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ONTOLOGY REPORT - ANNOTATIONS

Term:protein kinase inhibitor activity
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Accession:GO:0004860 term browser browse the term
Definition:Binds to and stops, prevents or reduces the activity of a protein kinase.


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protein kinase inhibitor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1S1 AKT1 substrate 1 enables IEA Ensembl GO_REF:0000107 NCBI chr19:46,882,073...46,890,404
Ensembl chr19:55,797,927...55,806,256 		JBrowse link
G CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr 1:19,437,761...19,441,573
Ensembl chr 1:20,479,562...20,482,600 		JBrowse link
G CAMK2N2 calcium/calmodulin dependent protein kinase II inhibitor 2 enables IEA InterPro GO_REF:0000002 NCBI chr 3:181,293,755...181,296,088 JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A enables IEA Ensembl
TreeGrafter
UniProt		 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:36,241,405...36,250,032
Ensembl chr 6:37,436,990...37,445,599 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B enables IEA UniProt
Ensembl		 GO_REF:0000043 GO_REF:0000107 NCBI chr12:12,742,258...12,747,404
Ensembl chr12:13,120,306...13,125,541 		JBrowse link
G CDKN1C cyclin dependent kinase inhibitor 1C enables ISO (PMID:11746698) CAFA PMID:11746698 NCBI chr11:2,908,537...2,911,134 JBrowse link
G CHP1 calcineurin like EF-hand protein 1 enables IEA UniProt GO_REF:0000043 NCBI chr15:20,172,874...20,223,382
Ensembl chr15:38,418,815...38,467,681 		JBrowse link
G DEPTOR DEP domain containing MTOR interacting protein enables IEA Ensembl GO_REF:0000107 NCBI chr 8:116,563,935...116,743,843
Ensembl chr 8:119,311,942...119,492,127 		JBrowse link
G DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 enables IEA Ensembl GO_REF:0000107 NCBI chr13:76,853,053...76,963,530
Ensembl chr13:96,033,605...96,114,165 		JBrowse link
G DUS2 dihydrouridine synthase 2 enables IEA Ensembl GO_REF:0000107 NCBI chr16:48,355,186...48,450,121
Ensembl chr16:67,787,953...67,845,287 		JBrowse link
G DUSP19 dual specificity phosphatase 19 enables ISO (MGI:2182169|PMID:11959862) BHF-UCL PMID:11959862 MGI:2182169 NCBI chr2B:70,347,712...70,371,852
Ensembl chr2B:188,157,061...188,178,266 		JBrowse link
G GPRC5B G protein-coupled receptor class C group 5 member B enables ISO (PMID:23169819) MGI PMID:23169819 NCBI chr16:18,425,987...18,454,305
Ensembl chr16:19,959,077...19,985,538 		JBrowse link
G GSKIP GSK3B interacting protein enables IEA Ensembl GO_REF:0000107 NCBI chr14:76,993,055...77,017,142
Ensembl chr14:96,329,936...96,339,378 		JBrowse link
G HEXIM1 HEXIM P-TEFb complex subunit 1 enables IEA Ensembl GO_REF:0000107 NCBI chr17:12,175,544...12,180,077
Ensembl chr17:12,353,590...12,354,669 		JBrowse link
G ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr10:100,911,715...100,938,543
Ensembl chr10:104,372,767...104,374,410 		JBrowse link
G MBIP MAP3K12 binding inhibitory protein 1 enables IEA Ensembl GO_REF:0000107 NCBI chr14:17,052,270...17,074,609
Ensembl chr14:35,231,398...35,253,746 		JBrowse link
G NCK1 NCK adaptor protein 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 3:133,902,463...133,990,414
Ensembl chr 3:141,427,870...141,451,444 		JBrowse link
G NPM1 nucleophosmin 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 5:166,735,904...166,756,321
Ensembl chr 5:173,490,197...173,510,656 		JBrowse link
G PARVA parvin alpha enables IEA Ensembl GO_REF:0000107 NCBI chr11:12,544,232...12,701,517
Ensembl chr11:12,237,446...12,387,584 		JBrowse link
G PKIA cAMP-dependent protein kinase inhibitor alpha enables IEA UniProt GO_REF:0000043 NCBI chr 8:75,046,316...75,136,264
Ensembl chr 8:76,734,210...76,766,673 		JBrowse link
