Trim12c (tripartite motif-containing 12C)

Gene: Trim12c (tripartite motif-containing 12C) Mus musculus

Analyze

No known orthologs.

Symbol:

Trim12c

Name:

tripartite motif-containing 12C

RGD ID:

1312099

MGI Page

MGI

Description:

Predicted to enable several functions, including protein homodimerization activity; transcription coactivator activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including defense response to symbiont; protein K63-linked ubiquitination; and regulation of signal transduction. Predicted to be located in P-body. Predicted to be active in cytosol and nucleoplasm. Predicted to colocalize with omegasome. Is expressed in genitourinary system. Orthologous to human TRIM5 (tripartite motif containing 5).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

9230105E10Rik; Trim12; Trim12-2; TRIM5; tripartite motif protein TRIM5

RGD Orthologs

Alliance Orthologs

More Info

homologs ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Other homologs ²				less info ...
Homo sapiens (human):	TRIM5 (tripartite motif containing 5)	HGNC	Ensembl, HomoloGene, OMA, OrthoDB, Panther, Treefam
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Trim5 (tripartite motif-containing 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TRIM5 (tripartite motif containing 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	trim47 (tripartite motif containing 47)	Alliance	DIOPT (Ensembl Compara\|OMA)
Danio rerio (zebrafish):	zgc:194990	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:dkey-219e21.2	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:dkey-18p12.4	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:ch211-114c12.5	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:ch73-364h19.2	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	si:ch211-120g10.1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Danio rerio (zebrafish):	btr16 (bloodthirsty-related gene family, member 16)	Alliance	DIOPT (Ensembl Compara\|OMA)
Caenorhabditis elegans (roundworm):	B0281.8	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Caenorhabditis elegans (roundworm):	Y47G6A.14	Alliance	DIOPT (Ensembl Compara\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ZK1240.5	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Caenorhabditis elegans (roundworm):	nhl-3	Alliance	DIOPT (Ensembl Compara\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ZK1240.8	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Caenorhabditis elegans (roundworm):	ZK1240.3	Alliance	DIOPT (Ensembl Compara\|InParanoid)
Caenorhabditis elegans (roundworm):	C28G1.6	Alliance	DIOPT (Ensembl Compara\|InParanoid)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	103,987,961 - 104,002,649 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	103,987,961 - 104,002,569 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	104,338,754 - 104,353,358 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	104,338,754 - 104,353,362 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	111,487,268 - 111,501,872 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	104,213,697 - 104,227,158 (-)	NCBI		MGSCv36	mm8
Celera	7	104,635,159 - 104,653,390 (-)	NCBI		Celera
Cytogenetic Map	7	E3	NCBI
cM Map	7	55.69	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

bisphenol A (EXP)

carbon nanotube (EXP)

epoxiconazole (EXP)

pentachlorophenol (EXP)

tetrachloromethane (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activation of innate immune response (ISO)

autophagy (ISO)

innate immune response (IBA,ISO)

negative regulation of viral entry into host cell (ISO)

positive regulation of autophagy (IBA)

positive regulation of canonical NF-kappaB signal transduction (IBA,ISO)

positive regulation of MAPK cascade (ISO)

protein K63-linked ubiquitination (ISO)

protein polyubiquitination (IBA)

regulation of lipopolysaccharide-mediated signaling pathway (ISO)

regulation of protein localization (IBA,ISO)

regulation of viral entry into host cell (IBA)

suppression of viral release by host (ISO)

Cellular Component

cytoplasm (IBA,ISO)

cytosol (IBA)

nucleoplasm (IBA)

omegasome (ISO)

P-body (ISO)

Molecular Function

identical protein binding (ISO)

pattern recognition receptor activity (ISO)

protein homodimerization activity (IBA,ISO)

protein kinase binding (IBA,ISO)

protein-macromolecule adaptor activity (ISO)

transcription coactivator activity (ISO)

ubiquitin protein ligase activity (IBA)

ubiquitin-protein transferase activity (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	MGDs mouse GO annotations	MGD data from the GO Consortium
2.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10349636	PMID:11042159	PMID:11076861	PMID:11217851	PMID:11812828	PMID:12477932	PMID:16141072	PMID:16141073	PMID:18287559	PMID:19147168	PMID:21873635	PMID:26503954

