HYAL2 (hyaluronidase 2) - Rat Genome Database

Name: HYAL2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: HYAL2 (hyaluronidase 2) Pan paniscus

Analyze

Symbol:

HYAL2

Name:

hyaluronidase 2

RGD ID:

12009018

Description:

ENCODES a protein that exhibits hyalurononglucosaminidase activity (ortholog); transcription coactivator activity (ortholog); virus receptor activity (ortholog); INVOLVED IN hematopoietic progenitor cell differentiation (ortholog); kidney development (ortholog); multicellular organismal-level iron ion homeostasis (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy (ortholog); early infantile epileptic encephalopathy (ortholog); genetic disease (ortholog); FOUND IN external side of plasma membrane (ortholog); Golgi membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

hyaluronidase-2; hyaluronoglucosaminidase 2

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HYAL2 (hyaluronidase 2)	NCBI	Ortholog
Mus musculus (house mouse):	Hyal2 (hyaluronoglucosaminidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Hyal2 (hyaluronidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Hyal2 (hyaluronidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	HYAL2 (hyaluronidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Hyal2 (hyaluronidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HYAL2 (hyaluronidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HYAL2 (hyaluronidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Hyal2 (hyaluronidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	50,298,400 - 50,303,389 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	50,303,163 - 50,308,164 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	50,243,926 - 50,248,972 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	51,479,020 - 51,484,638 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	51,479,020 - 51,482,551 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

developmental and epileptic encephalopathy (ISO)

early infantile epileptic encephalopathy (ISO)

genetic disease (ISO)

Kidney Reperfusion Injury (ISO)

primary ciliary dyskinesia (ISO)

pulmonary hypertension (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carbohydrate metabolic process (IEA)

cartilage development (IEA)

cellular response to fibroblast growth factor stimulus (IEA)

cellular response to interleukin-1 (IEA)

cellular response to transforming growth factor beta stimulus (IEA)

cellular response to tumor necrosis factor (IEA)

cellular response to UV-B (IEA)

defense response to virus (IEA)

fusion of virus membrane with host plasma membrane (IEA)

glycosaminoglycan catabolic process (IEA)

hematopoietic progenitor cell differentiation (IEA,ISO)

hyaluronan catabolic process (IEA)

kidney development (ISO)

monocyte activation (IEA)

multicellular organismal-level iron ion homeostasis (IEA,ISO)

negative regulation of cell growth (IEA)

negative regulation of fibroblast migration (IEA)

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (IEA)

positive regulation of extrinsic apoptotic signaling pathway (IEA,ISO)

positive regulation of inflammatory response (IEA)

positive regulation of interleukin-6 production (IEA)

positive regulation of interleukin-8 production (IEA)

positive regulation of protein import into nucleus (IEA)

positive regulation of transcription by RNA polymerase II (IEA)

positive regulation of urine volume (ISO)

renal water absorption (ISO)

response to antibiotic (IEA)

response to reactive oxygen species (IEA)

response to virus (IEA)

skeletal system morphogenesis (IEA,ISO)

symbiont entry into host cell (IEA,ISO)

Cellular Component

apical plasma membrane (IEA)

cell surface (IEA)

cytoplasm (IEA)

cytoplasmic vesicle (IEA)

cytosol (IEA)

endocytic vesicle (IEA)

external side of plasma membrane (IEA,ISO)

Golgi membrane (ISO)

lysosome (IEA)

membrane raft (IEA)

microvillus (IEA)

perinuclear region of cytoplasm (IEA)

plasma membrane (IEA)

RNA polymerase II transcription regulator complex (IEA)

Molecular Function

enzyme binding (IEA)

hyaluronic acid binding (IEA)

hyaluronoglucuronidase activity (IEA)

hyalurononglucosaminidase activity (IEA,ISO)

hydrolase activity, acting on glycosyl bonds (IEA)

protein binding (ISO)

receptor signaling protein tyrosine kinase inhibitor activity (IEA)

receptor tyrosine kinase binding (IEA)

transcription coactivator activity (IEA,ISO)

transforming growth factor beta binding (IEA)

virus receptor activity (IEA,ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