G PKIB cAMP-dependent protein kinase inhibitor beta enables IEA UniProt GO_REF:0000043 NCBI chr 6:120,373,497...120,517,119
Ensembl chr 6:124,612,910...124,640,260 		JBrowse link
G PKIG cAMP-dependent protein kinase inhibitor gamma enables IEA UniProt GO_REF:0000043 NCBI chr20:40,861,694...40,949,756
Ensembl chr20:42,039,676...42,049,064 		JBrowse link
G PRKRIP1 PRKR interacting protein 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 7:94,515,712...94,567,066
Ensembl chr13:24,723,062...24,734,122 		JBrowse link
G QARS1 glutaminyl-tRNA synthetase 1 enables ISO (PMID:11096076) CAFA PMID:11096076 NCBI chr 3:49,020,310...49,029,443
Ensembl chr 3:50,100,216...50,125,112 		JBrowse link
G SH3BP5 SH3 domain binding protein 5 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:15,180,369...15,257,951
Ensembl chr 3:15,517,447...15,594,971 		JBrowse link
G SH3BP5L SH3 binding domain protein 5 like enables IEA TreeGrafter GO_REF:0000118 NCBI chr 1:224,453,925...224,470,497 JBrowse link
G SMCR8 SMCR8-C9orf72 complex subunit enables IEA Ensembl GO_REF:0000107 NCBI chr17:32,858,205...32,871,132
Ensembl chr17:37,884,037...37,896,972 		JBrowse link
G SPRY4 sprouty RTK signaling antagonist 4 enables IEA Ensembl GO_REF:0000107 NCBI chr 5:137,667,280...137,683,578
Ensembl chr 5:143,778,785...143,791,939 		JBrowse link
G TESC tescalcin enables IEA UniProt GO_REF:0000043 NCBI chr12:114,615,155...114,675,932
Ensembl chr12:117,991,047...118,051,346 		JBrowse link
G TRIB1 tribbles pseudokinase 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 8:122,115,194...122,123,319
Ensembl chr 8:124,867,359...124,872,924 		JBrowse link
G TRIB2 tribbles pseudokinase 2 enables IEA UniProt GO_REF:0000043 NCBI chr2A:12,705,043...12,730,932
Ensembl chr2A:12,847,631...12,873,499 		JBrowse link
G YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta enables IEA Ensembl GO_REF:0000107 NCBI chr20:41,216,071...41,238,893
Ensembl chr20:42,309,155...42,331,695 		JBrowse link
calcium-dependent protein kinase inhibitor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 enables IEA TreeGrafter GO_REF:0000118 NCBI chr 1:19,437,761...19,441,573
Ensembl chr 1:20,479,562...20,482,600 		JBrowse link
G CAMK2N2 calcium/calmodulin dependent protein kinase II inhibitor 2 enables ISO
IEA		 RGD
TreeGrafter		 PMID:9724800 GO_REF:0000118 RGD:1302397 NCBI chr 3:181,293,755...181,296,088 JBrowse link
G CIB1 calcium and integrin binding 1 enables ISO (PMID:20473878) CACAO PMID:20473878 NCBI chr15:68,919,377...68,923,213 JBrowse link
cAMP-dependent protein kinase inhibitor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PKIA cAMP-dependent protein kinase inhibitor alpha enables IEA UniProt
TreeGrafter
InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:75,046,316...75,136,264
Ensembl chr 8:76,734,210...76,766,673 		JBrowse link
G PKIB cAMP-dependent protein kinase inhibitor beta enables IEA UniProt
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chr 6:120,373,497...120,517,119
Ensembl chr 6:124,612,910...124,640,260 		JBrowse link
G PKIG cAMP-dependent protein kinase inhibitor gamma enables ISO
IEA		 RGD
TreeGrafter
UniProt
InterPro
Ensembl		 PMID:15557275 GO_REF:0000002 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:1359036 NCBI chr20:40,861,694...40,949,756
Ensembl chr20:42,039,676...42,049,064 		JBrowse link
G PRKAG2 protein kinase AMP-activated non-catalytic subunit gamma 2 enables IEA Ensembl GO_REF:0000107 NCBI chr 7:143,143,556...143,463,492
Ensembl chr 7:155,293,748...155,610,078 		JBrowse link
G PRKAR1A protein kinase cAMP-dependent type I regulatory subunit alpha enables IEA Ensembl GO_REF:0000107 NCBI chr17:62,448,718...62,488,493
Ensembl chr17:67,838,484...67,877,943 		JBrowse link
G PRKAR1B protein kinase cAMP-dependent type I regulatory subunit beta enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:700,691...876,497
