Irf3 (interferon regulatory factor 3) - Rat Genome Database

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Gene: Irf3 (interferon regulatory factor 3) Mus musculus
Analyze
Symbol: Irf3
Name: interferon regulatory factor 3
RGD ID: 1558245
MGI Page MGI
Description: Enables DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and promoter-specific chromatin binding activity. Involved in positive regulation of macromolecule biosynthetic process; response to virus; and type I interferon-mediated signaling pathway. Acts upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; regulation of defense response; and response to exogenous dsRNA. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; eye; and genitourinary system. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human IRF3 (interferon regulatory factor 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C920001K05Rik; IRF; IRF-3; MGC91046
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,647,072 - 44,652,272 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl744,647,072 - 44,652,272 (+)EnsemblGRCm39 Ensembl
GRCm38744,997,648 - 45,002,848 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl744,997,648 - 45,002,848 (+)EnsemblGRCm38mm10GRCm38
MGSCv37752,253,030 - 52,258,218 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36744,865,702 - 44,870,890 (+)NCBIMGSCv36mm8
Celera740,449,220 - 40,454,417 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.07NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-phenylprop-2-enal  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
6-propyl-2-thiouracil  (ISO)
acrolein  (ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-pinene  (ISO)
amitrole  (ISO)
amlexanox  (EXP)
aristolochic acid A  (ISO)
arsenous acid  (EXP)
auranofin  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
chloroquine  (EXP)
chlorpyrifos  (EXP)
chrysin  (EXP)
Cirsimarin  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
cudratricusxanthone A  (EXP)
curcumin  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (EXP)
dibutyl phthalate  (EXP,ISO)
disodium selenite  (EXP)
elemental selenium  (ISO)
eriodictyol  (EXP)
ethanol  (EXP,ISO)
ferroheme b  (EXP)
folic acid  (EXP)
fructose  (EXP)
galactose  (EXP,ISO)
gemcitabine  (ISO)
genistein  (EXP)
gentamycin  (ISO)
heme b  (EXP)
hexadecanoic acid  (EXP,ISO)
hydroquinone  (EXP)
hydroxychloroquine  (EXP,ISO)
ivermectin  (ISO)
linuron  (EXP)
lipopolysaccharide  (EXP,ISO)
luteolin  (EXP)
lycopene  (EXP)
metam  (EXP)
metformin  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
microcystin-LR  (ISO)
monodansylcadaverine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel dichloride  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (EXP)
perfluorooctanoic acid  (ISO)
Phytolaccoside E  (ISO)
pirinixic acid  (EXP,ISO)
pitavastatin  (EXP)
pitavastatin(1-)  (EXP)
poly(I:C)  (EXP,ISO)
pravastatin  (EXP)
quercetin  (EXP,ISO)
resveratrol  (EXP)
scoparone  (EXP)
selenium atom  (ISO)
sodium arsenite  (EXP)
sulfadimethoxine  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
thioacetamide  (ISO)
thymoquinone  (ISO)
trametinib  (EXP)
Triptolide  (EXP)
triptonide  (EXP)
vadimezan  (EXP)
valproic acid  (ISO)
vinclozolin  (ISO)
zingerone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromatin  (ISO)
cytoplasm  (ISO)
cytosol  (ISO,TAS)
mitochondrion  (ISO)
nucleus  (IBA,IDA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. IFN regulatory factor 3 contributes to the host response during Pseudomonas aeruginosa lung infection in mice. Carrigan SO, etal., J Immunol. 2010 Sep 15;185(6):3602-9. Epub 2010 Aug 18.
2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, etal., Science 2004 Dec 24;306(5705):2255-7.
3. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
4. Paramyxovirus Sendai virus V protein counteracts innate virus clearance through IRF-3 activation, but not via interferon, in mice. Kiyotani K, etal., Virology. 2007 Mar 1;359(1):82-91. Epub 2006 Oct 6.
5. Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients. Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
6. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
7. Interferon response factor 3 is essential for house dust mite-induced airway allergy. Marichal T, etal., J Allergy Clin Immunol. 2010 Oct;126(4):836-844.e13. Epub 2010 Jul 31.
8. MGDs mouse GO annotations MGD data from the GO Consortium
9. MGD IEA MGD IEA
10. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9803267   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11070172   PMID:11076861   PMID:11854279   PMID:11940575   PMID:12444163   PMID:12477932   PMID:12604599   PMID:12821121  
PMID:12855817   PMID:12872135   PMID:14517278   PMID:14556004   PMID:14610273   PMID:14679297   PMID:14703513   PMID:15029200   PMID:15226823   PMID:15302901   PMID:15489334   PMID:15585830  
PMID:15585867   PMID:15661922   PMID:15761153   PMID:15800576   PMID:16051830   PMID:16141072   PMID:16141073   PMID:16148088   PMID:16219795   PMID:16286919   PMID:16362036   PMID:16394098  
PMID:16413926   PMID:16513254   PMID:16670275   PMID:16699525   PMID:16709859   PMID:16840729   PMID:16979567   PMID:17005672   PMID:17015689   PMID:17074929   PMID:17091495   PMID:17170125  
PMID:17178782   PMID:17251283   PMID:17273999   PMID:17275788   PMID:17360658   PMID:17360955   PMID:17452523   PMID:17513714   PMID:17548596   PMID:17562815   PMID:17618271   PMID:17676997  
PMID:17785847   PMID:17925397   PMID:18223009   PMID:18268344   PMID:18287559   PMID:18354186   PMID:18354215   PMID:18368052   PMID:18382764   PMID:18423196   PMID:18480050   PMID:18562536  
PMID:18635538   PMID:18641322   PMID:18713975   PMID:18724932   PMID:18799693   PMID:18802055   PMID:18818394   PMID:18851954   PMID:18981140   PMID:18991290   PMID:19006696   PMID:19017982  
PMID:19028691   PMID:19088287   PMID:19091986   PMID:19152337   PMID:19201871   PMID:19218087   PMID:19287954   PMID:19460690   PMID:19474102   PMID:19483718   PMID:19617565   PMID:19652017  
PMID:19657036   PMID:19701189   PMID:19706447   PMID:19759149   PMID:19798431   PMID:19805092   PMID:19864603   PMID:19890330   PMID:19915568   PMID:19956647   PMID:20059953   PMID:20083668  
PMID:20107183   PMID:20145605   PMID:20351107   PMID:20351692   PMID:20357099   PMID:20360684   PMID:20404081   PMID:20412781   PMID:20422028   PMID:20451243   PMID:20456021   PMID:20463082  
PMID:20592086   PMID:20605974   PMID:20610653   PMID:20637660   PMID:20660188   PMID:20886096   PMID:20886104   PMID:20890285   PMID:20947170   PMID:20975040   PMID:21059856   PMID:21085181  
PMID:21148557   PMID:21204785   PMID:21245146   PMID:21266535   PMID:21267068   PMID:21307186   PMID:21307205   PMID:21403398   PMID:21435586   PMID:21441453   PMID:21480215   PMID:21550664  
PMID:21567079   PMID:21602824   PMID:21606371   PMID:21622562   PMID:21653850   PMID:21723157   PMID:21765404   PMID:21788382   PMID:21810534   PMID:21813776   PMID:21820332   PMID:21829705  
PMID:21842368   PMID:21862579   PMID:21873635   PMID:21988875   PMID:21998457   PMID:21999375   PMID:22028379   PMID:22036947   PMID:22053377   PMID:22118374   PMID:22156592   PMID:22188870  
PMID:22252317   PMID:22285490   PMID:22308357   PMID:22345436   PMID:22366192   PMID:22371392   PMID:22379081   PMID:22379089   PMID:22474394   PMID:22479513   PMID:22514347   PMID:22532687  
PMID:22610141   PMID:22634618   PMID:22761364   PMID:22777843   PMID:22817838   PMID:22896628   PMID:22911267   PMID:22911673   PMID:22940097   PMID:23028052   PMID:23033912   PMID:23035219  
PMID:23048204   PMID:23093799   PMID:23160154   PMID:23192868   PMID:23213237   PMID:23251783   PMID:23300459   PMID:23307144   PMID:23349877   PMID:23422957   PMID:23440417   PMID:23499490  
PMID:23532979   PMID:23555875   PMID:23761407   PMID:23770228   PMID:23770239   PMID:23777662   PMID:23836649   PMID:23892079   PMID:23903655   PMID:23910378   PMID:23918362   PMID:24014876  
PMID:24042114   PMID:24043884   PMID:24052526   PMID:24078691   PMID:24096085   PMID:24123166   PMID:24140628   PMID:24154727   PMID:24185615   PMID:24244017   PMID:24248350   PMID:24275658  