HYAL2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	50,298,400 - 50,303,389 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	50,303,163 - 50,308,164 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	50,243,926 - 50,248,972 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	51,479,020 - 51,484,638 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	51,479,020 - 51,482,551 (-)	Ensembl	panpan1.1		panPan2

HYAL2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	50,317,808 - 50,322,745 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	50,317,790 - 50,322,782 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	50,355,239 - 50,360,176 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	50,330,244 - 50,335,146 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	50,330,243 - 50,333,903	NCBI
Celera	3	50,328,056 - 50,333,116 (-)	NCBI		Celera
Cytogenetic Map	3	p21.31	NCBI
HuRef	3	50,410,935 - 50,415,994 (-)	NCBI		HuRef
CHM1_1	3	50,307,488 - 50,312,547 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	50,347,534 - 50,352,469 (-)	NCBI		T2T-CHM13v2.0

Hyal2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	107,445,096 - 107,449,975 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	107,445,144 - 107,449,978 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	107,567,873 - 107,572,778 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	107,567,945 - 107,572,779 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	107,471,494 - 107,475,109 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	107,427,264 - 107,430,879 (+)	NCBI		MGSCv36	mm8
Celera	9	107,177,912 - 107,181,527 (+)	NCBI		Celera
Cytogenetic Map	9	F1	NCBI
cM Map	9	58.12	NCBI

Hyal2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	117,121,802 - 117,125,494 (+)	NCBI		GRCr8
mRatBN7.2	8	108,241,895 - 108,246,853 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	108,243,133 - 108,246,850 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	113,870,193 - 113,873,885 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	112,069,349 - 112,073,041 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	109,912,130 - 109,915,822 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	116,324,062 - 116,328,978 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	116,324,040 - 116,328,978 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	115,680,309 - 115,685,238 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	112,817,001 - 112,820,693 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	112,836,484 - 112,840,147 (+)	NCBI
Celera	8	107,549,728 - 107,586,609 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

Hyal2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955532	2,120,781 - 2,123,726 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955532	2,120,781 - 2,125,083 (-)	NCBI	ChiLan1.0	ChiLan1.0

HYAL2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	39,029,426 - 39,034,451 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	39,031,735 - 39,034,130 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	38,950,366 - 38,955,492 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	39,385,361 - 39,390,488 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	39,385,565 - 39,396,473 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	38,753,188 - 38,758,313 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	39,156,748 - 39,161,868 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	39,436,765 - 39,441,893 (+)	NCBI		UU_Cfam_GSD_1.0

Hyal2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	65,084,685 - 65,090,478 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936529	1,845,763 - 1,851,252 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936529	1,845,445 - 1,851,106 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HYAL2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	32,805,227 - 32,815,333 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	32,805,220 - 32,813,684 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	35,983,753 - 35,988,635 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	13	q21	NCBI

HYAL2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	11,704,422 - 11,710,013 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	11,703,790 - 11,709,454 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	155,277,024 - 155,282,088 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hyal2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	4,169,742 - 4,175,242 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624730	4,170,045 - 4,175,264 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003818822	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008972212	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008972213	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034956513	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_057301769	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000035208 ⟹ ENSPPAP00000012542

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	3	51,479,020 - 51,482,551 (-)	Ensembl

RefSeq Acc Id:

XM_003818822 ⟹ XP_003818870

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	2	50,298,400 - 50,303,389 (-)	NCBI
NHGRI_mPanPan1	3	50,303,163 - 50,308,164 (-)	NCBI
Mhudiblu_PPA_v0	3	50,243,926 - 50,248,927 (-)	NCBI
PanPan1.1	3	51,479,020 - 51,484,638 (-)	NCBI

