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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:urinary bladder cancer
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Accession:DOID:11054 term browser browse the term
Definition:An urinary system cancer that results_in malignant growth located_in the urinary bladder. (DO)
Synonyms:exact_synonym: bladder cancer;   bladder cancers;   cancer of bladder;   cancer of the bladder;   malignant tumor of urinary bladder;   tumor of the bladder
 narrow_synonym: BLADDER CANCER, TRANSITIONAL CELL, SOMATIC
 primary_id: MESH:D001749
 alt_id: OMIM:109800
 xref: GARD:12210;   ICD10CM:C67;   ICD9CM:188;   MONDO:0001187;   NCI:C2901;   NCI:C9334
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
urinary bladder cancer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase ISO CTD Direct Evidence: marker/mechanism CTD PMID:29644616 NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,441...8,738,605 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 disease_progression ISO protein:increased expression:urinary bladder
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:18190825 PMID:36115647 RGD:2291891
G ALOX12 arachidonate 12-lipoxygenase, 12S type ISO protein:increased expression:urinary bladder RGD PMID:14532840 RGD:2315608 NCBI chr12:52,401,861...52,414,913
Ensembl chr12:52,401,810...52,414,903 		JBrowse link
G AMACR alpha-methylacyl-CoA racemase severity ISO RGD PMID:18648853 RGD:2315629 NCBI chr16:20,005,741...20,023,339
Ensembl chr16:19,956,366...20,023,289 		JBrowse link
G AMFR autocrine motility factor receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:9241080 NCBI chr 6:29,366,812...29,417,800
Ensembl chr 6:29,366,936...29,413,697 		JBrowse link
G ANG angiogenin ISO protein:increased expression:plasma
protein:increased expression:urine		 RGD PMID:15329320 PMID:15912517 RGD:2325700 RGD:2325704 NCBI chr 7:78,249,479...78,262,846
Ensembl chr 7:78,249,487...78,250,138 		JBrowse link
G ANKFY1 ankyrin repeat and FYVE domain containing 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26039340 NCBI chr12:50,167,959...50,251,861
Ensembl chr12:50,168,049...50,251,768 		JBrowse link
G ANPEP alanyl aminopeptidase, membrane ISO CTD Direct Evidence: marker/mechanism CTD PMID:26039340 NCBI chr 7:55,351,081...55,373,856
Ensembl chr 7:55,351,087...55,373,881 		JBrowse link
G ANXA2R annexin A2 receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:26039340 NCBI chr16:27,744,342...27,744,896 JBrowse link
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 susceptibility ISO RGD PMID:19041121 RGD:2315660 NCBI chr 7:78,451,845...78,454,938
Ensembl chr 7:78,451,851...78,454,938 		JBrowse link
G APOBEC3B apolipoprotein B mRNA editing enzyme catalytic subunit 3B ISO CTD Direct Evidence: marker/mechanism CTD PMID:23852168 PMID:27643540 NCBI chr 5:9,098,676...9,115,965
Ensembl chr 5:9,097,719...9,116,369 		JBrowse link
G AQP3 aquaporin 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22306368 NCBI chr10:33,045,374...33,050,285
Ensembl chr10:33,045,245...33,051,082 		JBrowse link
G AREG amphiregulin disease_progression ISO mRNA:increased expression:urinary bladder RGD PMID:11133810 PMID:11507076 RGD:2292661 RGD:2292662 NCBI chr 8:70,417,935...70,428,106
Ensembl chr 8:70,417,923...70,428,102 		JBrowse link
G ARID1A AT-rich interaction domain 1A ISO ClinVar Annotator: match by term: Malignant tumor of urinary bladder ClinVar PMID:25741868 PMID:32888375 PMID:34942405 NCBI chr 6:84,049,729...84,124,302
Ensembl chr 6:84,049,087...84,123,349 		JBrowse link
G AS3MT arsenite methyltransferase ISO CTD Direct Evidence: marker/mechanism CTD PMID:22747749 PMID:29669044 PMID:29859237 PMID:32539094 NCBI chr14:113,844,107...113,867,880
Ensembl chr14:113,847,859...113,869,507 		JBrowse link
G ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26039340 NCBI chr 4:10,103,860...10,451,928
Ensembl chr 4:10,179,758...10,451,929 		JBrowse link
G ASXL2 ASXL transcriptional regulator 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24121791 NCBI chr 3:113,044,788...113,184,809
Ensembl chr 3:113,044,836...113,180,742 		JBrowse link
G ATM ATM serine/threonine kinase ISO ClinVar Annotator: match by term: Malignant tumor of urinary bladder ClinVar PMID:8755918 PMID:9043869 PMID:9450874 PMID:9463314 PMID:9497252 More... NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,658...36,759,552 		JBrowse link
G ATP5F1D ATP synthase F1 subunit delta ISO CTD Direct Evidence: marker/mechanism CTD PMID:26039340 NCBI chr 2:77,216,430...77,219,301
Ensembl chr 2:77,216,436...77,222,632 		JBrowse link
G ATP5MC2 ATP synthase membrane subunit c locus 2 ISO DNA:hypermethylation:promoter RGD PMID:26929985 RGD:14696811 NCBI chr 5:18,871,025...18,879,933
Ensembl chr 5:18,871,026...18,879,609 		JBrowse link
G AURKA aurora kinase A disease_progression ISO mRNA, protein:increased expression:urinary bladder RGD PMID:18485461 RGD:2293871 NCBI chr17:56,954,838...56,972,435 JBrowse link
G AXIN1 axin 1 susceptibility ISO DNA:SNPs:5'utr: (rs12921862, rs1805105, rs370681) (human) RGD PMID:31143301 RGD:150527861 NCBI chr 3:41,344,908...41,393,999
Ensembl chr 3:41,337,071...41,393,997 		JBrowse link
G BAP1 BRCA1 associated protein 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25231345 NCBI chr13:34,544,570...34,553,538
Ensembl chr13:34,544,581...34,553,483 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator ISO RGD PMID:18452128 RGD:2296023 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140 		JBrowse link
G BCL2 BCL2 apoptosis regulator severity ISO DNA:hypermethylation:promoter
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:18094410 PMID:18342927 PMID:36115647 RGD:2292910 RGD:2293014 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879 		JBrowse link
G BCL2L1 BCL2 like 1 disease_progression ISO RGD PMID:18342927 RGD:2292910 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694 		JBrowse link
G BGLAP bone gamma-carboxyglutamate protein disease_progression ISO RGD PMID:19088041 RGD:30296651 NCBI chr 4:93,807,703...93,808,806
Ensembl chr 4:93,807,706...93,808,968 		JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12926068 NCBI chr 9:33,003,570...33,020,252
Ensembl chr 9:33,003,276...33,020,242 		JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 disease_progression ISO protein:increased expression:urinary bladder RGD PMID:17905101 PMID:18089718 RGD:2293094 RGD:2293096 NCBI chr12:3,747,276...3,755,214
Ensembl chr12:3,747,279...3,755,215 		JBrowse link
G BPTF bromodomain PHD finger transcription factor ISO CTD Direct Evidence: marker/mechanism CTD PMID:24121791 NCBI chr12:14,112,943...14,254,810
Ensembl chr12:14,112,718...14,254,790 		JBrowse link
G BRCA1 BRCA1 DNA repair associated ISO ClinVar Annotator: match by term: Bladder cancer | ClinVar Annotator: match by term: Malignant tumor of urinary bladder ClinVar PMID:7894493 PMID:8460636 PMID:8554067 PMID:8968102 PMID:9150154 More... NCBI chr12:19,788,087...19,854,515
Ensembl chr12:19,786,020...19,854,668 		JBrowse link
G BRCA2 BRCA2 DNA repair associated ISO ClinVar Annotator: match by term: Malignant tumor of urinary bladder ClinVar PMID:2673801 PMID:8673091 PMID:8896551 PMID:8988179 PMID:9150172 More... NCBI chr11:8,805,950...8,858,128
Ensembl chr11:8,805,953...8,858,418 		JBrowse link
G C9H11orf65 chromosome 9 C11orf65 homolog ISO ClinVar Annotator: match by term: Malignant tumor of urinary bladder ClinVar PMID:8755918 PMID:9450874 PMID:9463314 PMID:9497252 PMID:9733514 More... NCBI chr 9:36,768,819...36,855,318
Ensembl chr 9:36,776,897...36,849,710 		JBrowse link
G CA9 carbonic anhydrase 9 disease_progression ISO RGD PMID:14520462 RGD:2293197 NCBI chr 1:236,393,727...236,400,994
Ensembl chr 1:236,394,306...236,400,822 		JBrowse link
G CASP3 caspase 3 disease_progression ISO RGD PMID:17267327 RGD:2298949 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G CASP9 caspase 9 susceptibility
disease_progression		 ISO DNA:polymorphism, deletion: :1263A>G, 293del (human)
DNA:SNP:exon:p.Q221R (rs1052576) (human)		 RGD PMID:19252927 PMID:19412632 RGD:2315929 RGD:2315930 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007 		JBrowse link
G CAT catalase ISO CTD Direct Evidence: marker/mechanism CTD PMID:35764155 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452 		JBrowse link
