RGD Reference Report - Polymorphisms of the human NRAMP1 gene are associated with response to bacillus Calmette-Guerin immunotherapy for superficial bladder cancer. - Rat Genome Database

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Polymorphisms of the human NRAMP1 gene are associated with response to bacillus Calmette-Guerin immunotherapy for superficial bladder cancer.

Authors: Decobert, M  Larue, H  Bergeron, A  Harel, F  Pfister, C  Rousseau, F  Lacombe, L  Fradet, Y 
Citation: Decobert M, etal., J Urol. 2006 Apr;175(4):1506-11.
RGD ID: 5684951
Pubmed: PMID:16516037   (View Abstract at PubMed)
DOI: DOI:10.1016/S0022-5347(05)00653-1   (Journal Full-text)

PURPOSE: Superficial bladder tumors have a high recurrence rate and 10% to 20% of recurrences progress to invasive cancer. Recurrence and progression can best be prevented by nonspecific immunotherapy using intravesical BCG instillations. The NRAMP1 gene has been implicated in susceptibility to infectious and autoimmune diseases, and in response to BCG in murine models. We evaluated the association of 5 NRAMP1 gene polymorphisms with the risk of superficial bladder cancer recurrence and response to immunotherapy. MATERIALS AND METHODS: The (GT)n, 274 C/T, 469 + 14 G/C, 1465-85 G/A and D534N polymorphisms were tested on peripheral blood DNA of individuals from three cohorts: 37 bladder tumor patients treated by transurethral resection and without recurrence after up to eight years, 67 patients at high risk of recurrence of their bladder tumors and treated with BCG and 109 controls, using restriction fragment length polymorphisms or microsatellite analysis following PCR amplification. RESULTS: The D543N G:A genotype was found more frequently in patients at high risk of recurrence (8 of 67 or 12%) than in controls (2 of 109 or 2%) (p = 0.007). Patients with nonrecurrent tumors showed no difference with controls (1 of 37 or 3%) (p = 1.0). Moreover, in multivariate and survival analyses, both D543N and (GT)n polymorphisms showed association with recurrence-free survival in the cohort of patients at high risk of recurrence, following BCG treatment. CONCLUSIONS: These data suggest the implication of the NRAMP1 gene in bladder cancer recurrence and response to BCG immunotherapy.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SLC11A1Humanurinary bladder cancer disease_progressionIAGP DNA:repeat more ...RGD 
Slc11a1Mouseurinary bladder cancer disease_progressionISOSLC11A1 (Homo sapiens)DNA:repeat more ...RGD 
Slc11a1Raturinary bladder cancer disease_progressionISOSLC11A1 (Homo sapiens)DNA:repeat more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Slc11a1  (solute carrier family 11 member 1)

Genes (Mus musculus)
Slc11a1  (solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1)

Genes (Homo sapiens)
SLC11A1  (solute carrier family 11 member 1)


Additional Information