Sequence:

show sequence

ATTCTGGAGGGAAACGGTCAAGGCGATCTCCTCCCCCGCGCCTGTTCCTGGCCCTTTCCTCTCA
GGGGGCAGCAGGAAGTGAGGAGAAAGGGCTGGGATGGGAGGCGGGAGCGGATGGGAGGGAATGG
GGTTTATCAAGTCCTCGGCGAGCTGCCCAACGGGCAGCAGCTGGCGCAAGTAGCCTAGCTGGAG
AGGCTCACCCCAGGAAGGAGGGAGGCCACCGACCTACTGGGCCGACGGACTCCCACACAGTTCC
TGAGCTGGTGCCAGGCAGGTGACACCTCCTGCAGCCCCCAGCATGCGGGCAGGCCCAGGCCCCA
CTGTTACACTGGCCCTGGTGCTGGCGGTGGCATGGGCCATGGAGCTCAAGCCCACAGCACCACC
CATCTTCACTGGCCGGCCCTTTGTGGTAGCGTGGGACGTGCCCACACAGGACTGTGGCCCACGC
CTCAAGGTGCCACTGGACCTGAATGCCTTTGATGTGCAGGCCTCACCTAATGAGGGTTTTGTGA
ACCAGAATATTACCATCTTCTACCGCGACCGTCTAGGCCTGTATCCACGCTTCGATTCTGCCGG
AAGGTCTGTGCATGGTGGTGTGCCACAGAATGTCAGCCTTTGGGCACACCGGAAGATGCTGCAG
AAACGTGTGGAGCACTACATTCGGACACAGGAGTCTGCGGGGCTGGCGGTCATCGACTGGGAGG
ACTGGCGACCTGTGTGGGTGCGCAACTGGCAGGACAAAGATGTGTATCGCCGGTTATCACGCCA
GCTAGTGGCCAGTCGTCACCCTGACTGGCCTCCAGACCGCGTAGTCAAACAGGCACAATATGAG
TTTGAGTTCGCAGCACAGCAGTTCATGCTGGAGACACTGCGTTATGTCAAGGCAGTGCGGCCCC
GGCACCTCTGGGGCTTCTACCTCTTTCCTGACTGCTACAATCATGATTATGTGCAGAACTGGGA
GAGCTACACAGGCCGCTGCCCTGATGTTGAGGTGGCCCGCAATGACCAGCTGGCCTGGCTATGG
GCTGAGAGCACGGCCCTCTTCCCGTCTGTCTACCTGGACGAGACACTCGCTTCCTCCCGCCATG
GCCGCAACTTTGTGAGCTTCCGTGTTCAGGAGGCCCTTCGTGTGGCTCGCACCCACCATGCCAA
CCATGCACTCCCAGTCTACGTCTTCACACGGCCCACCTATAGCCGCAGGCTCACGGGGCTTAGT
GAGATGGACCTCATCTCTACCATTGGCGAGAGTGCGGCCCTGGGCGCAGCTGGTGTCATCCTCT
GGGGCGACGCGGGGTACACCACAAGCACGGAGACCTGCCAGTACCTCAAAGATTATCTGACACG
GCTGCTGGTCCCCTACGTGGTCAATGTGTCCTGGGCCACCCAATATTGCAGCCGGGCCCAGTGC
CATGGCCATGGGCGCTGTGTGCGCCGCAACCCCAGTGCCAGTACCTTCCTGCATCTCAGCACCA
ACAGTTTCCGCCTAGTGCCTGGCCATGCACCTGGTGAACCCCAGCTGCGACCTGTGGGGGAGCT
CAGTTGGGCCGACCTTGACCACCTGCAGACACACTTCCGCTGCCAGTGCTACTTGGGCTGGAGT
GGTGAGCAATGCCAGTGGGACCATAGGCAGGCAGCTGGAGGTGCCAGCGAGGCCTGGGCTGGGT
CCCACCTCACCAGTCTGCTGGCTCTGGCAGCCCTGGCCTTTACCTGGACCTTGTAGGGGTCTCC
TGCCTAGCTGCCTAGCAAGCTGGCCTCTACCACAAGGGCTCTCTTAGGCATGTAGGACCCTGCA
GGGGGTGGACAAACTGGAGTCTGGAGTGGGCAGAGCCCCCAGGAAGCCCAGGAGGGCATCCATA
CCAGCTCGCACCCCCCTGTTCTAAGGGGGAGGGGAAGTCCCCTGGGAGGCCCCTTCTCTCCTTG
CCAGAGGGGAAGGAGGGTACAGCTGGGCTGGGGAGGACCTGACCCTACTCCCTTGCCCTGGATA
GTTTATTATTATTATTTTGGGGTCTCTTTTGTAAATTAAACATAAAACAATTGCTTCTCTGCTT
GGA

hide sequence

RefSeq Acc Id:

XM_008972212 ⟹ XP_008970460

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	2	50,298,400 - 50,302,098 (-)	NCBI
NHGRI_mPanPan1	3	50,303,163 - 50,306,709 (-)	NCBI
Mhudiblu_PPA_v0	3	50,243,926 - 50,247,481 (-)	NCBI
PanPan1.1	3	51,479,020 - 51,482,549 (-)	NCBI

Sequence:

show sequence

TTGGGCTGGGGTCTGAATCCCCGGGGGTGCTCGCGGAGAGGCGTCCCAGAAACCCCACCCCCAC
CCGACCGGGCGCAGGCCCCACGTGTGGGGCGGGGGCGGGGTCCCGCACAAAGACCCGGCGGAGC
GCGCTCTAGCCCTGAGCGGCCGGGCGGGGGAGGCGAGCGCGCGCATTCTCGGTGGCGGTGGAGG
GAAGGGCCGGTCGGCCGGCGCCGCCGTGGGAGGTCCGCTGCCCCTTTGTCCCCACGGGGCCTCC
TCCAAGCCGGGAGAGTGTCAGCGCTCGAGAGAAAGTCCGGACAGCCTCACTCTTCTGCCGGGCG
AGTGTTACACGGATAGAAGCCTCCCGGCAGCGTTCCTTCCAGCTTCCTAGCCTCTGGACGAGCT
GTTCCCTGCTTTACCCAAATGCTGTCGTTTCTCTGGATCAAGGGTTCTTCACGGTGTACAGGTT
CCTGAGCTGGTGCCAGGCAGGTGACACCTCCTGCAGCCCCCAGCATGCGGGCAGGCCCAGGCCC
CACTGTTACACTGGCCCTGGTGCTGGCGGTGGCATGGGCCATGGAGCTCAAGCCCACAGCACCA
CCCATCTTCACTGGCCGGCCCTTTGTGGTAGCGTGGGACGTGCCCACACAGGACTGTGGCCCAC
GCCTCAAGGTGCCACTGGACCTGAATGCCTTTGATGTGCAGGCCTCACCTAATGAGGGTTTTGT
GAACCAGAATATTACCATCTTCTACCGCGACCGTCTAGGCCTGTATCCACGCTTCGATTCTGCC
GGAAGGTCTGTGCATGGTGGTGTGCCACAGAATGTCAGCCTTTGGGCACACCGGAAGATGCTGC
AGAAACGTGTGGAGCACTACATTCGGACACAGGAGTCTGCGGGGCTGGCGGTCATCGACTGGGA
GGACTGGCGACCTGTGTGGGTGCGCAACTGGCAGGACAAAGATGTGTATCGCCGGTTATCACGC
CAGCTAGTGGCCAGTCGTCACCCTGACTGGCCTCCAGACCGCGTAGTCAAACAGGCACAATATG
AGTTTGAGTTCGCAGCACAGCAGTTCATGCTGGAGACACTGCGTTATGTCAAGGCAGTGCGGCC
CCGGCACCTCTGGGGCTTCTACCTCTTTCCTGACTGCTACAATCATGATTATGTGCAGAACTGG
GAGAGCTACACAGGCCGCTGCCCTGATGTTGAGGTGGCCCGCAATGACCAGCTGGCCTGGCTAT
GGGCTGAGAGCACGGCCCTCTTCCCGTCTGTCTACCTGGACGAGACACTCGCTTCCTCCCGCCA
TGGCCGCAACTTTGTGAGCTTCCGTGTTCAGGAGGCCCTTCGTGTGGCTCGCACCCACCATGCC
AACCATGCACTCCCAGTCTACGTCTTCACACGGCCCACCTATAGCCGCAGGCTCACGGGGCTTA
GTGAGATGGACCTCATCTCTACCATTGGCGAGAGTGCGGCCCTGGGCGCAGCTGGTGTCATCCT
CTGGGGCGACGCGGGGTACACCACAAGCACGGAGACCTGCCAGTACCTCAAAGATTATCTGACA
CGGCTGCTGGTCCCCTACGTGGTCAATGTGTCCTGGGCCACCCAATATTGCAGCCGGGCCCAGT
GCCATGGCCATGGGCGCTGTGTGCGCCGCAACCCCAGTGCCAGTACCTTCCTGCATCTCAGCAC
CAACAGTTTCCGCCTAGTGCCTGGCCATGCACCTGGTGAACCCCAGCTGCGACCTGTGGGGGAG
CTCAGTTGGGCCGACCTTGACCACCTGCAGACACACTTCCGCTGCCAGTGCTACTTGGGCTGGA
GTGGTGAGCAATGCCAGTGGGACCATAGGCAGGCAGCTGGAGGTGCCAGCGAGGCCTGGGCTGG
GTCCCACCTCACCAGTCTGCTGGCTCTGGCAGCCCTGGCCTTTACCTGGACCTTGTAGGGGTCT
CCTGCCTAGCTGCCTAGCAAGCTGGCCTCTACCACAAGGGCTCTCTTAGGCATGTAGGACCCTG
CAGGGGGTGGACAAACTGGAGTCTGGAGTGGGCAGAGCCCCCAGGAAGCCCAGGAGGGCATCCA
TACCAGCTCGCACCCCCCTGTTCTAAGGGGGAGGGGAAGTCCCCTGGGAGGCCCCTTCTCTCCT
TGCCAGAGGGGAAGGAGGGTACAGCTGGGCTGGGGAGGACCTGACCCTACTCCCTTGCCCTGGA
TAGTTTATTATTATTATTTTGGGGTCTCTTTTGTAAATTAAACATAAAACAATTGCTTCTCTGC
TTGGA

