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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pitavastatin(1-)
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Accession:CHEBI:71260 term browser browse the term
Definition:A hydroxy monocarboxylic acid anion that is the conjugate base of pitavastatin, obtained by deprotonation of the carboxy group.
Synonyms:exact_synonym: (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate
 related_synonym: (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate;   Formula=C25H23FNO4;   InChI=1S/C25H24FNO4/c26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31/h1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31)/p-1/b12-11+/t18-,19-/m1/s1;   InChIKey=VGYFMXBACGZSIL-MCBHFWOFSA-M;   SMILES=O[C@H](C[C@H](O)\\C=C\\c1c(nc2ccccc2c1-c1ccc(F)cc1)C1CC1)CC([O-])=O;   pitavastatin cation
 xref: CAS:147511-69-1;   KEGG:C13334
 xref_mesh: MESH:C108475
 xref: Reaxys:7952950
 cyclic_relationship: is_conjugate_base_of CHEBI:32020


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pitavastatin(1-) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP-binding cassette, sub-family A member 1 multiple interactions
increases expression		 ISO
EXP		 GW 6471 inhibits the reaction [pitavastatin results in increased expression of ABCA1 mRNA]
pitavastatin inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased expression of ABCA1 protein]
GW 6471 inhibits the reaction [pitavastatin results in increased expression of ABCA1 mRNA]; PPARA protein affects the reaction [pitavastatin results in increased expression of ABCA1 mRNA]		 CTD PMID:16415093 PMID:21554872 NCBI chr 4:53,030,789...53,159,988
Ensembl chr 4:53,030,787...53,159,895 		JBrowse link
G Abcb11 ATP-binding cassette, sub-family B member 11 multiple interactions
decreases activity		 ISO pitavastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]; pitavastatin inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
pitavastatin results in decreased activity of ABCB11 protein		 CTD PMID:15901796 PMID:24014644 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958 		JBrowse link
G Abcb1a ATP-binding cassette, sub-family B member 1A affects transport ISO ABCB1 protein affects the transport of pitavastatin CTD PMID:15955871 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcc2 ATP-binding cassette, sub-family member 2 multiple interactions
affects transport		 ISO ABCC2 protein binds to and results in increased uptake of pitavastatin analog; pitavastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]
ABCC2 protein affects the transport of pitavastatin		 CTD PMID:15955871 PMID:23562342 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) affects transport EXP
ISO		 ABCG2 protein affects the transport of pitavastatin CTD PMID:15955871 NCBI chr 6:58,561,476...58,669,436
Ensembl chr 6:58,561,508...58,672,661 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression		 ISO EIF2AK3 protein affects the reaction [pitavastatin results in increased expression of ATF4 protein] CTD PMID:37956312 NCBI chr15:80,139,385...80,141,746
Ensembl chr15:80,139,385...80,141,742 		JBrowse link
G Bbc3 BCL2 binding component 3 multiple interactions
affects response to substance
increases expression		 ISO BBC3 protein affects the susceptibility to [S63845 co-treated with pitavastatin]; BBC3 protein affects the susceptibility to [venetoclax co-treated with pitavastatin]
BBC3 protein affects the susceptibility to pitavastatin
pitavastatin results in increased expression of BBC3 mRNA; pitavastatin results in increased expression of BBC3 protein		 CTD PMID:37956312 NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA]; pitavastatin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA] CTD PMID:18323514 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO EIF2AK3 protein affects the reaction [pitavastatin results in increased expression of ATF4 protein] CTD PMID:37956312 NCBI chr 6:70,821,468...70,882,225
Ensembl chr 6:70,821,499...70,882,229 		JBrowse link
G Foxo1 forkhead box O1 decreases phosphorylation EXP pitavastatin results in decreased phosphorylation of FOXO1 protein CTD PMID:33034787 NCBI chr 3:52,175,758...52,257,530
Ensembl chr 3:52,175,757...52,260,642 		JBrowse link
G Ifnb1 interferon beta 1, fibroblast multiple interactions EXP pitavastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; pitavastatin inhibits the reaction [Palmitic Acid results in increased expression of IFNB1 mRNA]; pitavastatin inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA] CTD PMID:18323514 NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of IL6 mRNA]; pitavastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; pitavastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; pitavastatin inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]; pitavastatin inhibits the reaction [Poly I-C results in increased expression of IL6 mRNA] CTD PMID:18323514 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions EXP pitavastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]; pitavastatin inhibits the reaction [Palmitic Acid results in increased phosphorylation of IRF3 protein] CTD PMID:18323514 NCBI chr 7:44,647,072...44,652,272
Ensembl chr 7:44,647,072...44,652,272 		JBrowse link
G Irf4 interferon regulatory factor 4 decreases expression EXP pitavastatin results in decreased expression of IRF4 protein CTD PMID:33034787 NCBI chr13:30,933,191...30,950,965
