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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diprotium oxide
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Accession:CHEBI:29375 term browser browse the term
Definition:A water that has formula H2O.
Synonyms:related_synonym: ((1)H2)water;   Formula=[1H]2O;   InChI=1S/H2O/h1H2/i/hH2;   InChIKey=XLYOFNOQVPJJNP-YOGHCVPTSA-N;   SMILES=[1H]O[1H]
 xref: CAS:7732-18-5
 xref_mesh: MESH:D014867


show annotations for term's descendants           Sort by:
diprotium oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agrp agouti related neuropeptide multiple interactions ISO [Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of AGRP mRNA; AM 251 promotes the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of AGRP mRNA] CTD PMID:26468265 NCBI chr 8:106,293,327...106,306,477
Ensembl chr 8:106,293,330...106,364,025 		JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions EXP [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of AKT1 mRNA CTD PMID:29335169 NCBI chr12:112,620,260...112,641,266
Ensembl chr12:112,620,255...112,641,318 		JBrowse link
G Aqp1 aquaporin 1 increases transport
multiple interactions		 ISO
EXP		 AQP1 protein results in increased transport of Water
Mercuric Chloride inhibits the reaction [AQP1 protein results in increased transport of Water]
Mercuric Chloride inhibits the reaction [AQP1 protein results in increased transport of Water]; Mercury inhibits the reaction [AQP1 protein results in increased transport of Water]		 CTD PMID:7528928 PMID:8457558 PMID:10559675 PMID:11035042 PMID:11078688 More... NCBI chr 6:55,313,284...55,325,540
Ensembl chr 6:55,313,417...55,325,540 		JBrowse link
G Aqp11 aquaporin 11 multiple interactions
increases transport		 EXP Mercaptoethanol inhibits the reaction [Mercuric Chloride inhibits the reaction [AQP11 protein results in increased transport of Water]]; Mercuric Chloride inhibits the reaction [AQP11 protein results in increased transport of Water] CTD PMID:21251984 NCBI chr 7:97,375,586...97,387,454
Ensembl chr 7:97,373,213...97,387,496 		JBrowse link
G Aqp2 aquaporin 2 increases expression ISO Water deficiency results in increased expression of AQP2 mRNA CTD PMID:15462210 NCBI chr15:99,476,937...99,482,426
Ensembl chr15:99,476,936...99,482,428 		JBrowse link
G Aqp3 aquaporin 3 multiple interactions
increases transport
increases expression		 ISO Dexamethasone promotes the reaction [AQP3 protein results in increased transport of Water]; Mercaptoethanol inhibits the reaction [Mercuric Chloride inhibits the reaction [AQP3 protein results in increased transport of Water]]; Mercuric Chloride inhibits the reaction [AQP3 protein results in increased transport of Water]; Mercuric Chloride inhibits the reaction [Dexamethasone promotes the reaction [AQP3 protein results in increased transport of Water]]
Copper Sulfate inhibits the reaction [AQP3 protein results in increased transport of Water]; Mercuric Chloride inhibits the reaction [AQP3 protein results in increased transport of Water]
Water deficiency results in increased expression of AQP3 mRNA; Water deficiency results in increased expression of AQP3 protein		 CTD PMID:9124401 PMID:9374739 PMID:15462210 PMID:22687538 NCBI chr 4:41,092,724...41,098,183
Ensembl chr 4:41,092,722...41,098,183 		JBrowse link
G Aqp4 aquaporin 4 increases transport
affects transport
increases expression
increases response to substance		 ISO
EXP		 AQP4 protein results in increased transport of Water
AQP4 protein affects the transport of Water
Water deficiency results in increased expression of AQP4 mRNA
AQP4 protein results in increased susceptibility to Water		 CTD PMID:7528931 PMID:15462210 PMID:20815926 PMID:21251984 NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039 		JBrowse link
G Aqp7 aquaporin 7 affects transport
increases transport		 ISO AQP7 protein affects the transport of Water
AQP7 protein results in increased transport of Water		 CTD PMID:9252401 PMID:18059526 NCBI chr 4:41,033,074...41,048,237
Ensembl chr 4:41,033,074...41,048,139 		JBrowse link
G Aqp8 aquaporin 8 multiple interactions
affects transport
increases transport		 ISO Copper affects the reaction [AQP8 protein affects the transport of Water]; Mercury affects the reaction [AQP8 protein affects the transport of Water]
Mercuric Chloride inhibits the reaction [AQP8 protein results in increased transport of Water]		 CTD PMID:18059526 PMID:19840149 NCBI chr 7:123,061,517...123,067,226
Ensembl chr 7:123,061,514...123,067,227 		JBrowse link
G Aqp9 aquaporin 9 multiple interactions
affects transport
increases transport		 ISO CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]; lonidamine inhibits the reaction [CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]]; Mercuric Chloride inhibits the reaction [AQP9 protein results in increased transport of Water]; Mercury inhibits the reaction [AQP9 protein results in increased transport of Water]; Phloretin inhibits the reaction [AQP9 protein results in increased transport of Water]; Phloretin inhibits the reaction [CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]] CTD PMID:9514918 PMID:9733774 PMID:10205677 PMID:12606488 PMID:21259319 More... NCBI chr 9:71,017,941...71,075,170
