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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:lipopolysaccharide-mediated signaling pathway
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Accession:GO:0031663 term browser browse the term
Definition:The series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
Synonyms:exact_synonym: LPS-mediated signaling pathway;   lipopolysaccharide-mediated signalling pathway


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lipopolysaccharide-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 thymoma viral proto-oncogene 1 acts_upstream_of_or_within IDA (PMID:24740015) MGI PMID:24740015 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Bcl10 B cell leukemia/lymphoma 10 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 3:145,630,017...145,640,121
Ensembl chr 3:145,628,559...145,640,111 		JBrowse link
G Bpi bactericidal permeablility increasing protein involved_in IBA GO_Central GO_REF:0000033 NCBI chr 2:158,099,983...158,126,453
Ensembl chr 2:158,100,014...158,126,451 		JBrowse link
G Cd180 CD180 antigen acts_upstream_of IGI (PMID:10880523) MGI PMID:10880523 NCBI chr13:102,830,055...102,843,139
Ensembl chr13:102,830,066...102,876,137 		JBrowse link
G Cd6 CD6 antigen involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr19:10,766,703...10,807,427
Ensembl chr19:10,766,705...10,807,422 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 involved_in
acts_upstream_of_or_within		 ISO
IDA		 (PMID:10549626), (PMID:12855817) MGI PMID:10549626 PMID:12855817 GO_REF:0000119 MGI:4834177 NCBI chr  X:73,057,520...73,067,527
Ensembl chr  X:73,057,520...73,067,524 		JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 acts_upstream_of_or_within IDA (PMID:15082713) MGI PMID:15082713 NCBI chr 6:113,615,428...113,671,987
Ensembl chr 6:113,615,428...113,671,987 		JBrowse link
G Irf3 interferon regulatory factor 3 acts_upstream_of_or_within IDA (PMID:12855817), (PMID:12872135) MGI PMID:12855817 PMID:12872135 NCBI chr 7:44,647,072...44,652,272
Ensembl chr 7:44,647,072...44,652,272 		JBrowse link
G Lbp lipopolysaccharide binding protein involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 2:158,148,413...158,174,772
Ensembl chr 2:158,148,413...158,174,772 		JBrowse link
G Ly86 lymphocyte antigen 86 acts_upstream_of IDA
IGI		 (PMID:10880523) MGI PMID:10880523 NCBI chr13:37,529,276...37,603,012
Ensembl chr13:37,529,184...37,603,012 		JBrowse link
G Ly96 lymphocyte antigen 96 involved_in
acts_upstream_of		 IMP
IGI
IDA		 (MGI:5645195|PMID:24380872)
(PMID:10880523)		 UniProt
MGI		 PMID:10880523 PMID:24380872 MGI:5645195 NCBI chr 1:16,758,680...16,779,829
Ensembl chr 1:16,758,275...16,779,835 		JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in IMP (MGI:4456928|PMID:20385881) UniProt PMID:20385881 MGI:4456928 NCBI chr 4:3,676,865...3,791,613
Ensembl chr 4:3,678,115...3,813,122 		JBrowse link
G Malt1 MALT1 paracaspase involved_in IDA (MGI:3694380|PMID:16831874) UniProt PMID:16831874 MGI:3694380 NCBI chr18:65,564,010...65,612,138
Ensembl chr18:65,564,009...65,612,138 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 acts_upstream_of_or_within IDA (PMID:12872135) MGI PMID:12872135 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk14 mitogen-activated protein kinase 14 acts_upstream_of_or_within IDA (PMID:12872135) MGI PMID:12872135 NCBI chr17:28,910,316...28,967,379
Ensembl chr17:28,910,303...28,967,380 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 acts_upstream_of_or_within IDA (PMID:12872135) MGI PMID:12872135 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mtdh metadherin involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr15:34,082,613...34,143,683
Ensembl chr15:34,082,840...34,145,770 		JBrowse link
G Myd88 myeloid differentiation primary response gene 88 acts_upstream_of_or_within IMP (PMID:12855817) MGI PMID:12855817 NCBI chr 9:119,165,000...119,169,084
Ensembl chr 9:119,165,000...119,170,477 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha acts_upstream_of_or_within IDA (PMID:12872135), (PMID:18261938) MGI PMID:12872135 PMID:18261938 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell acts_upstream_of_or_within IMP (PMID:15647265) MGI PMID:15647265 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Nr2c2 nuclear receptor subfamily 2, group C, member 2 acts_upstream_of_or_within IMP (PMID:9851930) MGI PMID:9851930 NCBI chr 6:92,068,426...92,150,039
Ensembl chr 6:92,068,371...92,151,275 		JBrowse link
G Plcg2 phospholipase C, gamma 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 8:118,225,014...118,361,881
Ensembl chr 8:118,225,030...118,361,881 		JBrowse link
G Prkce protein kinase C, epsilon involved_in