PMID:24278020   PMID:24335288   PMID:24335302   PMID:24362933   PMID:24368188   PMID:24391507   PMID:24551175   PMID:24590060   PMID:24596398   PMID:24627105   PMID:24637670   PMID:24688022  
PMID:24696485   PMID:24726644   PMID:24743339   PMID:24745336   PMID:24808358   PMID:24929003   PMID:25008929   PMID:25049377   PMID:25069698   PMID:25149452   PMID:25239187   PMID:25320282  
PMID:25456137   PMID:25525875   PMID:25526531   PMID:25529558   PMID:25569216   PMID:25572843   PMID:25646421   PMID:25681338   PMID:25710914   PMID:25717109   PMID:25763818   PMID:25810395  
PMID:25811886   PMID:25843711   PMID:25848020   PMID:25896227   PMID:25964372   PMID:25994966   PMID:26468541   PMID:26590319   PMID:26595890   PMID:26682986   PMID:26692175   PMID:26740329  
PMID:26786557   PMID:26900919   PMID:26912623   PMID:26939124   PMID:27043414   PMID:27076643   PMID:27122612   PMID:27129230   PMID:27178468   PMID:27182740   PMID:27183626   PMID:27327515  
PMID:27374884   PMID:27400129   PMID:27448985   PMID:27481466   PMID:27503123   PMID:27546168   PMID:27565347   PMID:27576490   PMID:27641636   PMID:27709605   PMID:27742471   PMID:27793594  
PMID:27841872   PMID:27859049   PMID:28002730   PMID:28018864   PMID:28069950   PMID:28077630   PMID:28100675   PMID:28158275   PMID:28159912   PMID:28181039   PMID:28302626   PMID:28342759  
PMID:28363903   PMID:28400473   PMID:28410990   PMID:28464285   PMID:28468885   PMID:28468974   PMID:28564605   PMID:28630094   PMID:28651122   PMID:28763789   PMID:28801234   PMID:28898711  
PMID:28904192   PMID:28939760   PMID:28951494   PMID:29053748   PMID:29101251   PMID:29106401   PMID:29117564   PMID:29127186   PMID:29176737   PMID:29305462   PMID:29321276   PMID:29339449  
PMID:29352265   PMID:29429998   PMID:29576451   PMID:29632368   PMID:29712834   PMID:29914621   PMID:29963044   PMID:30021146   PMID:30094631   PMID:30170810   PMID:30209176   PMID:30442645  
PMID:30451651   PMID:30515151   PMID:30683688   PMID:30772497   PMID:30830879   PMID:30842237   PMID:30842273   PMID:30878284   PMID:30932349   PMID:30944222   PMID:31141689   PMID:31213650  
PMID:31281243   PMID:31390091   PMID:31477704   PMID:31577946   PMID:31731106   PMID:31733580   PMID:31799619   PMID:31840109   PMID:31865314   PMID:31956894   PMID:31993061   PMID:31999809  
PMID:32130408   PMID:32142632   PMID:32150572   PMID:32266378   PMID:32290105   PMID:32325033   PMID:32373120   PMID:32393626   PMID:32393794   PMID:32428860   PMID:32553167   PMID:32640258  
PMID:32750141   PMID:32907941   PMID:33065113   PMID:33101313   PMID:33188184   PMID:33191000   PMID:33278357   PMID:33304758   PMID:33326766   PMID:33388094   PMID:33513265   PMID:33571167  
PMID:33596642   PMID:33597211   PMID:33684176   PMID:34091599   PMID:34168080   PMID:34315861   PMID:34619149   PMID:34707113   PMID:34731629   PMID:35037428   PMID:35091453   PMID:35137688  
PMID:35245345   PMID:35320000   PMID:35351462   PMID:35471821   PMID:35963236   PMID:35997679   PMID:36067309   PMID:36417850   PMID:36446848   PMID:36958140   PMID:37296614   PMID:37733807  
PMID:37737190   PMID:38227600   PMID:38251349   PMID:38355793  


Genomics

Comparative Map Data
Irf3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39744,647,072 - 44,652,272 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl744,647,072 - 44,652,272 (+)EnsemblGRCm39 Ensembl
GRCm38744,997,648 - 45,002,848 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl744,997,648 - 45,002,848 (+)EnsemblGRCm38mm10GRCm38
MGSCv37752,253,030 - 52,258,218 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36744,865,702 - 44,870,890 (+)NCBIMGSCv36mm8
Celera740,449,220 - 40,454,417 (+)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.07NCBI
IRF3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381949,659,572 - 49,665,857 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1949,659,569 - 49,665,875 (-)EnsemblGRCh38hg38GRCh38
GRCh371950,162,829 - 50,169,114 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,854,641 - 54,860,936 (-)NCBINCBI36Build 36hg18NCBI36
