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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:dibenzofuran
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Accession:CHEBI:28145 term browser browse the term
Definition:A mancude organic heterotricyclic parent that consists of a furan ring flanked by two benzene rings ortho-fused across the 2,3- and 4,5-positions.
Synonyms:exact_synonym: dibenzo[b,d]furan
 related_synonym: DBF;   Diphenylene oxide;   Formula=C12H8O;   InChI=1S/C12H8O/c1-3-7-11-9(5-1)10-6-2-4-8-12(10)13-11/h1-8H;   InChIKey=TXCDCPKCNAJMEE-UHFFFAOYSA-N;   SMILES=c1ccc2c(c1)oc1ccccc21
 alt_id: CHEBI:23680;   CHEBI:4499
 xref: Beilstein:121100;   CAS:132-64-9;   Gmelin:67825;   KEGG:C07729
 xref_mesh: MESH:C023614
 xref: PMID:12009135;   PMID:20686914;   PMID:21554085;   Reaxys:121100;   UM-BBD_compID:c0039;   Wikipedia:Dibenzofuran


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dibenzofuran term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ackr3 atypical chemokine receptor 3 increases expression EXP dibenzofuran analog results in increased expression of ACKR3 mRNA CTD PMID:20566336 NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237 		JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide increases expression EXP dibenzofuran analog results in increased expression of ADH7 mRNA CTD PMID:20566336 NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects localization
increases activity		 EXP
ISO		 AHR protein promotes the reaction [dibenzofuran analog results in increased expression of CDKN1A mRNA]; AHR protein promotes the reaction [dibenzofuran analog results in increased expression of CDKN1B mRNA]; AHR protein promotes the reaction [dibenzofuran analog results in increased expression of GSTA2 mRNA]; AHR protein promotes the reaction [dibenzofuran analog results in increased expression of PLA2G2A mRNA]; AHR protein promotes the reaction [dibenzofuran analog results in increased expression of PTGS2 mRNA]; dibenzofuran binds to and results in increased activity of AHR protein
dibenzofuran analog affects the localization of AHR protein
dibenzofuran analog results in increased activity of AHR protein		 CTD PMID:20566336 PMID:21431309 PMID:28186253 PMID:28669845 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression EXP dibenzofuran analog results in increased expression of AHRR mRNA CTD PMID:20566336 NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 increases expression EXP dibenzofuran analog results in increased expression of ALDH3A1 mRNA CTD PMID:20566336 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681 		JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 increases expression EXP dibenzofuran analog results in increased expression of ALDH3A2 mRNA CTD PMID:20566336 NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281 		JBrowse link
G Aurkb aurora kinase B decreases expression EXP dibenzofuran analog results in decreased expression of AURKB mRNA CTD PMID:20566336 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837 		JBrowse link
G Bard1 BRCA1 associated RING domain 1 decreases expression EXP dibenzofuran analog results in decreased expression of BARD1 mRNA CTD PMID:20566336 NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265 		JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression EXP dibenzofuran analog results in decreased expression of BRCA1 mRNA CTD PMID:20566336 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304 		JBrowse link
G Brca2 BRCA2, DNA repair associated decreases expression EXP dibenzofuran analog results in decreased expression of BRCA2 mRNA CTD PMID:20566336 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression EXP dibenzofuran analog results in increased expression of CCL20 mRNA CTD PMID:20566336 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629 		JBrowse link
G Ccna2 cyclin A2 decreases expression EXP dibenzofuran analog results in decreased expression of CCNA2 mRNA CTD PMID:20566336 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 decreases expression EXP dibenzofuran analog results in decreased expression of CCNB1 mRNA CTD PMID:20566336 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions		 EXP dibenzofuran analog results in increased expression of CDKN1A mRNA
AHR protein promotes the reaction [dibenzofuran analog results in increased expression of CDKN1A mRNA]		 CTD PMID:20566336 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions		 EXP dibenzofuran analog results in increased expression of CDKN1B mRNA; dibenzofuran analog results in increased expression of CDKN1B protein
AHR protein promotes the reaction [dibenzofuran analog results in increased expression of CDKN1B mRNA]		 CTD PMID:20566336 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions EXP dibenzofuran analog inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR1 protein] CTD PMID:21880487 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Cnr2 cannabinoid receptor 2 multiple interactions ISO dibenzofuran analog inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol binds to CNR2 protein] CTD PMID:21880487 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548 		JBrowse link
G Cox4i2 cytochrome c oxidase subunit 4i2 decreases expression EXP dibenzofuran analog results in decreased expression of COX4I2 mRNA CTD PMID:20566336 NCBI chr 3:141,228,443...141,239,337
Ensembl chr 3:141,228,443...141,239,331 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 EXP 2,2',4,4',5-brominated diphenyl ether inhibits the reaction [dibenzofuran analog results in increased expression of CYP1A1 mRNA]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [dibenzofuran analog results in increased expression of CYP1A1 mRNA]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [dibenzofuran analog results in increased expression of CYP1A1 protein]
dibenzofuran analog results in increased expression of CYP1A1 mRNA; dibenzofuran analog results in increased expression of CYP1A1 protein		 CTD PMID:20566336 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
multiple interactions		 ISO dibenzofuran results in increased activity of CYP1A2 protein
[acenaphthylene co-treated with acenaphthene co-treated with dibenzofuran co-treated with fluorene co-treated with phenanthrene co-treated with anthracene] results in increased expression of CYP1A2 mRNA
