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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:clenbuterol
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Accession:CHEBI:174690 term browser browse the term
Definition:A substituted aniline that is 2,6-dichloroaniline in which the hydrogen at position 4 has been replaced by a 2-(tert-butylamino)-1-hydroxyethyl group.
Synonyms:exact_synonym: 1-(4-amino-3,5-dichlorophenyl)-2-(tert-butylamino)ethanol
 related_synonym: 1-(4-Amino-3,5-dichloro-phenyl)-2-tert-butylamino-ethanol;   4-amino-3,5-dichloro-alpha-(((1,1-dimethylethyl)amino)methyl)benzenemethanol;   4-amino-alpha-((tert-butylamino)methyl)-3,5-dichlorobenzyl alcohol;   Formula=C12H18Cl2N2O;   InChI=1S/C12H18Cl2N2O/c1-12(2,3)16-6-10(17)7-4-8(13)11(15)9(14)5-7/h4-5,10,16-17H,6,15H2,1-3H3;   InChIKey=STJMRWALKKWQGH-UHFFFAOYSA-N;   SMILES=CC(C)(C)NCC(O)c1cc(Cl)c(N)c(Cl)c1;   clenbuterolum
 xref: Beilstein:1076467;   CAS:37148-27-9;   DrugBank:DB01407;   Drug_Central:673;   KEGG:D07713;   LINCS:LSM-5144
 xref_mesh: MESH:D002976
 xref: PMID:22071161;   PMID:22241580;   PMID:22341861;   PMID:22447758;   PMID:22505058;   Patent:US3536712;   Reaxys:1076467;   VSDB:1884
 cyclic_relationship: is_conjugate_base_of CHEBI:61153


show annotations for term's descendants           Sort by:
clenbuterol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadm acyl-CoA dehydrogenase medium chain increases expression ISO Clenbuterol results in increased expression of ACADM mRNA CTD PMID:17446185 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions
increases activity		 ISO
EXP		 [Clenbuterol binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Glucose; ICI 118551 inhibits the reaction [[Clenbuterol binds to and results in increased activity of ADRB2 protein] which results in decreased uptake of Glucose]
Clenbuterol results in increased activity of ADRB2 protein		 CTD PMID:16007677 PMID:18552870 PMID:34601065 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Adrb3 adrenoceptor beta 3 multiple interactions EXP Clenbuterol binds to and results in increased activity of ADRB3 protein CTD PMID:7815362 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT1 protein] CTD PMID:16339297 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions EXP Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT2 protein] CTD PMID:16339297 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 multiple interactions EXP Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of AKT3 protein] CTD PMID:16339297 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP Clenbuterol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A1 protein]; Propranolol inhibits the reaction [Clenbuterol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A1 protein]] CTD PMID:15710352 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP Clenbuterol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein]; Propranolol inhibits the reaction [Clenbuterol inhibits the reaction [Lipopolysaccharides results in decreased activity of CYP1A2 protein]] CTD PMID:15710352 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Esrra estrogen related receptor, alpha increases expression ISO Clenbuterol results in increased expression of ESRRA mRNA CTD PMID:17446185 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268 		JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions EXP Clenbuterol inhibits the reaction [3-acetylpyridine results in increased expression of GAD1 mRNA]; Clenbuterol inhibits the reaction [Reserpine results in increased expression of GAD1 mRNA]; Propranolol inhibits the reaction [Clenbuterol inhibits the reaction [3-acetylpyridine results in increased expression of GAD1 mRNA]] CTD PMID:8774452 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Il10 interleukin 10 multiple interactions
affects expression		 ISO
EXP		 Clenbuterol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL10 protein]
Clenbuterol affects the expression of IL10 protein		 CTD PMID:15021963 PMID:15502056 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il18 interleukin 18 increases expression ISO Clenbuterol results in increased expression of IL18 mRNA; Clenbuterol results in increased expression of IL18 protein CTD PMID:15178407 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Clenbuterol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein] CTD PMID:15021963 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Clenbuterol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:15021963 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Clenbuterol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased degradation of NFKBIA protein] CTD PMID:15502056 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
increases activity
increases stability		 ISO Alprenolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein]; Metoprolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein]; Propranolol inhibits the reaction [Clenbuterol results in increased activity of ODC1 protein]
Clenbuterol results in increased stability of ODC1 protein		 CTD PMID:10353628 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440 		JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO Clenbuterol results in increased expression of PDK4 mRNA CTD PMID:17446185 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression
multiple interactions		 ISO
EXP		 Clenbuterol results in increased expression of PPARGC1A mRNA
Propranolol inhibits the reaction [Clenbuterol results in increased expression of PPARGC1A mRNA]		 CTD PMID:17446185 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP Clenbuterol inhibits the reaction [Oxidopamine results in decreased phosphorylation of PRKACA protein] CTD PMID:16339297 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Clenbuterol affects the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:15710352 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Clenbuterol results in increased expression of TFAM mRNA CTD PMID:17446185 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Clenbuterol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Clenbuterol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:15021963 PMID:15710352 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ucp1 uncoupling protein 1 increases expression ISO Clenbuterol results in increased expression of UCP1 protein CTD PMID:10465291 NCBI chr19:24,808,782...24,816,853
Ensembl chr19:24,808,783...24,816,852 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        pharmaceutical 19468
          drug 19468
            bronchodilator agent 3811
              clenbuterol 23
                (R)-clenbuterol 0
                (S)-clenbuterol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    main group molecular entity 19756
                      s-block molecular entity 19595
                        hydrogen molecular entity 19582
                          hydrides 19095
                            inorganic hydride 18093
                              pnictogen hydride 18082
                                nitrogen hydride 17989
                                  azane 17798
                                    ammonia 17797
                                      organic amino compound 17797
                                        aromatic amine 15400
                                          anilines 14398
                                            substituted aniline 14039
                                              clenbuterol 23
                                                (R)-clenbuterol 0
                                                (S)-clenbuterol 0
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