Genomics

Variants

Variants in Trim12c
611 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	705
Count of miRNA genes:	493
Interacting mature miRNAs:	575
Transcripts:	ENSMUST00000059037, ENSMUST00000130139
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
25314307	Mlh1fc2_m	MLH1 foci count 2 (mouse)					7	6502999	133501729	Mouse
12792978	Fbmd3_m	femoral bone mineral density 3, females only (mouse)					7	7050288	142367832	Mouse
10412199	Sst2_m	susceptibility to tuberculosis 2 (mouse)			Not determined		7	18728794	119485380	Mouse
1301158	Eae4_m	susceptibility to experimental allergic encephalomyelitis 4 (mouse)			Not determined		7	19147398	141919804	Mouse
26884404	Huml1_m	humerus length 1, 5 week (mouse)					7	30199425	108999207	Mouse
1301082	Bbaa16_m	B.burgdorferi-associated arthritis 16 (mouse)			Not determined		7	36280015	116416877	Mouse
10043926	Bw1n_m	body weight 1 in NSY (mouse)			Not determined		7	45161966	118693530	Mouse
13208555	Lgth10_m	body length 10 (mouse)					7	51649748	125599172	Mouse
27226751	Femd5_m	femur midshaft diameter 5, 10 week (mouse)					7	53249748	143153737	Mouse
25823170	Hrsq7_m	host response to SARS QTL 7, log titer (mouse)					7	54819589	116822815	Mouse
27226778	Femd11_m	femur midshaft diameter 11, 16 week (mouse)					7	56949748	134001729	Mouse
26884408	Bzwq13_m	bi-zygomatic width QTL 13, 16 week (mouse)					7	61749748	121399223	Mouse
27095916	Scvln15_m	sacral vertebrae length 2, 16 week (mouse)					7	61749748	123699223	Mouse
26884440	Sklq4_m	skull length QTL 4, 5 week (mouse)					7	65249748	126499172	Mouse
26884418	Bzwq7_m	bi-zygomatic width QTL 7, 10 week (mouse)					7	67849748	105449207	Mouse
27226715	Metcl3_m	metatarsal-calcaneal length 3, 5 week (mouse)					7	67849748	119499223	Mouse
26884444	Sklq8_m	skull length QTL 8, 10 week (mouse)					7	67849748	124199223	Mouse
26884451	Sklq14_m	skull length QTL 14, 16 week (mouse)					7	67849748	124999172	Mouse
27095907	Scvln4_m	sacral vertebrae length 2, 5 week (mouse)					7	69949748	120499223	Mouse
1301155	Bpq7_m	blood pressure QTL 7 (mouse)			Not determined		7	70143137	104143379	Mouse
10043973	Obq29_m	obesity QTL 29 (mouse)			Not determined		7	72263372	106263372	Mouse
27095910	Pglq13_m	pelvic girdle length QTL 13, 16 week (mouse)					7	73049748	125699172	Mouse
27095933	Ulnl3_m	ulna length 3, 5 week (mouse)					7	73149748	143153737	Mouse
11553869	Stmm2b_m	skin tumor modifier of MSM 2a (mouse)					7	73725965	107725965	Mouse
27226745	Metcl9_m	metatarsal-calcaneal length 9, 10 week (mouse)					7	74849748	122199223	Mouse
27226781	Tibl3_m	tibia length 3, 5 week (mouse)					7	74849748	122199223	Mouse
1301566	Adip3_m	adiposity 3 (mouse)			Not determined		7	75394215	109394346	Mouse
14746989	Manh62_m	mandible shape 62 (mouse)					7	75742528	109742528	Mouse
26884398	Humsd6_m	humerus midshaft diameter 6, 16 week (mouse)					7	78649748	136901729	Mouse
10412110	Cctq1_m	central corneal thickness QTL 1 (mouse)			Not determined		7	80551681	114551791	Mouse
4142500	Morq1_m	modifier of Rs1 QTL 1 (mouse)			Not determined			80551681	114551791	Mouse
27095930	Ulnl10_m	ulna length 10, 16 week (mouse)					7	80849748	126699172	Mouse
27095923	Pglq3_m	pelvic girdle length QTL 3, 5 week (mouse)					7	81249748	124199223	Mouse
27095903	Scvln10_m	sacral vertebrae length 2, 10 week (mouse)					7	81449748	126499172	Mouse
27226765	Tibl18_m	tibia length 18, 16 week (mouse)					7	81849748	126499172	Mouse
27226763	Feml20_m	femur length 20, 16 week (mouse)					7	85049208	124199223	Mouse
1301997	Cia7_m	collagen induced arthritis QTL 7 (mouse)			Not determined		7	85365595	112533819	Mouse
1301647	Elpt_m	elevated leptin (mouse)			Not determined		7	86500186	120500329	Mouse
1301188	Heal6_m	wound healing/regeneration 6 (mouse)			Not determined		7	87043932	121044066	Mouse
1302062	Stheal6_m	soft tissue heal 6 (mouse)			Not determined		7	87043932	121044066	Mouse
13463473	Hbbcq4_m	hemoglobin concentration QTL 4 (mouse)					7	87043932	121044066	Mouse
1301781	Capsq3_m	capsaicin sensitivity related QTL 3 (mouse)			Not determined		7	87143137	119485380	Mouse
27226769	Tibl12_m	tibia length 12, 10 week (mouse)					7	87249208	126499172	Mouse
27226790	Feml15_m	femur length 15, 10 week (mouse)					7	87249208	126499172	Mouse
27095929	Pglq8_m	pelvic girdle length QTL 8, 10 week (mouse)					7	87849208	108099207	Mouse
1357664	Nba3_m	New Zealand Black autoimmunity 3 (mouse)			Not determined		7	91482996	125483156	Mouse
1301937	Skull10_m	skull morphology 10 (mouse)			Not determined		7	91482996	125483156	Mouse
13464255	Ifvrq2_m	influenza virus resistance QTL 2 (mouse)					7	92500698	106455693	Mouse
1300528	Ssial3_m	susceptibility to sialadenitis 3 (mouse)			Not determined		7	93391848	127392041	Mouse
1301478	Eae26_m	susceptibility to experimental allergic encephalomyelitis 26 (mouse)			Not determined		7	98164922	132165010	Mouse
13524850	Asrq7_m	acoustic startle response 7 (mouse)					7	98394974	132394974	Mouse
10412104	Tons2_m	tongue size 2 (mouse)			Not determined		7	99837716	133837716	Mouse
11039524	Tbbr3_m	Trypanosoma brucei brucei response 3 (mouse)					7	100750722	134750843	Mouse
1301447	Fembm3_m	femoral bone morphometry 3 (mouse)			Not determined		7	100993261	134993342	Mouse
1357460	Vtbt4_m	vertebral trabecular bone trait 4 (mouse)			Not determined		7	101693381	135693530	Mouse
1301105	Cfld4_m	cystic fibrosis lung disease 4 (mouse)			Not determined		7	101693381	135693530	Mouse
1300721	Cfbw3_m	cystic fibrosis body weight 3 (mouse)			Not determined		7	101693381	135693530	Mouse
4142312	Nilac4_m	nicotine induced locomotor activity 4 (mouse)			Not determined		7	102485219	136485380	Mouse