hide sequence

RefSeq Acc Id:

XM_008972213 ⟹ XP_008970461

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	2	50,298,400 - 50,303,386 (-)	NCBI
NHGRI_mPanPan1	3	50,303,163 - 50,308,161 (-)	NCBI
Mhudiblu_PPA_v0	3	50,243,926 - 50,248,924 (-)	NCBI
PanPan1.1	3	51,479,020 - 51,484,515 (-)	NCBI

Sequence:

show sequence

AATGGGGTTTATCAAGTCCTCGGCGAGCTGCCCAACGGGCAGCAGCTGGCGCAAGTAGCCTAGC
TGGAGAGGCTCACCCCAGGAAGGAGGGAGGCCACCGACCTACTGGGCCGACGGACTCCCACACA
GGGCTGGCGGCGCCGCGGAGCTGGGAGGACTGAACCACCGGCCTCGGGCTGCAGGGGGAACATT
TCAGGCTGACTGGCGCTCGTGGCTGAGACTCCCACAGAAAGCCCGGCTCAGAGGGGCATTAGGG
TCCCAAATGGGCGGCCACGTCCCTCTGCAGAGGACCTGGGGCTCTTCGAGCCCGAAACGAGGCA
CCGGCACCGAGAAAGTTCCTGAGCTGGTGCCAGGCAGGTGACACCTCCTGCAGCCCCCAGCATG
CGGGCAGGCCCAGGCCCCACTGTTACACTGGCCCTGGTGCTGGCGGTGGCATGGGCCATGGAGC
TCAAGCCCACAGCACCACCCATCTTCACTGGCCGGCCCTTTGTGGTAGCGTGGGACGTGCCCAC
ACAGGACTGTGGCCCACGCCTCAAGGTGCCACTGGACCTGAATGCCTTTGATGTGCAGGCCTCA
CCTAATGAGGGTTTTGTGAACCAGAATATTACCATCTTCTACCGCGACCGTCTAGGCCTGTATC
CACGCTTCGATTCTGCCGGAAGGTCTGTGCATGGTGGTGTGCCACAGAATGTCAGCCTTTGGGC
ACACCGGAAGATGCTGCAGAAACGTGTGGAGCACTACATTCGGACACAGGAGTCTGCGGGGCTG
GCGGTCATCGACTGGGAGGACTGGCGACCTGTGTGGGTGCGCAACTGGCAGGACAAAGATGTGT
ATCGCCGGTTATCACGCCAGCTAGTGGCCAGTCGTCACCCTGACTGGCCTCCAGACCGCGTAGT
CAAACAGGCACAATATGAGTTTGAGTTCGCAGCACAGCAGTTCATGCTGGAGACACTGCGTTAT
GTCAAGGCAGTGCGGCCCCGGCACCTCTGGGGCTTCTACCTCTTTCCTGACTGCTACAATCATG
ATTATGTGCAGAACTGGGAGAGCTACACAGGCCGCTGCCCTGATGTTGAGGTGGCCCGCAATGA
CCAGCTGGCCTGGCTATGGGCTGAGAGCACGGCCCTCTTCCCGTCTGTCTACCTGGACGAGACA
CTCGCTTCCTCCCGCCATGGCCGCAACTTTGTGAGCTTCCGTGTTCAGGAGGCCCTTCGTGTGG
CTCGCACCCACCATGCCAACCATGCACTCCCAGTCTACGTCTTCACACGGCCCACCTATAGCCG
CAGGCTCACGGGGCTTAGTGAGATGGACCTCATCTCTACCATTGGCGAGAGTGCGGCCCTGGGC
GCAGCTGGTGTCATCCTCTGGGGCGACGCGGGGTACACCACAAGCACGGAGACCTGCCAGTACC
TCAAAGATTATCTGACACGGCTGCTGGTCCCCTACGTGGTCAATGTGTCCTGGGCCACCCAATA