dibenzofuran metabolite results in increased activity of CYP1A2 protein		 CTD PMID:7750161 PMID:8001243 PMID:26032510 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 increases expression EXP dibenzofuran analog results in increased expression of CYP2F4 mRNA CTD PMID:20566336 NCBI chr 1:82,416,107...82,429,897
Ensembl chr 1:82,416,130...82,429,896 		JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 increases expression EXP dibenzofuran analog results in increased expression of ENTPD1 mRNA CTD PMID:20566336 NCBI chr 1:239,425,515...239,552,323
Ensembl chr 1:239,425,430...239,552,317 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions
increases expression		 EXP AHR protein promotes the reaction [dibenzofuran analog results in increased expression of GSTA2 mRNA] CTD PMID:20566336 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP dibenzofuran analog results in increased expression of JUN mRNA CTD PMID:20566336 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta affects localization
increases expression		 ISO dibenzofuran affects the localization of MAP1LC3B protein
dibenzofuran results in increased expression of MAP1LC3B protein modified form		 CTD PMID:22173198 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Nptxr neuronal pentraxin receptor increases expression EXP dibenzofuran analog results in increased expression of NPTXR mRNA CTD PMID:20566336 NCBI chr 7:111,336,660...111,354,737
Ensembl chr 7:111,336,664...111,354,802 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP dibenzofuran analog results in increased expression of NQO1 mRNA CTD PMID:20566336 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression EXP dibenzofuran analog results in increased expression of NR1D2 mRNA CTD PMID:20566336 NCBI chr15:7,524,257...7,550,553
Ensembl chr15:7,524,257...7,550,553 		JBrowse link
G Pla2g2a phospholipase A2 group IIA multiple interactions
increases expression		 EXP AHR protein promotes the reaction [dibenzofuran analog results in increased expression of PLA2G2A mRNA] CTD PMID:20566336 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014 		JBrowse link
G Ptges prostaglandin E synthase increases expression EXP dibenzofuran analog results in increased expression of PTGES mRNA CTD PMID:20566336 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 EXP dibenzofuran analog results in increased expression of PTGS2 mRNA
AHR protein promotes the reaction [dibenzofuran analog results in increased expression of PTGS2 mRNA]		 CTD PMID:20566336 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rad51 RAD51 recombinase decreases expression EXP dibenzofuran analog results in decreased expression of RAD51 mRNA CTD PMID:20566336 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Rbp4 retinol binding protein 4 increases expression EXP dibenzofuran analog results in increased expression of RBP4 mRNA CTD PMID:20566336 NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399 		JBrowse link
G Serpine1 serpin family E member 1 increases expression EXP dibenzofuran analog results in increased expression of SERPINE1 mRNA CTD PMID:20566336 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sim2 SIM bHLH transcription factor 2 increases expression EXP dibenzofuran analog results in increased expression of SIM2 mRNA CTD PMID:20566336 NCBI chr11:33,414,218...33,453,663
Ensembl chr11:33,414,218...33,453,663 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO dibenzofuran results in decreased expression of SQSTM1 protein CTD PMID:22173198 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression EXP dibenzofuran analog results in increased expression of TIPARP mRNA CTD PMID:20566336 NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327 		JBrowse link
G Tmem150a transmembrane protein 150A increases expression EXP dibenzofuran analog results in increased expression of TMEM150A mRNA CTD PMID:20566336 NCBI chr 4:104,410,271...104,414,630
Ensembl chr 4:104,410,516...104,429,349 		JBrowse link
G Top2a DNA topoisomerase II alpha decreases expression EXP dibenzofuran analog results in decreased expression of TOP2A mRNA CTD PMID:20566336 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19844
    role 19820
      biological role 19818
        xenobiotic 18736
          dibenzofuran 39
            2,8-dihydroxy-3,4,7-trimethoxydibenzofuran 0
            3-hydroxy-2,8-dichlorodibenzofuran 0
            7-hydroxy-1,2,3,6,8-pentachlorodibenzofuran 0
            7-hydroxy-3,4-dichlorodibenzofuran 0
            8-chloro-2,7-dibenzofurandiol 0
            8-hydroxy-3-chlorodibenzofuran 0
            9-hydroxy-2,6-dichlorodibenzofuran 0
            9-hydroxy-3,4-dichlorodibenzofuran 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19844
    subatomic particle 19842
      composite particle 19842
        hadron 19842
          baryon 19842
            nucleon 19809
              atomic nucleus 19842
                atom 19842
                  main group element atom 19792
                    p-block element atom 19792
                      carbon group element atom 19738
                        carbon atom 19734
                          organic molecular entity 19734
                            organic molecule 19687
                              organic cyclic compound 19498
                                organic heterocyclic compound 18870
                                  organic heteropolycyclic compound 18300
                                    organic heterotricyclic compound 15657
                                      mancude organic heterotricyclic parent 375
                                        dibenzofuran 39
                                          2,8-dihydroxy-3,4,7-trimethoxydibenzofuran 0
                                          3-hydroxy-2,8-dichlorodibenzofuran 0
                                          7-hydroxy-1,2,3,6,8-pentachlorodibenzofuran 0
                                          7-hydroxy-3,4-dichlorodibenzofuran 0
                                          8-chloro-2,7-dibenzofurandiol 0
                                          8-hydroxy-3-chlorodibenzofuran 0
                                          9-hydroxy-2,6-dichlorodibenzofuran 0
                                          9-hydroxy-3,4-dichlorodibenzofuran 0
paths to the root