ERBB3 (erb-b2 receptor tyrosine kinase 3) - Rat Genome Database

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Gene: ERBB3 (erb-b2 receptor tyrosine kinase 3) Sus scrofa
Analyze
Symbol: ERBB3
Name: erb-b2 receptor tyrosine kinase 3
RGD ID: 14112474
Description: ENCODES a protein that exhibits neuregulin binding (ortholog); neuregulin receptor activity (ortholog); protein tyrosine kinase activity (ortholog); INVOLVED IN axonogenesis (ortholog); cellular response to insulin stimulus (ortholog); cellular response to mechanical stimulus (ortholog); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; epidermal growth factor/neuregulin signaling pathway; ASSOCIATED WITH amblyopia (ortholog); Breast Neoplasms (ortholog); chronic obstructive pulmonary disease (ortholog); FOUND IN apical part of cell (ortholog); neuronal cell body (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: receptor tyrosine-protein kinase erbB-3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,474,475 - 21,495,038 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,474,218 - 21,495,040 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,085,940 - 23,092,633 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axonogenesis  (ISO)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
cellular response to insulin stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
circadian rhythm  (ISO)
cranial nerve development  (IEA,ISO)
endocardial cushion development  (IEA,ISO)
epidermal growth factor receptor signaling pathway  (ISO)
ERBB2-ERBB3 signaling pathway  (IEA)
extrinsic apoptotic signaling pathway in absence of ligand  (IEA)
mammary gland involution  (ISO)
motor neuron apoptotic process  (IEA,ISO)
myelination  (IEA)
negative regulation of apoptotic process  (IEA)
negative regulation of cell adhesion  (IEA)
negative regulation of motor neuron apoptotic process  (IEA,ISO)
negative regulation of neuron apoptotic process  (IEA,ISO)
negative regulation of secretion  (IEA)
negative regulation of signal transduction  (IEA)
neurogenesis  (IEA)
neuron apoptotic process  (IEA,ISO)
peripheral nervous system development  (IEA,ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of calcineurin-NFAT signaling cascade  (IEA,ISO)
positive regulation of cardiac muscle tissue development  (IEA,ISO)
positive regulation of cell population proliferation  (IEA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glucose import  (ISO)
positive regulation of membrane permeability  (ISO)
regulation of cell population proliferation  (IEA)
response to xenobiotic stimulus  (ISO)
Schwann cell development  (IEA)
Schwann cell differentiation  (IEA,ISO)
signal transduction  (IEA)
skeletal muscle tissue development  (ISO)
tongue development  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ERBB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,474,475 - 21,495,038 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,474,218 - 21,495,040 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,085,940 - 23,092,633 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ERBB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,080,108 - 56,103,505 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,076,799 - 56,103,505 (+)EnsemblGRCh38hg38GRCh38
GRCh371256,473,892 - 56,497,289 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,760,159 - 54,783,395 (+)NCBINCBI36Build 36hg18NCBI36
Build 341254,760,158 - 54,783,395NCBI
Celera1256,125,560 - 56,149,315 (+)NCBICelera
Cytogenetic Map12q13.2NCBI
HuRef1253,512,788 - 53,536,430 (+)NCBIHuRef
CHM1_11256,441,254 - 56,464,656 (+)NCBICHM1_1
T2T-CHM13v2.01256,047,558 - 56,071,109 (+)NCBIT2T-CHM13v2.0
Erbb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,403,392 - 128,425,504 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,403,392 - 128,425,521 (-)EnsemblGRCm39 Ensembl