Build 341954,854,641 - 54,860,926NCBI
Celera1947,032,161 - 47,038,466 (-)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1946,539,596 - 46,545,904 (-)NCBIHuRef
CHM1_11950,164,615 - 50,170,921 (-)NCBICHM1_1
T2T-CHM13v2.01952,659,601 - 52,665,933 (-)NCBIT2T-CHM13v2.0
Irf3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81104,616,608 - 104,621,402 (+)NCBIGRCr8
mRatBN7.2195,479,966 - 95,484,926 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl195,479,821 - 95,484,935 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1100,865,527 - 100,870,321 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,338,193 - 109,342,987 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01102,628,586 - 102,633,382 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01100,992,244 - 100,997,202 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1100,992,405 - 100,997,198 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,056,847 - 102,061,805 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,470,284 - 95,475,078 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera189,741,455 - 89,746,249 (+)NCBICelera
Cytogenetic Map1q22NCBI
Irf3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,224,874 - 1,228,624 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,223,986 - 1,228,671 (+)NCBIChiLan1.0ChiLan1.0
IRF3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,776,859 - 55,783,043 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11957,697,602 - 57,703,818 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01946,674,193 - 46,680,464 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11955,593,627 - 55,599,903 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1955,593,627 - 55,599,903 (-)Ensemblpanpan1.1panPan2
IRF3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11106,875,016 - 106,879,065 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1106,875,118 - 106,879,065 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1106,457,016 - 106,462,843 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01107,394,678 - 107,400,508 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,394,687 - 107,400,506 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,066,914 - 107,072,739 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01106,709,002 - 106,714,828 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01107,550,123 - 107,555,958 (+)NCBIUU_Cfam_GSD_1.0
Irf3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,859,560 - 21,863,357 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366643,475,543 - 3,481,533 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366643,477,750 - 3,482,489 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IRF3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,701,668 - 54,707,151 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,701,733 - 54,706,079 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,430,689 - 50,441,627 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IRF3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,835,285 - 42,841,487 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,831,203 - 42,840,796 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607322,779,185 - 22,785,813 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Irf3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248324,612,374 - 4,616,276 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248324,611,445 - 4,616,319 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Irf3
234 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1518
Count of miRNA genes:523
Interacting mature miRNAs:608
Transcripts:ENSMUST00000003284, ENSMUST00000107834, ENSMUST00000107835, ENSMUST00000124069, ENSMUST00000127011, ENSMUST00000130610, ENSMUST00000145233, ENSMUST00000145728, ENSMUST00000146355
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7351172887142720Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360299972549748Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76502999133501729Mouse