acts_upstream_of_or_within		 IMP (MGI:3652658|PMID:16757566)
(PMID:11696589)		 UniProt
MGI		 PMID:11696589 PMID:16757566 MGI:3652658 NCBI chr17:86,472,631...86,965,347
Ensembl chr17:86,475,213...86,965,347 		JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 3:103,763,891...103,819,568
Ensembl chr 3:103,767,111...103,819,563 		JBrowse link
G Ripk2 receptor (TNFRSF)-interacting serine-threonine kinase 2 acts_upstream_of_or_within IMP (PMID:11894098) MGI PMID:11894098 NCBI chr 4:16,122,740...16,163,674
Ensembl chr 4:16,122,733...16,163,647 		JBrowse link
G Spi1 Spi-1 proto-oncogene involved_in IMP (MGI:6459415|PMID:30718772) ARUK-UCL PMID:30718772 MGI:6459415 NCBI chr 2:90,912,750...90,946,104
Ensembl chr 2:90,912,735...90,946,101 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 acts_upstream_of_or_within IDA (PMID:12872135) MGI PMID:12872135 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024 		JBrowse link
G Ticam1 TIR domain containing adaptor molecule 1 acts_upstream_of_or_within IMP (PMID:12872135)
(PMID:12855817)		 MGI PMID:12855817 PMID:12872135 NCBI chr17:56,576,462...56,583,767
Ensembl chr17:56,576,319...56,583,786 		JBrowse link
G Tifab TRAF-interacting protein with forkhead-associated domain, family member B acts_upstream_of_or_within IGI
IMP		 (PMID:26458771) MGI PMID:26458771 NCBI chr13:56,318,917...56,326,816
Ensembl chr13:56,321,517...56,326,698 		JBrowse link
G Tlr4 toll-like receptor 4 involved_in
acts_upstream_of_or_within
NOT|acts_upstream_of_or_within		 IDA
ISO
IGI		 (MGI:5913054|PMID:28098138)
(PMID:10880523)		 UniProt
MGI		 PMID:10880523 PMID:28098138 MGI:5913054 NCBI chr 4:66,745,788...66,765,338
Ensembl chr 4:66,745,821...66,848,521 		JBrowse link
G Traf6 TNF receptor-associated factor 6 involved_in
acts_upstream_of_or_within		 IBA
IMP
IGI		 (PMID:26458771) GO_Central
MGI		 PMID:26458771 GO_REF:0000033 NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in IC (MGI:5572888|PMID:12847223) BHF-UCL PMID:12847223 MGI:5572888 NCBI chr17:48,653,429...48,659,304
Ensembl chr17:48,653,429...48,661,175 		JBrowse link
negative regulation of lipopolysaccharide-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cactin cactin, spliceosome C complex subunit involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:81,156,937...81,162,085
Ensembl chr10:81,156,937...81,162,076 		JBrowse link
G Defb21 defensin beta 21 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:152,414,663...152,416,864
Ensembl chr 2:152,414,664...152,416,864 		JBrowse link
G Ltf lactotransferrin involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 9:110,848,360...110,871,834
Ensembl chr 9:110,848,339...110,871,835 		JBrowse link
G Nfkbil1 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor like 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr17:35,439,151...35,455,457
Ensembl chr17:35,439,151...35,454,768 		JBrowse link
G Prdx2 peroxiredoxin 2 acts_upstream_of_or_within IMP (PMID:17325201) MGI PMID:17325201 NCBI chr 8:85,696,251...85,701,440
Ensembl chr 8:85,696,216...85,701,463 		JBrowse link
G Trib1 tribbles pseudokinase 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr15:59,520,503...59,528,948
Ensembl chr15:59,520,199...59,528,948 		JBrowse link
positive regulation of lipopolysaccharide-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 involved_in IMP (MGI:4352622|PMID:19252488) BHF-UCL PMID:19252488 MGI:4352622 NCBI chr13:38,529,098...38,684,283
Ensembl chr13:38,529,083...38,684,278 		JBrowse link
G Cd14 CD14 antigen involved_in IMP (MGI:5645195|PMID:24380872) UniProt PMID:24380872 MGI:5645195 NCBI chr18:36,858,117...36,859,868
Ensembl chr18:36,858,120...36,859,851 		JBrowse link
G Cd180 CD180 antigen acts_upstream_of_or_within
involved_in		 ISO
IGI
IBA		 (PMID:10880523) MGI
GO_Central		 PMID:10880523 GO_REF:0000033 NCBI chr13:102,830,055...102,843,139
Ensembl chr13:102,830,066...102,876,137 		JBrowse link
G Ly86 lymphocyte antigen 86 involved_in
acts_upstream_of_or_within		 IBA
ISO
IGI
IDA		 (PMID:10880523) GO_Central
MGI		 PMID:10880523 GO_REF:0000033 NCBI chr13:37,529,276...37,603,012
Ensembl chr13:37,529,184...37,603,012 		JBrowse link
G Ly96 lymphocyte antigen 96 acts_upstream_of_or_within
involved_in		 IDA
IBA
ISO
IGI		 (PMID:10880523) MGI
GO_Central		 PMID:10880523 GO_REF:0000033 NCBI chr 1:16,758,680...16,779,829
Ensembl chr 1:16,758,275...16,779,835 		JBrowse link
G Mif macrophage migration inhibitory factor (glycosylation-inhibiting factor) involved_in IMP (MGI:2156302|PMID:11756671) BHF-UCL PMID:11756671 MGI:2156302 NCBI chr10:75,695,187...75,696,111
Ensembl chr10:75,695,187...75,696,074 		JBrowse link
G Prkca protein kinase C, alpha involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:107,824,213...108,237,360