Ensembl chr 9:71,017,941...71,075,964 		JBrowse link
G Avp arginine vasopressin multiple interactions ISO [Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of AVP mRNA; [Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased secretion of AVP protein; AM 251 promotes the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of AVP mRNA]; arachidonyl-2-chloroethylamide inhibits the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of AVP mRNA] CTD PMID:26468265 NCBI chr 2:130,422,540...130,424,508
Ensembl chr 2:130,422,540...130,424,474 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions EXP [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of BCL2 mRNA CTD PMID:29335169 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Becn1 beclin 1, autophagy related multiple interactions EXP [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of BECN1 protein; Berberine promotes the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of BECN1 protein] CTD PMID:38705399 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 multiple interactions EXP [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of BNIP3 protein; Berberine promotes the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of BNIP3 protein] CTD PMID:38705399 NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248 		JBrowse link
G Cartpt CART prepropeptide multiple interactions ISO [AM 251 co-treated with Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of CARTPT mRNA; [arachidonyl-2-chloroethylamide co-treated with Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of CARTPT mRNA CTD PMID:26468265 NCBI chr13:100,034,991...100,037,191
Ensembl chr13:100,034,997...100,037,599 		JBrowse link
G Casp1 caspase 1 multiple interactions EXP [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which affects the expression of CASP1 mRNA; [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of and results in increased cleavage of CASP1 protein; [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of CASP1 mRNA; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of and results in increased cleavage of CASP1 protein]; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of CASP1 mRNA] CTD PMID:29335169 PMID:38705399 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Water deficiency co-treated with Diclofenac] results in increased expression of CASP3 protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of CASP3 protein] CTD PMID:31042592 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cat catalase multiple interactions ISO
EXP		 [Water deficiency co-treated with Diclofenac] results in decreased activity of CAT protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in decreased activity of CAT protein]
[[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of CAT mRNA		 CTD PMID:29335169 PMID:31042592 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP		 [Water deficiency co-treated with Diclofenac] results in increased expression of CCL2 protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of CCL2 protein]
[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of CCL2 mRNA; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of CCL2 mRNA]		 CTD PMID:31042592 PMID:38705399 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Cftr cystic fibrosis transmembrane conductance regulator multiple interactions ISO 1-Methyl-3-isobutylxanthine promotes the reaction [CFTR protein affects the transport of Water]; CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]; lonidamine inhibits the reaction [CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [CFTR protein affects the transport of Water]; Phloretin inhibits the reaction [CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]] CTD PMID:12606488 NCBI chr 6:18,170,686...18,322,769
Ensembl chr 6:18,170,686...18,322,767 		JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions ISO [Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of CNR1 mRNA; [Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of CNR1 protein CTD PMID:26468265 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831 		JBrowse link
G Col3a1 collagen, type III, alpha 1 multiple interactions ISO [Water deficiency co-treated with Diclofenac] results in increased expression of COL3A1 protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of COL3A1 protein] CTD PMID:31042592 NCBI chr 1:45,350,698...45,388,866
Ensembl chr 1:45,350,698...45,388,866 		JBrowse link
G Cr1l complement C3b/C4b receptor 1 like multiple interactions ISO [Water deficiency co-treated with Diclofenac] results in decreased expression of CR1L protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in decreased expression of CR1L protein] CTD PMID:31042592 NCBI chr 1:194,781,019...194,813,878
