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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:felbamate
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Accession:CHEBI:4995 term browser browse the term
Definition:The bis(carbamate ester) of 2-phenylpropane-1,3-diol. An anticonvulsant, it is used in the treatment of epilepsy.
Synonyms:exact_synonym: 2-phenylpropane-1,3-diyl dicarbamate
 related_synonym: 2-phenyl-1,3-propanediol dicarbamate;   Carbamic acid 3-carbamoyloxy-2-phenyl-propyl ester;   Formula=C11H14N2O4;   InChI=1S/C11H14N2O4/c12-10(14)16-6-9(7-17-11(13)15)8-4-2-1-3-5-8/h1-5,9H,6-7H2,(H2,12,14)(H2,13,15);   InChIKey=WKGXYQFOCVYPAC-UHFFFAOYSA-N;   SMILES=NC(=O)OCC(COC(N)=O)c1ccccc1;   carbamic acid 2-phenyltrimethylene ester;   felbamato;   felbamatum
 alt_id: CHEBI:250451
 xref: CAS:25451-15-4;   DrugBank:DB00949;   Drug_Central:1140;   KEGG:C07501;   KEGG:D00536;   LINCS:LSM-4232
 xref_mesh: MESH:C047360
 xref: PMID:12825948;   PMID:12873507;   PMID:18311896;   Patent:US2884444;   Patent:US4978680;   Reaxys:3345236;   Wikipedia:Felbamate


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felbamate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC3 ATP binding cassette subfamily C member 3 increases expression ISO felbamate results in increased expression of ABCC3 mRNA CTD PMID:17381134 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253 		JBrowse link
G AKR7A3 aldo-keto reductase family 7 member A3 increases expression ISO felbamate results in increased expression of AKR7A3 mRNA CTD PMID:17381134 NCBI chr 1:19,274,229...19,288,770
Ensembl chr 1:19,282,573...19,288,770 		JBrowse link
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 increases expression ISO felbamate results in increased expression of ALDH1A1 mRNA CTD PMID:17381134 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442 		JBrowse link
G CES1 carboxylesterase 1 increases metabolic processing EXP CES1 protein alternative form results in increased metabolism of Felbamate CTD PMID:35786679 NCBI chr16:55,802,851...55,833,096
Ensembl chr16:55,802,851...55,833,337 		JBrowse link
G CP ceruloplasmin decreases expression ISO felbamate results in decreased expression of CP mRNA CTD PMID:17381134 NCBI chr 3:149,162,414...149,221,829
Ensembl chr 3:149,162,410...149,221,829 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases expression ISO felbamate results in increased expression of CYP1A1 mRNA CTD PMID:17381134 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases expression ISO felbamate results in decreased expression of CYP1A2 mRNA CTD PMID:17381134 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 increases metabolic processing EXP CYP2C8 protein results in increased metabolism of Felbamate CTD PMID:35786679 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497 		JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 increases metabolic processing EXP CYP2C9 protein results in increased metabolism of Felbamate CTD PMID:35786679 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases expression
increases metabolic processing		 ISO
EXP		 felbamate results in decreased expression of CYP2E1 mRNA
CYP2E1 protein results in increased metabolism of Felbamate		 CTD PMID:17381134 PMID:35786679 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions EXP felbamate affects the reaction [[CYP3A4 protein results in increased metabolism of Carbamazepine] which results in increased chemical synthesis of carbamazepine epoxide] CTD PMID:12606595 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G CYP4A22 cytochrome P450 family 4 subfamily A member 22 decreases expression ISO felbamate results in decreased expression of CYP4A1 mRNA CTD PMID:17381134 NCBI chr 1:47,137,441...47,149,727
Ensembl chr 1:47,137,435...47,149,727 		JBrowse link
G DRD2 dopamine receptor D2 multiple interactions ISO felbamate inhibits the reaction [Haloperidol affects the activity of DRD2 protein] CTD PMID:7845605 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691 		JBrowse link
G ENPEP glutamyl aminopeptidase increases expression ISO felbamate results in increased expression of ENPEP mRNA CTD PMID:17381134 NCBI chr 4:110,476,155...110,565,285
Ensembl chr 4:110,365,733...110,565,285 		JBrowse link
G EPHX1 epoxide hydrolase 1 increases expression ISO felbamate results in increased expression of EPHX1 mRNA CTD PMID:17381134 NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,124...225,845,563 		JBrowse link
G EPHX2 epoxide hydrolase 2 decreases expression ISO felbamate results in decreased expression of EPHX2 mRNA CTD PMID:17381134 NCBI chr 8:27,491,143...27,548,626
Ensembl chr 8:27,490,781...27,545,564 		JBrowse link
G F10 coagulation factor X decreases expression ISO felbamate results in decreased expression of F10 mRNA CTD PMID:17381134 NCBI chr13:113,122,799...113,149,529
Ensembl chr13:113,122,799...113,149,529 		JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 decreases expression ISO Felbamate results in decreased expression of G6PC1 mRNA CTD PMID:17381134 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438 		JBrowse link
