Oas1a (2'-5' oligoadenylate synthetase 1A)

Gene: Oas1a (2'-5' oligoadenylate synthetase 1A) Mus musculus

Analyze

No known orthologs.

Symbol:

Oas1a

Name:

2'-5' oligoadenylate synthetase 1A

RGD ID:

1557930

MGI Page

MGI

Description:

Enables 2'-5'-oligoadenylate synthetase activity and double-stranded RNA binding activity. Involved in purine nucleotide biosynthetic process. Acts upstream of or within negative regulation of viral process. Predicted to be located in mitochondrion; nucleus; and ribosome. Predicted to be active in cytosol; membrane; and nucleoplasm. Predicted to colocalize with cytoplasm. Is expressed in appendicular skeleton; axial skeleton; lower jaw; and testis. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human OAS1 (2'-5'-oligoadenylate synthetase 1).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

(2-5')oligo(A) synthase 1A; (2-5')oligo(A) synthetase 1A; 2'-5'-oligoadenylate synthase 1A; 2-5A synthase 1A; 2-5A synthetase 1A; L; L3; p42 OAS

RGD Orthologs

Alliance Orthologs

More Info

homologs ...

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	121,034,319 - 121,045,588 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	121,034,319 - 121,045,584 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	120,896,256 - 120,907,544 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	120,896,256 - 120,907,521 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	121,346,265 - 121,357,534 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	121,156,873 - 121,168,124 (-)	NCBI		MGSCv36	mm8
Celera	5	117,982,508 - 117,993,776 (-)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	60.65	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chemical and Drug Induced Liver Injury (EXP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(2,4,5-trichlorophenoxy)acetic acid (EXP)

1,2-dimethylhydrazine (EXP)

17alpha-ethynylestradiol (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

3-methylcholanthrene (EXP)

4,4'-diaminodiphenylmethane (EXP)

4-hydroxynon-2-enal (EXP)

aflatoxin B1 (EXP)

aldehydo-D-glucose (EXP)

all-trans-retinoic acid (EXP)

aluminium atom (EXP)

aluminium(0) (EXP)

benzo[a]pyrene (EXP)

bisphenol A (EXP)

cadmium atom (EXP)

cadmium dichloride (EXP)

carbon nanotube (EXP)

carnosic acid (EXP)

chlordecone (EXP)

cholesterol (EXP)

cyclosporin A (EXP)

D-glucose (EXP)

dibenz[a,h]anthracene (EXP)

doxorubicin (EXP)

fructose (EXP)

Genipin (EXP)

genistein (EXP)

glucose (EXP)

glyphosate (EXP)

inulin (EXP)

lipopolysaccharide (EXP)

metam (EXP)

mono(2-ethylhexyl) phthalate (EXP)

ozone (EXP)

pentachlorophenol (EXP)

perfluorooctane-1-sulfonic acid (EXP)

phorbol 13-acetate 12-myristate (EXP)

pirinixic acid (EXP)

progesterone (EXP)

silicon dioxide (EXP)

succimer (EXP)

tamoxifen (EXP)

tetrachloromethane (EXP)

titanium dioxide (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antiviral innate immune response (ISO)

cellular response to interferon-alpha (ISO)

cellular response to interferon-beta (ISO)

defense response to bacterium (ISO)

defense response to virus (IBA,ISO)

glucose homeostasis (ISO)

glucose metabolic process (ISO)

negative regulation of chemokine (C-X-C motif) ligand 2 production (ISO)

negative regulation of IP-10 production (ISO)

negative regulation of type I interferon-mediated signaling pathway (ISO)

negative regulation of viral genome replication (IBA,ISO)

negative regulation of viral process (IDA)

positive regulation of cellular respiration (ISO)

positive regulation of interferon-beta production (ISO)

positive regulation of monocyte chemotactic protein-1 production (ISO)

positive regulation of tumor necrosis factor production (ISO)

protein complex oligomerization (ISO)

purine nucleotide biosynthetic process (IDA)

response to virus (ISO,TAS)

surfactant homeostasis (ISO)

toll-like receptor 3 signaling pathway (ISO)

toll-like receptor 4 signaling pathway (ISO)

type I interferon-mediated signaling pathway (ISO)