Ensembl chr 1:194,779,690...194,813,894 		JBrowse link
G Crh corticotropin releasing hormone multiple interactions ISO [AM 251 co-treated with Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of CRH mRNA CTD PMID:26468265 NCBI chr 3:19,747,565...19,749,560
Ensembl chr 3:19,747,565...19,749,560 		JBrowse link
G Cst3 cystatin C multiple interactions EXP [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of CST3 protein; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of CST3 protein] CTD PMID:38705399 NCBI chr 2:148,713,642...148,717,432
Ensembl chr 2:148,713,642...148,717,612 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in decreased expression of CYP1A1 mRNA CTD PMID:29335169 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in decreased expression of CYP2E1 mRNA CTD PMID:29335169 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Edn1 endothelin 1 affects export EXP EDN1 protein affects the export of Water CTD PMID:16340664 NCBI chr13:42,454,952...42,461,466
Ensembl chr13:42,454,952...42,461,466 		JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO Water results in increased expression of FGF2 mRNA CTD PMID:26800359 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions EXP [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of GCLC mRNA CTD PMID:29335169 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of GPX1 mRNA CTD PMID:29335169 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Gsr glutathione reductase multiple interactions EXP [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of GSR mRNA CTD PMID:29335169 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor decreases expression ISO Water results in decreased expression of HBEGF mRNA CTD PMID:26800359 NCBI chr18:36,637,980...36,648,858
Ensembl chr18:36,637,980...36,648,858 		JBrowse link
G Hcrt hypocretin multiple interactions ISO [Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of HCRT mRNA; AM 251 inhibits the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of HCRT mRNA] CTD PMID:26468265 NCBI chr11:100,652,519...100,653,757
Ensembl chr11:100,651,895...100,653,757 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of HMGB1 protein; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of HMGB1 protein] CTD PMID:38705399 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO
EXP		 Water deficiency results in increased expression of HMOX1 protein
[[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of HMOX1 mRNA		 CTD PMID:22060896 PMID:29335169 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hpgds hematopoietic prostaglandin D synthase multiple interactions ISO Water affects the reaction [Isoquinolines analog binds to and results in decreased activity of HPGDS protein] CTD PMID:22546671 NCBI chr 6:65,094,019...65,121,960
Ensembl chr 6:65,094,277...65,121,892 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Gum Arabic co-treated with Water deficiency co-treated with Diclofenac] results in increased expression of IL10 protein CTD PMID:31042592 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 [Water deficiency co-treated with Diclofenac] results in increased expression of IL1B protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of IL1B protein]
[[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of IL1B mRNA; [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL1B mRNA; [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL1B protein; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL1B mRNA]; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL1B protein]		 CTD PMID:29335169 PMID:31042592 PMID:38705399 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL6 mRNA; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of IL6 mRNA] CTD PMID:38705399 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Mt2 metallothionein 2 multiple interactions EXP [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which affects the expression of MT2 mRNA CTD PMID:29335169 NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions EXP [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of NFE2L2 mRNA CTD PMID:29335169 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of NLRP3 mRNA; [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of NLRP3 protein; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of NLRP3 mRNA]; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of NLRP3 protein] CTD PMID:38705399 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of NOS2 mRNA CTD PMID:29335169 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Npy neuropeptide Y multiple interactions ISO [AM 251 co-treated with Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of NPY mRNA CTD PMID:26468265 NCBI chr 6:49,799,690...49,806,487
