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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Chronic Pancreatitis
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Accession:DOID:9006190 term browser browse the term
Definition:INFLAMMATION of the PANCREAS that is characterized by recurring or persistent ABDOMINAL PAIN with or without STEATORRHEA or DIABETES MELLITUS. It is characterized by the irregular destruction of the pancreatic parenchyma which may be focal, segmental, or diffuse.
Synonyms:related_synonym: chronic pancreatitis, susceptibility to
 primary_id: MESH:D050500
 alt_id: RDO:0003066
 xref: EFO:0000342;   NCI:C84637


show annotations for term's descendants           Sort by:
Chronic Pancreatitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa4 apolipoprotein A4 ISO protein:decreased expression:blood plasma (human) RGD PMID:11555832 RGD:5685680 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469 		JBrowse link
G Bad BCL2-associated agonist of cell death severity IEP RGD PMID:22549003 RGD:10053701 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger ISO protein:increased expression:pancreatic acinar cell:
protein:increased expression:exocrine pancreas: 		RGD PMID:19585519 PMID:19585519 RGD:9491843, RGD:9491843 NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690 		JBrowse link
G Cel carboxyl ester lipase ISO CTD Direct Evidence: marker/mechanism CTD PMID:25774637 NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035 		JBrowse link
G Cftr CF transmembrane conductance regulator ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Chronic pancreatitis		 CTD
ClinVar		 PMID:10746558 PMID:15536480 PMID:16189704 PMID:16193325 PMID:16244288 More... NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Col1a1 collagen type I alpha 1 chain treatment IDA RGD PMID:21926544 RGD:8552779 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Cpa1 carboxypeptidase A1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23955596 NCBI chr 4:59,257,417...59,263,544
Ensembl chr 4:59,257,417...59,263,544 		JBrowse link
G Ctrc chymotrypsin C ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Chronic pancreatitis | ClinVar Annotator: match by term: Pancreatitis, chronic, susceptibility to		 CTD
ClinVar		 PMID:18059268 PMID:18172691 PMID:19453252 PMID:20625975 PMID:22427236 More... NCBI chr 5:154,147,314...154,156,540
Ensembl chr 5:154,147,316...154,156,528 		JBrowse link
G Cygb cytoglobin IEP RGD PMID:14647402 RGD:9685173 NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442 		JBrowse link
G Dll1 delta like canonical Notch ligand 1 ISO mRNA,protein:increased expression:pancreas RGD PMID:17114010 RGD:6482236 NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179 		JBrowse link
G Ifng interferon gamma disease_progression IEP RGD PMID:11345142 RGD:10755767 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 ISO mRNA,protein:increased expression:pancreas RGD PMID:17114010 RGD:6482236 NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209 		JBrowse link
G Ngf nerve growth factor IEP protein:increased expression:pancreas RGD PMID:16098667 RGD:5144071 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Ngfr nerve growth factor receptor ISO mRNA:increased expression:pancreas (human) RGD PMID:12741461 RGD:5508378 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Prss1 serine protease 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18206817 NCBI chr 4:70,364,589...70,367,792
Ensembl chr 4:70,364,586...70,367,792 		JBrowse link
G Pthlh parathyroid hormone-like hormone ISO CTD Direct Evidence: marker/mechanism CTD PMID:25035110 NCBI chr 4:180,188,792...180,199,847
Ensembl chr 4:180,188,792...180,199,847 		JBrowse link
G Reg1a regenerating family member 1 alpha IEP protein:increased expression:pancreas, acinar cell, zymogen granule (rat) RGD PMID:12764608 RGD:9831428 NCBI chr 4:110,892,451...110,895,115
Ensembl chr 4:110,892,453...110,895,570 		JBrowse link
G Reg3b regenerating family member 3 beta treatment IDA
IEP		 protein:increased expression:pancreas, acinar cell, zymogen granule (rat) RGD PMID:10505754 PMID:12764608 RGD:9831401, RGD:9831428 NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015 		JBrowse link
G Rnf2 ring finger protein 2 ISO protein:increased expression:pancreas RGD PMID:19585519 RGD:9491843 NCBI chr13:63,553,964...63,584,047
Ensembl chr13:63,554,862...63,583,099 		JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 ISO ClinVar Annotator: match by term: Chronic pancreatitis | ClinVar Annotator: match by term: Pancreatitis, chronic, susceptibility to