G CAV1 caveolin 1 severity ISO protein:increased expression:urinary bladder RGD PMID:12866378 RGD:2289110 NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465 		JBrowse link
G CBX7 chromobox 7 severity ISO mRNA:decreased expression:urinary bladder (human) RGD PMID:18984978 RGD:9587361 NCBI chr 5:9,070,312...9,090,467
Ensembl chr 5:9,070,353...9,087,634 		JBrowse link
G CCND1 cyclin D1 ISO protein:increased expression:bladder
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:12372886 PMID:36115647 RGD:13602096 NCBI chr 2:3,621,242...3,633,380
Ensembl chr 2:3,621,246...3,633,296 		JBrowse link
G CCND3 cyclin D3 disease_progression ISO RGD PMID:16482499 RGD:2316012 NCBI chr 7:37,087,336...37,182,462
Ensembl chr 7:37,082,097...37,181,366 		JBrowse link
G CCNE1 cyclin E1 disease_progression
severity		 ISO protein:decreased expression:urinary bladder
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:16739882 PMID:18047954 PMID:20972438 PMID:27514407 RGD:2289267 RGD:2296035 NCBI chr 6:39,919,541...39,933,224
Ensembl chr 6:39,919,624...39,933,363 		JBrowse link
G CCNG1 cyclin G1 ISO mRNA:decreased expression:bladder (human) RGD PMID:27982046 RGD:151361200 NCBI chr16:60,349,255...60,356,737
Ensembl chr16:60,349,258...60,356,738 		JBrowse link
G CD40LG CD40 ligand treatment ISO RGD PMID:16361570 RGD:7248437 NCBI chr  X:111,778,666...111,788,901
Ensembl chr  X:111,778,493...111,789,709 		JBrowse link
G CD44 CD44 molecule ISO RGD PMID:16321281 RGD:2289357 NCBI chr 2:25,788,699...25,884,209
Ensembl chr 2:25,788,703...25,884,153 		JBrowse link
G CD82 CD82 molecule disease_progression ISO protein:decreased expression:urinary bladder RGD PMID:14706010 PMID:17290345 RGD:2289391 RGD:2289401 NCBI chr 2:17,751,153...17,803,172
Ensembl chr 2:17,750,660...17,803,126 		JBrowse link
G CD9 CD9 molecule disease_progression ISO RGD PMID:14534881 RGD:2326207 NCBI chr 5:64,420,177...64,459,783
Ensembl chr 5:64,420,182...64,460,304 		JBrowse link
G CDC25A cell division cycle 25A ISO RGD PMID:17145867 RGD:2715645
G CDC25B cell division cycle 25B disease_progression ISO RGD PMID:19383904 RGD:2739695 NCBI chr17:31,910,824...31,929,418
Ensembl chr17:31,910,825...31,929,242 		JBrowse link
G CDH1 cadherin 1 disease_progression ISO Protein:increased expression:cytoplasm
CTD Direct Evidence: marker/mechanism
protein:decreased expression:urinary bladder		 RGD
CTD		 PMID:17167984 PMID:17520682 PMID:17760743 PMID:26901067 RGD:1599549 RGD:2289491 NCBI chr 6:18,075,487...18,155,986
Ensembl chr 6:18,075,480...18,155,986 		JBrowse link
G CDH13 cadherin 13 ISO DNA:hypermethylation:promoter RGD PMID:18094410 RGD:2293014 NCBI chr 6:4,809,752...5,832,188
Ensembl chr 6:4,808,255...5,832,415 		JBrowse link
G CDK1 cyclin dependent kinase 1 ISO RGD PMID:17145867 RGD:2715645 NCBI chr14:64,233,945...64,255,290
Ensembl chr14:64,233,987...64,372,197 		JBrowse link
G CDK4 cyclin dependent kinase 4 disease_progression ISO DNA:amplification
protein:increased expression:urinary bladder		 RGD PMID:11971182 PMID:16896691 RGD:2289144 RGD:2299056 NCBI chr 5:23,039,206...23,041,959
Ensembl chr 5:23,038,891...23,042,061 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A ISO ClinVar Annotator: match by term: Malignant tumor of urinary bladder ClinVar NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,359,455...32,363,761 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B susceptibility
disease_progression		 ISO RGD PMID:18027869 PMID:18334837 RGD:2293592 RGD:2293595 NCBI chr 5:59,731,224...59,735,831
Ensembl chr 5:59,731,206...59,735,831 		JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A ISO ClinVar Annotator: match by term: Bladder cancer | ClinVar Annotator: match by term: Malignant tumor of urinary bladder ClinVar PMID:7777061 PMID:7987387 PMID:8668202 PMID:8755727 PMID:8834170 More... NCBI chr 1:200,774,496...200,799,149
Ensembl chr 1:200,792,469...200,798,854 		JBrowse link
G CDKN2B cyclin dependent kinase inhibitor 2B disease_progression ISO DNA:deletion:urinary bladder RGD PMID:15590562 PMID:16624482 RGD:2289696 RGD:7248757 NCBI chr 1:200,666,250...200,770,880
Ensembl chr 1:200,761,004...200,766,056 		JBrowse link
G CHD6 chromodomain helicase DNA binding protein 6 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21822268 NCBI chr17:44,048,056...44,265,472
Ensembl chr17:44,048,098...44,265,431 		JBrowse link
G CHEK2 checkpoint kinase 2 treatment
susceptibility		 ISO DNA:mutations: :multiple RGD PMID:17918154 PMID:21396995 RGD:10401655 RGD:2289704 NCBI chr14:45,699,833...45,967,350
Ensembl chr14:45,929,715...45,967,290 		JBrowse link
G CLPTM1L CLPTM1 like ISO CTD Direct Evidence: marker/mechanism CTD PMID:19151717 NCBI chr16:79,237,000...79,248,503
Ensembl chr16:79,237,061...79,248,500 		JBrowse link
G COL6A3 collagen type VI alpha 3 chain ISO mRNA, protein:increased expression:bladder (human) RGD PMID:30066698 RGD:401900123 NCBI chr15:137,011,549...137,103,687
Ensembl chr15:137,011,433...137,103,709 		JBrowse link
G COMT catechol-O-methyltransferase ISO protein:increased expression:urinary bladder, urine RGD PMID:15596044 RGD:2289726 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,738...51,403,998 		JBrowse link
G CREBBP CREB binding protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:21822268 NCBI chr 3:38,388,366...38,530,243
Ensembl chr 3:38,388,547...38,530,224 		JBrowse link
G CSF3 colony stimulating factor 3 ISO CTD Direct Evidence: therapeutic CTD PMID:7525883 PMID:17515069 NCBI chr12:22,333,445...22,335,949
Ensembl chr12:22,333,449...22,338,753 		JBrowse link
G CTNNA1 catenin alpha 1 disease_progression ISO RGD PMID:17760743 RGD:2289491 NCBI chr 2:140,682,776...140,869,828
Ensembl chr 2:140,682,371...140,871,334 		JBrowse link
G CTNNA3 catenin alpha 3 ISO ClinVar Annotator: match by term: Malignant tumor of urinary bladder ClinVar NCBI chr14:69,195,231...70,974,543
Ensembl chr14:69,195,961...70,938,204 		JBrowse link
G CTNNB1 catenin beta 1 disease_progression ISO ClinVar Annotator: match by term: Bladder cancer | ClinVar Annotator: match by term: Malignant tumor of urinary bladder RGD
ClinVar		 PMID:10192393 PMID:10666372 PMID:17175927 PMID:25157968 PMID:26619011 More... RGD:2289829 NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,164,277...25,208,311 		JBrowse link
G CTSB cathepsin B ISO protein:increased activity:transitional cell carcinoma (human) RGD PMID:15183956 RGD:2315615 NCBI chr14:15,014,139...15,035,081
Ensembl chr14:15,011,711...15,033,877 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22015448 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 ISO DNA:SNP RGD PMID:19252927 RGD:2315930 NCBI chr15:120,219,657...120,230,203 JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35764155 NCBI chr14:113,805,616...113,820,445
Ensembl chr14:113,805,611...113,812,041 		JBrowse link
G CYP19A2 cytochrome P450 19A2 ISO RGD PMID:17406000 RGD:7257712 NCBI chr 1:120,652,172...120,695,899
Ensembl chr 1:120,367,667...120,695,899 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 no_association ISO DNA:polymorphism: :2455A>G (human)
DNA:polymorphisms: :3801T>C (human)		 RGD PMID:18200441 PMID:18979064 PMID:21990318 RGD:7257730 RGD:7257733 RGD:7257736 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775 		JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 ISO RGD PMID:21990318 RGD:7257730 NCBI chr 3:102,195,743...102,205,687
Ensembl chr 3:102,195,741...102,205,683 		JBrowse link
G CYP4B1 cytochrome P450 family 4 subfamily B member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:18713828 NCBI chr 6:164,718,393...164,737,693
Ensembl chr 6:164,718,444...164,737,552 		JBrowse link
G DAPK1 death associated protein kinase 1 ISO DNA:hypermethylation RGD PMID:12124340 RGD:734875 NCBI chr10:27,724,644...27,954,708
Ensembl chr10:27,724,648...27,954,350 		JBrowse link
G DNMT1 DNA methyltransferase 1 ISO protein:increased expression RGD PMID:14634451 RGD:2301220 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844 		JBrowse link
G DUSP1 dual specificity phosphatase 1 disease_progression ISO RGD PMID:17690186 RGD:2298694 NCBI chr16:51,457,924...51,461,095
Ensembl chr16:51,458,020...51,461,086 		JBrowse link