Cellular Component

cytoplasm (ISO)

cytosol (IBA,ISO)

membrane (IBA)

mitochondrion (ISO)

nucleoplasm (IBA,ISO)

nucleus (ISO)

ribosome (ISO)

Molecular Function

2'-5'-oligoadenylate synthetase activity (IBA,IDA,ISO)

double-stranded RNA binding (IBA,IDA,ISO)

protein binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

hepatitis C pathway (IEA)

influenza A pathway (IEA)

measles pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Gene structure of the murine 2'-5'-oligoadenylate synthetase family.	Eskildsen S, etal., Cell Mol Life Sci 2002 Jul;59(7):1212-22.
2.	Structural and functional genomics and evolutionary relationships in the cluster of genes encoding murine 2',5'-oligoadenylate synthetases.	Mashimo T, etal., Genomics 2003 Nov;82(5):537-52.
3.	MGDs mouse GO annotations	MGD data from the GO Consortium
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	Positional cloning of the murine flavivirus resistance gene.	Perelygin AA, etal., Proc Natl Acad Sci U S A 2002 Jul 9;99(14):9322-7. Epub 2002 Jun 21.
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:1709495	PMID:2171206	PMID:3808949	PMID:10349636	PMID:10834841	PMID:11042159	PMID:11076861	PMID:11217851	PMID:12186974	PMID:12396720	PMID:12466851	PMID:12477932
PMID:14651853	PMID:15039538	PMID:15865429	PMID:15899864	PMID:16002711	PMID:16141072	PMID:16141073	PMID:17082620	PMID:17244351	PMID:21056894	PMID:21142819	PMID:21267068
PMID:21677750	PMID:21873635	PMID:22305621	PMID:22704621	PMID:24194600	PMID:26739051	PMID:30550785