GRCm3810128,567,523 - 128,589,635 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,567,523 - 128,589,652 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710128,006,424 - 128,026,557 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,972,317 - 127,992,450 (-)NCBIMGSCv36mm8
Celera10130,961,356 - 130,981,519 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1077.1NCBI
Erbb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,579,079 - 1,600,379 (-)NCBIGRCr8
mRatBN7.27994,549 - 1,015,876 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7996,225 - 1,015,525 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,758,331 - 3,777,703 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,634,321 - 5,653,694 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,932,064 - 5,951,447 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,989,202 - 3,010,610 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,989,340 - 3,010,350 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,962,964 - 2,984,938 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,858,057 - 1,877,353 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,858,056 - 1,877,353 (-)NCBI
Celera7866,587 - 885,873 (-)NCBICelera
Cytogenetic Map7q11NCBI
Erbb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,683,126 - 3,702,978 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,683,126 - 3,701,752 (+)NCBIChiLan1.0ChiLan1.0
ERBB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21038,228,227 - 38,251,623 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11238,224,995 - 38,248,393 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,811,533 - 32,834,958 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11233,062,681 - 33,085,426 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1233,063,434 - 33,084,994 (-)Ensemblpanpan1.1panPan2
ERBB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110406,856 - 424,746 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10406,633 - 424,264 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10468,642 - 486,495 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010416,919 - 431,621 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10417,394 - 431,614 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110391,236 - 409,084 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010634,155 - 651,980 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010758,352 - 776,205 (+)NCBIUU_Cfam_GSD_1.0
Erbb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,354,988 - 58,370,728 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646498,749 - 513,297 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646497,783 - 515,247 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERBB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,020,912 - 52,043,809 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,021,058 - 52,044,028 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037193,941,255 - 193,963,311 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Erbb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,905,271 - 11,925,707 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480211,906,279 - 11,925,530 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ERBB3
227 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 1 11 2 3 1
Low 2 4 3 4 2 12
Below cutoff 2

Sequence


RefSeq Acc Id: ENSSSCT00000027288   ⟹   ENSSSCP00000019799
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl521,474,475 - 21,495,037 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000037734   ⟹   ENSSSCP00000032875
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl521,478,168 - 21,495,038 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000053677   ⟹   ENSSSCP00000042037
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl521,491,665 - 21,495,037 (+)Ensembl
RefSeq Acc Id: XM_021091799   ⟹   XP_020947458
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1521,474,218 - 21,495,040 (+)NCBI