Ensembl chr 7:923,668...1,097,456 		JBrowse link
G PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:48,665,421...48,774,111
Ensembl chr 3:49,747,611...49,854,382 		JBrowse link
G PRKAR2B protein kinase cAMP-dependent type II regulatory subunit beta enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:99,021,209...99,140,652
Ensembl chr 7:111,748,463...111,866,044 		JBrowse link
G SMO smoothened, frizzled class receptor enables IEA Ensembl GO_REF:0000107 NCBI chr 7:121,143,968...121,168,873
Ensembl chr 7:133,668,304...133,693,048 		JBrowse link
cyclin-dependent protein serine/threonine kinase inhibitor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 enables IEA Ensembl GO_REF:0000107 NCBI chr 4:176,793,190...176,815,023
Ensembl chr 4:189,018,422...189,040,185 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A enables IEA Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000107 NCBI chr 6:36,241,405...36,250,032
Ensembl chr 6:37,436,990...37,445,599 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr12:12,742,258...12,747,404
Ensembl chr12:13,120,306...13,125,541 		JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A enables IEA TreeGrafter GO_REF:0000118 NCBI chr 9:21,803,862...21,831,322 JBrowse link
G CDKN2B cyclin dependent kinase inhibitor 2B enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:21,838,902...21,845,355
Ensembl chr 9:22,455,662...22,462,156 		JBrowse link
G CDKN2C cyclin dependent kinase inhibitor 2C enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:50,214,767...50,221,465
Ensembl chr 1:51,704,528...51,718,374 		JBrowse link
G CDKN2D cyclin dependent kinase inhibitor 2D enables ISO (PMID:8741839) BHF-UCL PMID:8741839 NCBI chr19:10,118,302...10,120,957 JBrowse link
G HEXIM1 HEXIM P-TEFb complex subunit 1 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr17:12,175,544...12,180,077
Ensembl chr17:12,353,590...12,354,669 		JBrowse link
G HEXIM2 HEXIM P-TEFb complex subunit 2 enables IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr17:12,157,392...12,167,281
Ensembl chr17:12,333,957...12,343,399 		JBrowse link
G INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr17:5,036,659...5,046,146
Ensembl chr17:5,024,740...5,034,216 		JBrowse link
G KAT2B lysine acetyltransferase 2B enables IEA Ensembl GO_REF:0000107 NCBI chr 3:19,956,067...20,070,637
Ensembl chr 3:20,286,865...20,400,770 		JBrowse link
protein kinase C inhibitor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPB1 heat shock protein family B (small) member 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 7:67,716,021...67,717,762
Ensembl chr 7:82,751,523...82,752,984 		JBrowse link
protein serine/threonine kinase inhibitor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 enables ISO PMID:8524413 BHF-UCL PMID:8524413 RGD:8554844 NCBI chr14:85,417,229...85,444,722
Ensembl chr14:105,208,128...105,236,756 		JBrowse link
G AKT1S1 AKT1 substrate 1 enables IEA Ensembl GO_REF:0000107 NCBI chr19:46,882,073...46,890,404
Ensembl chr19:55,797,927...55,806,256 		JBrowse link
G CIB1 calcium and integrin binding 1 enables ISO (PMID:20473878) CACAO PMID:20473878 NCBI chr15:68,919,377...68,923,213 JBrowse link
G CIT citron rho-interacting serine/threonine kinase enables IEA Ensembl GO_REF:0000107 NCBI chr12:117,264,627...117,456,069
Ensembl chr12:120,641,747...120,832,511 		JBrowse link
G DEPTOR DEP domain containing MTOR interacting protein enables IEA Ensembl GO_REF:0000107 NCBI chr 8:116,563,935...116,743,843
Ensembl chr 8:119,311,942...119,492,127 		JBrowse link
G HTRA2 HtrA serine peptidase 2 enables ISO (PMID:25118933) ParkinsonsUK-UCL PMID:25118933 NCBI chr2A:74,596,020...74,599,790
Ensembl chr2A:76,102,240...76,106,152 		JBrowse link