Genomics

Variants

Variants in Oas1a
378 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	283
Count of miRNA genes:	235
Interacting mature miRNAs:	254
Transcripts:	ENSMUST00000080322
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
11341716	Rvfs3_m	Rift Valley fever susceptibility 3 (mouse)					5	26441234	138455402	Mouse
4142064	Tmc1m4_m	Tmc1 modifier 4 (mouse)			Not determined		5	54500177	127001072	Mouse
26884395	Humsd2_m	humerus midshaft diameter 2, 10 week (mouse)					5	70057343	132528839	Mouse
27226719	Tibw6_m	tibia width 6, proximal, 16 week (mouse)					5	72857343	139985755	Mouse
25314315	Mlh1fc4_m	MLH1 foci count 4 (mouse)					5	74460661	132528839	Mouse
13506928	Recrq8_m	recombination rate in male meiosis QTL 8 (mouse)					5	74460661	132528839	Mouse
10043958	Chldq12_m	cholesterol and HDL QTL 12 (mouse)			Not determined		5	87386871	121387065	Mouse
1301126	Bwem1_m	body weight day 30 males 1 (mouse)			Not determined		5	87386871	121387065	Mouse
13464241	Ahl18_m	age related hearing loss, early onset 18 (mouse)					5	87386871	121387065	Mouse
1300801	Drb2_m	dopamine receptor binding 2 (mouse)			Not determined		5	87386871	121387065	Mouse
1301399	Cpfd3_m	cerebellum pattern fissures (mouse)			Not determined		5	87386871	121387065	Mouse
1300968	Skts4_m	skin tumor susceptibility 4 (mouse)			Not determined		5	89418876	124238239	Mouse
1301362	Prnr1_m	prion resistance 1 (mouse)			Not determined		5	89418876	146787935	Mouse
11049562	Lmr24f_m	leishmaniasis resistance 24f (mouse)					5	90320962	124321041	Mouse
1301457	Cfsw2_m	cystic fibrosis survival to weaning 2 (mouse)			Not determined		5	90561006	124561151	Mouse
1300993	Hycdc_m	hypercapnic duty cycle (mouse)			Not determined		5	90561006	124561151	Mouse
9587780	Afw16_m	abdominal fat weight QTL 16 (mouse)			Not determined		5	92830166	126830285	Mouse
1301974	Chab7_m	cholesterol absorption 7 (mouse)			Not determined		5	95233214	129233330	Mouse
1357644	Egrd1_m	early growth rate, direct effect 1 (mouse)			Not determined		5	95434580	129434786	Mouse
10402486	Dipa1_m	drug induced psychomotor activation 1 (mouse)			Not determined		5	95465549	129465722	Mouse
13464244	Ahl19_m	age related hearing loss, early onset 19 (mouse)					5	95465549	129465722	Mouse
1558774	Lith17_m	lithogenic gene 17 (mouse)			Not determined		5	95465549	129465722	Mouse
1300940	Actd3_m	activity-distance traveled 3 (mouse)			Not determined		5	96320385	130320533	Mouse
1300659	Pcd8ts1_m	p-glycoprotein positive CD8 T cell subset 1 (mouse)			Not determined		5	97021753	131021986	Mouse
1301858	Smdq1_m	segregation of mitochondrial DNA QTL 1 (mouse)			Not determined		5	97021753	131021986	Mouse
4141519	Hmtb5_m	hemostasis and thrombosis bleeding time 5 (mouse)			Not determined			99949422	126882944	Mouse
12904945	Tammq2_m	tibialis anterior muscle mass QTL 2 (mouse)					5	100665965	134665965	Mouse
12904959	Smmq1_m	soleus muscle mass QTL 1 (mouse)					5	100665965	134665965	Mouse
12859290	Criq2_m	Citrobacter rodentium infection QTL 2 (mouse)					5	101332579	135332579	Mouse
1301624	Aevm2_m	autoimmune extremity vasculitis in MRL mice 2 (mouse)			Not determined		5	101863832	135864028	Mouse
14746986	Manh58_m	mandible shape 58 (mouse)					5	102446283	136446283	Mouse
11532736	Sluc33b_m	susceptibility to lung cancer 33b (mouse)					5	102945037	136945196	Mouse
10412202	Bbaa26_m	B.burgdorferi-associated arthritis 26 (mouse)			Not determined		5	104583688	138555455	Mouse
10412239	Alpq7_m	alcohol preference QTL 7 (mouse)			Not determined		5	104705939	138705939	Mouse
10043890	Trigq4_m	triglyceride QTL 4 (mouse)			Not determined		5	107906299	141906412	Mouse
4142473	Chlq11_m	circulating hormone level QTL 11 (mouse)			Not determined		5	107906299	141906412	Mouse
13464243	Ahl20_m	age related hearing loss, early onset 20 (mouse)					5	107906299	141906412	Mouse
4141139	Hmtb4_m	hemostasis and thrombosis rebleeding time 4 (mouse)			Not determined			108762509	126882944	Mouse
10412197	Bbaa25_m	B.burgdorferi-associated arthritis 25 (mouse)			Not determined		5	109167240	143167381	Mouse
13464251	Ahl21_m	age related hearing loss, early onset 21 (mouse)					5	109167240	143167381	Mouse
1301543	Hypch_m	hypercholesterolemia (mouse)			Not determined		5	109238624	139118905	Mouse
1300913	Bwefm_m	body weight females and males day 10 (mouse)			Not determined		5	109439348	143439459	Mouse
1301102	Cia14_m	collagen induced arthritis 14 (mouse)			Not determined		5	113320385	138555455	Mouse
1357662	Lprq4_m	lipoprotein QTL 4 (mouse)			Not determined		5	114021753	129632606	Mouse
1301226	Bbaa2_m	B.burgdorferi-associated arthritis 2 (mouse)			Not determined		5	115156883	149157015	Mouse
1300827	Cora1_m	correlation in cytokine production 1 (mouse)			Not determined		5	115156883	149157015	Mouse
1301857	Bglq14_m	body growth late QTL 14 (mouse)			Not determined		5	118948964	151758149	Mouse
10412191	Bbaa24_m	B.burgdorferi-associated arthritis 24 (mouse)			Not determined		5	119945037	141700466	Mouse
4141081	Nidd7k_m	Nidd7 on KK-A (mouse)			Not determined			119945037	149347326	Mouse