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001146007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_175677	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_036153162	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC142110	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK033764	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK050485	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK146437	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC038937	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC062252	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BU923784	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSMUST00000059037 ⟹ ENSMUSP00000060100

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	7	103,987,961 - 104,002,569 (-)	Ensembl
GRCm38.p6 Ensembl	7	104,338,754 - 104,353,362 (-)	Ensembl

RefSeq Acc Id:

ENSMUST00000130139 ⟹ ENSMUSP00000116775

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	7	103,989,083 - 104,002,545 (-)	Ensembl
GRCm38.p6 Ensembl	7	104,339,876 - 104,353,338 (-)	Ensembl

RefSeq Acc Id:

NM_001146007 ⟹ NP_001139479

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	7	103,987,961 - 104,002,565 (-)	NCBI
GRCm38	7	104,338,754 - 104,353,358 (-)	NCBI
MGSCv37	7	111,487,268 - 111,501,872 (-)	RGD
Celera	7	104,635,159 - 104,653,390 (-)	NCBI

Sequence:

show sequence

CTCAAACTTTCGTTTCTCTAGCTTCGAGTCGGAAATACCTTGAAGTTCTGGATTGGTTAGTTAA
TTCTCCCTGGTTTACAACTTTCTGGCGTCTGATAACGGGCTGAGCAATTTTAGGGGGCAGACTT
TTGAAGACTTTGAAAGGAGAACATTGCTTTTGCTTGGGCACCTGAGCAGAAGTGCGAGGAGTCA
GGACAGTCATACACAGGATCACAGCAACTATGGCTTCACAATTCATGAAGAATTTAAAGGAGGA
AGTGACCTGTCCTCTCTGTCTGAACCTGATGGTGAAACCTGTGAGTGCAGATTGTGGTCACAGC
TTCTGCCAAGGCTGCATCACGGTGTACTTTGAATCCACCAAATGCGATAAGGAAATGTTCAGTT
GCCCTGTGTGCCGACTTAGTTACCAGTCTAGCAATCTGAGGCCTAATCTACATGTGGCCAACAT
AGTAGAGAGGCTCAAAGAGTTCAAGCCTAGCCCAGAAGAGGAGCAGAAAGTGTTTAACTGTGCA
AGACATGGAGAGAAACTCCAGCTCTTCTGTAGGAAGGACATGATGGCCATCTGCTGGCTTTGTG
AGCGATCTCAGGAGCACCGGGGCCACAAAACAGCTCTCATTGAAGAGGTGGCCCAGGAGTACAA
GGAGCAGCTGCAGGTAGTTCTGCAAAGGCTGATGGCAGACAAGAAAGAATTTGAAAACTGGAAA
GATGACCTTCAGAAGGATAGAACTTACTGGGAGAATCAAATACAGAAAGATGTGGAGAATGTTC
AGTCAGAGTTTAAACGAATGAGGGATATCATGAACTCTGAAGAGAAGAAGGAATTGCAGAAGCT
GAAGCAAGAGAAGGAAAACATTATCAACAAACTGGCAGAGTCTGAAAATGAGCATGCTCAGCAG
AGCAAGTTGCTAGAAGACTTCATTTCAGATGTGGAACATCAGTTACAGTGCTCAGACATAGAAA
TACTGCAGGGTGTGGAGAACATCATAAAACGGAGTCATACTTTTTCGATGAAGAAGCCCAAAGC
CATCGCCAGGGAACAAAGAAAGTTCCGAGCCCCTGACCTGCAAGGCATGCTGCAAGTGCTGCAA
GAGGTCACAGAGGCTCAACGCTACTGGGTTCAGGTGACGCTGGTTCAAAACAACAATCCAAACA
TTGCCATTACTGATGACAAAAGGCAAATACGATATGAAGACCTCCAAGCAAGGAATCTTGAACA
TGGCTGTGAAAACTCTCATGAAGGTGTCCTGGGACACCCAGTTATCCAATCAGGAAAACATTAC
TGGGAAGTAGATGTGTCTGGAAAAGGTGCTTGGGTTCTGGGGTTAAGTGATGGAAGCTACCTCT
