SMO (smoothened, frizzled class receptor)

Gene: SMO (smoothened, frizzled class receptor) Pan paniscus

Analyze

Symbol:

SMO

Name:

smoothened, frizzled class receptor

RGD ID:

11977895

Description:

ENCODES a protein that exhibits oxysterol binding (ortholog); protein kinase A catalytic subunit binding (ortholog); protein sequestering activity (ortholog); INVOLVED IN anterior/posterior pattern specification (ortholog); apoptotic process (ortholog); astrocyte activation (ortholog); PARTICIPATES IN altered Hedgehog signaling pathway; Hedgehog signaling pathway; ASSOCIATED WITH acute promyelocytic leukemia (ortholog); Adenomatous Polyps (ortholog); ameloblastoma (ortholog); FOUND IN 9+0 non-motile cilium (ortholog); axonal growth cone (ortholog); centriole (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

smoothened homolog; smoothened, frizzled family receptor

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	165,999,428 - 166,024,105 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	18,009,925 - 18,034,351 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	121,143,968 - 121,168,873 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	133,668,523 - 133,693,048 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	133,668,304 - 133,693,048 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute promyelocytic leukemia (ISO)

Adenomatous Polyps (ISO)

ameloblastoma (ISO)

Barrett's esophagus (ISO)

basal cell carcinoma (ISO)

Brain Neoplasms (ISO)

chondroma (ISO)

Choroidal Neovascularization, Experimental (ISO)

Chronic Experimental Pancreatitis (ISO)

colon cancer (ISO)

colorectal cancer (ISO)

esophagus adenocarcinoma (ISO)

Experimental Arthritis (ISO)

Female Infertility (ISO)

Fluoride Poisoning (ISO)

gastric papillary adenocarcinoma (ISO)

gastric tubular adenocarcinoma (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

hepatoblastoma (ISO)

hepatocellular carcinoma (ISO)

Jaw Abnormalities (ISO)

liver cirrhosis (ISO)

Lymphatic Metastasis (ISO)

malignant pleural mesothelioma (ISO)

Maxillary Neoplasms (ISO)

medulloblastoma (ISO)

meningioma (ISO)

microcephaly (ISO)

middle cerebral artery infarction (ISO)

Multiple Basal Cell Carcinoma (ISO)

Neoplasm Metastasis (ISO)

nevoid basal cell carcinoma syndrome (ISO)

ocular hypertension (ISO)

Osteoarthritis, Hip (ISO)

Pallister-Hall-like Syndrome (ISO)

pancreatic cancer (ISO)

pancreatic ductal carcinoma (ISO)

pancreatitis (ISO)

pleomorphic xanthoastrocytoma (ISO)

pre-malignant neoplasm (ISO)

Primitive Neuroectodermal Tumors (ISO)

Skin Neoplasms (ISO)

stomach cancer (ISO)

Subarachnoid Hemorrhage (ISO)

visual epilepsy (ISO)

Winter Shortland Temple Syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterior/posterior pattern specification (ISO)

apoptotic process (ISO)

astrocyte activation (ISO)

atrial septum morphogenesis (ISO)

axon extension involved in axon guidance (ISO)

cell development (ISO)

cell fate specification (ISO)

cell population proliferation (ISO)

cell surface receptor signaling pathway (IEA)

cellular response to cholesterol (ISO)

central nervous system development (IEA,ISO)

central nervous system neuron differentiation (ISO)

cerebellar cortex morphogenesis (ISO)

cerebral cortex development (ISO)

commissural neuron axon guidance (IEA,ISO)

contact inhibition (IEA)

dentate gyrus development (ISO)

determination of left/right asymmetry in lateral mesoderm (ISO)

determination of left/right symmetry (ISO)

developmental growth (ISO)

digestive tract development (ISO)

dopaminergic neuron differentiation (ISO)

dorsal/ventral neural tube patterning (ISO)

dorsal/ventral pattern formation (ISO)

embryonic organ development (ISO)

epithelial cell differentiation (ISO)

epithelial cell proliferation (ISO)

epithelial-mesenchymal cell signaling (ISO)

facial nerve development (ISO)

forebrain morphogenesis (ISO)