Markers in Region

AI449562

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	120,896,779 - 120,896,872	UniSTS	GRCm38
GRCm38	5	120,876,782 - 120,876,875	UniSTS	GRCm38
MGSCv37	5	121,326,791 - 121,326,884	UniSTS	GRCm37
MGSCv37	5	121,346,788 - 121,346,881	UniSTS	GRCm37
Celera	5	117,963,034 - 117,963,127	UniSTS
Celera	5	117,983,031 - 117,983,124	UniSTS
Cytogenetic Map	5	F	UniSTS
cM Map	5	67.0	UniSTS
cM Map	5	67.0	UniSTS
Whitehead/MRC_RH	5	1473.05	UniSTS

X58077

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	5	120,896,549 - 120,896,742	UniSTS	GRCm38
GRCm38	5	120,876,552 - 120,876,745	UniSTS	GRCm38
MGSCv37	5	121,326,561 - 121,326,754	UniSTS	GRCm37
MGSCv37	5	121,346,558 - 121,346,751	UniSTS	GRCm37
Celera	5	117,962,804 - 117,962,997	UniSTS
Celera	5	117,982,801 - 117,982,994	UniSTS
Cytogenetic Map	5	F	UniSTS
cM Map	5	67.0	UniSTS
cM Map	5	67.0	UniSTS
Whitehead_YAC	5		UniSTS

Oas1g

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	5	F	UniSTS
cM Map	5	67.0	UniSTS

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001424703	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001424704	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001424705	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001424706	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001424707	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001424708	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001424709	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001424710	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001424711	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_145211	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NR_188861	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NR_188862	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NR_188863	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC015535	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK149613	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC013715	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC057878	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BU699042	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466529	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M33863	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X04958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSMUST00000080322 ⟹ ENSMUSP00000079198

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	5	121,034,319 - 121,045,584 (-)	Ensembl
GRCm38.p6 Ensembl	5	120,896,256 - 120,907,521 (-)	Ensembl

RefSeq Acc Id:

NM_001424703 ⟹ NP_001411632

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	121,034,319 - 121,045,588 (-)	NCBI

RefSeq Acc Id:

NM_001424704 ⟹ NP_001411633

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	121,034,319 - 121,045,588 (-)	NCBI

RefSeq Acc Id:

NM_001424705 ⟹ NP_001411634

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	121,034,319 - 121,045,588 (-)	NCBI

RefSeq Acc Id:

NM_001424706 ⟹ NP_001411635

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	121,034,319 - 121,045,588 (-)	NCBI

RefSeq Acc Id:

NM_001424707 ⟹ NP_001411636

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	121,034,319 - 121,045,588 (-)	NCBI

RefSeq Acc Id:

NM_001424708 ⟹ NP_001411637

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	121,034,319 - 121,045,588 (-)	NCBI

RefSeq Acc Id:

NM_001424709 ⟹ NP_001411638

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	121,034,319 - 121,045,588 (-)	NCBI

RefSeq Acc Id:

NM_001424710 ⟹ NP_001411639

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	121,034,319 - 121,045,588 (-)	NCBI

RefSeq Acc Id:

NM_001424711 ⟹ NP_001411640

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	121,034,319 - 121,045,588 (-)	NCBI

RefSeq Acc Id:

NM_145211 ⟹ NP_660212

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	121,034,319 - 121,045,588 (-)	NCBI
GRCm38	5	120,896,256 - 120,907,525 (-)	NCBI
MGSCv37	5	121,346,265 - 121,357,534 (-)	RGD
Celera	5	117,982,508 - 117,993,776 (-)	RGD
cM Map	5		ENTREZGENE

Sequence:

show sequence

ACTTCCCATTTCAGCTAGGCTGGGAGACCCAGGAAGCTCCAGACTTAGCATGGAGCACGGACTC
AGGAGCATCCCAGCCTGGACGCTGGACAAGTTCATAGAGGATTACCTCCTTCCCGACACCACCT
TTGGTGCTGATGTCAAATCAGCCGTCAATGTCGTGTGTGATTTCCTGAAGGAGAGATGCTTCCA
AGGTGCTGCCCACCCAGTGAGGGTCTCCAAGGTGGTGAAGGGTGGCTCCTCAGGCAAAGGCACC
ACACTCAAGGGCAAGTCAGACGCTGACCTGGTGGTGTTCCTTAACAATCTCACCAGCTTTGAGG
ATCAGTTAAACCGACGGGGAGAGTTCATCAAGGAAATTAAGAAACAGCTGTACGAGGTTCAGCA
TGAGAGACGTTTTAGAGTCAAGTTTGAGGTCCAGAGTTCATGGTGGCCCAACGCCCGGTCTCTG
AGCTTCAAGCTGAGCGCCCCCCATCTGCATCAGGAGGTGGAGTTTGATGTGCTGCCAGCCTTTG
ATGTCCTGGGTCATGTTAATACTTCCAGCAAGCCTGATCCCAGAATCTATGCCATCCTCATCGA
GGAATGTACCTCCCTGGGGAAGGATGGCGAGTTCTCTACCTGCTTCACGGAGCTCCAGCGGAAC
TTCCTGAAGCAGCGCCCAACCAAGCTGAAGAGTCTCATCCGCCTGGTCAAGCACTGGTACCAAC
TGTGTAAGGAGAAGCTGGGGAAGCCATTGCCTCCACAGTACGCCCTAGAGTTGCTCACTGTCTT
TGCCTGGGAACAAGGGAATGGATGTTATGAGTTCAACACAGCCCAGGGCTTCCGGACCGTCTTG
GAACTGGTCATCAATTATCAGCATCTTCGAATCTACTGGACAAAGTATTATGACTTTCAACACC
AGGAGGTCTCCAAATACCTGCACAGACAGCTCAGAAAAGCCAGGCCTGTGATCCTGGACCCAGC
TGACCCAACAGGGAATGTGGCCGGTGGGAACCCAGAGGGCTGGAGGCGGTTGGCTGAAGAGGCT
GATGTGTGGCTATGGTACCCATGTTTTATTAAAAAGGATGGTTCCCGAGTGAGCTCCTGGGATG
TGCCGACGGTGGTTCCTGTACCTTTTGAGCAGGTAGAAGAGAACTGGACATGTATCCTGCTGTG
AGCACAGCAGCACCTGCCCAGGAGACTGCTGGTCAGGGGCATTTGCTGCTCTGCTGCAGGCCCA
TGACCCAGTGAGGGAGGGCCCCACCTGGCATCAGACTCCGTGCTTCTGATGCCTGCCAGCCATG
TTTGACTCCTGTCCAATCACAGCCAGCCTTCCTCAACAGATTCAGAAGGAGAGGAAAGAACACA
CGCTTGGTGTCCATCTGTCCACCTGTTGGAAGGTTCTGTCTGACAAAGTCTGATCAACAATAAA
CCACAGCAGGTGCCGTCATGGTGTGTGAACTCTGAGGAGTGGGCCATACAAGAACAGTGCAGGT
GTGTGAGCGTGTGTGTGCCCATGCACATGCGTGTGTGTCTTCACGGTTCAACTAGATGCATTTA
GTGAGCACTTACTACATATGCTACATGATTCAGATGTTCAGCAGTGGTTAGAGCAAAGCCTAAC
TGCTAGGCTTTTTGATGCAAGTTGGATTGGGATCCTTCCAGGTCTCTTCTTATACATACACACA
AGAGAGGAACCCTTGGTTTCTTCTGCCCATGACCCCAAGACAAGATTCTAGCCCTGCCCTATCT
GACACATTAGCGGTTCTCTGGCTACACATGGACATGGAACACTGAGATTGTGGCCTGTGCTCTC
AGGGTGCCCTTGAGTGGCTACAACATGCAGGCTGGGGGACCATAGATATGATGAAAATAAAAGG
TACCTGGAATTTTTGACACATGTAACTTTGAAA

