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ONTOLOGY REPORT - ANNOTATIONS

Term:attachment of spindle microtubules to kinetochore
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Accession:GO:0008608 term browser browse the term
Definition:The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex.
Comment:This class covers all attachments of spindle microtubules to the kinetochore, including the many incorrect attachments which initially form and are later corrected to stable attachments with the correct orientation for segregation to proceed (sister chromatid biorientation).
Synonyms:exact_synonym: attachment of spindle microtubules to chromosome;   kinetochore-microtubule attachment;   microtubule anchoring at kinetochore;   spindle chromosome attachment;   spindle kinetochore attachment
 narrow_synonym: microtubule capture
 broad_synonym: kinetochore microtubule interaction;   microtubule and chromosome interaction;   spindle-chromosome interaction
 related_synonym: amphotelic attachment;   bipolar attachment;   microtubule and kinetochore interaction
 alt_id: GO:0051313


show annotations for term's descendants           Sort by:
attachment of spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abraxas1 abraxas 1, BRCA1 A complex subunit involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:8,796,281...8,810,625
Ensembl chr14:8,796,266...8,810,622 		JBrowse link
G Abraxas2 abraxas 2, BRISC complex subunit involved_in ISO
IBA		 (PMID:26195665)
GO_REF:0000033		 RGD
GO_Central		 PMID:26195665 GO_REF:0000033 NCBI chr 1:187,647,078...187,672,660
Ensembl chr 1:187,647,067...187,672,655 		JBrowse link
G Bub3 BUB3 mitotic checkpoint protein involved_in ISO (PMID:18199686) RGD PMID:18199686 NCBI chr 1:186,330,358...186,340,969
Ensembl chr 1:186,327,931...186,395,036 		JBrowse link
G Cenpe centromere protein E involved_in ISO (MGI:2673075|PMID:12925705) RGD PMID:12925705 MGI:2673075 NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669 		JBrowse link
G Eml4 EMAP like 4 involved_in ISO (PMID:25789526) RGD PMID:25789526 NCBI chr 6:11,219,545...11,334,824
Ensembl chr 6:11,219,566...11,334,879 		JBrowse link
G Knl1 kinetochore scaffold 1 involved_in ISO
IBA		 (PMID:17981135)
GO_REF:0000033		 RGD
GO_Central		 PMID:17981135 GO_REF:0000033 NCBI chr 3:106,029,627...106,091,915
Ensembl chr 3:106,029,661...106,091,915 		JBrowse link
G Ndc80 NDC80 kinetochore complex component involved_in ISO (PMID:18455984), (PMID:19468067) RGD PMID:18455984 PMID:19468067 NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924 		JBrowse link
G Nuf2 NUF2 component of NDC80 kinetochore complex involved_in ISO (PMID:18455984) RGD PMID:18455984 NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766 		JBrowse link
G Sgo1 shugoshin 1 involved_in ISO (PMID:17621308) RGD PMID:17621308 NCBI chr 9:6,672,109...6,687,908
Ensembl chr 9:6,672,123...6,687,805 		JBrowse link
G Spc24 SPC24 component of NDC80 kinetochore complex involved_in ISO (PMID:18455984) RGD PMID:18455984 NCBI chr 8:20,300,315...20,305,354
Ensembl chr 8:20,300,319...20,305,310 		JBrowse link
G Spc25 SPC25 component of NDC80 kinetochore complex involved_in ISO (PMID:18455984) RGD PMID:18455984 NCBI chr 3:53,930,013...53,988,940
Ensembl chr 3:53,975,704...53,988,959 		JBrowse link
G Tex14 testis expressed 14, intercellular bridge forming factor involved_in IEA
IBA
ISO
ISS		 GO_REF:0000107
GO_REF:0000033
GO_REF:0000002
(MGI:5318128|PMID:22405274)
GO_REF:0000024		 Ensembl
GO_Central
InterPro
RGD
UniProt		 PMID:22405274 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:5318128 NCBI chr10:72,231,766...72,356,938
Ensembl chr10:72,231,801...72,355,805 		JBrowse link
G Zfp207 zinc finger protein 207 involved_in ISO (PMID:24462186), (PMID:24462187) RGD PMID:24462186 PMID:24462187 NCBI chr10:65,385,807...65,398,086
Ensembl chr10:65,385,740...65,397,386 		JBrowse link
attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 involved_in ISO (PMID:22581055) RGD PMID:22581055 NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659 		JBrowse link
G Cenpc centromere protein C involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:21,988,067...22,046,732
Ensembl chr14:21,988,144...22,055,476 		JBrowse link
G Cenpe centromere protein E involved_in ISO (PMID:15843429) RGD PMID:15843429 NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669 		JBrowse link
G Champ1 chromosome alignment maintaining phosphoprotein 1 involved_in ISO
IBA		 (PMID:21063390)
GO_REF:0000033		 RGD
GO_Central		 PMID:21063390 GO_REF:0000033 NCBI chr16:75,733,958...75,744,931