TCAATCCAATATTTCGTTCAAATGCTGAAAGAAACCCTTTATTTCGCAGGGGGATTAAGAATGA
TTCACATTATCAACCAAAATATGGCTTCTGGGTTATAGGGCTGTGGAAAAAGTCTGTGTATAAT
GCTTTTGAGGAGTGTCCTTTCACAGGCAAGCCCAGTGTCTTGACCCTGTCTCTGATGGTCCCGC
CCTGTCGTGTTGGTGTTTTCCTTGACTATGCAGCTGGGACTCTCTCATTTTACAATATTTCCAA
CAATGGGACTCTTATCTACAGATTCTGTACAGCTTCCTTTCCTGATAGGGTTTTTCCATATTTT
AATCCCATGGGAAGTTCAGAGCCCATGACAATTTGCTGGCCAGACTCTTAACATTTGCCTGTTT
ACTTGCAGGGTCTCTGGCTCTGATATGTATGTCCATTTGCCTGAGCTCATCGTACCATTTTCTC
TCTCTTTTTTTTTTTCCTGACTCTAGTCTTTCTGTGTGAATGTCTTTCATTGGTAAAAAAGGAT
ATATTCATTTCTCTAGGTCAGATTCTTCTCAGTTTCTTTCAGTTTTGTTTTGTTTTAGATGAGA
ATAGTAAATCACTTCCCATTTGGTCAAGGAAAAGTGCCTGAGTGCTCATTGTGTAAGATAACAC
TGCTGCAAAGTTCTCTTATTCTTCATGCCAGAGGTGGAAGCCAAGGCCTTGTGCATGGTGAGGA
GGTGCTCCACCCCTGAGGAGGTGCTCCACCACTGAGCTAATTACCTCAGCTCTGTCAGTTCTCT
ATAACTTCATCCTGCATATCAATGAAAGAAGATTAAAGAAAGTTCAACAACTTGTCCATTCATT
CTGAAAATTATAGGTAGGAATCTGTGGTTAAGAAATGCACCCTTAGCTGTAGGCCAGTTTTACC
AGGATGCATCTTCATCAAAGAATGAAGGAGAAGCATCACAATGAGGCACACTGTGTTCTTGCTC
AGGCGTCATGTGTTCCCAAAGTAGAATGATCAGGGAATGTTAATATGGCCCCTGCTCATAGATG
ACATGCGAGTTTATGAAGCATTCCATATTTTTGAAGAGCATTGATAGTCTAAATCATGTTAGAG
AGGAGGGAAGGGAAGGGAAGGGAAGGGAAGGGAAGGGAAGGGAAGGGAAGGGAAGGGAAGGGAA
GGGAAGGGAAGGGAAGGGAAGGAAAGGAAAGGAAAGGAAGAAAGAAAGAAAGCTAAAGAAGATA
CTGTGTTCGGAAGGGAAGGGAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGA
AAGAAAGAAAGAAAGAAAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAA
GAAAGAAAGAAAGAAAGAAAGCTAAAGAAGATACTGTGTTCAGAGTATCTGAGCTCCAGTCATA
GTTCCAAACGTGTCAGCAGTGGCAGTGTGACTATGCTTATTTTCGTACTCTGCCTCAAGCCAGT
ATGAGAAATGGGCCAGTGGGAAATAGTCCTTGTCAACAAGCCTGAGCACTTGAGTTCAATTCCC
TGCACCTGACTTCCACACATATGTTGTAGCATGTAGAGGCCCAGACATGTACACAAACACAAAT
TGTGTAAATATAATTTTTTTCATGAAAAGAAACTAGGTAAGGGTAGAGCATCCACTGAATTATA
TCAGTGTTTATTCTGTTAATTACTGTGAGATACATGCTGTGTTATAGTGTCCCATGAAACCATG
GGAAAATAAACAAGGGTTAGCTTTCCTGAAGTCTTATTACTAGTCCCTTAAATAACAATTATCA
TTACCTGACCATTCCGCTTTTTTATGGAGGGGTGTGTGTGTATTCTTAGTGATCACTTTCTTTA
GTCACAATAAAGACCCCAAATGAATAAGGTACCATGTGTGTATATATATACACATATATACACA
CACACATATATATATCAACTACTAAATTGTTATATTCATTTTATTTTTAGTAATAATGGCAGTA
ATAAATTTATCTTTTGGTATATTGTAAAACATAAATAAGAGTTATTACTAAGATTTACATTGTT
TCAGGCATGTGACTGGCAGTCCAGTATGGTGTCTTATTCCTTTGGGAAACCTTATCACTGTGAC
TAAATTAAATGATCATTAAGACCCTGTATCAGAACCTTGCATGGGAGCTCATACCTGCCGTGCT
GCATCTGGGAAGTTGTGGCAGGAAGATTGCTCTGTATTTGAAGCCAACCTTGTATACAGAGTAA
GACCCTGTTTAACATAATAAAGAATATATATTGGTTTATTACTCCATTATGTTTTAAGAAATGG
AATGACTATATTGCAGAACTGCAGGTTTTTGATTGTTTTTACAATTTATAATTCTTTTGTCTAC
TACAAATAAATGCTCGTAACTTCA

hide sequence

RefSeq Acc Id:

NM_175677 ⟹ NP_783608

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	7	103,987,961 - 104,002,556 (-)	NCBI
GRCm38	7	104,338,754 - 104,353,349 (-)	NCBI
MGSCv37	7	111,487,268 - 111,501,872 (-)	RGD
Celera	7	104,635,159 - 104,653,390 (-)	NCBI

