CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: milrinone
Accession: CHEBI:50693
browse the term
Definition: A member of the class of bipyridines that is 2-pyridone which is substituted at positions 3, 5, and 6 by cyano, pyrid-4-yl, and methyl groups, respectively. It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure.
Synonyms: related_synonym: 1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile; Formula=C12H9N3O; InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16); InChIKey=PZRHRDRVRGEVNW-UHFFFAOYSA-N; SMILES=Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N; milrinona; milrinonum
alt_id: CHEBI:44019; CHEBI:6938
xref: Beilstein:3546821; CAS:78415-72-2; DrugBank:DB00235; Drug_Central:1809; HMDB:HMDB0014380; KEGG:C07224; KEGG:D00417; LINCS:LSM-3493
xref_mesh: MESH:D020105
xref: PDBeChem:MIL; PMID:10634314; PMID:14624413; PMID:14638547; PMID:21905056; PMID:21971319; Patent:BE886336; Patent:US4313951; Patent:US4413127; Reaxys:3546821; Wikipedia:Milrinone
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Adh1c
alcohol dehydrogenase 1C (class I), gamma polypeptide
increases expression
EXP
Milrinone results in increased expression of ADH1 mRNA
CTD
PMID:22936366
NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
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Akip1
A-kinase interacting protein 1
increases expression
EXP
Milrinone results in increased expression of AKIP1 mRNA
CTD
PMID:22936366
NCBI chr 1:163,734,730...163,743,648
Ensembl chr 1:163,734,798...163,743,648
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Angptl4
angiopoietin-like 4
decreases expression
EXP
Milrinone results in decreased expression of ANGPTL4 mRNA
CTD
PMID:22936366
NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
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Aqp7
aquaporin 7
decreases expression
EXP
Milrinone results in decreased expression of AQP7 mRNA
CTD
PMID:22936366
NCBI chr 5:56,171,649...56,186,642
Ensembl chr 5:56,172,519...56,186,642
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Aspn
asporin
increases expression
EXP
Milrinone results in increased expression of ASPN mRNA
CTD
PMID:22936366
NCBI chr17:15,079,910...15,104,369
Ensembl chr17:15,080,639...15,104,041
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Bmal1
basic helix-loop-helix ARNT like 1
decreases expression
EXP
Milrinone results in decreased expression of BMAL1 mRNA
CTD
PMID:22936366
NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
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Cftr
CF transmembrane conductance regulator
multiple interactions increases activity
ISO
Milrinone promotes the reaction [CFTR protein affects the secretion of Chlorides] Milrinone results in increased activity of CFTR protein
CTD
PMID:12714375
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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Chtf8
chromosome transmission fidelity factor 8
increases expression
EXP
Milrinone results in increased expression of CHTF8 mRNA
CTD
PMID:22936366
NCBI chr19:34,782,005...34,792,306
Ensembl chr19:34,781,856...34,792,578
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Crem
cAMP responsive element modulator
increases expression
EXP
Milrinone results in increased expression of CREM mRNA
CTD
PMID:22936366
NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
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Crp
C-reactive protein
decreases expression
ISO
Milrinone results in decreased expression of CRP protein
CTD
PMID:11772795
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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Csrp2
cysteine and glycine-rich protein 2
increases expression
EXP
Milrinone results in increased expression of CSRP2 mRNA
CTD
PMID:22936366
NCBI chr 7:46,349,109...46,367,743
Ensembl chr 7:46,348,686...46,367,745
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Cthrc1
collagen triple helix repeat containing 1
increases expression
EXP
Milrinone results in increased expression of CTHRC1 mRNA
CTD
PMID:22936366
NCBI chr 7:70,122,474...70,132,756
Ensembl chr 7:70,122,474...70,132,756
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Dbp
D-box binding PAR bZIP transcription factor
increases expression
EXP
Milrinone results in increased expression of DBP mRNA
CTD
PMID:22936366
NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745
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Eif4ebp2
eukaryotic translation initiation factor 4E binding protein 2
decreases expression
EXP
Milrinone results in decreased expression of EIF4EBP2 mRNA
CTD
PMID:22936366
NCBI chr20:29,379,444...29,400,110
Ensembl chr20:29,382,668...29,399,946
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Fam171a1
family with sequence similarity 171, member A1
decreases expression
EXP
Milrinone results in decreased expression of FAM171A1 mRNA
CTD
PMID:22936366
NCBI chr17:75,024,582...75,148,348
Ensembl chr17:75,024,575...75,150,255
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Fhl1
four and a half LIM domains 1
increases expression
EXP
Milrinone results in increased expression of FHL1 mRNA
CTD
PMID:22936366
NCBI chr X:134,555,399...134,614,930
Ensembl chr X:134,555,479...134,614,928
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Gadd45g
