Mir320 (microRNA 320) - Rat Genome Database

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Gene: Mir320 (microRNA 320) Mus musculus
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Symbol: Mir320
Name: microRNA 320
RGD ID: 1608214
MGI Page MGI
Description: Acts upstream of or within several processes, including cellular response to glucose stimulus; long-term synaptic potentiation; and positive regulation of stem cell proliferation. Part of RISC complex. Is expressed in several structures, including appendicular skeleton; gonad; hemolymphoid system gland; liver; and sensory organ. Human ortholog(s) of this gene implicated in multiple myeloma. Orthologous to human MIR320A (microRNA 320a).
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-320; Mirn; Mirn320; mmu-mir-3; mmu-mir-320
RGD Orthologs
Human
Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,680,950 - 70,681,031 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1470,680,950 - 70,681,031 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381470,443,510 - 70,443,591 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1470,443,510 - 70,443,591 (+)Ensemblmm10GRCm38
MGSCv371470,843,317 - 70,843,398 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera1467,984,999 - 67,985,080 (+)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.32NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. MiR-320a contributes to atherogenesis by augmenting multiple risk factors and down-regulating SRF. Chen C, etal., J Cell Mol Med. 2015 May;19(5):970-85. doi: 10.1111/jcmm.12483. Epub 2015 Feb 27.
2. Micro RNA-320 as a novel potential biomarker in renal ischemia reperfusion. Güçlü A, etal., Ren Fail. 2016 Oct;38(9):1468-1475. doi: 10.1080/0886022X.2016.1227915. Epub 2016 Oct 19.
3. Inhibition of micro-ribonucleic acid-320 attenuates neurologic injuries after spinal cord ischemia. He F, etal., J Thorac Cardiovasc Surg. 2015 Aug;150(2):398-406. doi: 10.1016/j.jtcvs.2015.03.066. Epub 2015 May 14.
4. Knockdown of lncRNA MALAT1 attenuates acute myocardial infarction through miR-320-Pten axis. Hu H, etal., Biomed Pharmacother. 2018 Oct;106:738-746. doi: 10.1016/j.biopha.2018.06.122. Epub 2018 Jul 11.
5. Luteolin confers renoprotection against ischemia-reperfusion injury via involving Nrf2 pathway and regulating miR320. Kalbolandi SM, etal., Mol Biol Rep. 2019 Aug;46(4):4039-4047. doi: 10.1007/s11033-019-04853-0. Epub 2019 May 14.
6. miR-320a regulates cell proliferation and apoptosis in multiple myeloma by targeting pre-B-cell leukemia transcription factor 3. Lu Y, etal., Biochem Biophys Res Commun. 2016 May 13;473(4):1315-1320. doi: 10.1016/j.bbrc.2016.04.069. Epub 2016 Apr 14.
7. Downregulation of circulating miR-320a and target gene prediction in patients with diabetic retinopathy. Prado MSG, etal., BMC Res Notes. 2020 Mar 16;13(1):155. doi: 10.1186/s13104-020-05001-9.
8. MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20. Ren XP, etal., Circulation. 2009 May 5;119(17):2357-2366. doi: 10.1161/CIRCULATIONAHA.108.814145. Epub 2009 Apr 20.
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. MiR-320a as a Potential Novel Circulating Biomarker of Arrhythmogenic CardioMyopathy. Sommariva E, etal., Sci Rep. 2017 Jul 6;7(1):4802. doi: 10.1038/s41598-017-05001-z.
11. The protective effect of microRNA-320 on left ventricular remodeling after myocardial ischemia-reperfusion injury in the rat model. Song CL, etal., Int J Mol Sci. 2014 Sep 29;15(10):17442-56. doi: 10.3390/ijms151017442.
12. Down-regulation of microRNA-320 suppresses cardiomyocyte apoptosis and protects against myocardial ischemia and reperfusion injury by targeting IGF-1. Song CL, etal., Oncotarget. 2016 Jun 28;7(26):39740-39757. doi: 10.18632/oncotarget.9240.
13. Correlation between microRNA-320 and postoperative delirium in patients undergoing tibial fracture internal fixation surgery. Wang B, etal., BMC Anesthesiol. 2022 Mar 22;22(1):75. doi: 10.1186/s12871-022-01612-w.
14. Down-regulation of miR-320 exerts protective effects on myocardial I-R injury via facilitating Nrf2 expression. Zhu XA, etal., Eur Rev Med Pharmacol Sci. 2019 Feb;23(4):1730-1741. doi: 10.26355/eurrev_201902_17135.
Additional References at PubMed
PMID:14573789   PMID:15634332   PMID:16381832   PMID:16766679   PMID:17369397   PMID:17597072   PMID:17604727   PMID:18452032   PMID:18923076   PMID:19473196   PMID:19559694   PMID:20215419  
PMID:20413612   PMID:20417623   PMID:21037258   PMID:21267068   PMID:21822254   PMID:22144232   PMID:22179046   PMID:22442487   PMID:22570807   PMID:22617447   PMID:22767230   PMID:22925886  
PMID:23185045   PMID:24828505   PMID:25732513   PMID:25858512   PMID:26438731   PMID:26753959   PMID:26774733   PMID:26837315   PMID:27626380   PMID:27721258   PMID:28338235   PMID:28696844  
PMID:29152656   PMID:29549732   PMID:29551500   PMID:30181740   PMID:30224451   PMID:30851060   PMID:31591913   PMID:31634961   PMID:31638474   PMID:32271402   PMID:32296071   PMID:32427900  
PMID:33186123   PMID:33597502   PMID:33760151   PMID:34551709   PMID:34623609   PMID:34927445   PMID:34933640   PMID:35054986   PMID:35587745   PMID:35786454   PMID:36099512   PMID:36113364  
PMID:38158679   PMID:38260139   PMID:40015214  