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 multiple interactions EXP felbamate results in decreased activity of [GABRA1 protein binds to GABRB1 protein]; felbamate results in decreased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr 5:161,847,191...161,899,971
Ensembl chr 5:161,847,063...161,899,981 		JBrowse link
G GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 multiple interactions EXP felbamate results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr 4:46,243,548...46,390,300
Ensembl chr 4:46,243,548...46,475,230 		JBrowse link
G GABRA4 gamma-aminobutyric acid type A receptor subunit alpha4 multiple interactions EXP felbamate results in decreased activity of [GABRA4 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]; felbamate results in decreased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr 4:46,918,900...46,993,581
Ensembl chr 4:46,918,900...46,993,581 		JBrowse link
G GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions EXP felbamate results in decreased activity of [GABRA6 protein binds to GABRB1 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr 5:161,685,721...161,702,592
Ensembl chr 5:161,547,063...161,702,593 		JBrowse link
G GABRB1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions EXP Felbamate results in decreased activity of [GABRA1 protein binds to GABRB1 protein]; Felbamate results in decreased activity of [GABRA4 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]; Felbamate results in decreased activity of [GABRA6 protein binds to GABRB1 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr 4:46,993,647...47,426,447
Ensembl chr 4:46,993,723...47,426,447 		JBrowse link
G GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 multiple interactions EXP felbamate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr 5:161,288,436...161,548,404
Ensembl chr 5:161,288,429...161,549,044 		JBrowse link
G GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 multiple interactions EXP felbamate results in decreased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; felbamate results in decreased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr15:26,543,552...26,773,763
Ensembl chr15:26,543,552...26,939,539 		JBrowse link
G GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 multiple interactions EXP felbamate results in decreased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; felbamate results in decreased activity of [GABRA4 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]; felbamate results in decreased activity of [GABRA4 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; felbamate results in decreased activity of [GABRA6 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; felbamate results in increased activity of [GABRA2 protein binds to GABRB3 protein binds to GABRG2 protein alternative form] CTD PMID:17056029 NCBI chr 5:162,067,465...162,155,539
Ensembl chr 5:162,000,057...162,162,977 		JBrowse link
G GLUL glutamate-ammonia ligase decreases activity ISO felbamate results in decreased activity of GLUL protein CTD PMID:10323596 NCBI chr 1:182,378,098...182,391,790
Ensembl chr 1:182,378,098...182,392,206 		JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions
affects binding		 ISO felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2A protein]; felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2B protein]; felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2C protein]
GRIN1 protein binds to felbamate		 CTD PMID:10690753 PMID:18311896 NCBI chr 9:137,139,154...137,168,756
Ensembl chr 9:137,138,346...137,168,756 		JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A multiple interactions ISO felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2A protein] CTD PMID:10690753 NCBI chr16:9,753,404...10,182,908
Ensembl chr16:9,753,404...10,182,928 		JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
affects binding		 ISO felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2B protein]
GRIN2B protein binds to felbamate		 CTD PMID:10690753 PMID:18311896 NCBI chr12:13,537,337...13,982,134
Ensembl chr12:13,437,942...13,982,002 		JBrowse link
G GRIN2C glutamate ionotropic receptor NMDA type subunit 2C multiple interactions ISO felbamate results in decreased activity of [GRIN1 protein alternative form binds to GRIN2C protein] CTD PMID:10690753 NCBI chr17:74,842,023...74,861,532
Ensembl chr17:74,842,023...74,861,504 		JBrowse link
G GRN granulin precursor decreases expression ISO felbamate results in decreased expression of GRN mRNA CTD PMID:17381134 NCBI chr17:44,345,302...44,353,106
Ensembl chr17:44,345,246...44,353,106 		JBrowse link
G GSTA2 glutathione S-transferase alpha 2 increases expression ISO felbamate results in increased expression of GSTA2 mRNA CTD PMID:17381134 NCBI chr 6:52,750,087...52,763,475
Ensembl chr 6:52,750,087...52,763,475 		JBrowse link
G GSTM1 glutathione S-transferase mu 1 increases expression ISO felbamate results in increased expression of GSTM1 mRNA CTD PMID:17381134 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039 		JBrowse link
G GSTM2 glutathione S-transferase mu 2 increases expression ISO felbamate results in increased expression of GSTM2 mRNA CTD PMID:17381134 NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551 		JBrowse link