Sequence:

show sequence

TCGTTTCTCTAGCTTCGAGTCGGAAATACCTTGAAGTTCTGGATTGGCACCTGAGCAGAAGTGC
GAGGAGTCAGGACAGTCATACACAGGATCACAGCAACTATGGCTTCACAATTCATGAAGAATTT
AAAGGAGGAAGTGACCTGTCCTCTCTGTCTGAACCTGATGGTGAAACCTGTGAGTGCAGATTGT
GGTCACAGCTTCTGCCAAGGCTGCATCACGGTGTACTTTGAATCCACCAAATGCGATAAGGAAA
TGTTCAGTTGCCCTGTGTGCCGACTTAGTTACCAGTCTAGCAATCTGAGGCCTAATCTACATGT
GGCCAACATAGTAGAGAGGCTCAAAGAGTTCAAGCCTAGCCCAGAAGAGGAGCAGAAAGTGTTT
AACTGTGCAAGACATGGAGAGAAACTCCAGCTCTTCTGTAGGAAGGACATGATGGCCATCTGCT
GGCTTTGTGAGCGATCTCAGGAGCACCGGGGCCACAAAACAGCTCTCATTGAAGAGGTGGCCCA
GGAGTACAAGGAGCAGCTGCAGGTAGTTCTGCAAAGGCTGATGGCAGACAAGAAAGAATTTGAA
AACTGGAAAGATGACCTTCAGAAGGATAGAACTTACTGGGAGAATCAAATACAGAAAGATGTGG
AGAATGTTCAGTCAGAGTTTAAACGAATGAGGGATATCATGAACTCTGAAGAGAAGAAGGAATT
GCAGAAGCTGAAGCAAGAGAAGGAAAACATTATCAACAAACTGGCAGAGTCTGAAAATGAGCAT
GCTCAGCAGAGCAAGTTGCTAGAAGACTTCATTTCAGATGTGGAACATCAGTTACAGTGCTCAG
ACATAGAAATACTGCAGGGTGTGGAGAACATCATAAAACGGAGTCATACTTTTTCGATGAAGAA
GCCCAAAGCCATCGCCAGGGAACAAAGAAAGTTCCGAGCCCCTGACCTGCAAGGCATGCTGCAA
GTGCTGCAAGAGGTCACAGAGGCTCAACGCTACTGGGTTCAGGTGACGCTGGTTCAAAACAACA
ATCCAAACATTGCCATTACTGATGACAAAAGGCAAATACGATATGAAGACCTCCAAGCAAGGAA
TCTTGAACATGGCTGTGAAAACTCTCATGAAGGTGTCCTGGGACACCCAGTTATCCAATCAGGA
AAACATTACTGGGAAGTAGATGTGTCTGGAAAAGGTGCTTGGGTTCTGGGGTTAAGTGATGGAA
GCTACCTCTTCAATCCAATATTTCGTTCAAATGCTGAAAGAAACCCTTTATTTCGCAGGGGGAT
TAAGAATGATTCACATTATCAACCAAAATATGGCTTCTGGGTTATAGGGCTGTGGAAAAAGTCT
GTGTATAATGCTTTTGAGGAGTGTCCTTTCACAGGCAAGCCCAGTGTCTTGACCCTGTCTCTGA
TGGTCCCGCCCTGTCGTGTTGGTGTTTTCCTTGACTATGCAGCTGGGACTCTCTCATTTTACAA
TATTTCCAACAATGGGACTCTTATCTACAGATTCTGTACAGCTTCCTTTCCTGATAGGGTTTTT
CCATATTTTAATCCCATGGGAAGTTCAGAGCCCATGACAATTTGCTGGCCAGACTCTTAACATT
TGCCTGTTTACTTGCAGGGTCTCTGGCTCTGATATGTATGTCCATTTGCCTGAGCTCATCGTAC
CATTTTCTCTCTCTTTTTTTTTTTCCTGACTCTAGTCTTTCTGTGTGAATGTCTTTCATTGGTA
AAAAAGGATATATTCATTTCTCTAGGTCAGATTCTTCTCAGTTTCTTTCAGTTTTGTTTTGTTT