growth arrest and DNA-damage-inducible, gamma
increases expression
EXP
Milrinone results in increased expression of GADD45G mRNA
CTD
PMID:22936366
NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
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Gpnmb
glycoprotein nmb
increases expression
EXP
Milrinone results in increased expression of GPNMB mRNA
CTD
PMID:22936366
NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
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Hadh
hydroxyacyl-CoA dehydrogenase
increases expression
EXP
Milrinone results in increased expression of HADH mRNA
CTD
PMID:22936366
NCBI chr 2:219,787,935...219,830,335
Ensembl chr 2:219,787,927...219,830,353
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Igkc
immunoglobulin kappa constant
decreases expression
EXP
Milrinone results in decreased expression of IGKC mRNA
CTD
PMID:22936366
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Il6
interleukin 6
multiple interactions
ISO
Milrinone promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
CTD
PMID:21088047
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Lyz2
lysozyme 2
increases expression
EXP
Milrinone results in increased expression of LYZ2 mRNA
CTD
PMID:22936366
NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
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Msi2
musashi RNA-binding protein 2
increases expression
EXP
Milrinone results in increased expression of MSI2 mRNA
CTD
PMID:22936366
NCBI chr10:73,143,760...73,510,566
Ensembl chr10:73,147,380...73,510,157
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Myh7
myosin heavy chain 7
increases expression
EXP
Milrinone results in increased expression of MYH7 mRNA
CTD
PMID:22936366
NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
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Myl1
myosin, light chain 1
increases expression
EXP
Milrinone results in increased expression of MYL1 mRNA
CTD
PMID:22936366
NCBI chr 9:68,437,514...68,458,256
Ensembl chr 9:68,437,517...68,458,261
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Noct
nocturnin
increases expression
EXP
Milrinone results in increased expression of NOCT mRNA
CTD
PMID:22936366
NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400
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Nos1
nitric oxide synthase 1
multiple interactions
ISO
Milrinone inhibits the reaction [NOS1 gene mutant form results in decreased secretion of REN1 protein]
CTD
PMID:20651700
NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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Nppa
natriuretic peptide A
increases expression
EXP
Milrinone results in increased expression of NPPA mRNA
CTD
PMID:22936366
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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Nr4a3
nuclear receptor subfamily 4, group A, member 3
increases expression
EXP
Milrinone results in increased expression of NR4A3 mRNA
CTD
PMID:22936366
NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
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Per2
period circadian regulator 2
increases expression
EXP
Milrinone results in increased expression of PER2 mRNA
CTD
PMID:22936366
NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
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Postn
periostin
increases expression
EXP
Milrinone results in increased expression of POSTN mRNA
CTD
PMID:22936366
NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
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Reg3b
regenerating family member 3 beta
increases expression
EXP
Milrinone results in increased expression of REG3B mRNA
CTD
PMID:22936366
NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015
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Ren
renin
multiple interactions
ISO
Milrinone inhibits the reaction [NOS1 gene mutant form results in decreased secretion of REN1 protein]
CTD
PMID:20651700
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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S100a4
S100 calcium-binding protein A4
increases expression
EXP
Milrinone results in increased expression of S100A4 mRNA
CTD
PMID:22936366
NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
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Spp1
secreted phosphoprotein 1
increases expression
EXP
Milrinone results in increased expression of SPP1 mRNA
CTD
PMID:22936366
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
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Thbs4
thrombospondin 4
increases expression
EXP
Milrinone results in increased expression of THBS4 mRNA
CTD
PMID:22936366
NCBI chr 2:23,983,158...24,025,289
Ensembl chr 2:23,983,158...24,026,313
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Timp1
TIMP metallopeptidase inhibitor 1
increases expression
EXP
Milrinone results in increased expression of TIMP1 mRNA
CTD
PMID:22936366
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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Tnf
tumor necrosis factor
multiple interactions
ISO
Milrinone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD
PMID:8937731
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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