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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:SB-239063
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Accession:CHEBI:90681 term browser browse the term
Definition:A member of the class of imidazoles carrying 4-hydroxycyclohexyl, 4-fluorophenyl and 2-methoxypyrimidin-4-yl substituents at positions 1, 4 and 5 respectively.
Synonyms:exact_synonym: trans-4-[4-(4-fluorophenyl)-5-(2-methoxypyrimidin-4-yl)-1H-imidazol-1-yl]cyclohexan-1-ol
 related_synonym: Formula=C20H21FN4O2;   InChI=1S/C20H21FN4O2/c1-27-20-22-11-10-17(24-20)19-18(13-2-4-14(21)5-3-13)23-12-25(19)15-6-8-16(26)9-7-15/h2-5,10-12,15-16,26H,6-9H2,1H3/t15-,16-;   InChIKey=ZQUSFAUAYSEREK-WKILWMFISA-N;   SB239063;   SMILES=C=1(N(C=NC1C=2C=CC(=CC2)F)[C@H]3CC[C@@H](CC3)O)C4=NC(OC)=NC=C4
 xref: CAS:193551-21-2
 xref_mesh: MESH:C406525
 xref: PDBeChem:SB0;   PMID:23840427;   PMID:24188200;   PMID:24307181;   Reaxys:9010076



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SB-239063 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AQP4 aquaporin 4 multiple interactions ISO SB 239063 inhibits the reaction [manganese(III) acetate dihydrate results in increased expression of AQP4 protein] CTD PMID:20648640 NCBI chr18:26,852,038...26,865,803
Ensembl chr18:26,852,043...26,865,771
JBrowse link
G ATF4 activating transcription factor 4 multiple interactions EXP SB 239063 inhibits the reaction [perhexiline maleate results in increased expression of ATF4 protein] CTD PMID:33309543 NCBI chr22:39,520,559...39,522,686
Ensembl chr22:39,519,695...39,522,683
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions ISO SB 239063 inhibits the reaction [Particulate Matter results in decreased expression of BCL2 protein] CTD PMID:26472149 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CASP3 caspase 3 multiple interactions ISO SB 239063 inhibits the reaction [prostaglandin E2 glyceryl ester results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:17539917 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 multiple interactions ISO [alpha-Tocopherol co-treated with SB 239063] inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of CXCL1 mRNA]] CTD PMID:29284473 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP SB 239063 inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein] CTD PMID:21956143 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716
JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 multiple interactions ISO SB 239063 inhibits the reaction [bisphenol A results in increased expression of and results in increased activity of CYP19A1 protein] CTD PMID:20096755 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601
JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions EXP SB 239063 inhibits the reaction [perhexiline maleate results in increased expression of DDIT3 protein] CTD PMID:33309543 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G DNM1L dynamin 1 like multiple interactions ISO [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in decreased expression of DNM1L protein CTD PMID:26116440 NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650
JBrowse link
G DUSP1 dual specificity phosphatase 1 multiple interactions ISO SB 239063 inhibits the reaction [[Air Pollutants results in increased abundance of Ozone] promotes the reaction [Ovalbumin results in decreased expression of DUSP1 protein]] CTD PMID:24188200 NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195
JBrowse link
G EDNRB endothelin receptor type B multiple interactions ISO SB 239063 inhibits the reaction [Smoke results in increased expression of EDNRB mRNA]; SB 239063 inhibits the reaction [Smoke results in increased expression of EDNRB protein] CTD PMID:18718921 NCBI chr13:77,895,481...77,975,527
Ensembl chr13:77,895,481...77,975,529
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions ISO [alpha-Tocopherol co-treated with SB 239063] inhibits the reaction [Ovalbumin promotes the reaction [Ozone results in increased activity of GPX1 protein]] CTD PMID:29284473 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605
JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions ISO [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in increased phosphorylation of GSK3B protein CTD PMID:26116440 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994
JBrowse link
G HSPB1 heat shock protein family B (small) member 1 multiple interactions ISO SB 239063 inhibits the reaction [[[Air Pollutants results in increased abundance of Ozone] which co-treated with Ovalbumin] results in increased phosphorylation of HSPB1 protein] CTD PMID:24188200 NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295
JBrowse link
G IFNG interferon gamma multiple interactions ISO SB 239063 inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IFNG protein]] CTD PMID:29284473 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL13 interleukin 13 multiple interactions ISO [alpha-Tocopherol co-treated with SB 239063] inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL13 protein]]; SB 239063 inhibits the reaction [Ovalbumin results in increased expression of IL13 protein]; SB 239063 inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL13 protein]] CTD PMID:25287866 PMID:29284473 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110
JBrowse link
G IL17A interleukin 17A multiple interactions ISO SB 239063 inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL17A mRNA]] CTD PMID:29284473 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638
JBrowse link
G IL6 interleukin 6 multiple interactions ISO SB 239063 inhibits the reaction [Ovalbumin results in increased expression of IL6 protein]; SB 239063 inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased expression of IL6 protein]] CTD PMID:25287866 PMID:29284473 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in increased phosphorylation of MAPK1 protein CTD PMID:26116440 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions ISO SB 239063 inhibits the reaction [[[Air Pollutants results in increased abundance of Ozone] which co-treated with Ovalbumin] results in increased phosphorylation of MAPK14 protein]; SB 239063 inhibits the reaction [[Air Pollutants results in increased abundance of Ozone] promotes the reaction [Ovalbumin results in increased phosphorylation of MAPK14 protein]]; SB 239063 inhibits the reaction [[Ovalbumin co-treated with Ozone] results in increased phosphorylation of MAPK14 protein]; SB 239063 inhibits the reaction [Ozone promotes the reaction [Ovalbumin results in increased phosphorylation of MAPK14 protein]] CTD PMID:24188200 PMID:25287866 PMID:29284473 NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in increased phosphorylation of MAPK3 protein CTD PMID:26116440 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MFF mitochondrial fission factor multiple interactions ISO [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in decreased expression of MFF protein CTD PMID:26116440 NCBI chr 2:227,325,251...227,357,836
Ensembl chr 2:227,325,151...227,357,833
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO SB 239063 inhibits the reaction [25-hydroxyprotopanaxadiol results in increased phosphorylation of PPARG protein] CTD PMID:33676887 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha multiple interactions ISO SB 239063 inhibits the reaction [25-hydroxyprotopanaxadiol results in increased phosphorylation of PPARGC1A protein] CTD PMID:33676887 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G SQSTM1 sequestosome 1 multiple interactions ISO [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased susceptibility to SB 239063] which results in increased expression of SQSTM1 protein CTD PMID:26116440 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26050
    chemical entity 26029
      molecular entity 26007
        polyatomic entity 25892
          heteroatomic molecular entity 25544
            hydroxides 24065
              organic hydroxy compound 22075
                alcohol 16639
                  cyclohexanols 236
                    SB-239063 25
Path 2
Term Annotations click to browse term
  CHEBI ontology 26050
    subatomic particle 26025
      composite particle 26025
        hadron 26025
          baryon 26025
            nucleon 26025
              atomic nucleus 26025
                atom 26025
                  main group element atom 25850
                    p-block element atom 25850
                      carbon group element atom 25447
                        carbon atom 25405
                          organic molecular entity 25405
                            organic molecule 25233
                              organic cyclic compound 24287
                                organic heterocyclic compound 22334
                                  heteroarene 18785
                                    monocyclic heteroarene 16147
                                      azole 15702
                                        diazole 11201
                                          imidazoles 10357
                                            SB-239063 25
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