TAGATGAGAATAGTAAATCACTTCCCATTTGGTCAAGGAAAAGTGCCTGAGTGCTCATTGTGTA
AGATAACACTGCTGCAAAGTTCTCTTATTCTTCATGCCAGAGGTGGAAGCCAAGGCCTTGTGCA
TGGTGAGGAGGTGCTCCACCCCTGAGGAGGTGCTCCACCACTGAGCTAATTACCTCAGCTCTGT
CAGTTCTCTATAACTTCATCCTGCATATCAATGAAAGAAGATTAAAGAAAGTTCAACAACTTGT
CCATTCATTCTGAAAATTATAGGTAGGAATCTGTGGTTAAGAAATGCACCCTTAGCTGTAGGCC
AGTTTTACCAGGATGCATCTTCATCAAAGAATGAAGGAGAAGCATCACAATGAGGCACACTGTG
TTCTTGCTCAGGCGTCATGTGTTCCCAAAGTAGAATGATCAGGGAATGTTAATATGGCCCCTGC
TCATAGATGACATGCGAGTTTATGAAGCATTCCATATTTTTGAAGAGCATTGATAGTCTAAATC
ATGTTAGAGAGGAGGGAAGGGAAGGGAAGGGAAGGGAAGGGAAGGGAAGGGAAGGGAAGGGAAG
GGAAGGGAAGGGAAGGGAAGGGAAGGGAAGGAAAGGAAAGGAAAGGAAGAAAGAAAGAAAGCTA
AAGAAGATACTGTGTTCGGAAGGGAAGGGAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAG
AAAGAAAGAAAGAAAGAAAGAAAGAAAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAAAGAA
AGAAAGAAAGAAAGAAAGAAAGAAAGAAAGCTAAAGAAGATACTGTGTTCAGAGTATCTGAGCT
CCAGTCATAGTTCCAAACGTGTCAGCAGTGGCAGTGTGACTATGCTTATTTTCGTACTCTGCCT
CAAGCCAGTATGAGAAATGGGCCAGTGGGAAATAGTCCTTGTCAACAAGCCTGAGCACTTGAGT
TCAATTCCCTGCACCTGACTTCCACACATATGTTGTAGCATGTAGAGGCCCAGACATGTACACA
AACACAAATTGTGTAAATATAATTTTTTTCATGAAAAGAAACTAGGTAAGGGTAGAGCATCCAC
TGAATTATATCAGTGTTTATTCTGTTAATTACTGTGAGATACATGCTGTGTTATAGTGTCCCAT
GAAACCATGGGAAAATAAACAAGGGTTAGCTTTCCTGAAGTCTTATTACTAGTCCCTTAAATAA
CAATTATCATTACCTGACCATTCCGCTTTTTTATGGAGGGGTGTGTGTGTATTCTTAGTGATCA
CTTTCTTTAGTCACAATAAAGACCCCAAATGAATAAGGTACCATGTGTGTATATATATACACAT
ATATACACACACACATATATATATCAACTACTAAATTGTTATATTCATTTTATTTTTAGTAATA
ATGGCAGTAATAAATTTATCTTTTGGTATATTGTAAAACATAAATAAGAGTTATTACTAAGATT
TACATTGTTTCAGGCATGTGACTGGCAGTCCAGTATGGTGTCTTATTCCTTTGGGAAACCTTAT
CACTGTGACTAAATTAAATGATCATTAAGACCCTGTATCAGAACCTTGCATGGGAGCTCATACC
TGCCGTGCTGCATCTGGGAAGTTGTGGCAGGAAGATTGCTCTGTATTTGAAGCCAACCTTGTAT
ACAGAGTAAGACCCTGTTTAACATAATAAAGAATATATATTGGTTTATTACTCCATTATGTTTT
AAGAAATGGAATGACTATATTGCAGAACTGCAGGTTTTTGATTGTTTTTACAATTTATAATTCT
TTTGTCTACTACAAATAAATGCTCGTAACTTCA

