CYP19A1 (cytochrome P450, family 19, subfamily A, polypeptide 1)

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Keyword

Gene: CYP19A1 (cytochrome P450, family 19, subfamily A, polypeptide 1) Homo sapiens

Symbol:

CYP19A1

Name:

cytochrome P450, family 19, subfamily A, polypeptide 1

Description:

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

ARO; ARO1; aromatase; CPV1; CYAR; CYP19; CYPXIX; CYPXIX; cytochrome P-450AROM; cytochrome P450 19A1; cytochrome P450, subfamily XIX (aromatization of androgens); estrogen synthase; estrogen synthetase; flavoprotein-linked monooxygenase; MGC104309; microsomal monooxygenase; OTTHUMP00000162543; OTTHUMP00000198350; P-450AROM

Orthologs:

Mus musculus : Cyp19a1 (cytochrome P450, family 19, subfamily a, polypeptide 1) MGI
Rattus norvegicus : Cyp19a1 (cytochrome P450, family 19, subfamily a, polypeptide 1)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	15	31,566,686 - 31,697,393	-	NCBI
Human Genome Assembly HuRef	15	28,330,314 - 28,460,872	-	NCBI
Human Genome Assembly GRCh37	15	51,500,254 - 51,630,795	-	NCBI
Human Genome Assembly Build 36	15	49,288,961 - 49,418,086	-	NCBI
Human Cytogenetic Map	15	q21.1		NCBI