Genomics

Comparative Map Data
Mir320
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,680,950 - 70,681,031 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1470,680,950 - 70,681,031 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381470,443,510 - 70,443,591 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1470,443,510 - 70,443,591 (+)Ensemblmm10GRCm38
MGSCv371470,843,317 - 70,843,398 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
Celera1467,984,999 - 67,985,080 (+)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.32NCBI
MIR320A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38822,244,966 - 22,245,037 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl822,244,962 - 22,245,043 (-)Ensemblhg38GRCh38
GRCh37822,102,479 - 22,102,550 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36822,158,419 - 22,158,500 (-)NCBIBuild 36Build 36hg18NCBI36
Celera821,064,808 - 21,064,889 (-)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef820,644,669 - 20,644,750 (-)NCBIHuRef
CHM1_1822,304,138 - 22,304,219 (-)NCBICHM1_1
T2T-CHM13v2.0822,518,920 - 22,518,991 (-)NCBIT2T-CHM13v2.0
Mir320a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81551,926,088 - 51,926,169 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1551,926,088 - 51,926,169 (+)EnsemblGRCr8
mRatBN7.21545,516,392 - 45,516,473 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1545,516,392 - 45,516,473 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1549,634,254 - 49,634,335 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01550,745,751 - 50,745,832 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01547,605,058 - 47,605,139 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01552,134,276 - 52,134,357 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1552,134,276 - 52,134,357 (+)Ensemblrn6Rnor6.0
Rnor_5.01555,857,793 - 55,857,874 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1545,195,518 - 45,195,599 (+)NCBICelera
Cytogenetic Map15p11NCBI

Variants

.
Variants in Mir320
6 total Variants
miRNA Target Status (No longer updated)

Predicted Targets
Summary Value
Count of predictions:33850
Count of gene targets:12102
Count of transcripts:21069
Interacting mature miRNAs:mmu-miR-320-3p, mmu-miR-320-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357589Kdnw2_mkidney weight 2 (mouse)Not determined1420887473121269804Mouse
1301489Lbm10_mlean body mass 10 (mouse)Not determined145376129687761529Mouse
1301777Bglq15_mbody growth late QTL 15 (mouse)Not determined144296241676962593Mouse
1301424Skull21_mskull morphology 21 (mouse)Not determined144296241676962593Mouse
1357527Epfpq1_mepididymal fat percentage QTL 1 (mouse)Not determined142106245071885801Mouse
4142364Pbwg18_mpostnatal body weight growth 18 (mouse)Not determined145228198486282125Mouse
4141400Nilac8_mnicotine induced locomotor activity 8 (mouse)Not determined144306584777066045Mouse
10043889Cia52_mcollagen induced arthritis QTL 52 (mouse)Not determined145608238190082509Mouse
1301562Hwq1_mheart weight quantitative locus 1 (mouse)Not determined145654674590546941Mouse
1300666Fembm2_mfemoral bone morphometry 2 (mouse)Not determined146239746096397680Mouse
1357565wrmod1_mwobbler modifier 1 (mouse)Not determined1458179640101859473Mouse
27226774Tibl15_mtibia length 15, 10 week (mouse)143032195787937436Mouse
4142419Tgq26_mtriglyceride QTL 26 (mouse)Not determined4033731974337319Mouse
1300605El5_mepilepsy 5 (mouse)Not determined144945542583455556Mouse
11039527Ccc2_mcolitis susceptibility in the Collaborative Cross 2 (mouse)145991861294138217Mouse
1301091Bbaa21_mB.burgdorferi-associated arthritis 21 (mouse)Not determined144306584777066045Mouse
12880432Fgf23lq3_mFGF23 serum level QTL 3 (mouse)145393744087937440Mouse
1300805Mors3_mmodifier of obesity related sterility 3 (mouse)Not determined144303727077037418Mouse
10043887Cia50_mcollagen induced arthritis QTL 50 (mouse)Not determined143743018571430320Mouse
14747006Mancz12_mmandible centroid size 12 (mouse)1470071977104071977Mouse


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000083594
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1470,680,950 - 70,681,031 (+)Ensembl
GRCm38.p6 Ensembl1470,443,510 - 70,443,591 (+)Ensembl
RefSeq Acc Id: NR_029802
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391470,680,950 - 70,681,031 (+)NCBI
GRCm381470,443,510 - 70,443,591 (+)ENTREZGENE
MGSCv371470,843,317 - 70,843,398 (+)RGD
Celera1467,984,999 - 67,985,080 (+)RGD
cM Map14 ENTREZGENE
Sequence:
Promoters
RGD ID:8682910
Promoter ID:EPDNEW_M19486
Type:multiple initiation site
Name:Mir320_1
Description:Mus musculus microRNA 320 , microRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381470,443,525 - 70,443,585EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3619332 AgrOrtholog
Ensembl Genes ENSMUSG00000065528 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000083594 ENTREZGENE
MGD MGI:3619332 ENTREZGENE
miRBase MI0000704 ENTREZGENE
NCBI Gene 723838 ENTREZGENE
PhenoGen Mir320 PhenoGen
RNAcentral URS00003CF1AD RNACentral
  URS000042A57E RNACentral
  URS00006B1A8C RNACentral