G protein-coupled receptor signaling pathway (IEA)

gene expression (ISO)

hair follicle development (ISO)

hair follicle morphogenesis (ISO)

heart looping (ISO)

heart morphogenesis (ISO)

homeostasis of number of cells within a tissue (ISO)

in utero embryonic development (ISO)

left/right axis specification (ISO)

mammary gland epithelial cell differentiation (ISO)

mesenchymal to epithelial transition (ISO)

mesenchymal to epithelial transition involved in metanephric renal vesicle formation (ISO)

midgut development (ISO)

multicellular organism growth (ISO)

myoblast migration (ISO)

negative regulation of apoptotic process (ISO)

negative regulation of cellular process (ISO)

negative regulation of DNA-templated transcription (ISO)

negative regulation of epithelial cell differentiation (ISO)

negative regulation of gene expression (ISO)

negative regulation of hair follicle development (ISO)

negative regulation of hepatocyte proliferation (ISO)

negative regulation of neuron apoptotic process (ISO)

negative regulation of protein phosphorylation (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

neural crest cell migration (ISO)

neuroblast proliferation (ISO)

neuron projection regeneration (ISO)

odontogenesis of dentin-containing tooth (ISO)

ossification (ISO)

osteoblast differentiation (ISO)

pancreas morphogenesis (ISO)

pattern specification process (IEA,ISO)

positive regulation of autophagy (ISO)

positive regulation of branching involved in ureteric bud morphogenesis (ISO)

positive regulation of cell migration (IEA)

positive regulation of cell population proliferation (ISO)

positive regulation of DNA-templated transcription (ISO)

positive regulation of epithelial cell proliferation (ISO)

positive regulation of gene expression (IEA,ISO)

positive regulation of hepatic stellate cell activation (ISO)

positive regulation of mesenchymal cell proliferation (ISO)

positive regulation of multicellular organism growth (ISO)

positive regulation of neural precursor cell proliferation (ISO)

positive regulation of neuroblast proliferation (ISO)

positive regulation of organ growth (ISO)

positive regulation of protein import into nucleus (ISO)

positive regulation of smoothened signaling pathway (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

positive regulation of vascular associated smooth muscle cell migration (ISO)

protein import into nucleus (ISO)

protein localization to nucleus (ISO)

protein stabilization (ISO)

regulation of gene expression (ISO)

regulation of heart morphogenesis (ISO)

regulation of somatic stem cell population maintenance (ISO)

response to organic substance (ISO)

signal transduction (IEA)

skeletal muscle fiber development (ISO)

smooth muscle tissue development (IEA)

smoothened signaling pathway (IEA,ISO)

somite development (ISO)

spermatogenesis (ISO)

spinal cord dorsal/ventral patterning (ISO)

thalamus development (ISO)

tissue development (IEA)

type B pancreatic cell development (ISO)

vasculogenesis (ISO)

ventral midline determination (ISO)

Cellular Component

9+0 non-motile cilium (ISO)

axonal growth cone (ISO)

caveola (IEA)

cell projection (IEA)

centriole (ISO)

ciliary membrane (ISO)

cilium (IEA,ISO)

cytoplasm (ISO)

dendrite (IEA,ISO)

dendritic growth cone (ISO)

endoplasmic reticulum (ISO)

endoplasmic reticulum-Golgi intermediate compartment (ISO)

Golgi apparatus (IEA,ISO)

intracellular membrane-bounded organelle (IEA)

late endosome (ISO)

membrane (IEA)

neuronal cell body (ISO)

plasma membrane (IEA)

plasma membrane bounded cell projection (IEA)

Molecular Function

cAMP-dependent protein kinase inhibitor activity (IEA)

G protein-coupled receptor activity (IEA)

oxysterol binding (ISO)

patched binding (IEA)

protein binding (ISO)

protein kinase A catalytic subunit binding (ISO)

protein sequestering activity (ISO)

transmembrane signaling receptor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

altered Hedgehog signaling pathway (ISO)

Hedgehog signaling pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

SMO
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	165,999,428 - 166,024,105 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	18,009,925 - 18,034,351 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	121,143,968 - 121,168,873 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	133,668,523 - 133,693,048 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	133,668,304 - 133,693,048 (+)	Ensembl	panpan1.1		panPan2

SMO
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	129,188,633 - 129,213,545 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	129,188,633 - 129,213,545 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	128,828,474 - 128,853,386 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	128,615,949 - 128,640,622 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	128,422,663 - 128,447,334	NCBI
Celera	7	123,625,432 - 123,650,109 (+)	NCBI		Celera
Cytogenetic Map	7	q32.1	NCBI
HuRef	7	123,189,938 - 123,214,626 (+)	NCBI		HuRef
CHM1_1	7	128,762,307 - 128,786,971 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	130,501,540 - 130,526,468 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	128,212,668 - 128,237,345 (+)	NCBI