hide sequence

RefSeq Acc Id:

XM_036153162 ⟹ XP_036009055

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	7	103,989,251 - 104,002,649 (-)	NCBI

Sequence:

show sequence

TCCTCAGTCAGTGTGGGCCCTGCAGGCTTATGCAAAGGCATCTCATTGGTCTGTAGAGTTGTGG
TTTCTGTTTCATTTCCAGCTCTCAAACTTTCGTTTCTCTAGCTTCGAGTCGGAAATACCTTGAA
GTTCTGGATTGGTTAGTTAATTCTCCCTGGTTTACAACTTTCTGGCGTCTGATAACGGGCTGAG
CAATTTTAGGGGGCAGACTTTTGAAGACTTTGAAAGGAGAACATTGCTTTTGCTTGGGCACCTG
AGCAGAAGTGCGAGGAGTCAGGACAGTCATACACAGGATCACAGCAACTATGGCTTCACAATTC
ATGAAGAATTTAAAGGAGGAAGTGACCTGTCCTCTCTGTCTGAACCTGATGGTGAAACCTGTGA
GTGCAGATTGTGGTCACAGCTTCTGCCAAGGCTGCATCACGGTGTACTTTGAATCCACCAAATG
CGATAAGGAAATGTTCAGTTGCCCTGTGTGCCGACTTAGTTACCAGTCTAGCAATCTGAGGCCT
AATCTACATGTGGCCAACATAGTAGAGAGGCTCAAAGAGTTCAAGCCTAGCCCAGAAGAGGAGC
AGAAAGTGTTTAACTGTGCAAGACATGGAGAGAAACTCCAGCTCTTCTGTAGGAAGGACATGAT
GGCCATCTGCTGGCTTTGTGAGCGATCTCAGGAGCACCGGGGCCACAAAACAGCTCTCATTGAA
GAGGTGGCCCAGGAGTACAAGGAGCAGCTGCAGGTAGTTCTGCAAAGGCTGATGGCAGACAAGA
AAGAATTTGAAAACTGGAAAGATGACCTTCAGAAGGATAGAACTTACTGGGAGAATCAAATACA
GAAAGATGTGGAGAATGTTCAGTCAGAGTTTAAACGAATGAGGGATATCATGAACTCTGAAGAG
AAGAAGGAATTGCAGAAGCTGAAGCAAGAGAAGGAAAACATTATCAACAAACTGGCAGAGTCTG
AAAATGAGCATGCTCAGCAGAGCAAGTTGCTAGAAGACTTCATTTCAGATGTGGAACATCAGTT
ACAGTGCTCAGACATAGAAATACTGCAGGGTGTGGAGAACATCATAAAACGGAGTCATACTTTT
TCGATGAAGAAGCCCAAAGCCATCGCCAGGGAACAAAGAAAGTTCCGAGCCCCTGACCTGCAAG
GCATGCTGCAAGTGCTGCAAGAGGTCACAGAGGCTCAACGCTACTGGGGTGACGCTGGTTCAAA
ACAACAATCCAAACATTGCCATTACTGATGACAAAAGGCAAATACGATATGAAGACCTCCAAGC
AAGGAATCTTGAACATGGCTGTGAAAACTCTCATGAAGGTGTCCTGGGACACCCAGTTATCCAA
TCAGGAAAACATTACTGGGAAGTAGATGTGTCTGGAAAAGGTGCTTGGGTTCTGGGGTTAAGTG
ATGGAAGCTACCTCTTCAATCCAATATTTCGTTCAAATGCTGAAAGAAACCCTTTATTTCGCAG
GGGGATTAAGAATGATTCACATTATCAACCAAAATATGGCTTCTGGGTTATAGGGCTGTGGAAA
AAGTCTGTGTATAATGCTTTTGAGGAGTGTCCTTTCACAGGCAAGCCCAGTGTCTTGACCCTGT
CTCTGATGGTCCCGCCCTGTCGTGTTGGTGTTTTCCTTGACTATGCAGCTGGGACTCTCTCATT
TTACAATATTTCCAACAATGGGACTCTTATCTACAGATTCTGTACAGCTTCCTTTCCTGATAGG
GTTTTTCCATATTTTAATCCCATGGGAAGTTCAGAGCCCATGACAATTTGCTGGCCAGACTCTT
AACATTTGCCTGTTTACTTGCAGGGTCTCTGGCTCTGATATGTATGTCCATTTGCCTGAGCTCA
TCGTACCATTTTCTCTCTCTTTTTTTTTTTCCTGACTCTAGTCTTTCTGTGTGAATGTCTTTCA
TTGGTAAAAAAGGATATATTCATTTCTCTAGGTCAGATTCTTCTCAGTTTCTTTCAGTTTTGTT
TTGTTTTAGATGAGAATAGTAAATCACTTCCCATTTGGTCAAGGAAAAGTGCCTGAGTGCTCAT
TGTGTAAGATAACACTGCTGCAAAGTTCTCTTATTCTTCATGCCAGAGGTGGAAGCCAAGGCCT
TGTGCATGGTGAGGAGGTGCTCCACCCCTGAGGAGGTGCTCCACCACTGAGCTAATTACCTCAG
CTCTGTCAGTTCTCTATAACTTCATCCTGCATATCAATGAAAGAAGATTAAAGAAAGTTCAACA
ACTTGTCCATTCATTCTGAAAATTATAGGTAGGAATCTGTGGTTAAGAAATGCACCCTTAGCTG
TAGGCCAGTTTTACCAGGATGCATCTTCATCAAAGAATGAAGGAGAAGCATCACAATGAGGCAC
ACTGTGTTCTTGCTCAGGCGTCATGTGTTCCCAAAGTAGAATGATCAGGGAATGTTAATATGGC
CCCTGCTCATAGATGACATGCGAGTTTATGAAGCATTCCATATTTTTGAAGAGCATTGATAGTC
TAAATCATGTTAGAGAGGAGGGAAGGGAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001139479	(Get FASTA)	NCBI Sequence Viewer
	NP_783608	(Get FASTA)	NCBI Sequence Viewer
	XP_036009055	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH38937	(Get FASTA)	NCBI Sequence Viewer
	AAH62252	(Get FASTA)	NCBI Sequence Viewer
	BAC28467	(Get FASTA)	NCBI Sequence Viewer
	BAE27171	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000060100
	ENSMUSP00000060100.9
	ENSMUSP00000116775
	ENSMUSP00000116775.3

RefSeq Acc Id:

NP_783608 ⟸ NM_175677

- UniProtKB:

D3Z3L3 (UniProtKB/TrEMBL), E9Q987 (UniProtKB/TrEMBL), Q8CHU6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASQFMKNLKEEVTCPLCLNLMVKPVSADCGHSFCQGCITVYFESTKCDKEMFSCPVCRLSYQS
SNLRPNLHVANIVERLKEFKPSPEEEQKVFNCARHGEKLQLFCRKDMMAICWLCERSQEHRGHK
TALIEEVAQEYKEQLQVVLQRLMADKKEFENWKDDLQKDRTYWENQIQKDVENVQSEFKRMRDI
MNSEEKKELQKLKQEKENIINKLAESENEHAQQSKLLEDFISDVEHQLQCSDIEILQGVENIIK
RSHTFSMKKPKAIAREQRKFRAPDLQGMLQVLQEVTEAQRYWVQVTLVQNNNPNIAITDDKRQI
RYEDLQARNLEHGCENSHEGVLGHPVIQSGKHYWEVDVSGKGAWVLGLSDGSYLFNPIFRSNAE
RNPLFRRGIKNDSHYQPKYGFWVIGLWKKSVYNAFEECPFTGKPSVLTLSLMVPPCRVGVFLDY
AAGTLSFYNISNNGTLIYRFCTASFPDRVFPYFNPMGSSEPMTICWPDS

hide sequence

RefSeq Acc Id:

NP_001139479 ⟸ NM_001146007

- UniProtKB:

D3Z3L3 (UniProtKB/TrEMBL), E9Q987 (UniProtKB/TrEMBL), Q8CHU6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASQFMKNLKEEVTCPLCLNLMVKPVSADCGHSFCQGCITVYFESTKCDKEMFSCPVCRLSYQS
SNLRPNLHVANIVERLKEFKPSPEEEQKVFNCARHGEKLQLFCRKDMMAICWLCERSQEHRGHK
TALIEEVAQEYKEQLQVVLQRLMADKKEFENWKDDLQKDRTYWENQIQKDVENVQSEFKRMRDI
MNSEEKKELQKLKQEKENIINKLAESENEHAQQSKLLEDFISDVEHQLQCSDIEILQGVENIIK
RSHTFSMKKPKAIAREQRKFRAPDLQGMLQVLQEVTEAQRYWVQVTLVQNNNPNIAITDDKRQI
RYEDLQARNLEHGCENSHEGVLGHPVIQSGKHYWEVDVSGKGAWVLGLSDGSYLFNPIFRSNAE
RNPLFRRGIKNDSHYQPKYGFWVIGLWKKSVYNAFEECPFTGKPSVLTLSLMVPPCRVGVFLDY
AAGTLSFYNISNNGTLIYRFCTASFPDRVFPYFNPMGSSEPMTICWPDS

hide sequence

RefSeq Acc Id:

ENSMUSP00000116775 ⟸ ENSMUST00000130139

RefSeq Acc Id:

ENSMUSP00000060100 ⟸ ENSMUST00000059037

RefSeq Acc Id:	XP_036009055 ⟸ XM_036153162
- Peptide Label:	isoform X1
- UniProtKB:	Q8CC73 (UniProtKB/TrEMBL)

Protein Domains

B box-type B30.2/SPRY RING-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3Z3L3-F1-model_v2	AlphaFold	D3Z3L3	1-497	view protein structure

Promoters

RGD ID:

8665079

Promoter ID:

EPDNEW_M10571

Type:

initiation region

Name:

Trim12c_1

Description:

Mus musculus tripartite motif-containing 12C , transcript variant1, mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	7	104,353,347 - 104,353,407	EPDNEW

RGD ID:

6840416

Promoter ID:

MM_KWN:52006

Type:

Non-CpG

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, ES_Cell, Liver, Lung

Transcripts:

ENSMUST00000098178, NM_175677, OTTMUST00000045997, OTTMUST00000045998

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	7	111,501,796 - 111,502,296 (-)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:4821183	AgrOrtholog
Ensembl Genes	ENSMUSG00000057143	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSMUST00000059037	ENTREZGENE
	ENSMUST00000059037.15	UniProtKB/TrEMBL
	ENSMUST00000130139	ENTREZGENE
	ENSMUST00000130139.3	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.920	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
	Classic Zinc Finger	UniProtKB/TrEMBL
InterPro	B30.2/SPRY	UniProtKB/TrEMBL
	B30.2/SPRY_sf	UniProtKB/TrEMBL
	Butyrophylin	UniProtKB/TrEMBL
	ConA-like_dom	UniProtKB/TrEMBL
	SPRY_rcpt	UniProtKB/TrEMBL
	Znf_B-box	UniProtKB/TrEMBL
	Znf_RING	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
	Znf_RING_CS	UniProtKB/TrEMBL
KEGG Report	mmu:319236	UniProtKB/TrEMBL
MGD	MGI:4821183	ENTREZGENE
NCBI Gene	319236	ENTREZGENE
PANTHER	E3 UBIQUITIN-PROTEIN LIGASE TRIM	UniProtKB/TrEMBL
	PTHR24103:SF416	UniProtKB/TrEMBL
Pfam	SPRY	UniProtKB/TrEMBL
	zf-B_box	UniProtKB/TrEMBL
	zf-C3HC4_4	UniProtKB/TrEMBL
PhenoGen	Trim12c	PhenoGen
PRINTS	BUTYPHLNCDUF	UniProtKB/TrEMBL
PROSITE	B302_SPRY	UniProtKB/TrEMBL
	ZF_BBOX	UniProtKB/TrEMBL
	ZF_RING_1	UniProtKB/TrEMBL
	ZF_RING_2	UniProtKB/TrEMBL
SMART	BBOX	UniProtKB/TrEMBL
	RING	UniProtKB/TrEMBL
	SPRY	UniProtKB/TrEMBL
Superfamily-SCOP	B-box zinc-binding domain	UniProtKB/TrEMBL
	ConA_like_lec_gl	UniProtKB/TrEMBL
	RING/U-box	UniProtKB/TrEMBL
UniProt	D3Z3L3	ENTREZGENE, UniProtKB/TrEMBL
	E9Q987	ENTREZGENE
	Q6P6F6_MOUSE	UniProtKB/TrEMBL
	Q8CC73	ENTREZGENE, UniProtKB/TrEMBL
	Q8CHU6	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	E9Q987	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2014-09-17	Trim12c	tripartite motif-containing 12C	9230105E10Rik	RIKEN cDNA 9230105E10 gene	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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