Ensembl chr13:30,933,209...30,950,959 		JBrowse link
G Lep leptin multiple interactions EXP pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA]; pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of IL6 mRNA]; pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of TNF mRNA] CTD PMID:18323514 NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876 		JBrowse link
G Mstn myostatin increases expression EXP pitavastatin results in increased expression of MSTN protein CTD PMID:33034787 NCBI chr 1:53,100,799...53,107,238
Ensembl chr 1:53,100,799...53,107,238 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP pitavastatin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; pitavastatin inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]; pitavastatin inhibits the reaction [Poly I-C results in increased expression of NOS2 mRNA] CTD PMID:18323514 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 multiple interactions EXP NR1H2 gene mutant form inhibits the reaction [pitavastatin inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased export of Cholesterol]]; NR1H2 gene mutant form inhibits the reaction [pitavastatin results in decreased export of Cholesterol] CTD PMID:16415093 NCBI chr 7:44,199,040...44,204,928
Ensembl chr 7:44,199,040...44,203,375 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions EXP NR1H3 gene mutant form inhibits the reaction [pitavastatin inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP results in increased export of Cholesterol]]; NR1H3 gene mutant form inhibits the reaction [pitavastatin results in decreased export of Cholesterol] CTD PMID:16415093 NCBI chr 2:91,014,406...91,033,189
Ensembl chr 2:91,014,406...91,033,179 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO pitavastatin results in increased cleavage of PARP1 protein CTD PMID:37956312 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 multiple interactions
increases expression		 ISO 2-(4-chlorophenoxy)-N-(4-(2-(4-chlorophenoxy)acetamido)cyclohexyl)acetamide inhibits the reaction [pitavastatin results in increased expression of PMAIP1 protein] CTD PMID:37956312 NCBI chr18:66,591,675...66,598,629
Ensembl chr18:66,591,604...66,598,636 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions
increases expression		 ISO farnesyl pyrophosphate inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA]; Mevalonic Acid inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA]; Plicamycin inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA] CTD PMID:15690306 NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression
multiple interactions		 ISO pitavastatin results in increased expression of PPARA mRNA
pitavastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]; PPARA protein affects the reaction [pitavastatin results in increased expression of ABCA1 mRNA]		 CTD PMID:11779144 PMID:21554872 NCBI chr15:85,619,112...85,691,052
Ensembl chr15:85,619,184...85,687,020 		JBrowse link
G Ppard peroxisome proliferator activator receptor delta increases expression ISO pitavastatin results in increased expression of PPARD mRNA CTD PMID:21554872 NCBI chr17:28,451,715...28,520,446
Ensembl chr17:28,451,674...28,520,448 		JBrowse link
G Rap1a RAS-related protein 1a decreases prenylation
decreases expression		 ISO pitavastatin results in decreased prenylation of RAP1A protein
pitavastatin results in decreased expression of RAP1A protein alternative form		 CTD PMID:37956312 NCBI chr 3:105,634,576...105,708,740
Ensembl chr 3:105,634,583...105,708,652 		JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO pitavastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]] CTD PMID:11779144 NCBI chr 2:27,566,457...27,653,331
Ensembl chr 2:27,566,452...27,652,969 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects transport EXP SLCO1A4 protein affects the transport of pitavastatin CTD PMID:19833843 NCBI chr 6:141,751,164...141,802,011
Ensembl chr 6:141,751,166...141,801,925 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions EXP pitavastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein] CTD PMID:18323514 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP pitavastatin inhibits the reaction [LEP gene mutant form results in increased expression of TNF mRNA]; pitavastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:18323514 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    chemical entity 22193
      molecular entity 22185
        ion 17694
          anion 16956
            organic anion 3685
              carboxylic acid anion 2524
                monocarboxylic acid anion 1606
                  hydroxy monocarboxylic acid anion 77
                    pitavastatin(1-) 29
                      pitavastatin calcium 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    p-block element atom 22120
                      carbon group element atom 21921
                        carbon atom 21847
                          organic molecular entity 21847
                            organic ion 10082
                              organic anion 3685
                                carboxylic acid anion 2524
                                  monocarboxylic acid anion 1606
                                    hydroxy monocarboxylic acid anion 77
                                      pitavastatin(1-) 29
                                        pitavastatin calcium 0
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