Ensembl chr 6:49,799,690...49,806,487 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions EXP [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of NQO1 mRNA CTD PMID:29335169 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Oxt oxytocin multiple interactions ISO [Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of OXT mRNA; [Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased secretion of OXT protein; AM 251 promotes the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of OXT mRNA]; arachidonyl-2-chloroethylamide inhibits the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of OXT mRNA]; arachidonyl-2-chloroethylamide inhibits the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased secretion of OXT protein] CTD PMID:26468265 NCBI chr 2:130,416,432...130,418,974
Ensembl chr 2:130,418,093...130,418,974 		JBrowse link
G Pmch pro-melanin-concentrating hormone multiple interactions ISO [Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of PMCH mRNA; arachidonyl-2-chloroethylamide promotes the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of PMCH mRNA] CTD PMID:26468265 NCBI chr10:87,926,934...87,928,236
Ensembl chr10:87,926,934...87,928,237 		JBrowse link
G Pomc pro-opiomelanocortin-alpha multiple interactions ISO [Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of POMC mRNA; AM 251 promotes the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of POMC mRNA]; arachidonyl-2-chloroethylamide inhibits the reaction [[Water deficiency co-treated with Sodium Chloride, Dietary deficiency] results in increased expression of POMC mRNA] CTD PMID:26468265 NCBI chr12:4,004,945...4,010,643
Ensembl chr12:4,004,951...4,010,642 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions EXP [Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of PYCARD mRNA; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of PYCARD mRNA] CTD PMID:38705399 NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039 		JBrowse link
G Slc12a1 solute carrier family 12, member 1 multiple interactions
increases import		 ISO [Glucose results in increased activity of SLC12A1 protein] which results in increased import of Water; [Mannitol results in increased activity of SLC12A1 protein] which results in increased import of Water
SLC12A1 protein results in increased import of Water		 CTD PMID:12433675 NCBI chr 2:124,994,430...125,071,922
Ensembl chr 2:124,994,425...125,071,922 		JBrowse link
G Slc5a3 solute carrier family 5 (inositol transporters), member 3 increases expression EXP Water deficiency results in increased expression of SLC5A3 mRNA CTD PMID:21219332 NCBI chr16:91,855,210...91,884,361
Ensembl chr16:91,855,210...91,884,361 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions EXP [[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of SOD1 mRNA CTD PMID:29335169 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial increases expression
multiple interactions		 EXP Water deficiency results in increased expression of SOD2 protein
[[Particulate Matter co-treated with Water] results in increased abundance of Metals] which results in increased expression of SOD2 mRNA		 CTD PMID:22718889 PMID:29335169 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP [Berberine co-treated with Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of SQSTM1 protein CTD PMID:38705399 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Tac1 tachykinin 1 multiple interactions ISO TAC1 protein alternative form inhibits the reaction [Cholera Toxin results in increased secretion of Water]; TAC1 protein inhibits the reaction [Cholera Toxin results in increased secretion of Water] CTD PMID:11040190 NCBI chr 6:7,555,061...7,562,978
Ensembl chr 6:7,554,879...7,565,834 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 [Water deficiency co-treated with Diclofenac] results in increased expression of TNF protein; Gum Arabic inhibits the reaction [[Water deficiency co-treated with Diclofenac] results in increased expression of TNF protein]
[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of TNF mRNA; Berberine inhibits the reaction [[Water deficiency co-treated with NG-Nitroarginine Methyl Ester co-treated with Indomethacin co-treated with Iohexol] results in increased expression of TNF mRNA]		 CTD PMID:31042592 PMID:38705399 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22205
    role 22190
      chemical role 21439
        greenhouse gas 13198
          water 762
            diprotium oxide 57
Path 2
Term Annotations click to browse term
  CHEBI ontology 22205
    subatomic particle 22197
      composite particle 22197
        hadron 22197
          baryon 22197
            nucleon 22169
              atomic nucleus 22197
                atom 22197
                  main group element atom 22131
                    main group molecular entity 22131
                      s-block molecular entity 21729
                        hydrogen molecular entity 21646
                          hydrides 20783
                            inorganic hydride 18707
                              chalcogen hydride 2625
                                oxygen hydride 812
                                  water 762
                                    diprotium oxide 57
paths to the root