hide sequence

RefSeq Acc Id:

NR_188861

RefSeq Status:

VALIDATED

Type:

NON-CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	121,034,319 - 121,045,588 (-)	NCBI

RefSeq Acc Id:

NR_188862

RefSeq Status:

VALIDATED

Type:

NON-CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	121,034,319 - 121,045,588 (-)	NCBI

RefSeq Acc Id:

NR_188863

RefSeq Status:

VALIDATED

Type:

NON-CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	5	121,034,319 - 121,045,588 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001411632	(Get FASTA)	NCBI Sequence Viewer
	NP_001411633	(Get FASTA)	NCBI Sequence Viewer
	NP_001411634	(Get FASTA)	NCBI Sequence Viewer
	NP_001411635	(Get FASTA)	NCBI Sequence Viewer
	NP_001411636	(Get FASTA)	NCBI Sequence Viewer
	NP_001411637	(Get FASTA)	NCBI Sequence Viewer
	NP_001411638	(Get FASTA)	NCBI Sequence Viewer
	NP_001411639	(Get FASTA)	NCBI Sequence Viewer
	NP_001411640	(Get FASTA)	NCBI Sequence Viewer
	NP_660212	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA37116	(Get FASTA)	NCBI Sequence Viewer
	AAH13715	(Get FASTA)	NCBI Sequence Viewer
	AAH57878	(Get FASTA)	NCBI Sequence Viewer
	BAE28990	(Get FASTA)	NCBI Sequence Viewer
	CAA28620	(Get FASTA)	NCBI Sequence Viewer
	EDL19743	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000079198
	ENSMUSP00000079198.8
GenBank Protein	P11928	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_660212 ⟸ NM_145211
- Peptide Label:	isoform 1
- UniProtKB:	Q64440 (UniProtKB/Swiss-Prot), Q3UEC1 (UniProtKB/Swiss-Prot), F2Z419 (UniProtKB/Swiss-Prot), Q91VI0 (UniProtKB/Swiss-Prot), P11928 (UniProtKB/Swiss-Prot), Q8VEH7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEHGLRSIPAWTLDKFIEDYLLPDTTFGADVKSAVNVVCDFLKERCFQGAAHPVRVSKVVKGGS SGKGTTLKGKSDADLVVFLNNLTSFEDQLNRRGEFIKEIKKQLYEVQHERRFRVKFEVQSSWWP NARSLSFKLSAPHLHQEVEFDVLPAFDVLGHVNTSSKPDPRIYAILIEECTSLGKDGEFSTCFT ELQRNFLKQRPTKLKSLIRLVKHWYQLCKEKLGKPLPPQYALELLTVFAWEQGNGCYEFNTAQG FRTVLELVINYQHLRIYWTKYYDFQHQEVSKYLHRQLRKARPVILDPADPTGNVAGGNPEGWRR LAEEADVWLWYPCFIKKDGSRVSSWDVPTVVPVPFEQVEENWTCILL hide sequence