12792978Fbmd3_mfemoral bone mineral density 3, females only (mouse)77050288142367832Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71248087746480877Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71248087746480877Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1303248547032621Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71313520447135204Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71333392547349748Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71663729349159331Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718728794119485380Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719147398141919804Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71928001553280104Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined71984225053842367Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72267388756674033Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72288857256888716Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72306653157066531Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72684761560851775Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72754054961540549Mouse
4141805Sle19_msystematic lupus erythematosus susceptibility 19 (mouse)Not determined3003248581135653Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730199425108999207Mouse
1301175Ap7q_malcohol preference 7 QTL (mouse)Not determined73171484565715077Mouse
1300996Aorls2_maortic lesion size 2 (mouse)Not determined73239453266394681Mouse
4142003W3q10_mweight 3 weeks QTL 10 (mouse)Not determined3349772758148965Mouse
4142102Tailq5_mtail length QTL 5 (mouse)Not determined3349772758148965Mouse
4142218W6q17_mweight 6 weeks QTL 17 (mouse)Not determined3349772758148965Mouse
4141909W10q18_mweight 10 weeks QTL 18 (mouse)Not determined3349772758148965Mouse
1357883Epfq5_mepididymal fat pad weight QTL 5 (mouse)Not determined73349772758148965Mouse
1357634Splq7_mspleen weight QTL 7 (mouse)Not determined73349772758148965Mouse
39128210Lwq19_mliver weight QTL 19 (mouse)73349772758148965Mouse
1357469Kidq5_mkidney weight QTL 5 (mouse)Not determined73349772758148965Mouse
1559000Ossc1_mosteosarcoma susceptibility 1 (mouse)Not determined73405302568053223Mouse
38501071Stsl6_mSalmonella typhimurium susceptibility locus 6 (mouse)73419942551149748Mouse
10045622Heal20_mwound healing/regeneration 20 (mouse)Not determined73431688768317043Mouse
1357586Mdmsc3_mmodifier of muscularity 3 (mouse)Not determined73444786968448018Mouse
1301514Rigs1_mradiation induced gastroschisis 1 (mouse)Not determined73628001592394346Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736280015116416877Mouse
25314301Vmm3_mvariable multisystem mineralization 3, lung (mouse)73729942572049748Mouse
25314303Vmm4_mvariable multisystem mineralization 4, kidney (mouse)73729942587049208Mouse
1300878Skts1_mskin tumor susceptibility 1 (mouse)Not determined73789138671891582Mouse
10402488Dipa2_mdrug induced psychomotor activation 2 (mouse)Not determined73842154872421684Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined739673887103510010Mouse
11252140Fdr1_mfat response to dietary restriction 1 (mouse)74114882075148965Mouse
4141929Chlq18_mcirculating hormone level QTL 18 (mouse)Not determined74114882075148965Mouse
25394571Skmw59_mskeletal muscle weight 59, TA (mouse)74422494344675382Mouse
25394574Skmw61_mskeletal muscle weight 61, EDL (mouse)74422494344675382Mouse
25394572Skmw60_mskeletal muscle weight 60, gastroc (mouse)74455116444702447Mouse

Markers in Region
RH126884  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38745,002,951 - 45,003,187UniSTSGRCm38
MGSCv37752,258,321 - 52,258,557UniSTSGRCm37
Celera740,454,520 - 40,454,757UniSTS
Cytogenetic Map7B2UniSTS
Cytogenetic Map7B4UniSTS