G E2F1 E2F transcription factor 1 disease_progression ISO mRNA:increased expression:bladder RGD PMID:20421545 RGD:13602004 NCBI chr17:37,178,587...37,190,118
Ensembl chr17:37,178,599...37,189,883 		JBrowse link
G EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 disease_progression ISO protein:decreased expression:urothelium: RGD PMID:24917520 RGD:10401219 NCBI chr 7:5,368,341...5,390,665
Ensembl chr 7:5,370,967...5,390,633 		JBrowse link
G EGFR epidermal growth factor receptor disease_progression ISO protein:increased expression:urinary bladder
ClinVar Annotator: match by term: Malignant tumor of urinary bladder		 RGD
ClinVar		 PMID:16685269 PMID:18006009 PMID:28492532 RGD:2289943 RGD:2298502 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589 		JBrowse link
G ENO2 enolase 2 ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:17951193 PMID:22613180 RGD:2293738 NCBI chr 5:63,799,927...63,809,067
Ensembl chr 5:63,799,930...63,809,410 		JBrowse link
G EOMES eomesodermin ISO CTD Direct Evidence: marker/mechanism CTD PMID:26039340 NCBI chr13:14,209,590...14,216,184
Ensembl chr13:14,209,736...14,215,797 		JBrowse link
G EP300 E1A binding protein p300 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21822268 NCBI chr 5:7,311,165...7,394,515
Ensembl chr 5:7,311,171...7,393,760 		JBrowse link
G EPHX1 epoxide hydrolase 1 disease_progression ISO DNA:SNPs RGD PMID:19252927 RGD:2315930 NCBI chr10:13,757,489...13,773,071
Ensembl chr10:13,751,881...13,773,072 		JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 disease_progression ISO ClinVar Annotator: match by term: Malignant tumor of urinary bladder RGD
ClinVar		 PMID:16685269 PMID:22908275 RGD:2298502 NCBI chr12:22,591,621...22,621,384
Ensembl chr12:22,590,725...22,621,351 		JBrowse link
G ERBB3 erb-b2 receptor tyrosine kinase 3 disease_progression ISO ClinVar Annotator: match by term: Bladder cancer | ClinVar Annotator: match by term: Malignant tumor of urinary bladder RGD
ClinVar		 PMID:16685269 PMID:26619011 RGD:2298502 NCBI chr 5:21,474,218...21,495,040
Ensembl chr 5:21,474,475...21,495,038 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 disease_progression ISO protein:decreased expression:urinary bladder RGD PMID:16685269 PMID:18006009 RGD:2289943 RGD:2298502 NCBI chr15:113,966,573...115,096,984
Ensembl chr15:113,974,437...115,096,565 		JBrowse link
G ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit disease_progression ISO ClinVar Annotator: match by term: Malignant tumor of urinary bladder RGD
ClinVar		 PMID:9238033 PMID:11335038 PMID:19085937 PMID:19934020 PMID:25316812 More... RGD:11252208 NCBI chr 6:51,734,318...51,757,508
Ensembl chr 6:51,734,320...51,757,553 		JBrowse link
G ERCC4 ERCC excision repair 4, endonuclease catalytic subunit ISO CTD Direct Evidence: marker/mechanism CTD PMID:20062074 NCBI chr 3:29,266,234...29,306,109
Ensembl chr 3:29,269,989...29,306,151 		JBrowse link
G ESPL1 extra spindle pole bodies like 1, separase ISO CTD Direct Evidence: marker/mechanism CTD PMID:24121792 NCBI chr 5:18,486,969...18,509,913
Ensembl chr 5:18,487,052...18,509,913 		JBrowse link
G ESR1 estrogen receptor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16712894 PMID:35764155 NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363 		JBrowse link
G ESR2 estrogen receptor 2 severity ISO protein:increased expression:urinary bladder urothelium (human)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:16700038 PMID:23612777 RGD:7364758 NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,829,560...193,906,565 		JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit ISO mRNA:increased expression:urinary bladder RGD PMID:21539681 RGD:126781700 NCBI chr 9:109,384,976...109,450,943
Ensembl chr 9:109,385,015...109,450,941 		JBrowse link
G F2 coagulation factor II, thrombin severity ISO protein:increased expression:urine RGD PMID:22236518 RGD:6893573 NCBI chr 2:15,793,257...15,819,151
Ensembl chr 2:15,791,455...15,819,137 		JBrowse link
G FANCA FA complementation group A ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19237606 PMID:24121791 RGD:11344902 NCBI chr 6:253,207...300,159
Ensembl chr 6:253,207...300,152 		JBrowse link
G FAS Fas cell surface death receptor susceptibility ISO CTD Direct Evidence: marker/mechanism
DNA:polymorphisms:promoter:-1377G>A,-670A>G		 CTD
RGD		 PMID:9070496 PMID:16538171 RGD:2290063 NCBI chr14:100,927,305...100,954,781
Ensembl chr14:100,927,089...100,956,716 		JBrowse link
G FASLG Fas ligand susceptibility ISO DNA:polymorphisms:promoter:-844T>C RGD PMID:16538171 RGD:2290063 NCBI chr 9:115,068,314...115,075,147
Ensembl chr 9:115,068,090...115,076,464 		JBrowse link
G FBXW8 F-box and WD repeat domain containing 8 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26039340 NCBI chr14:35,445,020...35,613,725
Ensembl chr14:35,444,281...35,575,705 		JBrowse link
G FERMT2 FERM domain containing kindlin 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21624607 NCBI chr 1:182,519,681...182,606,890
Ensembl chr 1:182,519,684...182,606,869 		JBrowse link
G FGF1 fibroblast growth factor 1 ISO RGD PMID:11908679 RGD:2290291 NCBI chr 2:144,133,846...144,241,345
Ensembl chr 2:144,133,392...144,241,323 		JBrowse link
G FGF2 fibroblast growth factor 2 ISO RGD PMID:11908679 RGD:2290291 NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,885...101,343,916 		JBrowse link
G FGFR2 fibroblast growth factor receptor 2 ISO DNA:hypermethylation, loss of heterozygosity, deletions:exon (human)
associated with Acrocephalosyndactylia/Apert Syndrome (MeSH:D000168); DNA:transversion:cds:758C>G amino acid P253R		 RGD PMID:10602477 PMID:16969861 RGD:2289664 RGD:2301193 NCBI chr14:131,183,095...131,285,001
Ensembl chr14:131,181,713...131,289,425 		JBrowse link
G FGFR3 fibroblast growth factor receptor 3 disease_progression
severity		 ISO ClinVar Annotator: match by term: Bladder cancer | ClinVar Annotator: match by term: Malignant tumor of urinary bladder | ClinVar Annotator: match by term: Urinary bladder cancer
protein:increased expression:urinary bladder
DNA:mutations		 OMIM
ClinVar
RGD		 PMID:1908846 PMID:7647778 PMID:7649548 PMID:7670477 PMID:7702086 More... RGD:2301223 RGD:2301224 RGD:2301225 NCBI chr 8:879,151...894,968
Ensembl chr 8:879,159...894,964 		JBrowse link
G FHIT fragile histidine triad diadenosine triphosphatase ISO protein:decreased expression:urinary bladder
associated with Schistosomiasis;DNA:hypermethylation:urinary bladder
DNA:hypermethylation:promoter:hypermethylation found in 16/98 (16%) of tumors, associated with poor survival		 RGD PMID:11751381 PMID:15154012 PMID:15591090 RGD:2289897 RGD:2301232 RGD:2301233 NCBI chr13:41,443,963...42,884,799
Ensembl chr13:41,443,965...42,392,817 		JBrowse link
G FN1 fibronectin 1 ISO protein:increased expression:urine RGD PMID:20012564 RGD:7205680 NCBI chr15:117,658,158...117,737,145
Ensembl chr15:117,658,099...117,731,014 		JBrowse link
G GGH gamma-glutamyl hydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:19815704 NCBI chr 4:70,996,730...71,020,513
Ensembl chr 4:70,996,755...71,021,838 		JBrowse link
G GLI1 GLI family zinc finger 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20179202 NCBI chr 5:22,736,325...22,747,421
Ensembl chr 5:22,739,900...22,747,421 		JBrowse link
G GPX1 glutathione peroxidase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15247771 PMID:35764155 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:36115647 NCBI chr13:140,136,109...140,370,197
Ensembl chr13:140,136,158...140,369,569 		JBrowse link
G GSTO2 glutathione S-transferase omega 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22306368 NCBI chr14:115,218,179...115,242,377
Ensembl chr14:115,217,879...115,251,435 		JBrowse link
G GSTZ1 glutathione S-transferase zeta 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22306368 NCBI chr 7:100,392,217...100,404,025
Ensembl chr 7:100,392,271...100,408,420 		JBrowse link
G HDAC4 histone deacetylase 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21507255 NCBI chr15:138,378,237...138,657,266
Ensembl chr15:138,381,635...138,614,301 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:36115647 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845 		JBrowse link
G HK1 hexokinase 1 treatment ISO RGD PMID:23893687 RGD:11353960 NCBI chr14:72,383,328...72,460,927
Ensembl chr14:72,351,246...72,460,924 		JBrowse link