RefSeq Acc Id:

ENSMUSP00000079198 ⟸ ENSMUST00000080322

RefSeq Acc Id:	NP_001411636 ⟸ NM_001424707
- Peptide Label:	isoform 6

RefSeq Acc Id:	NP_001411635 ⟸ NM_001424706
- Peptide Label:	isoform 5

RefSeq Acc Id:	NP_001411634 ⟸ NM_001424705
- Peptide Label:	isoform 4

RefSeq Acc Id:	NP_001411638 ⟸ NM_001424709
- Peptide Label:	isoform 8

RefSeq Acc Id:	NP_001411640 ⟸ NM_001424711
- Peptide Label:	isoform 10

RefSeq Acc Id:	NP_001411639 ⟸ NM_001424710
- Peptide Label:	isoform 9

RefSeq Acc Id:	NP_001411637 ⟸ NM_001424708
- Peptide Label:	isoform 7

RefSeq Acc Id:	NP_001411632 ⟸ NM_001424703
- Peptide Label:	isoform 2

RefSeq Acc Id:	NP_001411633 ⟸ NM_001424704
- Peptide Label:	isoform 3

Protein Domains

2'-5'-oligoadenylate synthetase Polymerase nucleotidyl transferase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P11928-F1-model_v2	AlphaFold	P11928	1-367	view protein structure

Promoters

RGD ID:

6887898

Promoter ID:

EPDNEW_M7400

Type:

initiation region

Name:

Oas1a_1

Description:

Mus musculus 2'-5' oligoadenylate synthetase 1A , mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	5	120,907,485 - 120,907,545	EPDNEW

RGD ID:

6837973

Promoter ID:

MM_KWN:43855

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

BoneMarrow_2Hour, BoneMarrow_4Hour, ES_Cell

Transcripts:

ENSMUST00000111842, OTTMUST00000066360

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	5	121,357,356 - 121,357,902 (-)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:2180860	AgrOrtholog
Ensembl Genes	ENSMUSG00000052776	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000080322	ENTREZGENE
	ENSMUST00000080322.8	UniProtKB/Swiss-Prot
Gene3D-CATH	2'-5'-oligoadenylate synthetase 1, domain 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.460.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	2-5-oligoadenylate_synth_CS	UniProtKB/Swiss-Prot
	2-5-oligoadenylate_synth_N	UniProtKB/Swiss-Prot
	2-5-oligoAdlate_synth_1_dom2/C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2-5OAS_C_CS	UniProtKB/TrEMBL
	2-5OAS_N_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	NT_2-5OAS_ClassI-CCAase	UniProtKB/TrEMBL
	NT_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Polymerase_NTP_transf_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	mmu:246730	UniProtKB/Swiss-Prot
MGD	MGI:2180860	ENTREZGENE
NCBI Gene	246730	ENTREZGENE
PANTHER	2'-5'-OLIGOADENYLATE SYNTHASE 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2-5 OLIGOADENYLATE SYNTHETASE	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
Pfam	NTP_transf_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	OAS1_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Oas1a	PhenoGen
PROSITE	25A_SYNTH_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	25A_SYNTH_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	25A_SYNTH_3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Nucleotidyltransferase	UniProtKB/TrEMBL
	PAP/OAS1 substrate-binding domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF81301	UniProtKB/Swiss-Prot
UniProt	F2Z419	ENTREZGENE
	OAS1A_MOUSE	UniProtKB/Swiss-Prot, ENTREZGENE
	Q3UEC1	ENTREZGENE
	Q64440	ENTREZGENE
	Q8VEH7	ENTREZGENE, UniProtKB/TrEMBL
	Q91VI0	ENTREZGENE
UniProt Secondary	F2Z419	UniProtKB/Swiss-Prot
	Q3UEC1	UniProtKB/Swiss-Prot
	Q64440	UniProtKB/Swiss-Prot
	Q91VI0	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)