Ensembl chr11:107,824,213...108,234,754 		JBrowse link
G Sash1 SAM and SH3 domain containing 1 acts_upstream_of_or_within ISO (PMID:23776175) MGI PMID:23776175 NCBI chr10:8,597,981...8,821,290
Ensembl chr10:8,597,983...8,761,814 		JBrowse link
G Scimp SLP adaptor and CSK interacting membrane protein involved_in IDA (MGI:5913054|PMID:28098138) UniProt PMID:28098138 MGI:5913054 NCBI chr11:70,681,758...70,703,387
Ensembl chr11:70,681,758...70,703,412 		JBrowse link
G Traf6 TNF receptor-associated factor 6 involved_in IMP (MGI:1335941|PMID:10215628) UniProt PMID:10215628 MGI:1335941 NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014 		JBrowse link
regulation of lipopolysaccharide-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd55 CD55 molecule, decay accelerating factor for complement involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:130,357,526...130,390,513
Ensembl chr 1:130,366,764...130,390,481 		JBrowse link
G Cd55b CD55 molecule, decay accelerating factor for complement B involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:130,316,263...130,350,831
Ensembl chr 1:130,316,274...130,350,746 		JBrowse link
G Cd84 CD84 antigen involved_in IDA (MGI:5700297|PMID:20628063) UniProt PMID:20628063 MGI:5700297 NCBI chr 1:171,667,261...171,718,288
Ensembl chr 1:171,667,265...171,718,285 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 8:95,498,808...95,509,055
Ensembl chr 8:95,498,637...95,509,055 		JBrowse link
G Trim12a tripartite motif-containing 12A involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:103,949,100...103,964,765
Ensembl chr 7:103,949,101...103,964,673 		JBrowse link
G Trim12c tripartite motif-containing 12C involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:103,987,961...104,002,649
Ensembl chr 7:103,987,961...104,002,569 		JBrowse link
G Trim30a tripartite motif-containing 30A involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:104,058,232...104,114,400
Ensembl chr 7:104,058,232...104,114,400 		JBrowse link
G Trim30b tripartite motif-containing 30B involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:104,004,605...104,007,853
Ensembl chr 7:104,004,589...104,019,091 		JBrowse link
G Trim30c tripartite motif-containing 30C involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:104,028,324...104,050,059
Ensembl chr 7:104,031,272...104,050,044 		JBrowse link
G Trim30d tripartite motif-containing 30D involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:104,119,221...104,157,062
Ensembl chr 7:104,119,221...104,157,056 		JBrowse link
G Trim5 tripartite motif-containing 5 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:103,912,593...103,937,448
Ensembl chr 7:103,912,593...103,937,301 		JBrowse link
G Tut4 terminal uridylyl transferase 4 acts_upstream_of_or_within IDA (PMID:16643855) MGI PMID:16643855 NCBI chr 4:108,316,607...108,416,612
Ensembl chr 4:108,316,623...108,416,618 		JBrowse link
tolerance induction to lipopolysaccharide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acod1 aconitate decarboxylase 1 involved_in IDA
ISO		 (MGI:5490396|PMID:23609450) UniProt
MGI		 PMID:23609450 GO_REF:0000119 MGI:4834177 MGI:5490396 NCBI chr14:103,284,448...103,294,009
Ensembl chr14:103,284,413...103,294,009 		JBrowse link
G Tnfaip3 tumor necrosis factor, alpha-induced protein 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:18,876,658...18,891,158
Ensembl chr10:18,876,658...18,891,405 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28577
    cellular process 17497
      signal transduction 6663
        cell surface receptor signaling pathway 2924
          lipopolysaccharide-mediated signaling pathway 58
            negative regulation of lipopolysaccharide-mediated signaling pathway + 8
            positive regulation of lipopolysaccharide-mediated signaling pathway 10
            regulation of lipopolysaccharide-mediated signaling pathway + 30
Path 2
Term Annotations click to browse term
  biological_process 28577
    response to stimulus 10767
      response to biotic stimulus 2060
        response to external biotic stimulus 2016
          response to other organism 2013
            response to bacterium 1130
              response to molecule of bacterial origin 625
                cellular response to molecule of bacterial origin 404
                  cellular response to lipopolysaccharide 390
                    lipopolysaccharide-mediated signaling pathway 58
                      negative regulation of lipopolysaccharide-mediated signaling pathway + 8
                      positive regulation of lipopolysaccharide-mediated signaling pathway 10
                      regulation of lipopolysaccharide-mediated signaling pathway + 30
paths to the root