Sequence:
RefSeq Acc Id: XP_020947458   ⟸   XM_021091799
- UniProtKB: A0A8D1BXK2 (UniProtKB/TrEMBL),   I3L6Z7 (UniProtKB/TrEMBL),   A0A480J4F4 (UniProtKB/TrEMBL),   A0A4X1W9N6 (UniProtKB/TrEMBL),   A0A8D0IAR2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000019799   ⟸   ENSSSCT00000027288
RefSeq Acc Id: ENSSSCP00000042037   ⟸   ENSSSCT00000053677
RefSeq Acc Id: ENSSSCP00000032875   ⟸   ENSSSCT00000037734

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000020725 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005011205 UniProtKB/TrEMBL
  ENSSSCG00015062304 UniProtKB/TrEMBL
  ENSSSCG00025044651 UniProtKB/TrEMBL
  ENSSSCG00030046438 UniProtKB/TrEMBL
  ENSSSCG00040003987 UniProtKB/TrEMBL
  ENSSSCG00045036801 UniProtKB/TrEMBL
  ENSSSCG00050076402 UniProtKB/TrEMBL
  ENSSSCG00055009229 UniProtKB/TrEMBL
  ENSSSCG00060076040 UniProtKB/TrEMBL
  ENSSSCG00065050788 UniProtKB/TrEMBL
  ENSSSCG00070029749 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000027288 ENTREZGENE
  ENSSSCT00000027288.4 UniProtKB/TrEMBL
  ENSSSCT00000037734.3 UniProtKB/TrEMBL
  ENSSSCT00000053677.2 UniProtKB/TrEMBL
  ENSSSCT00005017415.1 UniProtKB/TrEMBL
  ENSSSCT00005017481.1 UniProtKB/TrEMBL
  ENSSSCT00005017513.1 UniProtKB/TrEMBL
  ENSSSCT00015083184.1 UniProtKB/TrEMBL
  ENSSSCT00015083517.1 UniProtKB/TrEMBL
  ENSSSCT00015083674.1 UniProtKB/TrEMBL
  ENSSSCT00015083754.1 UniProtKB/TrEMBL
  ENSSSCT00015083884.1 UniProtKB/TrEMBL
  ENSSSCT00025060829.1 UniProtKB/TrEMBL
  ENSSSCT00025061158.1 UniProtKB/TrEMBL
  ENSSSCT00030064827.1 UniProtKB/TrEMBL
  ENSSSCT00030064862.1 UniProtKB/TrEMBL
  ENSSSCT00040005136.1 UniProtKB/TrEMBL
  ENSSSCT00045063368.1 UniProtKB/TrEMBL
  ENSSSCT00045063511.1 UniProtKB/TrEMBL
  ENSSSCT00045063609.1 UniProtKB/TrEMBL
  ENSSSCT00045063693.1 UniProtKB/TrEMBL
  ENSSSCT00045063775.1 UniProtKB/TrEMBL
  ENSSSCT00050104961.1 UniProtKB/TrEMBL
  ENSSSCT00050104963.1 UniProtKB/TrEMBL
  ENSSSCT00055018217.1 UniProtKB/TrEMBL
  ENSSSCT00055018392.1 UniProtKB/TrEMBL
  ENSSSCT00055018478.1 UniProtKB/TrEMBL
  ENSSSCT00060104198.1 UniProtKB/TrEMBL
  ENSSSCT00060104331.1 UniProtKB/TrEMBL
  ENSSSCT00060104380.1 UniProtKB/TrEMBL
  ENSSSCT00060104638.1 UniProtKB/TrEMBL
  ENSSSCT00060104673.1 UniProtKB/TrEMBL
  ENSSSCT00065069561.1 UniProtKB/TrEMBL
  ENSSSCT00065069583.1 UniProtKB/TrEMBL
  ENSSSCT00065069589.1 UniProtKB/TrEMBL
  ENSSSCT00065069594.1 UniProtKB/TrEMBL
  ENSSSCT00065069601.1 UniProtKB/TrEMBL
  ENSSSCT00070059798.1 UniProtKB/TrEMBL
  ENSSSCT00070059800.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.20.20 UniProtKB/TrEMBL
  cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Furin-like_Cys-rich_dom UniProtKB/TrEMBL
  Furin_repeat UniProtKB/TrEMBL
  GF_recep_IV UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Rcpt_L-dom UniProtKB/TrEMBL
  Rcpt_L-dom_sf UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_EGF/ERB/XmrK_rcpt UniProtKB/TrEMBL
NCBI Gene ERBB3 ENTREZGENE
PANTHER RECEPTOR TYROSINE-PROTEIN KINASE ERBB-3 UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/TrEMBL
Pfam Furin-like UniProtKB/TrEMBL
  GF_recep_IV UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  Recep_L_domain UniProtKB/TrEMBL
PIRSF TyrPK_EGF-R UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_DOM UniProtKB/TrEMBL
SMART SM00261 UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A287ADX1_PIG UniProtKB/TrEMBL
  A0A480J4F4 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1W9N6 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1WAT0_PIG UniProtKB/TrEMBL
  A0A8D0IAR2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0S685_PIG UniProtKB/TrEMBL
  A0A8D0U959_PIG UniProtKB/TrEMBL
  A0A8D1BXK2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1TR45_PIG UniProtKB/TrEMBL
  A0A8D1WWY3_PIG UniProtKB/TrEMBL
  I3L6Z7 ENTREZGENE
UniProt Secondary A0A286ZMT1 UniProtKB/TrEMBL
  I3L6Z7 UniProtKB/TrEMBL
VGNC ID VGNC:87760 ENTREZGENE