TTGCAGCCGGGCCCAGTGCCATGGCCATGGGCGCTGTGTGCGCCGCAACCCCAGTGCCAGTACC
TTCCTGCATCTCAGCACCAACAGTTTCCGCCTAGTGCCTGGCCATGCACCTGGTGAACCCCAGC
TGCGACCTGTGGGGGAGCTCAGTTGGGCCGACCTTGACCACCTGCAGACACACTTCCGCTGCCA
GTGCTACTTGGGCTGGAGTGGTGAGCAATGCCAGTGGGACCATAGGCAGGCAGCTGGAGGTGCC
AGCGAGGCCTGGGCTGGGTCCCACCTCACCAGTCTGCTGGCTCTGGCAGCCCTGGCCTTTACCT
GGACCTTGTAGGGGTCTCCTGCCTAGCTGCCTAGCAAGCTGGCCTCTACCACAAGGGCTCTCTT
AGGCATGTAGGACCCTGCAGGGGGTGGACAAACTGGAGTCTGGAGTGGGCAGAGCCCCCAGGAA
GCCCAGGAGGGCATCCATACCAGCTCGCACCCCCCTGTTCTAAGGGGGAGGGGAAGTCCCCTGG
GAGGCCCCTTCTCTCCTTGCCAGAGGGGAAGGAGGGTACAGCTGGGCTGGGGAGGACCTGACCC
TACTCCCTTGCCCTGGATAGTTTATTATTATTATTTTGGGGTCTCTTTTGTAAATTAAACATAA
AACAATTGCTTCTCTGCTTGGA

hide sequence

RefSeq Acc Id:

XM_057301769 ⟹ XP_057157752

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	2	50,298,400 - 50,303,386 (-)	NCBI
NHGRI_mPanPan1	3	50,303,163 - 50,308,161 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_003818870	(Get FASTA)	NCBI Sequence Viewer
	XP_008970460	(Get FASTA)	NCBI Sequence Viewer
	XP_008970461	(Get FASTA)	NCBI Sequence Viewer
	XP_057157752	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000012542.1

RefSeq Acc Id:

XP_003818870 ⟸ XM_003818822

- UniProtKB:

A0A2R9AAT0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRAGPGPTVTLALVLAVAWAMELKPTAPPIFTGRPFVVAWDVPTQDCGPRLKVPLDLNAFDVQA
SPNEGFVNQNITIFYRDRLGLYPRFDSAGRSVHGGVPQNVSLWAHRKMLQKRVEHYIRTQESAG
LAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPDRVVKQAQYEFEFAAQQFMLETLR
YVKAVRPRHLWGFYLFPDCYNHDYVQNWESYTGRCPDVEVARNDQLAWLWAESTALFPSVYLDE
TLASSRHGRNFVSFRVQEALRVARTHHANHALPVYVFTRPTYSRRLTGLSEMDLISTIGESAAL
GAAGVILWGDAGYTTSTETCQYLKDYLTRLLVPYVVNVSWATQYCSRAQCHGHGRCVRRNPSAS
TFLHLSTNSFRLVPGHAPGEPQLRPVGELSWADLDHLQTHFRCQCYLGWSGEQCQWDHRQAAGG
ASEAWAGSHLTSLLALAALAFTWTL

hide sequence

RefSeq Acc Id:

XP_008970461 ⟸ XM_008972213

- UniProtKB:

A0A2R9AAT0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRAGPGPTVTLALVLAVAWAMELKPTAPPIFTGRPFVVAWDVPTQDCGPRLKVPLDLNAFDVQA
SPNEGFVNQNITIFYRDRLGLYPRFDSAGRSVHGGVPQNVSLWAHRKMLQKRVEHYIRTQESAG
LAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPDRVVKQAQYEFEFAAQQFMLETLR
YVKAVRPRHLWGFYLFPDCYNHDYVQNWESYTGRCPDVEVARNDQLAWLWAESTALFPSVYLDE
TLASSRHGRNFVSFRVQEALRVARTHHANHALPVYVFTRPTYSRRLTGLSEMDLISTIGESAAL
GAAGVILWGDAGYTTSTETCQYLKDYLTRLLVPYVVNVSWATQYCSRAQCHGHGRCVRRNPSAS
TFLHLSTNSFRLVPGHAPGEPQLRPVGELSWADLDHLQTHFRCQCYLGWSGEQCQWDHRQAAGG
ASEAWAGSHLTSLLALAALAFTWTL

hide sequence

RefSeq Acc Id:

XP_008970460 ⟸ XM_008972212

- UniProtKB:

A0A2R9AAT0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRAGPGPTVTLALVLAVAWAMELKPTAPPIFTGRPFVVAWDVPTQDCGPRLKVPLDLNAFDVQA
SPNEGFVNQNITIFYRDRLGLYPRFDSAGRSVHGGVPQNVSLWAHRKMLQKRVEHYIRTQESAG
LAVIDWEDWRPVWVRNWQDKDVYRRLSRQLVASRHPDWPPDRVVKQAQYEFEFAAQQFMLETLR
YVKAVRPRHLWGFYLFPDCYNHDYVQNWESYTGRCPDVEVARNDQLAWLWAESTALFPSVYLDE
TLASSRHGRNFVSFRVQEALRVARTHHANHALPVYVFTRPTYSRRLTGLSEMDLISTIGESAAL
GAAGVILWGDAGYTTSTETCQYLKDYLTRLLVPYVVNVSWATQYCSRAQCHGHGRCVRRNPSAS
TFLHLSTNSFRLVPGHAPGEPQLRPVGELSWADLDHLQTHFRCQCYLGWSGEQCQWDHRQAAGG
ASEAWAGSHLTSLLALAALAFTWTL

hide sequence

RefSeq Acc Id:

ENSPPAP00000012542 ⟸ ENSPPAT00000035208

RefSeq Acc Id:

XP_057157752 ⟸ XM_057301769

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000029458	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000035208.1	UniProtKB/TrEMBL
Gene3D-CATH	3.20.20.70	UniProtKB/TrEMBL
InterPro	Aldolase_TIM	UniProtKB/TrEMBL
	Glycoside_hydrolase_SF	UniProtKB/TrEMBL
	Hyaluronidase	UniProtKB/TrEMBL
KEGG Report	pps:100975669	UniProtKB/TrEMBL
NCBI Gene	HYAL2	ENTREZGENE
PANTHER	HYALURONIDASE-2	UniProtKB/TrEMBL
	PTHR11769	UniProtKB/TrEMBL
Pfam	Glyco_hydro_56	UniProtKB/TrEMBL
PIRSF	Hyaluronidase	UniProtKB/TrEMBL
PRINTS	GLHYDRLASE56	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51445	UniProtKB/TrEMBL
UniProt	A0A2R9AAT0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-08-07	HYAL2	hyaluronidase 2		hyaluronoglucosaminidase 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar