RGD Reference Report - miR-320a regulates cell proliferation and apoptosis in multiple myeloma by targeting pre-B-cell leukemia transcription factor 3. - Rat Genome Database

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miR-320a regulates cell proliferation and apoptosis in multiple myeloma by targeting pre-B-cell leukemia transcription factor 3.

Authors: Lu, Yinghao  Wu, Depei  Wang, Jishi  Li, Yan  Chai, Xiao  Kang, Qian 
Citation: Lu Y, etal., Biochem Biophys Res Commun. 2016 May 13;473(4):1315-1320. doi: 10.1016/j.bbrc.2016.04.069. Epub 2016 Apr 14.
RGD ID: 155882577
Pubmed: PMID:27086852   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2016.04.069   (Journal Full-text)

Aberrant expression of microRNAs (miRNAs) is implicated in cancer development and progression. While miR-320a is reported to be deregulated in many malignancy types, its biological role in multiple myeloma (MM) remains unclear. Here, we observed reduced expression of miR-320a in MM samples and cell lines. Ectopic expression of miR-320a dramatically suppressed cell viability and clonogenicity and induced apoptosis in vitro. Mechanistic investigation led to the identification of Pre-B-cellleukemia transcription factor 3 (PBX3) as a novel and direct downstream target of miR-320a. Interestingly, reintroduction of PBX3 abrogated miR-320a-induced MM cell growth inhibition and apoptosis. In a mouse xenograft model, miR-320a overexpression inhibited tumorigenicity and promoted apoptosis. Our findings collectively indicate that miR-320a inhibits cell proliferation and induces apoptosis in MM cells by directly targeting PBX3, supporting its utility as a novel and potential therapeutic agent for miRNA-based MM therapy.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MIR320AHumanmultiple myeloma amelioratesIMP human gene in mouse modelRGD 
Mir320Mousemultiple myeloma amelioratesISOMIR320A (Homo sapiens)human gene in mouse modelRGD 
Mir320aRatmultiple myeloma amelioratesISOMIR320A (Homo sapiens)human gene in mouse modelRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mir320a  (microRNA 320a)

Genes (Mus musculus)
Mir320  (microRNA 320)

Genes (Homo sapiens)
MIR320A  (microRNA 320a)


Additional Information