CTD Direct Evidence: marker/mechanism		 ClinVar
CTD
RGD		 PMID:10691414 PMID:10835640 PMID:11950815 PMID:12011155 PMID:12187509 More... RGD:1599102 NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642 		JBrowse link
autoimmune pancreatitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RT1-Bb RT1 class II, locus Bb severity ISO DNA:polymorphisms, haplotype:cds:HLA-DQB1*0302 (human) RGD PMID:18155707 RGD:5147621 NCBI chr20:4,596,558...4,602,201
Ensembl chr20:4,596,559...4,607,597 		JBrowse link
Calcific Pancreatitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Reg1a regenerating family member 1 alpha ISO protein:decreased expression:pancreatic juice (human) RGD PMID:3147713 RGD:9850117 NCBI chr 4:110,892,451...110,895,115
Ensembl chr 4:110,892,453...110,895,570 		JBrowse link
Chronic Experimental Pancreatitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase IEP protein:increased expression:arcuate nucleus (rat) RGD PMID:27778022 RGD:38456012 NCBI chr20:9,708,089...9,732,623
Ensembl chr20:9,708,090...9,732,764 		JBrowse link
G Gli1 GLI family zinc finger 1 IEP RGD PMID:24782623 RGD:12879405 NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251 		JBrowse link
G Il1b interleukin 1 beta ISO RGD PMID:22173919 RGD:10044253 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 treatment IEP RGD PMID:22359633 RGD:11035224 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Ptch1 patched 1 IEP RGD PMID:24782623 RGD:12879405 NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333 		JBrowse link
G Smo smoothened, frizzled class receptor IEP RGD PMID:24782623 RGD:12879405 NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829 		JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 treatment IDA
IEP		 protein:increased secretion:pancreatic juice: RGD PMID:19904222 PMID:12123090 PMID:22173919 RGD:10043091, RGD:10044261, RGD:10044253 NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 IEP RGD PMID:26645248 RGD:14995470 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
Hereditary Pancreatitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agmat agmatinase ISO ClinVar Annotator: match by term: Hereditary pancreatitis ClinVar PMID:23721890 PMID:28492532 NCBI chr 5:154,043,665...154,074,278
Ensembl chr 5:154,060,151...154,074,276 		JBrowse link
G Casp9 caspase 9 ISO ClinVar Annotator: match by term: Hereditary pancreatitis ClinVar PMID:23721890 PMID:28492532 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cela2a chymotrypsin like elastase 2A ISO ClinVar Annotator: match by term: Hereditary pancreatitis ClinVar PMID:23721890 PMID:28492532 NCBI chr 5:154,126,879...154,136,630
Ensembl chr 5:154,126,878...154,136,632 		JBrowse link
G Cftr CF transmembrane conductance regulator ISO ClinVar Annotator: match by term: Hereditary chronic pancreatitis | ClinVar Annotator: match by term: Hereditary pancreatitis | ClinVar Annotator: match by term: Pancreatitis, idiopathic, susceptibility to
CTD Direct Evidence: marker/mechanism		 OMIM
ClinVar
CTD		 PMID:754013 PMID:1282016 PMID:1283148 PMID:1284477 PMID:1284530 More... NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Clec5a C-type lectin domain containing 5A ISO ClinVar Annotator: match by term: Hereditary pancreatitis ClinVar PMID:25741868 NCBI chr 4:69,407,125...69,416,872
Ensembl chr 4:69,407,835...69,416,859 		JBrowse link
G Cpa1 carboxypeptidase A1 ISO ClinVar Annotator: match by term: Hereditary chronic pancreatitis | ClinVar Annotator: match by term: Hereditary pancreatitis ClinVar PMID:9536098 PMID:16199547 PMID:17576681 PMID:23955596 PMID:24522117 More... NCBI chr 4:59,257,417...59,263,544
Ensembl chr 4:59,257,417...59,263,544 		JBrowse link
G Ctrc chymotrypsin C susceptibility ISO ClinVar Annotator: match by term: Hereditary chronic pancreatitis | ClinVar Annotator: match by term: Hereditary pancreatitis
CTD Direct Evidence: marker/mechanism		 ClinVar
CTD
OMIM		 PMID:190101 PMID:5256061 PMID:8168476 PMID:9536098 PMID:16199547 More... NCBI chr 5:154,147,314...154,156,540
Ensembl chr 5:154,147,316...154,156,528 		JBrowse link
G Ddi2 DNA damage inducible 1 homolog 2 ISO ClinVar Annotator: match by term: Hereditary pancreatitis ClinVar PMID:23721890 PMID:28492532 NCBI chr 5:153,989,591...154,035,342
Ensembl chr 5:153,995,589...154,035,283 		JBrowse link
G Dnajc16 DnaJ heat shock protein family (Hsp40) member C16 ISO ClinVar Annotator: match by term: Hereditary pancreatitis ClinVar PMID:23721890 PMID:28492532 NCBI chr 5:154,073,372...154,106,246
