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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:7,8-dihydroxycoumarin
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Accession:CHEBI:17313 term browser browse the term
Definition:A hydroxycoumarin that has formula C9H6O4.
Synonyms:exact_synonym: 7,8-dihydroxy-2H-chromen-2-one
 related_synonym: 7,8-Dihydroxy-2H-1-benzopyran-2-one;   Daphnetin;   Daphnetol;   Formula=C9H6O4;   InChI=1S/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12H;   InChIKey=ATEFPOUAMCWAQS-UHFFFAOYSA-N;   SMILES=C12=C(C=CC(=C1O)O)C=CC(O2)=O
 alt_id: CHEBI:12246;   CHEBI:20770;   CHEBI:2252
 xref: CAS:486-35-1;   KEGG:C03093;   KNApSAcK:C00002462;   LINCS:LSM-3366
 xref_mesh: MESH:C039952


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7,8-dihydroxycoumarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions EXP daphnetin inhibits the reaction [Benzene results in decreased expression of ALB protein] CTD PMID:33749080 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; daphnetin inhibits the reaction [sodium arsenite results in increased expression of BAX protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]
daphnetin inhibits the reaction [Dextran Sulfate results in increased expression of BAX protein]		 CTD PMID:30738023 PMID:37209277 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; daphnetin inhibits the reaction [sodium arsenite results in decreased expression of BCL2 protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]
daphnetin inhibits the reaction [Dextran Sulfate results in decreased expression of BCL2 protein]		 CTD PMID:30738023 PMID:37209277 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO daphnetin inhibits the reaction [Dextran Sulfate results in increased cleavage of CASP3 protein]
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]		 CTD PMID:37209277 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP daphnetin inhibits the reaction [Benzene results in increased expression of CYP2E1 mRNA] CTD PMID:33749080 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO daphnetin results in increased expression of GCLC protein CTD PMID:30738023 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO daphnetin results in increased expression of GCLM protein CTD PMID:30738023 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP daphnetin inhibits the reaction [Benzene results in increased expression of GPT protein] CTD PMID:33749080 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO daphnetin results in increased expression of HMOX1 protein
[sodium arsenite co-treated with daphnetin] results in increased expression of HMOX1 protein; NFE2L2 protein affects the reaction [daphnetin results in increased expression of HMOX1 protein]		 CTD PMID:30738023 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO		 daphnetin inhibits the reaction [Benzene results in increased expression of IL1B protein]
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]
daphnetin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]		 CTD PMID:33749080 PMID:37209277 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions EXP daphnetin inhibits the reaction [Benzene results in increased expression of IL2 protein] CTD PMID:33749080 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO		 daphnetin inhibits the reaction [Benzene results in increased expression of IL6 protein]
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]
daphnetin inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]		 CTD PMID:33749080 PMID:37209277 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK2 protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK2 protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK2 protein]] CTD PMID:37209277 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression ISO daphnetin results in decreased expression of KEAP1 protein CTD PMID:30738023 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO daphnetin results in increased phosphorylation of MAPK1 protein CTD PMID:30738023 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO daphnetin results in increased phosphorylation of MAPK3 protein CTD PMID:30738023 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO [sodium arsenite co-treated with daphnetin] results in increased expression of NFE2L2 protein; daphnetin results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [daphnetin results in increased expression of HMOX1 protein] CTD PMID:30738023 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO daphnetin results in increased expression of NQO1 protein CTD PMID:30738023 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Ocln occludin multiple interactions ISO daphnetin inhibits the reaction [Dextran Sulfate results in decreased expression of OCLN protein] CTD PMID:37209277 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Reg3b regenerating family member 3 beta multiple interactions ISO daphnetin inhibits the reaction [Lipopolysaccharides results in increased expression of REG3A protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK2 protein]]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]] CTD PMID:37209277 NCBI chr 4:110,861,775...110,865,015
Ensembl chr 4:110,861,775...110,865,015 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 multiple interactions EXP daphnetin inhibits the reaction [Benzene results in increased expression of S1PR1 mRNA] CTD PMID:33749080 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]] CTD PMID:37209277 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO daphnetin inhibits the reaction [Dextran Sulfate results in decreased expression of TJP1 protein] CTD PMID:37209277 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 daphnetin inhibits the reaction [Benzene results in increased expression of TNF protein]
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]
daphnetin inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]		 CTD PMID:33749080 PMID:37209277 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      molecular entity 19806
        polyatomic entity 19764
          molecule 19670
            cyclic compound 19486
              aromatic compound 19336
                organic aromatic compound 19336
                  phenylpropanoid 11275
                    coumarins 4140
                      hydroxycoumarin 353
                        7,8-dihydroxycoumarin 24
                          7-hydroxy-8-methoxycoumarin 0
                          daphnin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  oxacycle 17866
                                    benzopyran 11952
                                      1-benzopyran 11704
                                        chromenes 4418
                                          chromenone 4371
                                            coumarins 4140
                                              hydroxycoumarin 353
                                                7,8-dihydroxycoumarin 24
                                                  7-hydroxy-8-methoxycoumarin 0
                                                  daphnin 0
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