G HMBS hydroxymethylbilane synthase ISO urinary bladder transitional cell carcinoma; mRNA:decreased expression:tumor:in matched malignant and non-malignant sample pairs (p = 0.008) RGD PMID:16600798 RGD:2301681 NCBI chr 9:46,300,039...46,308,681
Ensembl chr 9:46,300,050...46,308,868 		JBrowse link
G HMGB3 high mobility group box 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30639441 NCBI chr  X:122,591,413...122,599,496
Ensembl chr  X:122,592,936...122,599,493 		JBrowse link
G HMGN5 high mobility group nucleosome binding domain 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:22109888 NCBI chr  X:64,541,310...64,617,345 JBrowse link
G HOXA9 homeobox A9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26332997 NCBI chr18:45,404,594...45,411,512
Ensembl chr18:45,408,375...45,411,509 		JBrowse link
G HRAS HRas proto-oncogene, GTPase disease_progression ISO ClinVar Annotator: match by term: Bladder cancer | ClinVar Annotator: match by term: Urinary bladder cancer OMIM
ClinVar
RGD		 PMID:2999610 PMID:3537694 PMID:6092966 PMID:6330729 PMID:7177195 More... RGD:2314833 NCBI chr 2:299,662...302,539
Ensembl chr 2:299,660...302,501 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO protein:increased expression:serum: RGD PMID:7686390 RGD:11520780 NCBI chr 2:69,097,136...69,107,722
Ensembl chr 2:69,097,122...69,108,205 		JBrowse link
G IFNB1 interferon beta 1 ISO CTD Direct Evidence: therapeutic CTD PMID:2297754 NCBI chr 1:201,850,935...201,851,495
Ensembl chr 1:201,850,935...201,851,495 		JBrowse link
G IFNG interferon gamma treatment ISO protein:decreased expression:serum RGD PMID:11219496 PMID:22906662 RGD:6893349 RGD:8157619 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670 		JBrowse link
G IGF1 insulin like growth factor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19415693 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,033 		JBrowse link
G IGFBP3 insulin like growth factor binding protein 3 ISO protein:decreased expression:plasma:level significantly lower in cases than controls (p<0.01), highest quartile levels associated with reduced risk (OR=0.38)
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:12544349 PMID:21347663 RGD:2290028 NCBI chr18:50,002,921...50,009,425
Ensembl chr18:50,003,022...50,010,690 		JBrowse link
G IGFBP5 insulin like growth factor binding protein 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26039340 NCBI chr15:118,861,816...118,877,787
Ensembl chr15:118,857,625...118,878,120 		JBrowse link
G IGSF21 immunoglobin superfamily member 21 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26039340 NCBI chr 6:76,688,238...76,947,296
Ensembl chr 6:76,688,278...76,947,293 		JBrowse link
G IL1RN interleukin 1 receptor antagonist susceptibility ISO DNA:repeats:intron:IVS2+914_1000dup IL1RN*2 (human)
DNA:repeats:intron:IVS2+914_1000dup multiple (human)		 RGD PMID:16698387 PMID:19489682 RGD:6907081 RGD:6907367
G IL2 interleukin 2 treatment ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:1949363 PMID:3262172 PMID:3495671 RGD:8663471 NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609 		JBrowse link
G INPP4B inositol polyphosphate-4-phosphatase type II B ISO CTD Direct Evidence: marker/mechanism CTD PMID:29415082 NCBI chr 8:84,812,041...85,555,200
Ensembl chr 8:85,084,133...85,514,516 		JBrowse link
G ISL1 ISL LIM homeobox 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26332997 NCBI chr16:30,962,994...30,974,201
Ensembl chr16:30,963,000...30,973,907 		JBrowse link
G JAK2 Janus kinase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:36115647 NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,689...217,002,148 		JBrowse link
G JUP junction plakoglobin disease_progression
severity		 ISO DNA, protein:mutations, increased expression:urinary bladder
protein:decreased expression:tumor:significant association with tumor grade and stage (p < 0.001)
protein:altered localization:tumor:loss of membrane expression associated with higher grade (p<0.05), higher stage (p<0.05), and poor survival (p<0.05)		 RGD PMID:9783980 PMID:11585741 PMID:17363521 RGD:2289818 RGD:2291880 RGD:2301748 NCBI chr12:20,902,395...20,931,208
Ensembl chr12:20,901,396...20,931,210 		JBrowse link
G KCNJ12 potassium inwardly rectifying channel subfamily J member 12 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34755307 NCBI chr12:61,424,459...61,511,373
Ensembl chr12:61,506,577...61,507,870 		JBrowse link
G KDM4A lysine demethylase 4A ISO mRNA:increased expression:urinary bladder (human) RGD PMID:23603248 RGD:9587435 NCBI chr 6:167,597,954...167,642,381
Ensembl chr 6:167,597,956...167,642,333 		JBrowse link
G KDM4B lysine demethylase 4B ISO mRNA, protein:increased expression:urinary bladder (human) RGD PMID:21930796 RGD:9587740 NCBI chr 2:73,746,379...73,889,881
Ensembl chr 2:73,747,669...73,889,866 		JBrowse link
G KDM5B lysine demethylase 5B ISO mRNA:increased expression:urinary bladder (human) RGD PMID:20226085 RGD:9587778 NCBI chr10:24,739,115...24,831,537
Ensembl chr10:24,736,838...24,831,447 		JBrowse link
G KDM6A lysine demethylase 6A ISO ClinVar Annotator: match by term: Malignant tumor of urinary bladder ClinVar PMID:23076834 PMID:23913813 PMID:25741868 PMID:27777708 PMID:28492532 NCBI chr  X:39,953,764...40,154,197
Ensembl chr  X:39,953,814...40,154,029 		JBrowse link
G KDR kinase insert domain receptor severity ISO protein::tumor:expression in >50% of non-endothelial cells associated with increased survival (p=0.0119) RGD PMID:12215294 PMID:12940780 RGD:2291949 RGD:2301758 NCBI chr 8:41,809,116...41,856,379
Ensembl chr 8:41,809,122...41,856,336 		JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase ISO urinary bladder small cell carcinoma; protein:increased expression:tumor:14/52 (27%) positive (>10% staining) RGD PMID:15502806 RGD:2292430 NCBI chr 8:41,402,334...41,492,306
Ensembl chr 8:41,402,043...41,493,734 		JBrowse link
G KLF5 KLF transcription factor 5 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27514407 NCBI chr11:45,370,009...45,386,673
Ensembl chr11:45,369,810...45,388,314 		JBrowse link
G KMT2A lysine methyltransferase 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:21822268 NCBI chr 9:45,743,566...45,828,559
Ensembl chr 9:45,743,397...45,824,884 		JBrowse link
G KMT2C lysine methyltransferase 2C ISO CTD Direct Evidence: marker/mechanism CTD PMID:21822268 NCBI chr18:4,993,213...5,279,668
Ensembl chr18:4,993,227...5,278,723 		JBrowse link
G KMT2D lysine methyltransferase 2D ISO CTD Direct Evidence: marker/mechanism CTD PMID:24121791 NCBI chr 5:15,049,827...15,091,622 JBrowse link
G KRAS KRAS proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Bladder cancer | ClinVar Annotator: match by term: Bladder cancer, transitional cell, somatic | ClinVar Annotator: match by term: Urinary bladder cancer OMIM
ClinVar		 PMID:1553789 PMID:6695174 PMID:12110640 PMID:12460918 PMID:14982869 More... NCBI chr 5:48,508,774...48,546,260
Ensembl chr 5:48,508,811...48,549,358 		JBrowse link
G KRT5 keratin 5 ISO RGD PMID:7507402 RGD:1600196 NCBI chr 5:17,862,047...17,868,397
Ensembl chr 5:17,862,051...17,868,402 		JBrowse link
G LAMA2 laminin subunit alpha 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26039340 NCBI chr 1:33,765,412...34,359,741
Ensembl chr 1:33,866,850...34,359,698 		JBrowse link
G LIG1 DNA ligase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:8631603 NCBI chr 6:53,620,483...53,660,020
Ensembl chr 6:53,620,483...53,686,562 		JBrowse link
G LOC100157433 calcium homeostasis modulator protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26039340 NCBI chr14:114,380,467...114,393,845
Ensembl chr14:114,380,479...114,385,694
Ensembl chr14:114,380,479...114,385,694 		JBrowse link
G LOC100511905 arylamine N-acetyltransferase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16003747 NCBI chr17:13,383,478...13,393,287 JBrowse link
G LOC100623255 UDP-glucuronosyltransferase 2B31 ISO CTD Direct Evidence: marker/mechanism CTD PMID:15615884 NCBI chr 8:65,915,718...65,936,113 JBrowse link
G LOC100737977 tumor necrosis factor receptor superfamily member 10B-like ISO DNA:missense mutation:cds:p.E228A (c.683A>C) (human) RGD PMID:16217763 RGD:11038717 NCBI chr14:7,344,788...7,371,086 JBrowse link