Smo
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	29,735,480 - 29,761,359 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	29,735,502 - 29,761,364 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	29,735,497 - 29,761,366 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	29,735,503 - 29,761,365 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	29,685,497 - 29,711,366 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	29,685,513 - 29,711,369 (+)	NCBI		MGSCv36	mm8
Celera	6	29,744,569 - 29,772,611 (+)	NCBI		Celera
Cytogenetic Map	6	A3.3	NCBI
cM Map	6	12.36	NCBI

Smo
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	59,311,084 - 59,341,280 (+)	NCBI		GRCr8
mRatBN7.2	4	58,343,626 - 58,373,823 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	58,343,529 - 58,373,829 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	63,327,690 - 63,351,689 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	59,243,861 - 59,267,857 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	57,645,743 - 57,669,741 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	57,019,941 - 57,041,779 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	57,019,941 - 57,042,770 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	56,787,102 - 56,809,935 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	56,623,494 - 56,645,571 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	56,898,313 - 56,920,866 (+)	NCBI
Celera	4	53,450,322 - 53,474,674 (+)	NCBI		Celera
Cytogenetic Map	4	q22	NCBI

Smo
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955479	9,964,170 - 9,993,165 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955479	9,963,377 - 9,991,670 (+)	NCBI	ChiLan1.0	ChiLan1.0

SMO
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	7,518,871 - 7,527,703 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	7,518,856 - 7,528,033 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	7,206,323 - 7,229,356 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	7,284,734 - 7,307,875 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	7,284,738 - 7,307,899 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	7,489,837 - 7,512,985 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	7,231,685 - 7,254,904 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	7,376,821 - 7,399,952 (-)	NCBI		UU_Cfam_GSD_1.0

Smo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	25,760,467 - 25,784,726 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936579	5,892,542 - 5,917,281 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936579	5,893,064 - 5,917,021 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SMO
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	19,450,743 - 19,478,898 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	19,450,730 - 19,478,796 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	20,520,306 - 20,548,303 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SMO
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	97,788,955 - 97,814,549 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	97,788,624 - 97,814,709 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	5,588,304 - 5,614,118 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Smo
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624783	7,011,899 - 7,039,921 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624783	7,012,385 - 7,039,302 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_014345829	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034964966	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000040940 ⟹ ENSPPAP00000018211

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	7	133,668,304 - 133,693,048 (+)	Ensembl

RefSeq Acc Id:

XM_014345829 ⟹ XP_014201315

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	165,999,428 - 166,024,105 (+)	NCBI
NHGRI_mPanPan1	7	18,009,925 - 18,034,351 (+)	NCBI
Mhudiblu_PPA_v0	7	121,143,968 - 121,168,873 (+)	NCBI
PanPan1.1	7	133,668,523 - 133,693,048 (+)	NCBI

Sequence:

show sequence

GGGCTGAAGACAACTTGGATTGCGAGGCTAGGGCTTGGGGAGTCGTGCATCCCGGTCCGGGCCT
CCGCAGCCCAACATGGGCCCCGGGTTCCAAAGTTTGCGAAGTTGGGCGCCGAGGGGCCGGGGCG
CGCGGAGCGTCCGGGGGGGCCCGGGCCCGGATTCTCTGGGCGCACAGGTCGCCTGAGCCGCCTC
CGCGGCCGCCGGGGTCGTGCGTGTGGCCGGGGGGGCCGTTCCGACGGAGNAGCGGGCGCGGGCT
TTTGCTGAGTTGGCGGGTTGGCCACTGGCCGCTGCCGCCAGCGCGGGGCCGGAGCTCCCGCTCC
TGTAGGCTGCTGCGTGTTGCGTGGCTGGGGGCCCGGGGCCGGGGTCGGCCTCGAGCGGGAACGC
GACCGGGCCTGGGCCTCGGAGCGCGGGCGGGAGCGCGGGCGGGAGCGCGAGGAGGAGCGCGGCG
GTGACCGGCCCTCCGCCGCCGCTGAGCCACTGCGGGCCGGGCTCGCCCCCTGCGAGCCGCTGCG
CTACAACGTGTGCCTGGGCTCGGTGCTGCCCGTACGGGGCCACCTCCACACTGCTGGCCGGAGA
CTCGGACTCCCAGGAGGAAGCGCACGGCAAGCTCGTGCTCTGGTCGGGCCTCCGGAATGCCCCC
CGCTGCTGGGCAGTGATCCAGCCCCTGCTGTGTGCCGTATACATGCCCAAGTGTGAGAATGACC
GGGTGGAGCTGCCCAGCCGCACCCTCTGCCAGGCCACCCGAGGCCCCTGTGCCATCGTGGAGAG
GGAACGGGGCTGGCCTGACTTCCTGCGCTGCACTCCTGACCGCTTCCCTGAAGGCTGCACGAAT
GAGGTGCAGAACATCAAGTTCAACAGTTCAGGCCAGTGCGAAGTGCCCTTGGTTCGGACAGACA
ACCCCAAGAGCTGGTACGAGGACGTGGAGGGCTGCGGCATCCAGTGCCAGAACCCGCTCTTCAC
AGAGGCTGAGCACCAGGACATGCACAGCTACATCGCGGCCTTCGGGGCCGTCACGGGCCTCTGC
ACGCTCTTCACCCTGGCCACATTCGTGGCTGACTGGCGGAACTCGAATCGCTACCCTGCTGTTA
TTCTCTTCTACGTCAATGCGTGCTTCTTTGTGGGCAGCATTGGCTGGCTGGCCCAGTTCATGGA
TGGTGCCCGCCGAGAGATCGTCTGCCGTGCAGATGGCACCATGAGGCTTGGGGAGCCCACCTCC
AATGAGACTCTGTCCTGCGTCATCATCTTTGTCATCGTGTACTACGCCCTGATGGCTGGTGTGG
TTTGGTTTGTGGTCCTCACCTATGCCTGGCACACTTCCTTCAAAGCCCTGGGCACCACCTACCA
GCCTCTCTCGGGCAAGACCTCCTACTTCCACCTGCTCACCTGGTCACTCCCCTTTGTCCTCACT
GTGGCAATCCTTGCTGTGGCGCAGGTGGATGGGGACTCTGTGAGTGGCATTTGTTTTGTGGGCT
ACAAGAACTACCGATACCGTGCGGGCTTCGTGCTGGCCCCGATCGGCCTGGTGCTCATCGTGGG
AGGCTACTTCCTCATCCGAGGAGTCATGACTCTGTTCTCCATCAAGAGCAACCACCCCGGGCTG
CTGAGTGAGAAGGCTGCCAGCAAGATCAACGAGACCATGCTGCGCCTGGGCATTTTTGGCTTCC
TGGCCTTTGGCTTTGTGCTCATTACCTTCAGCTGCCACTTCTACGACTTCTTCAACCAGGCTGA
GTGGGAGCGCAGCTTCCGGGACTATGTGCTATGTCAGGCCAATGTGACCATCGGGCTGCCCACC
AAGCAGCCCATCCCTGACTGTGAGATCAAGAATCGCCCGAGCCTTCTGGTGGAGAAGATCAACC
TGTTTGCCATGTTTGGAACTGGCATCGCCATGAGCACCTGGGTCTGGACCAAGGCCACGCTGCT
CATCTGGAGGCGTACCTGGTGCAGGTTGACTGGGCAGAGTGACGATGAGCCAAAGCGGATCAAG
AAGAGCAAGATGATTGCCAAGGCCTTCTCCAAGCGGCACGAGCTCCTGCAGAACCCAGGCCAGG
AGCTGTCCTTCAGCATGCACACTGTGTCCCACGACGGGCCCGTGGCGGGCTTGGCCTTTGACCT
CAATGAGCCCTCAGCTGATGTCTCCTCTGCCTGGGCCCAGCATGTCACCAAGATGGTGGCTCGG
AGAGGAGCCATACTGCCCCAGGATATTTCTGTCACCCCTGTGGCAACTCCAGTGCCCCCAGAGG
AACAAGCCAACCTGTGGCTGGTTGAGGCAGAGATCTCCCCAGAGCTGCAGAAGCGCCTGGGCCG
GAAGAAGAAGAGGAGGAAGAGGAAGAAGGAGGTGTGCCCTCTGGCACCGCCCCCTGAGCTTCAC
CCCCCTGCCCCTGCCCCCAGTACCATTCCTCGACTGCCTCAGCTGCCCCGGCAGAAATGCCTGG
TGGCTGCAGGTGCCTGGGGAGCTGGGGACTCTTGCCGACAGGGAGCGTGGACCCTGGTCTCCAA
CCCATTCTGCCCAGAGCCCAGTCCCCCTCAGGATCCATTTCTGCCCAGTGCACCGGCCCCCATG
GCATGGGCTCATGGCCGCCGACAGGGCCTGGGGCCTATTCACTCCCGCACCAACCTGATGGACG
CAGAACTCATGGATGCAGACTCGGACTTCTGAGCCTGCAGAGCAGGACCTGGGACAGGAAAGAG
AGGAACCAATACCTTCAAGGCTCTTCTTCATCACCGAGCATGCTTCCCTAGGATCCCGTCTTCC
AGAGAACCTGTGGGCTGACTGCCCTCCGAAGAGAGTTCTGGATGTCTGGCTCAAAGCAGCAGGA
CTGTGGGAAAGAGCCTAACATCTCCATGGGGAGGCCTCACCCCAGGGACAGGGCCCTGGAGCTC
AGGGTCCTTGTTTCTGCCCCACCAGCTGCAGCCTGGTTGGCAGCATCTGCTCCATCGGGGCAGG
GGGTATGCAGAGCTTGTGGTGGGGCAGGAACGGTGGAGGCAGAGGTGACAGTTCCCAGAGTGGG
CTTTGGTGGCCAGGGAGGCAGCCTAGCCTATGTCTGGCAGATGAGGGCTGGCTGCCGTTTTCTG
GGCTGATGGGTGCCCTTTCCTGGCAGTCTCAGTCCAAAAGTGTTGACTGTGTCATCAGTCCTTT
GTCTAAGTAGGGCCAGGGCGCCGTATTCCTCTCCCAGGTGTTTGTGGGGCTGGAAGGACCTGCT
CCCACAGGGGCCATGTCCTCTCTTAATAGGTGGCCCTACCCCAAACCCATCTTTTGTTCTCCTA
TATCCTCCTTCTCCTGTTCCATTTCAGTTCAGTTTCAGCGGTGCCAACCTCTTTGCGTTTCCTT
TTTGTTGATGAGGACCCAGAGCTGCTGCACACACTCACCTCTAACCCCCTCCCCTCGCTGCTGG
GCCCCATCTCCACAGGAGAGACTGGTTCAGCTCTAGGGCCTCAGTCTGGAGTGGGATAGGAGCA
GTGAGTGACAAAGCCTCTGAAAGATGCATCATCTCTTCCTCACACCCATTCAGTGGGGCTCTAG
ACTTGAGGGGCTACCCTGGGAAGCTGCTGTAGCTTCAGCCAGGCAAGAAAGCTTCCTTCAACCT
GCATAGCCAGTGGATGAGGAGATTCCCACCTTCCATAGCCTCCAAACATGTTCCCAAGGCCCCA
CTTTCAAGAATCAGACAGCAGGAAGCCATAGATGCTGGCTGGGTTCCAGGTTATGGGGAGAAGA
AATACAGTCAATAAAAGGTTTTTGTATAAA