Whitehead/MRC_RH7565.77UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_016849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_045611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006540995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006540996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC155806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF036341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK013944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK050570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145977 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK152689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC023244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC050882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY089035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU545481 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U75839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U75840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000003284   ⟹   ENSMUSP00000003284
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl744,647,072 - 44,652,272 (+)Ensembl
GRCm38.p6 Ensembl744,997,648 - 45,002,848 (+)Ensembl
RefSeq Acc Id: ENSMUST00000107834   ⟹   ENSMUSP00000103465
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl744,647,373 - 44,651,813 (+)Ensembl
GRCm38.p6 Ensembl744,997,949 - 45,002,389 (+)Ensembl
RefSeq Acc Id: ENSMUST00000207128   ⟹   ENSMUSP00000147187
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl744,649,637 - 44,651,821 (+)Ensembl
GRCm38.p6 Ensembl745,000,213 - 45,002,397 (+)Ensembl
RefSeq Acc Id: ENSMUST00000207129   ⟹   ENSMUSP00000147175
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl744,650,157 - 44,651,814 (+)Ensembl
GRCm38.p6 Ensembl745,000,733 - 45,002,390 (+)Ensembl
RefSeq Acc Id: ENSMUST00000207476
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl744,647,104 - 44,651,814 (+)Ensembl
GRCm38.p6 Ensembl744,997,680 - 45,002,390 (+)Ensembl
RefSeq Acc Id: ENSMUST00000207521   ⟹   ENSMUSP00000146383
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl744,647,750 - 44,649,869 (+)Ensembl
GRCm38.p6 Ensembl744,998,326 - 45,000,445 (+)Ensembl
RefSeq Acc Id: ENSMUST00000207555
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl744,647,113 - 44,651,825 (+)Ensembl
GRCm38.p6 Ensembl744,997,689 - 45,002,401 (+)Ensembl
RefSeq Acc Id: ENSMUST00000208143
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl744,649,925 - 44,650,681 (+)Ensembl
GRCm38.p6 Ensembl745,000,501 - 45,001,257 (+)Ensembl
RefSeq Acc Id: ENSMUST00000208767
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl744,649,591 - 44,650,511 (+)Ensembl
GRCm38.p6 Ensembl745,000,167 - 45,001,087 (+)Ensembl
RefSeq Acc Id: ENSMUST00000208906
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl744,650,811 - 44,651,814 (+)Ensembl
GRCm38.p6 Ensembl745,001,387 - 45,002,390 (+)Ensembl
RefSeq Acc Id: ENSMUST00000208958   ⟹   ENSMUSP00000146729
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl744,650,172 - 44,651,771 (+)Ensembl
GRCm38.p6 Ensembl745,000,748 - 45,002,347 (+)Ensembl
RefSeq Acc Id: ENSMUST00000209006
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl744,647,111 - 44,647,745 (+)Ensembl
GRCm38.p6 Ensembl744,997,687 - 44,998,321 (+)Ensembl
RefSeq Acc Id: ENSMUST00000209066   ⟹   ENSMUSP00000146773
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl744,647,090 - 44,651,813 (+)Ensembl
GRCm38.p6 Ensembl744,997,666 - 45,002,389 (+)Ensembl
RefSeq Acc Id: NM_016849   ⟹   NP_058545
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39744,647,072 - 44,652,272 (+)NCBI
GRCm38744,997,648 - 45,002,848 (+)ENTREZGENE
MGSCv37752,253,030 - 52,258,218 (+)RGD
Celera740,449,208 - 40,454,417 (+)ENTREZGENE
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: NR_045611
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39744,647,072 - 44,652,272 (+)NCBI
GRCm38744,997,648 - 45,002,848 (+)ENTREZGENE
Celera740,449,208 - 40,454,417 (+)ENTREZGENE
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006540995   ⟹   XP_006541058
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39744,647,078 - 44,651,816 (+)NCBI
GRCm38744,997,650 - 45,002,392 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006540996   ⟹   XP_006541059
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39744,647,078 - 44,651,816 (+)NCBI
GRCm38744,997,650 - 45,002,392 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_058545   ⟸   NM_016849
- UniProtKB: P70671 (UniProtKB/Swiss-Prot),   Q3U9K6 (UniProtKB/TrEMBL),   Q3UJM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006541058   ⟸   XM_006540995
- Peptide Label: isoform X1
- UniProtKB: P70671 (UniProtKB/Swiss-Prot),   Q3U9K6 (UniProtKB/TrEMBL),   Q3UJM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006541059   ⟸   XM_006540996
- Peptide Label: isoform X1
- UniProtKB: P70671 (UniProtKB/Swiss-Prot),   Q3U9K6 (UniProtKB/TrEMBL),   Q3UJM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000103465   ⟸   ENSMUST00000107834
RefSeq Acc Id: ENSMUSP00000003284   ⟸   ENSMUST00000003284
RefSeq Acc Id: ENSMUSP00000146729   ⟸   ENSMUST00000208958
RefSeq Acc Id: ENSMUSP00000147175   ⟸   ENSMUST00000207129
RefSeq Acc Id: ENSMUSP00000147187   ⟸   ENSMUST00000207128
RefSeq Acc Id: ENSMUSP00000146383   ⟸   ENSMUST00000207521
RefSeq Acc Id: ENSMUSP00000146773   ⟸   ENSMUST00000209066
Protein Domains
Interferon regulatory factor-3   IRF tryptophan pentad repeat

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70671-F1-model_v2 AlphaFold P70671 1-419 view protein structure

Promoters
RGD ID:8663937
Promoter ID:EPDNEW_M9999
Type:multiple initiation site
Name:Irf3_1
Description:Mus musculus interferon regulatory factor 3 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38744,997,670 - 44,997,730EPDNEW
RGD ID:6841352
Promoter ID:MM_KWN:50327
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000048513,   OTTMUST00000048515,   OTTMUST00000048516,   OTTMUST00000048518,   OTTMUST00000057116,   OTTMUST00000057117,   OTTMUST00000057118,   UC009GSK.1,   UC009GSL.1,   UC009GSN.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36752,252,421 - 52,254,132 (+)MPROMDB
RGD ID:6841351
Promoter ID:MM_KWN:50329
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4
Transcripts:OTTMUST00000048519,   OTTMUST00000048520
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36752,254,736 - 52,255,677 (+)MPROMDB
RGD ID:6841353
Promoter ID:MM_KWN:50330
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000048521
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36752,255,936 - 52,257,122 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1859179 AgrOrtholog
Ensembl Genes ENSMUSG00000003184 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000003284 ENTREZGENE
  ENSMUST00000003284.16 UniProtKB/Swiss-Prot
  ENSMUST00000107834.2 UniProtKB/Swiss-Prot
  ENSMUST00000207128.2 UniProtKB/TrEMBL
  ENSMUST00000207129.2 UniProtKB/TrEMBL
  ENSMUST00000207521.2 UniProtKB/TrEMBL
  ENSMUST00000207555 ENTREZGENE
  ENSMUST00000208958.2 UniProtKB/TrEMBL
  ENSMUST00000209066 ENTREZGENE
  ENSMUST00000209066.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.200.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Interferon_reg_fac_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interferon_reg_fact_DNA-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interferon_reg_factor-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SMAD_FHA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:54131 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1859179 ENTREZGENE
NCBI Gene 54131 ENTREZGENE
PANTHER INTERFERON REGULATORY FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTERFERON REGULATORY FACTOR 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IRF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRF-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Irf3 PhenoGen
PRINTS INTFRNREGFCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IRF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IRF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IRF-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49879 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140LHE6_MOUSE UniProtKB/TrEMBL
  A0A140LI96_MOUSE UniProtKB/TrEMBL
  A0A140LJD9_MOUSE UniProtKB/TrEMBL
  A0A140LJE8_MOUSE UniProtKB/TrEMBL
  C0IXK2_MOUSE UniProtKB/TrEMBL
  IRF3_MOUSE UniProtKB/Swiss-Prot
  O54726_MOUSE UniProtKB/TrEMBL
  P70671 ENTREZGENE
  Q3U9K6 ENTREZGENE, UniProtKB/TrEMBL
  Q3UJM9 ENTREZGENE, UniProtKB/TrEMBL