Ensembl chr16:75,733,805...75,744,984 		JBrowse link
G Kif2c kinesin family member 2C involved_in ISO
ISS
IEA		 (PMID:23891108)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:23891108 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:130,637,347...130,662,680
Ensembl chr 5:130,637,347...130,662,637 		JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703 		JBrowse link
G Mapre1 microtubule-associated protein, RP/EB family, member 1 involved_in ISS
ISO
IEA		 GO_REF:0000024
UniProtKB:Q96BD8 (PMID:23001180), (PMID:36592928)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:23001180 PMID:36592928 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:142,218,846...142,246,990
Ensembl chr 3:142,212,955...142,246,983 		JBrowse link
G Mis12 MIS12 kinetochore complex component involved_in ISO
IEA
ISS		 (PMID:23891108)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:23891108 GO_REF:0000024 GO_REF:0000107 NCBI chr10:55,739,741...55,747,915
Ensembl chr10:55,739,564...55,751,068 		JBrowse link
G Ndc80 NDC80 kinetochore complex component involved_in ISO
IBA		 (PMID:22581055), (PMID:23891108), (PMID:25743205), (PMID:30409912)
GO_REF:0000033		 RGD
GO_Central		 PMID:22581055 PMID:23891108 PMID:25743205 PMID:30409912 GO_REF:0000033 NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924 		JBrowse link
G Nuf2 NUF2 component of NDC80 kinetochore complex involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766 		JBrowse link
G Seh1l SEH1-like nucleoporin involved_in ISO (PMID:17363900) RGD PMID:17363900 NCBI chr18:61,346,986...61,369,987 JBrowse link
G Ska1 spindle and kinetochore associated complex subunit 1 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:29487209), (PMID:36592928)		 Ensembl
UniProt
RGD		 PMID:29487209 PMID:36592928 GO_REF:0000024 GO_REF:0000107 NCBI chr18:67,794,722...67,805,037
Ensembl chr18:67,794,725...67,805,037 		JBrowse link
G Ska2 spindle and kinetochore associated complex subunit 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:29487209)		 UniProt
RGD		 PMID:29487209 GO_REF:0000024 NCBI chr10:71,921,474...71,939,461
Ensembl chr10:71,921,582...71,939,458 		JBrowse link
G Ska3 spindle and kinetochore associated complex subunit 3 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:28479321), (PMID:29487209)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:28479321 PMID:29487209 GO_REF:0000024 GO_REF:0000107 NCBI chr15:31,951,812...31,971,010
Ensembl chr15:31,951,825...31,971,010 		JBrowse link
lateral attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cenpe centromere protein E involved_in ISO (PMID:23891108) RGD PMID:23891108 NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669 		JBrowse link
mitotic sister chromatid biorientation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bod1 biorientation of chromosomes in cell division 1 involved_in ISO (PMID:17938248), (PMID:24157919) RGD PMID:17938248 PMID:24157919 NCBI chr10:15,993,454...15,999,795
Ensembl chr10:15,993,454...15,999,787 		JBrowse link
negative regulation of attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 involved_in ISO (PMID:30409912) RGD PMID:30409912 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
positive regulation of attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 involved_in ISO (PMID:23478334) RGD PMID:23478334 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Hnrnpu heterogeneous nuclear ribonucleoprotein U involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:21242313)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:21242313 GO_REF:0000024 GO_REF:0000107 NCBI chr13:90,069,058...90,086,905
Ensembl chr13:90,074,181...90,086,588 		JBrowse link
G Kat2b lysine acetyltransferase 2B involved_in ISO (PMID:23001180) RGD PMID:23001180 NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064 		JBrowse link
G Kat5 lysine acetyltransferase 5 involved_in ISO
ISS
IEA		 (PMID:30409912)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:30409912 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:202,895,751...202,903,178
Ensembl chr 1:202,895,751...202,903,458 		JBrowse link
positive regulation of attachment of spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnb1 cyclin B1 involved_in ISO
IEA		 (PMID:18195732)
GO_REF:0000107		 RGD
Ensembl		 PMID:18195732 GO_REF:0000107 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cenpe centromere protein E involved_in ISO (MGI:2447982|PMID:12361599) RGD PMID:12361599 MGI:2447982 NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669 		JBrowse link