G LOC100739163 glutathione S-transferase P-like ISO mRNA:increased expression:urinary bladder RGD PMID:21213404 RGD:10401939 NCBI chr 2:4,978,761...4,982,233 JBrowse link
G LOC100739508 glutathione S-transferase P-like ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:7729958 PMID:9111193 PMID:12500666 PMID:18544563 PMID:22306368 RGD:6906879 RGD:6906883 NCBI chr 2:5,005,498...5,009,247 JBrowse link
G LOC110258578 interleukin-1 beta-like disease_progression ISO mRNA:increased expression:urinary bladder tumor (human) RGD PMID:21308147 RGD:7175327
G LOC110260593 olfactory receptor 8S1-like ISO CTD Direct Evidence: marker/mechanism CTD PMID:26039340 NCBI chr 5:78,983,912...78,985,955
Ensembl chr 5:78,984,960...78,985,892 		JBrowse link
G LOXL1 lysyl oxidase like 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17456585 NCBI chr 7:59,481,410...59,505,161
Ensembl chr 7:59,481,412...59,505,149 		JBrowse link
G LOXL4 lysyl oxidase like 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:17456585 NCBI chr14:109,571,942...109,593,408
Ensembl chr14:109,571,947...109,589,160 		JBrowse link
G LRRC56 leucine rich repeat containing 56 ISO ClinVar Annotator: match by term: Bladder cancer | ClinVar Annotator: match by term: Malignant tumor of urinary bladder | ClinVar Annotator: match by term: Urinary bladder cancer ClinVar PMID:2999610 PMID:3537694 PMID:6092966 PMID:6330729 PMID:7177195 More... NCBI chr 2:303,836...323,701
Ensembl chr 2:304,430...323,699 		JBrowse link
G MAP2K4 mitogen-activated protein kinase kinase 4 ISO RGD PMID:15665277 RGD:2306057 NCBI chr12:56,402,029...56,516,217
Ensembl chr12:56,402,075...56,516,238 		JBrowse link
G MAP2K7 mitogen-activated protein kinase kinase 7 ISO mRNA:splice variant:exon 2: (human) RGD PMID:32601196 RGD:155230826 NCBI chr 2:71,299,010...71,308,432
Ensembl chr 2:71,298,325...71,308,124 		JBrowse link
G MAPK15 mitogen-activated protein kinase 15 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26039340 NCBI chr 4:909,266...915,537
Ensembl chr 4:909,268...915,475 		JBrowse link
G MDM2 MDM2 proto-oncogene severity ISO mRNA:increased expression:bladder RGD PMID:27798881 RGD:13602098 NCBI chr 5:33,105,717...33,137,602
Ensembl chr 5:33,105,759...33,137,739 		JBrowse link
G MGMT O-6-methylguanine-DNA methyltransferase susceptibility ISO DNA:polymorphisms:cds:p.L53L, p.L84F (human) RGD PMID:15885889 RGD:2317672 NCBI chr14:138,502,005...138,771,543
Ensembl chr14:138,499,309...138,771,540 		JBrowse link
G MIR100 microRNA mir-100 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30026881 NCBI chr 9:49,157,909...49,157,988
Ensembl chr 9:49,157,909...49,157,988 		JBrowse link
G MIR132 microRNA mir-132 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34755307 NCBI chr12:48,162,625...48,162,702
Ensembl chr12:48,162,614...48,162,714 		JBrowse link
G MIR145 microRNA mir-145 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30026881 NCBI chr 2:150,580,126...150,580,211
Ensembl chr 2:150,580,126...150,580,211 		JBrowse link
G MIR152 microRNA mir-152 severity ISO miRNA:decreased expression:urinary bladder RGD PMID:30015946 RGD:19165141 NCBI chr12:24,292,249...24,292,328
Ensembl chr12:24,292,251...24,292,336 		JBrowse link
G MIR186 microRNA mir-186 ISO CTD Direct Evidence: marker/mechanism CTD PMID:34291859 NCBI chr 6:141,943,328...141,943,409
Ensembl chr 6:141,943,328...141,943,409 		JBrowse link
G MIR221 microRNA mir-221 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35764155 NCBI chr  X:40,571,068...40,571,137
Ensembl chr  X:40,571,068...40,571,137 		JBrowse link
G MIR27A microRNA mir-27a ISO CTD Direct Evidence: marker/mechanism CTD PMID:35764155 NCBI chr 2:65,308,294...65,308,375
Ensembl chr 2:65,308,294...65,308,375 		JBrowse link
G MIR29C microRNA mir-29c ISO CTD Direct Evidence: marker/mechanism CTD PMID:30026881 NCBI chr 9:135,019,638...135,019,725
Ensembl chr 9:135,019,638...135,019,725 		JBrowse link
G MIR532 microRNA mir-532 ISO CTD Direct Evidence: marker/mechanism CTD PMID:30639441 NCBI chr  X:43,705,258...43,705,337
Ensembl chr  X:43,705,258...43,705,337 		JBrowse link
G MIR99A microRNA mir-99a ISO CTD Direct Evidence: marker/mechanism CTD PMID:30026881 NCBI chr13:181,302,483...181,302,562
Ensembl chr13:181,302,478...181,302,567 		JBrowse link
G MKI67 marker of proliferation Ki-67 ISO protein:increased expression:urinary bladder RGD PMID:20367636 RGD:2317708 NCBI chr14:137,266,622...137,296,312 JBrowse link
G MLH1 mutL homolog 1 disease_progression ISO RGD PMID:15296997 RGD:2293518 NCBI chr13:21,791,276...21,877,789
Ensembl chr13:21,791,203...21,877,757 		JBrowse link
G MMP1 matrix metallopeptidase 1 severity ISO DNA:insertion:promoter:g.-1607insG (human)
protein:increased expression:urine (human)		 RGD PMID:11705862 PMID:17986285 RGD:7207077 RGD:7207140 NCBI chr 9:33,411,738...33,420,205
Ensembl chr 9:33,411,065...33,420,076 		JBrowse link
G MMP13 matrix metallopeptidase 13 ISO urinary bladder transitional-cell carcinomas; mRNA:increased expression:tumor:13/23 (52%) tumors vs no expression in normal urothelium, expression at the invading edge of tumors RGD PMID:11054671 RGD:2293609 NCBI chr 9:33,549,003...33,616,700
Ensembl chr 9:33,549,008...33,561,162 		JBrowse link
G MMP2 matrix metallopeptidase 2 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17466450 PMID:30548095 RGD:2290395 NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,595...30,086,982 		JBrowse link
G MMP9 matrix metallopeptidase 9 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:17466450 PMID:30548095 RGD:2290395 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788 		JBrowse link
G MPO myeloperoxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:14729580 NCBI chr12:34,557,031...34,570,091
Ensembl chr12:34,556,408...34,567,904 		JBrowse link
G MRE11 MRE11 homolog, double strand break repair nuclease susceptibility ISO DNA:snp:3' utr:c.2501A>G rs2155209 (human)
ClinVar Annotator: match by term: Malignant tumor of urinary bladder		 RGD
ClinVar		 PMID:18638378 PMID:28492532 RGD:2317733 NCBI chr 9:26,572,352...26,634,596
Ensembl chr 9:26,572,361...26,634,567 		JBrowse link
G MSH2 mutS homolog 2 disease_progression ISO DNA:mutation
DNA:mutations: :multiple
associated with Lynch syndrome
protein:decreased expression:urinary bladder		 RGD PMID:18254781 PMID:18389386 PMID:22883484 PMID:26385421 RGD:126790557 RGD:126790580 RGD:2293502 RGD:2293503 NCBI chr 3:93,082,958...93,163,556
Ensembl chr 3:93,081,219...93,163,585 		JBrowse link
G MSH6 mutS homolog 6 disease_progression ISO protein:decreased expression:urinary bladder RGD PMID:18254781 RGD:2293503 NCBI chr 3:92,792,590...92,814,154
Ensembl chr 3:92,785,664...92,814,238 		JBrowse link
G MT-2B metallothionein-2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:7729958 PMID:16565513 NCBI chr 6:18,645,125...18,646,034
Ensembl chr 6:18,645,153...18,646,033 		JBrowse link
G MT-ATP8 mitochondrially encoded ATP synthase membrane subunit 8 ISO DNA:deletion: :(human) RGD PMID:15254717 RGD:2302294 NCBI chr MT:8,959...9,162
Ensembl chr MT:8,959...9,162 		JBrowse link
G MT-CYB mitochondrially encoded cytochrome b ISO DNA:deletion:cds RGD PMID:18245469 RGD:2298953 NCBI chr MT:15,342...16,481
Ensembl chr MT:15,342...16,481 		JBrowse link
G MT1A metallothionein 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:16565513 NCBI chr 6:18,672,016...18,673,673
Ensembl chr 6:18,672,001...18,673,672 		JBrowse link
G MT3 metallothionein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16854967 NCBI chr 6:18,634,735...18,636,134
Ensembl chr 6:18,634,261...18,636,131 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase no_association
susceptibility		 ISO protein:missense mutation:cds:p.A222V (human)
CTD Direct Evidence: marker/mechanism
DNA:transition:cds:g.677C>T (human)
DNA:transition, transversion, haplotype:cds:g.677C>T, g.1298A>C (human)
DNA:transversion:cds:g.1298A>C (human)		 RGD
CTD		 PMID:17311259 PMID:19837268 PMID:20146887 PMID:22126575 PMID:22747749 RGD:6893457 RGD:6893516 RGD:6893521 RGD:6893597 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820 		JBrowse link
G MTOR mechanistic target of rapamycin kinase treatment ISO CTD Direct Evidence: marker/mechanism RGD
CTD		 PMID:19261747 PMID:36115647 RGD:10040979 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase susceptibility ISO DNA:polymorphism: :2756A>G(human) RGD PMID:19837268 RGD:6893521 NCBI chr14:54,546,978...54,652,780