hide sequence

RefSeq Acc Id:

XM_034964966 ⟹ XP_034820857

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	165,999,911 - 166,024,105 (+)	NCBI
NHGRI_mPanPan1	7	18,010,157 - 18,034,351 (+)	NCBI
Mhudiblu_PPA_v0	7	121,144,686 - 121,168,873 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_014201315	(Get FASTA)	NCBI Sequence Viewer
	XP_034820857	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000018211.1

RefSeq Acc Id:	XP_014201315 ⟸ XM_014345829
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9ALJ4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTNEVQNIKFNSSGQCE VPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRN SNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRLGEPTSNETLSCVIIFVIVY YALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSV SGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETML RLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPS LLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHE LLQNPGQELSFSMHTVSHDGPVAGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPV ATPVPPEEQANLWLVEAEISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQ LPRQKCLVAAGAWGAGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPMAWAHGRRQGLGPIH SRTNLMDAELMDADSDF hide sequence

RefSeq Acc Id:	XP_034820857 ⟸ XM_034964966
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9ALJ4 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSPPAP00000018211 ⟸ ENSPPAT00000040940

Protein Domains

FZ G-protein coupled receptors family 2 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000032237	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000040940.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.2000.10	UniProtKB/TrEMBL
	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	Frizzled/SFRP	UniProtKB/TrEMBL
	Frizzled/Smoothened_TM	UniProtKB/TrEMBL
	Frizzled_dom	UniProtKB/TrEMBL
	Frizzled_dom_sf	UniProtKB/TrEMBL
	GPCR_2-like	UniProtKB/TrEMBL
	SMO_7TM	UniProtKB/TrEMBL
	SMO_CRD	UniProtKB/TrEMBL
NCBI Gene	SMO	ENTREZGENE
PANTHER	PTHR11309	UniProtKB/TrEMBL
	PTHR11309:SF35	UniProtKB/TrEMBL
Pfam	Frizzled	UniProtKB/TrEMBL
	PF01392	UniProtKB/TrEMBL
PRINTS	FRIZZLED	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F2_4	UniProtKB/TrEMBL
	PS50038	UniProtKB/TrEMBL
SMART	FRI	UniProtKB/TrEMBL
	Frizzled	UniProtKB/TrEMBL
Superfamily-SCOP	SSF63501	UniProtKB/TrEMBL
UniProt	A0A2R9ALJ4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)