G Rcc2 regulator of chromosome condensation 2 involved_in ISO (PMID:12919680) RGD PMID:12919680 NCBI chr 5:152,994,406...153,017,223
Ensembl chr 5:152,993,665...153,017,205 		JBrowse link
G Sirt2 sirtuin 2 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:5567889|PMID:24334550)		 UniProt
Ensembl
RGD		 PMID:24334550 GO_REF:0000024 GO_REF:0000107 MGI:5567889 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975 		JBrowse link
positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aurkb aurora kinase B involved_in ISO
IEA		 (PMID:28751710)
GO_REF:0000107		 RGD
Ensembl		 PMID:28751710 GO_REF:0000107 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837 		JBrowse link
regulation of attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk1 cyclin-dependent kinase 1 involved_in ISO
ISS		 (PMID:28479321)
GO_REF:0000024		 RGD
UniProt		 PMID:28479321 GO_REF:0000024 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
regulation of attachment of spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:17227893)
GO_REF:0000107		 RGD
Ensembl		 PMID:17227893 GO_REF:0000107 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696 		JBrowse link
G Cdc42 cell division cycle 42 involved_in ISO
ISS		 (PMID:15642749)
GO_REF:0000024		 RGD
UniProt		 PMID:15642749 GO_REF:0000024 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Ect2 epithelial cell transforming 2 involved_in ISO (PMID:15642749) RGD PMID:15642749 NCBI chr 2:109,975,813...110,037,911
Ensembl chr 2:109,975,813...110,037,911 		JBrowse link
G Knstrn kinetochore-localized astrin/SPAG5 binding protein involved_in ISO
IBA
IEA
ISS		 (PMID:21402792)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024		 RGD
GO_Central
Ensembl
UniProt		 PMID:21402792 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:105,800,762...105,820,555
Ensembl chr 3:105,800,954...105,820,715 		JBrowse link
G Nek2 NIMA-related kinase 2 involved_in ISO (PMID:18297113) RGD PMID:18297113 NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051 		JBrowse link
G Racgap1 Rac GTPase-activating protein 1 involved_in ISO (PMID:15642749) RGD PMID:15642749 NCBI chr 7:130,750,936...130,780,891
Ensembl chr 7:130,750,936...130,780,831 		JBrowse link
G Spag5 sperm associated antigen 5 involved_in ISO (PMID:21402792) RGD PMID:21402792 NCBI chr10:63,198,717...63,216,746
Ensembl chr10:63,198,768...63,216,745 		JBrowse link
sister chromatid biorientation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Champ1 chromosome alignment maintaining phosphoprotein 1 involved_in ISO
IBA		 (PMID:21063390)
GO_REF:0000033		 RGD
GO_Central		 PMID:21063390 GO_REF:0000033 NCBI chr16:75,733,958...75,744,931
Ensembl chr16:75,733,805...75,744,984 		JBrowse link
G Rb1 RB transcriptional corepressor 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:20551165)		 Ensembl
RGD		 PMID:20551165 GO_REF:0000107 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
spindle attachment to meiosis I kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cenpc centromere protein C involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:21,988,067...22,046,732
Ensembl chr14:21,988,144...22,055,476 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19692
    cellular process 18195
      cell cycle process 1290
        attachment of spindle microtubules to kinetochore 43
          attachment of meiotic spindle microtubules to kinetochore + 1
          attachment of mitotic spindle microtubules to kinetochore + 22
          negative regulation of attachment of spindle microtubules to kinetochore + 1
          positive regulation of attachment of spindle microtubules to kinetochore + 9
          regulation of attachment of spindle microtubules to kinetochore + 18
          sister chromatid biorientation + 3
Path 2
Term Annotations click to browse term
  biological_process 19692
    cellular process 18195
      cell cycle 1611
        cell cycle process 1290
          chromosome segregation 395
            nuclear chromosome segregation 296
              metaphase chromosome alignment 95
                attachment of spindle microtubules to kinetochore 43
                  attachment of meiotic spindle microtubules to kinetochore + 1
                  attachment of mitotic spindle microtubules to kinetochore + 22
                  negative regulation of attachment of spindle microtubules to kinetochore + 1
                  positive regulation of attachment of spindle microtubules to kinetochore + 9
                  regulation of attachment of spindle microtubules to kinetochore + 18
                  sister chromatid biorientation + 3
paths to the root