G HMOX1 heme oxygenase 1 increases expression ISO felbamate results in increased expression of HMOX1 mRNA CTD PMID:17381134 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 decreases expression
increases expression		 ISO felbamate results in decreased expression of HSP90AA1 mRNA
felbamate results in increased expression of HSP90AA1 mRNA		 CTD PMID:17381134 NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,742...102,139,699 		JBrowse link
G IGF1 insulin like growth factor 1 decreases expression ISO felbamate results in decreased expression of IGF1 mRNA CTD PMID:17381134 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G KYAT1 kynurenine aminotransferase 1 increases activity ISO felbamate results in increased activity of KYAT1 protein CTD PMID:16765940 NCBI chr 9:128,832,942...128,882,523
Ensembl chr 9:128,832,942...128,882,494
Ensembl chr 9:128,832,942...128,882,494 		JBrowse link
G MBL1P mannose binding lectin 1, pseudogene decreases expression ISO felbamate results in decreased expression of MBL1 mRNA CTD PMID:17381134 NCBI chr10:79,920,178...79,923,119
Ensembl chr10:79,920,327...79,923,032
Ensembl chr10:79,920,327...79,923,032 		JBrowse link
G ME1 malic enzyme 1 increases expression ISO felbamate results in increased expression of ME1 mRNA CTD PMID:17381134 NCBI chr 6:83,210,402...83,431,051
Ensembl chr 6:83,210,402...83,431,051 		JBrowse link
G NCL nucleolin decreases expression ISO felbamate results in decreased expression of NCL mRNA CTD PMID:17381134 NCBI chr 2:231,453,531...231,464,484
Ensembl chr 2:231,453,531...231,483,641 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression ISO felbamate results in increased expression of NQO1 mRNA CTD PMID:17381134 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668 		JBrowse link
G PGRMC1 progesterone receptor membrane component 1 increases expression ISO felbamate results in increased expression of PGRMC1 mRNA CTD PMID:17381134 NCBI chr  X:119,236,285...119,244,466
Ensembl chr  X:119,236,245...119,244,466 		JBrowse link
G SLC22A7 solute carrier family 22 member 7 decreases expression ISO felbamate results in decreased expression of SLC22A7 mRNA CTD PMID:17381134 NCBI chr 6:43,295,714...43,305,538
Ensembl chr 6:43,295,694...43,305,538 		JBrowse link
G ST13 ST13 Hsp70 interacting protein increases expression ISO felbamate results in increased expression of ST13 mRNA CTD PMID:17381134 NCBI chr22:40,824,535...40,856,639
Ensembl chr22:40,824,535...40,856,639 		JBrowse link
G SULT1A1 sulfotransferase family 1A member 1 decreases expression ISO felbamate results in decreased expression of SULT1A1 mRNA CTD PMID:17381134 NCBI chr16:28,605,258...28,623,375
Ensembl chr16:28,605,196...28,610,044 		JBrowse link
G TKT transketolase increases expression ISO felbamate results in increased expression of TKT mRNA CTD PMID:17381134 NCBI chr 3:53,224,712...53,256,022
Ensembl chr 3:53,224,712...53,256,052 		JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression ISO felbamate results in increased expression of TXNRD1 mRNA CTD PMID:17381134 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307 		JBrowse link
G UGDH UDP-glucose 6-dehydrogenase decreases expression
increases expression		 ISO felbamate results in decreased expression of UGDH mRNA
felbamate results in increased expression of UGDH mRNA		 CTD PMID:17381134 NCBI chr 4:39,498,755...39,527,439
Ensembl chr 4:39,498,755...39,528,311 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO felbamate results in increased expression of UGT1A1 mRNA CTD PMID:17381134 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 increases expression ISO Felbamate results in increased expression of UGT1A6 mRNA CTD PMID:17381134 NCBI chr 2:233,691,702...233,773,300
Ensembl chr 2:233,691,607...233,773,300 		JBrowse link
G UGT2B17 UDP glucuronosyltransferase family 2 member B17 increases expression ISO felbamate results in increased expression of UGT2B1 mRNA CTD PMID:17381134 NCBI chr 4:68,537,173...68,576,322
Ensembl chr 4:68,537,173...68,576,413 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 26089
    role 26005
      application 25223
        pharmaceutical 24588
          drug 24585
            protective agent 20761
              neuroprotective agent 17684
                felbamate 53
Path 2
Term Annotations click to browse term
  CHEBI ontology 26089
    subatomic particle 26064
      composite particle 26064
        hadron 26064
          baryon 26064
            nucleon 26016
              atomic nucleus 26064
                atom 26064
                  main group element atom 25891
                    p-block element atom 25891
                      carbon group element atom 25478
                        carbon atom 25437
                          organic molecular entity 25437
                            heteroorganic entity 24805
                              organochalcogen compound 24413
                                organooxygen compound 24093
                                  carbon oxoacid 22778
                                    carbamic acid 19662
                                      carbamate ester 7987
                                        felbamate 53
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