CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: cilazapril monohydrate
Accession: CHEBI:145568
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Definition: A hydrate that is the monohydrate of cilazapril. It is used for the treatment of hypertension and heart failure.
Synonyms: exact_synonym: (1S,9S)-9-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid--water (1/1)
related_synonym: (1S,9S)-9-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid hydrate; Formula=C22H31N3O5.H2O; InChI=1S/C22H31N3O5.H2O/c1-2-30-22(29)18(13-12-16-8-4-3-5-9-16)23-17-10-6-14-24-15-7-11-19(21(27)28)25(24)20(17)26;/h3-5,8-9,17-19,23H,2,6-7,10-15H2,1H3,(H,27,28);1H2/t17-,18-,19-;/m0./s1; InChIKey=JQRZBPFGBRIWSN-YOTVLOEGSA-N; Inhibace; Justor; Ro 31-2848 monohydrate; SMILES=C1CC[C@@H](C(N2N1CCC[C@H]2C(=O)O)=O)N[C@H](C(OCC)=O)CCC3=CC=CC=C3.O; cilazapril; cilazapril hydrate; cilazapril.H2O
xref: CAS:92077-78-6; DrugBank:DBSALT001097; KEGG:D01069
xref_mesh: MESH:D017315
xref: PMID:1836986; PMID:1839765
G
Ace
angiotensin I converting enzyme
affects response to substance
ISO
ACE gene polymorphism affects the susceptibility to Cilazapril
CTD
PMID:15498266
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
G
Adipoq
adiponectin, C1Q and collagen domain containing
increases expression
ISO
Cilazapril results in increased expression of ADIPOQ protein
CTD
PMID:19789415
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
G
Agtr1a
angiotensin II receptor, type 1a
multiple interactions
EXP
[Cilazapril co-treated with Losartan] promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]; Cilazapril promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]
CTD
PMID:15331931
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
G
Agtr2
angiotensin II receptor, type 2
multiple interactions
EXP
[Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]; Cilazapril inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]
CTD
PMID:15331931
NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057
G
Fgf2
fibroblast growth factor 2
decreases expression
EXP
Cilazapril results in decreased expression of FGF2 mRNA; Cilazapril results in decreased expression of FGF2 protein
CTD
PMID:9640960
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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Nppa
natriuretic peptide A
multiple interactions affects secretion
ISO
[Cilazapril co-treated with Verapamil] affects the secretion of NPPA protein Cilazapril affects the secretion of NPPA protein
CTD
PMID:1457087
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
G
Ren
renin
increases activity
EXP
Cilazapril results in increased activity of REN protein
CTD
PMID:2425185
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
G
Slc15a1
solute carrier family 15 member 1
multiple interactions
ISO
Cilazapril inhibits the reaction [SLC15A1 protein results in increased uptake of glycylsarcosine]
CTD
PMID:18713951
NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
G
Slc15a2
solute carrier family 15 member 2
multiple interactions
EXP
Cilazapril inhibits the reaction [SLC15A2 protein results in increased uptake of glycylsarcosine]
CTD
PMID:18713951
NCBI chr11:64,014,182...64,043,228
Ensembl chr11:64,014,182...64,043,225
G
Tgfb1
transforming growth factor, beta 1
multiple interactions
EXP
[Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; Cilazapril inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]
CTD
PMID:15331931
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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