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Msh members

There are five highly conserved Msh members (Msh2-Msh6) but only Msh2, Msh3 and Msh6 have been shown to be involved in mismatch repair. Evidence for Msh4 and Msh5 in MMR is lacking but they are believed to be involved in meiotic recombination. Mammals have two MutS activities: the alpha activity is represented by a Msh2-Msh6 heterodimer while beta is represented by a Msh2-Msh3 heterodimer. Msh members involved in MMR are listed with aliases in parentheses, full names and links to gene report pages:

Msh2 – mutS homolog 2
Msh3 – mutS homolog 3
Msh6 – mutS homolog 6

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.