Ensembl chr14:54,546,978...54,652,763 		JBrowse link
G MUC1 mucin 1, cell surface associated ISO protein:increased expression:serum: RGD PMID:10468735 RGD:7245967 NCBI chr 4:94,626,317...94,631,194 JBrowse link
G MUC5B mucin 5B, oligomeric mucus/gel-forming ISO DNA:repeats RGD PMID:19191526 RGD:7349339 NCBI chr 2:807,685...842,096 JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor susceptibility
disease_progression		 ISO DNA:snp, haplotype:enhancer:g.-30772G>T rs9642880 (human)
CTD Direct Evidence: marker/mechanism
protein:decreased expression:urinary bladder urothelium (human)		 RGD
CTD		 PMID:2228319 PMID:20939013 PMID:22028816 PMID:23284801 RGD:7207401 RGD:7207418 RGD:7207427 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078 		JBrowse link
G NCAN neurocan ISO CTD Direct Evidence: marker/mechanism CTD PMID:26039340 NCBI chr 2:58,638,808...58,669,757
Ensembl chr 2:58,638,808...58,674,130 		JBrowse link
G NCOR1 nuclear receptor corepressor 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21822268 NCBI chr12:59,256,868...59,392,564
Ensembl chr12:59,273,100...59,392,562 		JBrowse link
G NCSTN nicastrin ISO OMIM:109800 MouseDO NCBI chr 4:90,121,209...90,142,934
Ensembl chr 4:90,119,002...90,142,890 		JBrowse link
G ND2 NADH dehydrogenase subunit 2 ISO DNA:deletion: :(human) RGD PMID:15254717 RGD:2302294 NCBI chr MT:5,087...6,128
Ensembl chr MT:5,087...6,128 		JBrowse link
G NECTIN2 nectin cell adhesion molecule 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29321541 NCBI chr 6:51,317,386...51,358,665 JBrowse link
G NF1 neurofibromin 1 ISO ClinVar Annotator: match by term: Bladder cancer | ClinVar Annotator: match by term: Malignant tumor of urinary bladder ClinVar PMID:8069310 PMID:10090487 PMID:10712197 PMID:10862084 PMID:10980545 More... NCBI chr12:43,487,098...43,754,205
Ensembl chr12:43,489,813...43,753,969 		JBrowse link
G NME1 NME/NM23 nucleoside diphosphate kinase 1 ISO mRNA:increased expression:urinary bladder RGD PMID:7614395 RGD:2299071 NCBI chr12:27,416,308...27,435,044
Ensembl chr12:27,416,346...27,436,140 		JBrowse link
G NME2 NME/NM23 nucleoside diphosphate kinase 2 ISO mRNA:increased expression:urinary bladder RGD PMID:7614395 RGD:2299071 NCBI chr12:27,439,529...27,445,025
Ensembl chr12:27,439,260...27,445,027 		JBrowse link
G NOS3 nitric oxide synthase 3 ISO protein:increased expression:urinary bladder RGD PMID:10475345 RGD:2292089 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:8631603 PMID:21213404 RGD:10401939 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590 		JBrowse link
G NRSN1 neurensin 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26039340 NCBI chr 7:19,007,781...19,027,226
Ensembl chr 7:19,007,781...19,027,226 		JBrowse link
G PABPC1 poly(A) binding protein cytoplasmic 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25783786 NCBI chr 4:36,137,644...36,228,075
Ensembl chr 4:36,209,164...36,228,073 		JBrowse link
G PHB1 prohibitin 1 ISO mRNA:increased expression:urinary bladder RGD PMID:8062216 RGD:2292407 NCBI chr12:25,596,520...25,609,693
Ensembl chr12:25,596,523...25,609,706 		JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha ISO ClinVar Annotator: match by term: Malignant tumor of urinary bladder ClinVar NCBI chr13:117,193,935...117,282,151
Ensembl chr13:117,180,544...117,274,587 		JBrowse link
G PIP5K1A phosphatidylinositol-4-phosphate 5-kinase type 1 alpha ISO CTD Direct Evidence: marker/mechanism CTD PMID:34755307 NCBI chr 4:98,012,941...98,062,166
Ensembl chr 4:98,012,945...98,056,815 		JBrowse link
G PLAU plasminogen activator, urokinase treatment ISO protein:increased expression:urinary bladder (human)
DNA:snp:3' utr:g.4065C>T (human)		 RGD PMID:16825821 PMID:18336603 PMID:19010488 RGD:4144867 RGD:7241144 RGD:7241213 NCBI chr14:76,629,313...76,635,173
Ensembl chr14:76,629,299...76,635,172 		JBrowse link
G PLK1 polo like kinase 1 severity ISO RGD PMID:15761500 PMID:16837776 RGD:2299938 RGD:2299940 NCBI chr 3:22,537,814...22,550,901
Ensembl chr 3:22,537,831...22,552,380 		JBrowse link
G PMS2 PMS1 homolog 2, mismatch repair system component susceptibility ISO DNA:SNP: :rs6463524 (human) RGD PMID:19692168 RGD:2315025 NCBI chr 3:5,118,002...5,145,634
Ensembl chr 3:5,118,018...5,145,628 		JBrowse link
G POLB DNA polymerase beta ISO CTD Direct Evidence: marker/mechanism CTD PMID:8631603 NCBI chr17:11,356,130...11,388,122
Ensembl chr17:11,356,129...11,388,821 		JBrowse link
G PON1 paraoxonase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35764155 NCBI chr 9:74,943,646...74,974,720
Ensembl chr 9:74,926,048...74,974,723 		JBrowse link
G POR cytochrome p450 oxidoreductase ISO CTD Direct Evidence: marker/mechanism CTD PMID:8631603 NCBI chr 3:10,212,734...10,272,184
Ensembl chr 3:10,212,735...10,281,823 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma ISO protein:decreased expression:urinary bladder RGD PMID:18712722 RGD:2301870 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944 		JBrowse link
G PPP3CC protein phosphatase 3 catalytic subunit gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:29275364 NCBI chr14:6,711,789...6,799,318
Ensembl chr14:6,711,442...6,794,667 		JBrowse link
G PRDM2 PR/SET domain 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26039340 NCBI chr 6:73,135,872...73,240,271
Ensembl chr 6:73,118,177...73,239,423 		JBrowse link
G PRKCA protein kinase C alpha disease_progression
severity		 ISO protein:altered localization:urinary bladder
protein:increased expression:urinary bladder		 RGD PMID:15922420 PMID:16008942 RGD:2292455 RGD:2298669 NCBI chr12:12,882,287...13,268,647
Ensembl chr12:12,882,064...13,263,554 		JBrowse link
G PSCA prostate stem cell antigen ISO CTD Direct Evidence: marker/mechanism CTD PMID:19648920 PMID:20083643 NCBI chr 4:1,479,872...1,484,245
Ensembl chr 4:1,479,879...1,482,354 		JBrowse link
G PSMB2 proteasome 20S subunit beta 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26039340 NCBI chr 6:91,792,055...91,829,942
Ensembl chr 6:91,783,058...91,829,908 		JBrowse link
G PTEN phosphatase and tensin homolog disease_progression ISO protein:decreased expression:urinary bladder
ClinVar Annotator: match by term: Malignant tumor of urinary bladder | ClinVar Annotator: match by term: Urinary bladder cancer		 RGD
ClinVar		 PMID:9140396 PMID:9256433 PMID:9735393 PMID:9811831 PMID:10051603 More... RGD:2291891 NCBI chr14:99,929,590...100,021,619 JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 disease_progression
susceptibility		 ISO CTD Direct Evidence: marker/mechanism
DNA:SNP:3' utr:837T>C (human)		 RGD
CTD		 PMID:10582676 PMID:10873095 PMID:12442003 PMID:12664575 PMID:16098373 More... RGD:2300127 RGD:2300200 RGD:5508302 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
G RAB27A RAB27A, member RAS oncogene family ISO CTD Direct Evidence: marker/mechanism CTD PMID:34291859 NCBI chr 1:116,532,816...116,606,477
Ensembl chr 1:116,532,974...116,606,474 		JBrowse link
G RAB27B RAB27B, member RAS oncogene family ISO CTD Direct Evidence: marker/mechanism CTD PMID:34291859 NCBI chr 1:104,241,500...104,418,721
Ensembl chr 1:104,241,571...104,417,084 		JBrowse link
G RALBP1 ralA binding protein 1 ISO mRNA, protein:increased expression:urinary bladder RGD PMID:17606711 RGD:2324917 NCBI chr 6:98,550,925...98,598,945
Ensembl chr 6:98,550,933...98,598,206 		JBrowse link
G RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26039340 NCBI chr 1:267,437,066...267,770,444
Ensembl chr 1:267,480,750...267,770,440 		JBrowse link
G RASSF1 Ras association domain family member 1 ISO CTD Direct Evidence: marker/mechanism
DNA:hypermethylation		 CTD
RGD		 PMID:15987713 PMID:18702824 RGD:2299860 NCBI chr13:32,816,156...32,825,486
Ensembl chr13:32,816,156...32,825,226 		JBrowse link
G RB1 RB transcriptional corepressor 1 disease_progression ISO ClinVar Annotator: match by term: Bladder cancer | ClinVar Annotator: match by term: Malignant tumor of urinary bladder | ClinVar Annotator: match by term: Urinary bladder cancer OMIM
ClinVar
RGD		 PMID:1352883 PMID:2181449 PMID:2601691 PMID:7704558 PMID:7881418 More... RGD:2299888 NCBI chr11:19,186,754...19,317,642