Ensembl chr 5:154,075,261...154,106,136 		JBrowse link
G Ephb6 Eph receptor B6 ISO ClinVar Annotator: match by term: Hereditary pancreatitis ClinVar PMID:25741868 NCBI chr 4:70,491,973...70,507,230
Ensembl chr 4:70,491,973...70,507,230 		JBrowse link
G Mgam maltase-glucoamylase ISO ClinVar Annotator: match by term: Hereditary pancreatitis ClinVar PMID:25741868 NCBI chr 4:69,441,626...69,602,068
Ensembl chr 4:69,446,150...69,692,715 		JBrowse link
G Or9a4 olfactory receptor family 9 subfamily A member 4 ISO ClinVar Annotator: match by term: Hereditary pancreatitis ClinVar PMID:25741868 NCBI chr 4:69,401,606...69,402,550
Ensembl chr 4:69,399,601...69,404,723 		JBrowse link
G Plekhm2 pleckstrin homology and RUN domain containing M2 ISO ClinVar Annotator: match by term: Hereditary pancreatitis ClinVar PMID:23721890 PMID:28492532 NCBI chr 5:153,939,582...153,978,625
Ensembl chr 5:153,940,262...153,978,689 		JBrowse link
G Prss1 serine protease 1 ISO ClinVar Annotator: match by term: Hereditary chronic pancreatitis | ClinVar Annotator: match by term: Hereditary pancreatitis
CTD Direct Evidence: marker/mechanism		 OMIM
ClinVar
CTD		 PMID:2539344 PMID:6023921 PMID:8841182 PMID:9322498 PMID:9536098 More... NCBI chr 4:70,364,589...70,367,792
Ensembl chr 4:70,364,586...70,367,792 		JBrowse link
G Prss37 serine protease 37 ISO ClinVar Annotator: match by term: Hereditary pancreatitis ClinVar PMID:25741868 NCBI chr 4:69,322,977...69,334,555
Ensembl chr 4:69,322,977...69,334,555 		JBrowse link
G Prss58 serine protease 58 ISO ClinVar Annotator: match by term: Hereditary pancreatitis ClinVar PMID:25741868 NCBI chr 4:69,752,646...69,757,306
Ensembl chr 4:69,752,573...69,756,962 		JBrowse link
G Sar1b secretion associated, Ras related GTPase 1B ISO ClinVar Annotator: match by term: Hereditary pancreatitis ClinVar PMID:12692552 PMID:25741868 NCBI chr10:36,024,415...36,054,069
Ensembl chr10:36,024,382...36,054,066 		JBrowse link
G Slc25a34 solute carrier family 25, member 34 ISO ClinVar Annotator: match by term: Hereditary pancreatitis ClinVar PMID:23721890 PMID:28492532 NCBI chr 5:153,932,081...153,936,854 JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Hereditary chronic pancreatitis | ClinVar Annotator: match by term: Hereditary pancreatitis		 CTD
OMIM
ClinVar		 PMID:120111 PMID:1613792 PMID:1870127 PMID:3501289 PMID:9536098 More... NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642 		JBrowse link
G Ssbp1 single stranded DNA binding protein 1 ISO ClinVar Annotator: match by term: Hereditary pancreatitis ClinVar PMID:25741868 NCBI chr 4:69,266,024...69,276,135
Ensembl chr 4:69,266,102...69,276,135 		JBrowse link
G Tas2r108 taste receptor, type 2, member 108 ISO ClinVar Annotator: match by term: Hereditary pancreatitis ClinVar PMID:25741868 NCBI chr 4:69,287,667...69,288,581
Ensembl chr 4:69,287,667...69,288,581 		JBrowse link
G Tas2r137 taste receptor, type 2, member 137 ISO ClinVar Annotator: match by term: Hereditary pancreatitis ClinVar PMID:25741868 NCBI chr 4:69,279,276...69,286,935
Ensembl chr 4:69,284,391...69,285,341 		JBrowse link
G Tas2r138 taste receptor, type 2, member 138 ISO ClinVar Annotator: match by term: Hereditary pancreatitis ClinVar PMID:25741868 NCBI chr 4:69,428,344...69,429,339
Ensembl chr 4:69,428,344...69,429,339 		JBrowse link
G Trpv6 transient receptor potential cation channel, subfamily V, member 6 ISO ClinVar Annotator: match by term: Hereditary pancreatitis ClinVar PMID:25741868 NCBI chr 4:70,507,347...70,523,013
Ensembl chr 4:70,507,348...70,523,017 		JBrowse link
Tropical Calcific Pancreatitis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spink1 serine peptidase inhibitor, Kazal type 1 ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Tropical calcific pancreatitis		 CTD
OMIM
ClinVar		 PMID:10691414 PMID:10835640 PMID:11265669 PMID:11950815 PMID:12011155 More... NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18976
    disease of anatomical entity 18260
      endocrine system disease 6819
        pancreas disease 1257
          pancreatitis 216
            Chronic Pancreatitis 49
              Calcific Pancreatitis 1
              Chronic Experimental Pancreatitis 8
              Hereditary Pancreatitis 24
              Pancreatitis, Sclerosing Cholangitis, and Sicca Complex 0
              Tropical Calcific Pancreatitis 1
              autoimmune pancreatitis 1
paths to the root