactose binding, soluble 9 involved_in ISO PMID:25158758 UniProt PMID:25158758 RGD:10054077 NCBI chr11:78,853,805...78,875,750
Ensembl chr11:78,853,800...78,875,772 		JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:121,034,319...121,045,588
Ensembl chr 5:121,034,319...121,045,584 		JBrowse link
G Oas1b 2'-5' oligoadenylate synthetase 1B involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:120,950,700...120,962,228
Ensembl chr 5:120,950,700...120,962,228 		JBrowse link
G Oas1c 2'-5' oligoadenylate synthetase 1C involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:120,938,259...120,950,605
Ensembl chr 5:120,938,259...120,950,579 		JBrowse link
G Oas1d 2'-5' oligoadenylate synthetase 1D involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:121,052,881...121,059,711
Ensembl chr 5:121,052,599...121,059,715 		JBrowse link
G Oas1e 2'-5' oligoadenylate synthetase 1E involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:120,924,377...120,933,595
Ensembl chr 5:120,924,291...120,933,595 		JBrowse link
G Oas1f 2'-5' oligoadenylate synthetase 1F involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:120,985,432...120,996,049
Ensembl chr 5:120,985,432...120,996,049 		JBrowse link
G Oas1g 2'-5' oligoadenylate synthetase 1G involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:121,014,205...121,025,676
Ensembl chr 5:121,014,205...121,025,676 		JBrowse link
G Oas1h 2'-5' oligoadenylate synthetase 1H involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:120,999,485...121,011,569
Ensembl chr 5:120,999,484...121,011,569 		JBrowse link
G Rftn1 raftlin lipid raft linker 1 acts_upstream_of_or_within ISO (PMID:21266579) MGI PMID:21266579 NCBI chr17:50,300,287...50,497,525
Ensembl chr17:50,299,285...50,497,702 		JBrowse link
G Scara3 scavenger receptor class A, member 3 NOT|involved_in ISO (PMID:25204797) UniProt PMID:25204797 NCBI chr14:66,156,844...66,191,427
Ensembl chr14:66,156,843...66,191,384 		JBrowse link
G Scimp SLP adaptor and CSK interacting membrane protein involved_in IMP (MGI:5913054|PMID:28098138) UniProt PMID:28098138 MGI:5913054 NCBI chr11:70,681,758...70,703,387
Ensembl chr11:70,681,758...70,703,412 		JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr17:56,576,462...56,583,767
Ensembl chr17:56,576,319...56,583,786 		JBrowse link
G Tlr3 toll-like receptor 3 involved_in
acts_upstream_of_or_within		 ISO (PMID:28970238) MGI PMID:28970238 GO_REF:0000119 MGI:4834177 NCBI chr 8:45,848,702...45,864,112
Ensembl chr 8:45,848,702...45,864,117 		JBrowse link
G Tnf tumor necrosis factor involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnip2 TNFAIP3 interacting protein 2 involved_in IMP
IBA		 (MGI:3656197|PMID:16633345) UniProt
GO_Central		 PMID:16633345 GO_REF:0000033 MGI:3656197 NCBI chr 5:34,653,440...34,671,323
Ensembl chr 5:34,653,431...34,671,335 		JBrowse link
G Unc93b1 unc-93 homolog B1, TLR signaling regulator involved_in IMP
IBA
ISO		 (MGI:3615690|PMID:16415873) UniProt
GO_Central
MGI		 PMID:16415873 GO_REF:0000033 GO_REF:0000119 MGI:3615690 MGI:4834177 NCBI chr19:3,985,222...3,999,340
Ensembl chr19:3,985,186...3,999,340 		JBrowse link
negative regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2rl1 F2R like trypsin receptor 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:95,648,226...95,661,748
Ensembl chr13:95,648,240...95,661,735 		JBrowse link
G Rnf170 ring finger protein 170 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 8:26,609,396...26,633,903
Ensembl chr 8:26,609,396...26,641,818 		JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405 		JBrowse link
G Ubqln1 ubiquilin 1 involved_in IMP (MGI:5619743|PMID:21695056) CACAO PMID:21695056 MGI:5619743 NCBI chr13:58,323,970...58,363,467
Ensembl chr13:58,323,970...58,363,467 		JBrowse link
positive regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav1 caveolin 1, caveolae protein involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:95,648,226...95,661,748
Ensembl chr13:95,648,240...95,661,735 		JBrowse link
G Flot1 flotillin 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr17:36,134,243...36,143,674
Ensembl chr17:36,134,122...36,143,683 		JBrowse link
G Peli1 pellino 1 acts_upstream_of_or_within IMP (PMID:19734906) MGI PMID:19734906 NCBI chr11:21,041,283...21,100,327
Ensembl chr11:21,041,291...21,100,323 		JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) involved_in IMP
ISO		 (MGI:5562517|PMID:23871208) UniProt
MGI		 PMID:23871208 GO_REF:0000119 MGI:4834177 MGI:5562517 NCBI chr 3:103,763,891...103,819,568
Ensembl chr 3:103,767,111...103,819,563 		JBrowse link
G Tirap toll-interleukin 1 receptor (TIR) domain-containing adaptor protein involved_in IDA (MGI:4943396|PMID:17322885) BHF-UCL PMID:17322885 MGI:4943396 NCBI chr 9:35,095,687...35,111,587
Ensembl chr 9:35,095,847...35,111,587 		JBrowse link
G Trim3 tripartite motif-containing 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:105,253,670...105,282,805
Ensembl chr 7:105,253,670...105,282,778 		JBrowse link
G Wdfy1 WD repeat and FYVE domain containing 1 involved_in IMP
ISO
IBA		 (MGI:5688815|PMID:25736436) UniProt
MGI
GO_Central		 PMID:25736436 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:5688815 NCBI chr 1:79,679,979...79,753,764
Ensembl chr 1:79,679,979...79,753,860 		JBrowse link
regulation of toll-like receptor 3 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Flot2 flotillin 2 NOT|involved_in ISO (PMID:25204797) UniProt PMID:25204797 NCBI chr11:77,928,757...77,951,260
Ensembl chr11:77,928,757...77,951,260 		JBrowse link
G Hcfc2 host cell factor C2 acts_upstream_of_or_within IMP (PMID:28970238) MGI PMID:28970238 NCBI chr10:82,534,841...82,631,699
Ensembl chr10:82,531,994...82,578,262 		JBrowse link
G Src Rous sarcoma oncogene involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:157,265,828...157,313,758
Ensembl chr 2:157,260,364...157,313,782 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28577
    cellular process 17497
      signal transduction 6663
        intracellular receptor signaling pathway 372
          cytoplasmic pattern recognition receptor signaling pathway 186
            endolysosomal toll-like receptor signaling pathway 58
              toll-like receptor 3 signaling pathway 36
                negative regulation of toll-like receptor 3 signaling pathway 4
                positive regulation of toll-like receptor 3 signaling pathway 8
                regulation of toll-like receptor 3 signaling pathway + 14
Path 2
Term Annotations click to browse term
  biological_process 28577
    response to stimulus 10767
      response to biotic stimulus 2060
        response to external biotic stimulus 2016
          response to other organism 2013
            defense response to other organism 1411
              defense response to symbiont 1281
                innate immune response 1079
                  regulation of innate immune response 501
                    positive regulation of innate immune response 409
                      activation of innate immune response 332
                        innate immune response-activating signaling pathway 295
                          pattern recognition receptor signaling pathway 284
                            cytoplasmic pattern recognition receptor signaling pathway 186
                              endolysosomal toll-like receptor signaling pathway 58
                                toll-like receptor 3 signaling pathway 36
                                  negative regulation of toll-like receptor 3 signaling pathway 4
                                  positive regulation of toll-like receptor 3 signaling pathway 8
                                  regulation of toll-like receptor 3 signaling pathway + 14
paths to the root