Ensembl chr11:19,186,761...19,317,690 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit disease_progression ISO RGD PMID:18089718 PMID:18188593 RGD:2293094 RGD:2298753 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469 		JBrowse link
G RETN resistin ISO protein:increased expression:urine RGD PMID:18373357 RGD:7207154 NCBI chr 2:71,484,164...71,485,577
Ensembl chr 2:71,484,169...71,485,616 		JBrowse link
G RHOA ras homolog family member A disease_progression ISO protein:increased expression:urinary bladder
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:12855641 PMID:19896475 RGD:2298872 NCBI chr13:31,918,484...31,991,207
Ensembl chr13:31,918,834...31,986,607 		JBrowse link
G RRM2 ribonucleotide reductase regulatory subunit M2 ISO mRNA:increased expression:bladder (rat)
mRNA:increased expression:bladder (mouse)
mRNA:increased expression:bladder (human)		 RGD PMID:21139803 RGD:5133688 NCBI chr 3:126,357,198...126,367,145
Ensembl chr 3:126,347,819...126,365,644 		JBrowse link
G RUNX3 RUNX family transcription factor 3 ISO DNA:promoter:aberrant methylation RGD PMID:16230397 RGD:2302553 NCBI chr 6:82,531,203...82,595,044
Ensembl chr 6:82,531,559...82,595,026 		JBrowse link
G S100A8 S100 calcium binding protein A8 ISO mRNA:increased expression:urinary bladder RGD PMID:17970044 RGD:2316906 NCBI chr 4:96,209,670...96,210,603
Ensembl chr 4:96,209,659...96,210,602 		JBrowse link
G S100A9 S100 calcium binding protein A9 ISO mRNA:increased expression:urinary bladder RGD PMID:17970044 RGD:2316906 NCBI chr 4:96,236,114...96,238,989 JBrowse link
G S100B S100 calcium binding protein B ISO mRNA:decreased expression:urinary bladder urothelium
mRNA:increased expression:urinary bladder urothelium		 RGD PMID:17970044 RGD:2316906
G SERPINE1 serpin family E member 1 ISO RGD PMID:19010488 RGD:4144867 NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,547 		JBrowse link
G SFN stratifin disease_progression ISO protein:increased expression:urothelium (human) RGD PMID:17645415 RGD:2299928 NCBI chr 6:84,188,521...84,189,824
Ensembl chr 6:84,188,445...84,189,827 		JBrowse link
G SLC11A1 solute carrier family 11 member 1 disease_progression ISO DNA:repeat, polymorphism:promoter, cds:p.D543N (human) RGD PMID:16516037 RGD:5684951 NCBI chr15:120,434,100...120,446,396
Ensembl chr15:120,433,952...120,446,396 		JBrowse link
G SLC12A7 solute carrier family 12 member 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26039340 NCBI chr16:79,356,868...79,396,652
Ensembl chr16:79,357,010...79,396,656 		JBrowse link
G SLC19A1 solute carrier family 19 member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21760912 NCBI chr13:207,986,094...208,007,855
Ensembl chr13:207,986,098...208,007,675 		JBrowse link
G SMAD2 SMAD family member 2 ISO RGD PMID:15548366 RGD:2299964 NCBI chr 1:97,415,360...97,511,388
Ensembl chr 1:97,415,716...97,511,357 		JBrowse link
G SMAD4 SMAD family member 4 ISO protein:decreased expression:urinary bladder RGD PMID:11783019 RGD:2299972 NCBI chr 1:100,521,843...100,633,501
Ensembl chr 1:100,589,850...100,628,029 		JBrowse link
G SMC1A structural maintenance of chromosomes 1A ISO CTD Direct Evidence: marker/mechanism CTD PMID:24121791 NCBI chr  X:46,143,738...46,202,187
Ensembl chr  X:46,144,920...46,218,543 		JBrowse link
G SMC1B structural maintenance of chromosomes 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:24121791 NCBI chr 5:3,976,098...4,067,148
Ensembl chr 5:3,976,140...4,067,395 		JBrowse link
G SOCS1 suppressor of cytokine signaling 1 disease_progression ISO DNA:hypermethylation:promoter RGD PMID:16242928 PMID:17522834 RGD:2298903 RGD:2298906 NCBI chr 3:31,879,143...31,883,041
Ensembl chr 3:31,881,225...31,884,967 		JBrowse link
G SOD1 superoxide dismutase 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35764155 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729 		JBrowse link
G SOD2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:14729580 PMID:17974967 PMID:18930813 RGD:7175539 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560 		JBrowse link
G SOX2 SRY-box transcription factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:29396848 NCBI chr13:119,668,476...119,669,435
Ensembl chr13:119,668,476...119,669,435 		JBrowse link
G SOX4 SRY-box transcription factor 4 ISO RGD PMID:16585165 RGD:1581304 NCBI chr 7:16,886,834...16,895,488
Ensembl chr 7:16,891,319...16,892,752 		JBrowse link
G SPARC secreted protein acidic and cysteine rich disease_progression ISO RGD PMID:11696817 PMID:17149610 RGD:2300021 RGD:2300024 NCBI chr16:71,368,164...71,380,972
Ensembl chr16:71,357,586...71,381,161 		JBrowse link
G SPINK1 serine peptidase inhibitor Kazal type 1 disease_progression ISO mRNA, protein:decreased expression:urinary bladder RGD PMID:16327984 RGD:2300384 NCBI chr 2:149,072,652...149,079,529
Ensembl chr 2:149,071,703...149,079,499 		JBrowse link
G SPP1 secreted phosphoprotein 1 ISO RGD PMID:21483670 RGD:6903265 NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:11723127 PMID:17093206 NCBI chr17:40,470,970...40,524,862
Ensembl chr17:40,471,009...40,524,860 		JBrowse link
G SRSF9 serine and arginine rich splicing factor 9 ISO mRNA:increased expression:urinary bladder epithelium (human) RGD PMID:22178073 RGD:11040443 NCBI chr14:40,425,412...40,433,950
Ensembl chr14:40,419,093...40,434,047 		JBrowse link
G STAG2 STAG2 cohesin complex component ISO CTD Direct Evidence: marker/mechanism CTD PMID:24121789 PMID:24121791 PMID:24121792 NCBI chr  X:101,476,117...101,617,405
Ensembl chr  X:101,478,247...101,617,563 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:36115647 NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992 		JBrowse link
G TACC3 transforming acidic coiled-coil containing protein 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24121792 NCBI chr 8:825,433...835,425
Ensembl chr 8:824,999...837,322 		JBrowse link
G TERT telomerase reverse transcriptase ISO ClinVar Annotator: match by term: Malignant tumor of urinary bladder ClinVar PMID:20871597 PMID:22037553 PMID:23066086 PMID:23348503 PMID:23535731 More... NCBI chr16:79,258,591...79,276,421
Ensembl chr16:79,258,591...79,276,421 		JBrowse link
G TFF1 trefoil factor 1 ISO protein:increased expression:urinary bladder RGD PMID:18283638 RGD:2291996 NCBI chr13:205,687,558...205,691,512
Ensembl chr13:205,687,560...205,691,460 		JBrowse link
G TFRC transferrin receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:16904380 NCBI chr13:133,976,765...133,997,554
Ensembl chr13:133,970,985...134,000,276 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 ISO RGD PMID:9363992 RGD:2302036 NCBI chr 1:240,842,735...240,918,267
Ensembl chr 1:240,860,156...240,918,528 		JBrowse link
G THBS1 thrombospondin 1 severity ISO protein:decreased expression:bladder RGD PMID:20299037 RGD:13602099 NCBI chr 1:131,728,781...131,746,098
Ensembl chr 1:131,728,784...131,746,115 		JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 disease_progression ISO protein:decreased expression:serum
CTD Direct Evidence: marker/mechanism		 RGD
CTD		 PMID:17374529 PMID:17466450 PMID:30548095 RGD:2290395 RGD:2298521 NCBI chr12:3,254,794...3,300,835
Ensembl chr12:3,254,493...3,300,834 		JBrowse link
G TIMP3 TIMP metallopeptidase inhibitor 3 ISO DNA:hypermethylation:promoter RGD PMID:18082200 RGD:2290411 NCBI chr 5:12,185,816...12,242,599
Ensembl chr 5:12,185,818...12,242,581 		JBrowse link
G TLR2 toll like receptor 2 ISO DNA:deletion:promoter:−196_−174del (human) RGD PMID:23142523 RGD:7207893 NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,993...75,428,330 		JBrowse link
G TLR4 toll like receptor 4 treatment ISO RGD PMID:19788935 RGD:7240556 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970 		JBrowse link
G TMEFF2 transmembrane protein with EGF like and two follistatin like domains 2 ISO DNA:hypermethylation:promoter RGD PMID:16234815 RGD:2290489 NCBI chr15:96,594,901...96,856,848
Ensembl chr15:96,594,970...96,855,743 		JBrowse link
G TNF tumor necrosis factor ISO CTD Direct Evidence: therapeutic CTD PMID:1674182 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
G TOP2A DNA topoisomerase II alpha disease_progression ISO RGD PMID:19913893 RGD:2315121 NCBI chr12:22,001,300...22,028,452
Ensembl chr12:22,001,282...22,028,450 		JBrowse link
G TP53 tumor protein p53 disease_progression ISO protein:increased expression:urinary bladder