G INKA1 inka box actin regulator 1 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 3:49,734,616...49,736,838
Ensembl chr 3:50,971,394...50,972,993 		JBrowse link
G INKA2 inka box actin regulator 2 enables IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chr 1:114,389,334...114,402,277
Ensembl chr 1:125,929,817...125,963,744 		JBrowse link
G LOC100974858 core histone macro-H2A.1 enables IEA Ensembl GO_REF:0000107 NCBI chr 5:130,727,065...130,791,932
Ensembl chr 5:136,868,521...136,933,834 		JBrowse link
G PRKCH protein kinase C eta enables ISO (PMID:34593629) UniProt PMID:34593629 NCBI chr14:41,882,022...42,151,305
Ensembl chr14:60,179,081...60,408,251 		JBrowse link
G PYDC1 pyrin domain containing 1 enables ISO (PMID:12656673) HGNC-UCL PMID:12656673 NCBI chr16:23,748,695...23,750,461
Ensembl chr16:31,588,129...31,588,398 		JBrowse link
G RPTOR regulatory associated protein of MTOR complex 1 enables IEA Ensembl GO_REF:0000107 NCBI chr17:74,973,420...75,389,339
Ensembl chr17:80,705,544...81,118,708 		JBrowse link
G SPRED1 sprouty related EVH1 domain containing 1 enables IEA Ensembl GO_REF:0000107 NCBI chr15:17,182,976...17,286,566
Ensembl chr15:35,439,762...35,536,565 		JBrowse link
G SPRED2 sprouty related EVH1 domain containing 2 enables ISO (MGI:5318016|PMID:20736167) BHF-UCL PMID:20736167 MGI:5318016 NCBI chr2A:65,380,608...65,503,139
Ensembl chr2A:66,503,260...66,624,840 		JBrowse link
G WNK1 WNK lysine deficient protein kinase 1 ISO due to an autoinhibitory domain RGD PMID:15081430 RGD:2298791 NCBI chr12:825,659...985,016
Ensembl chr12:791,153...944,602 		JBrowse link
protein tyrosine kinase inhibitor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV1 caveolin 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 7:108,497,125...108,533,090
Ensembl chr 7:121,193,424...121,229,655 		JBrowse link
G CEP43 centrosomal protein 43 enables IEA Ensembl GO_REF:0000107 NCBI chr 6:164,969,391...165,011,935
Ensembl chr 6:169,945,218...169,988,027 		JBrowse link
G IBTK inhibitor of Bruton tyrosine kinase enables IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:80,061,649...80,139,393
Ensembl chr 6:83,325,428...83,402,670 		JBrowse link
G RACK1 receptor for activated C kinase 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 5:176,462,991...176,470,153
Ensembl chr 5:183,712,665...183,720,128 		JBrowse link
G SOCS3 suppressor of cytokine signaling 3 enables IEA Ensembl GO_REF:0000107 NCBI chr17:72,433,206...72,436,500
Ensembl chr17:77,983,389...77,984,066 		JBrowse link
receptor signaling protein tyrosine kinase inhibitor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHSG alpha 2-HS glycoprotein ISO RGD PMID:2766355 RGD:632173 NCBI chr 3:183,644,223...183,652,620
Ensembl chr 3:192,110,770...192,119,915 		JBrowse link
G HYAL2 hyaluronidase 2 enables IEA Ensembl GO_REF:0000107 NCBI chr 3:50,243,926...50,248,972
Ensembl chr 3:51,479,020...51,482,551 		JBrowse link
transmembrane receptor protein tyrosine kinase inhibitor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LILRB4 leukocyte immunoglobulin like receptor B4 enables ISO (PMID:16493035)
(PMID:9151699)		 ARUK-UCL PMID:9151699 PMID:16493035 NCBI chr19:51,606,681...51,612,751 JBrowse link
Term paths to the root
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Term Annotations click to browse term
  molecular_function 17494
    molecular function regulator activity 1870
      enzyme regulator activity 1171
        enzyme inhibitor activity 339
          kinase inhibitor activity 73
            protein kinase inhibitor activity 68
              calcium-dependent protein kinase inhibitor activity 3
              protein serine/threonine kinase inhibitor activity + 36
              protein tyrosine kinase inhibitor activity + 8
paths to the root