ClinVar Annotator: match by term: Bladder cancer | ClinVar Annotator: match by term: Malignant tumor of urinary bladder		 RGD
ClinVar		 PMID:224644 PMID:1565143 PMID:1591732 PMID:1631151 PMID:1683921 More... RGD:2290536 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818 		JBrowse link
G TP63 tumor protein p63 disease_progression ISO RGD PMID:19690775 RGD:2315430 NCBI chr13:127,115,990...127,347,082
Ensembl chr13:127,116,105...127,347,068 		JBrowse link
G TP73 tumor protein p73 disease_progression ISO mRNA:increased expression:urinary bladder RGD PMID:10383132 RGD:2291836 NCBI chr 6:65,169,770...65,228,997
Ensembl chr 6:65,182,456...65,228,990 		JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19502594 NCBI chr12:49,676,536...49,709,634
Ensembl chr12:49,677,291...49,713,977 		JBrowse link
G TSC1 TSC complex subunit 1 ISO ClinVar Annotator: match by term: Bladder cancer | ClinVar Annotator: match by term: Malignant tumor of urinary bladder ClinVar PMID:9242607 PMID:9328481 PMID:9803264 PMID:9863590 PMID:9924605 More... NCBI chr 1:272,636,530...272,685,948
Ensembl chr 1:272,636,532...272,685,951 		JBrowse link
G TYMS thymidylate synthetase ISO RGD PMID:18463958 RGD:2317413 NCBI chr 6:105,642,730...105,660,279
Ensembl chr 6:105,642,381...105,660,578 		JBrowse link
G UBE2I ubiquitin conjugating enzyme E2 I ISO radiation-induced dysplasia and carcinoma in situ; protein:increased expression:bladder urothelium:increased in Chernobyl victims vs controls from uncontaminated areas of the Ukraine (p<0.001) RGD PMID:16407042 RGD:2301343 NCBI chr 3:40,556,556...40,586,382 JBrowse link
G USP7 ubiquitin specific peptidase 7 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26039340 NCBI chr 3:33,754,357...33,810,480
Ensembl chr 3:33,775,829...33,810,465 		JBrowse link
G VEGFA vascular endothelial growth factor A ISO mRNA:increased expression:bladder RGD PMID:22895562 RGD:13605607 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366 		JBrowse link
G VEGFC vascular endothelial growth factor C disease_progression ISO RGD PMID:17094484 RGD:2315482 NCBI chr15:39,037,764...39,136,234
Ensembl chr15:39,039,311...39,132,936 		JBrowse link
G VEGFD vascular endothelial growth factor D disease_progression ISO RGD PMID:17970053 RGD:2315479 NCBI chr  X:11,893,254...11,933,923
Ensembl chr  X:11,893,259...11,933,809 		JBrowse link
G VHL von Hippel-Lindau tumor suppressor ISO mRNA:decreased expression:urinary bladder RGD PMID:19399409 RGD:2325183 NCBI chr13:66,334,535...66,342,401
Ensembl chr13:66,334,591...66,342,654 		JBrowse link
G VWA3A von Willebrand factor A domain containing 3A ISO CTD Direct Evidence: marker/mechanism CTD PMID:26039340 NCBI chr 3:24,028,836...24,097,582
Ensembl chr 3:24,031,331...24,097,393 		JBrowse link
G WIF1 WNT inhibitory factor 1 disease_progression ISO DNA:hypermethylation:promoter
protein:decreased expression:urinary bladder		 RGD PMID:14517837 PMID:18325051 RGD:2291868 RGD:727214 NCBI chr 5:29,450,442...29,543,913
Ensembl chr 5:29,450,442...29,543,913 		JBrowse link
G WNT7B Wnt family member 7B ISO mRNA:increased expression:superficial tumors vs normal bladder tissue (p=0.002) or invasive tumors (p=0.003) RGD PMID:9461004 RGD:2299932 NCBI chr 5:3,521,412...3,572,322
Ensembl chr 5:3,521,288...3,572,314 		JBrowse link
G XDH xanthine dehydrogenase ISO protein:decreased activity:urinary bladder RGD PMID:20087949 RGD:7247647 NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,987,126...108,053,169 		JBrowse link
G XRCC1 X-ray repair cross complementing 1 no_association
susceptibility		 ISO DNA:polymorphisms: :multiple
DNA:polymorphism: :p.R399Q
DNA:SNP: p.R399Q (human)		 RGD PMID:17425776 PMID:18272472 PMID:18765423 RGD:150530493 RGD:2302568 RGD:2302572 NCBI chr 6:50,403,691...50,425,730
Ensembl chr 6:50,403,689...50,425,729 		JBrowse link
G YJEFN3 YjeF N-terminal domain containing 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:26039340 NCBI chr 2:58,392,515...58,401,408
Ensembl chr 2:58,392,514...58,401,070 		JBrowse link
G ZNF609 zinc finger protein 609 ISO CTD Direct Evidence: marker/mechanism CTD PMID:35567596 NCBI chr 1:107,338,608...107,583,347
Ensembl chr 1:107,340,542...107,583,273 		JBrowse link
bladder carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BGLAP bone gamma-carboxyglutamate protein disease_progression ISO RGD PMID:22682992 RGD:30296649 NCBI chr 4:93,807,703...93,808,806
Ensembl chr 4:93,807,706...93,808,968 		JBrowse link
G FGFR3 fibroblast growth factor receptor 3 ISO ClinVar Annotator: match by term: Urinary bladder carcinoma ClinVar PMID:7773297 PMID:8589699 PMID:8845844 PMID:9438390 PMID:9790257 More... NCBI chr 8:879,151...894,968
Ensembl chr 8:879,159...894,964 		JBrowse link
G HRAS HRas proto-oncogene, GTPase ISO ClinVar Annotator: match by term: Urinary bladder carcinoma ClinVar PMID:16170316 PMID:16372351 PMID:16443854 PMID:16835863 PMID:17601930 More... NCBI chr 2:299,662...302,539
Ensembl chr 2:299,660...302,501 		JBrowse link
G LRRC56 leucine rich repeat containing 56 ISO ClinVar Annotator: match by term: Urinary bladder carcinoma ClinVar PMID:16170316 PMID:16372351 PMID:16443854 PMID:16835863 PMID:17601930 More... NCBI chr 2:303,836...323,701
Ensembl chr 2:304,430...323,699 		JBrowse link
bladder squamous cell carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTEN phosphatase and tensin homolog disease_progression ISO associated with schistosomiasis;protein:decreased expression:urothelium (human) RGD PMID:26916953 RGD:127285612 NCBI chr14:99,929,590...100,021,619 JBrowse link
bladder urothelial carcinoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTL7A actin like 7A ISO RGD PMID:29058301 RGD:13831338 NCBI chr 1:249,883,247...249,884,760
Ensembl chr 1:249,883,311...249,884,630 		JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 disease_progression ISO mRNA:increased expression:urinary bladder (human) RGD PMID:31964418 RGD:153344516 NCBI chr12:3,747,276...3,755,214
Ensembl chr12:3,747,279...3,755,215 		JBrowse link
G BIRC7 baculoviral IAP repeat containing 7 disease_progression ISO mRNA:increased expression:urinary bladder (human) RGD PMID:31964418 RGD:153344516 NCBI chr17:62,351,663...62,356,220 JBrowse link
G FGFR3 fibroblast growth factor receptor 3 severity ISO protein:increased expression:urothelial cells (human) RGD PMID:28507621 RGD:38500205 NCBI chr 8:879,151...894,968
Ensembl chr 8:879,159...894,964 		JBrowse link
G KDM6A lysine demethylase 6A susceptibility ISO associated with upper tract urothelial carcinoma; DNA:mutations:multiple: (human) RGD PMID:30352907 RGD:150429735 NCBI chr  X:39,953,764...40,154,197
Ensembl chr  X:39,953,814...40,154,029 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15289
    disease of cellular proliferation 7230
      cancer 5280
        organ system cancer 5052
          urinary system cancer 645
            urinary bladder cancer 293
              Urachal Adenocarcinoma 0
              bladder carcinoma + 9
              bladder dome cancer 0
              bladder lateral wall cancer 0
              bladder lymphoma 0
              bladder neck cancer 0
              bladder sarcoma 0
              bladder sarcomatoid transitional cell carcinoma 0
              bladder trigone cancer 0
              urachus cancer + 0
              ureteric orifice cancer 0
              urinary bladder anterior wall cancer 0
              urinary bladder posterior wall cancer 0
Path 2
Term Annotations click to browse term
  disease 15289
    disease of cellular proliferation 7230
      Neoplasms by Site 6716
        Urogenital Neoplasms 2104
          Urologic Neoplasms 697
            urinary system cancer 645
              urinary bladder cancer 293
                Urachal Adenocarcinoma 0
                bladder carcinoma + 9
                bladder dome cancer 0
                bladder lateral wall cancer 0
                bladder lymphoma 0
                bladder neck cancer 0
                bladder sarcoma 0
                bladder sarcomatoid transitional cell carcinoma 0
                bladder trigone cancer 0
                urachus cancer + 0
                ureteric orifice cancer 0
                urinary bladder anterior wall cancer 0
                urinary bladder posterior wall cancer 0
paths to the root