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Gene: Eprs1 (glutamyl-prolyl-tRNA synthetase 1) Chinchilla lanigera

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Symbol:

Eprs1

Name:

glutamyl-prolyl-tRNA synthetase 1

RGD ID:

8889380

Description:

ENCODES a protein that exhibits glutamate-tRNA ligase activity (ortholog); GTPase binding (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to insulin stimulus (ortholog); cellular response to type II interferon (ortholog); glutamyl-tRNA aminoacylation (ortholog); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; ASSOCIATED WITH Developmental Disabilities (ortholog); genetic disease (ortholog); hypomyelinating leukodystrophy 15 (ortholog); FOUND IN aminoacyl-tRNA synthetase multienzyme complex (ortholog); cytoplasm (ortholog); cytosol (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

bifunctional glutamate/proline--tRNA ligase; Eprs; glutamyl-prolyl-tRNA synthetase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955520	3,550,558 - 3,606,697 (+)	Ensembl
ChiLan1.0	NW_004955520	3,550,558 - 3,606,015 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Developmental Disabilities (ISO)

genetic disease (ISO)

hypomyelinating leukodystrophy 15 (ISO)

intellectual disability (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to insulin stimulus (ISO)

cellular response to type II interferon (ISO)

glutamyl-tRNA aminoacylation (ISO)

negative regulation of translation (ISO)

prolyl-tRNA aminoacylation (ISO)

regulation of long-chain fatty acid import into cell (ISO)

Cellular Component

aminoacyl-tRNA synthetase multienzyme complex (ISO)

cytoplasm (ISO)

cytosol (ISO)

GAIT complex (ISO)

plasma membrane (ISO)

ribonucleoprotein complex (ISO)

Molecular Function

glutamate-tRNA ligase activity (ISO)

GTPase binding (ISO)

identical protein binding (ISO)

proline-tRNA ligase activity (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

RNA stem-loop binding (ISO)

zinc ion binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

AGAT deficiency pathway (ISO)

arginine and proline metabolic pathway (ISO)

guanidinoacetate methyltransferase deficiency pathway (ISO)

gyrate atrophy pathway (ISO)

hyperprolinemia type I pathway (ISO)

hyperprolinemia type II pathway (ISO)

ornithine translocase deficiency pathway (ISO)

prolidase deficiency pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Eprs1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955520	3,550,558 - 3,606,697 (+)	Ensembl
ChiLan1.0	NW_004955520	3,550,558 - 3,606,015 (+)	NCBI	ChiLan1.0	ChiLan1.0

EPRS1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	219,968,600 - 220,046,505 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	219,968,598 - 220,046,616 (-)	Ensembl			hg38	GRCh38
GRCh37	1	220,141,942 - 220,219,847 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	218,208,565 - 218,286,623 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	1	216,530,337 - 216,596,723	NCBI
Celera	1	193,361,173 - 193,439,298 (-)	NCBI		Celera
Cytogenetic Map	1	q41	NCBI
HuRef	1	190,816,669 - 190,894,723 (-)	NCBI		HuRef
CHM1_1	1	221,414,886 - 221,492,894 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	219,207,867 - 219,285,874 (-)	NCBI		T2T-CHM13v2.0

Eprs1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	185,093,614 - 185,160,557 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	185,095,241 - 185,160,557 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	1	185,361,417 - 185,428,360 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	185,363,044 - 185,428,360 (+)	Ensembl			mm10	GRCm38
MGSCv37	1	187,186,974 - 187,252,234 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	1	187,063,883 - 187,129,143 (+)	NCBI		MGSCv36	mm8
MGSCv36	1	186,479,177 - 186,544,604 (+)	NCBI		MGSCv36	mm8
Celera	1	192,317,193 - 192,381,950 (+)	NCBI		Celera
Cytogenetic Map	1	H5	NCBI
cM Map	1	89.5	NCBI

Eprs1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	99,431,955 - 99,503,510 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	13	99,433,130 - 99,503,509 (+)	Ensembl				GRCr8
mRatBN7.2	13	96,901,548 - 96,971,966 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	96,901,575 - 96,971,966 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	13	99,400,886 - 99,471,298 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	100,806,806 - 100,876,877 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	97,983,145 - 98,053,557 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	103,300,911 - 103,371,651 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	103,300,932 - 103,371,577 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	13	107,973,665 - 108,044,298 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	13	101,375,656 - 101,448,175 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	13	96,415,061 - 96,484,921 (+)	NCBI		Celera
RGSC_v3.1	13	101,564,698 - 101,637,217 (+)	NCBI
Cytogenetic Map	13	q26	NCBI

EPRS1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	29,367,592 - 29,448,533 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	29,329,946 - 29,411,197 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	195,537,319 - 195,618,257 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	200,575,257 - 200,655,958 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	200,575,259 - 200,656,197 (-)	Ensembl			panPan2	panpan1.1

EPRS1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	14,754,628 - 14,823,626 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	14,754,632 - 14,823,621 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	14,797,419 - 14,866,312 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	14,791,854 - 14,860,285 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	38	14,791,858 - 14,856,528 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	38	14,800,874 - 14,869,666 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	15,145,457 - 15,214,419 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	15,435,096 - 15,504,056 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Eprs1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	56,897,415 - 56,971,602 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936650	2,145,607 - 2,220,019 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936650	2,145,614 - 2,219,812 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EPRS1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	9,579,304 - 9,648,414 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	10	9,579,301 - 9,648,416 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	11,663,038 - 11,730,358 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EPRS1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	9,534,747 - 9,618,119 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	9,534,114 - 9,618,141 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666055	9,840,725 - 9,924,504 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Eprs1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624835	3,635,457 - 3,695,909 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624835	3,635,829 - 3,695,875 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Eprs1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	10	63,514,087 - 63,582,249 (+)	NCBI		Rrattus_CSIRO_v1

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005409277	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01068105	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AGCD01068106	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01046961	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000005528 ⟹ ENSCLAP00000005431

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955520	3,550,558 - 3,606,697 (+)	Ensembl

Ensembl Acc Id:

ENSCLAT00000005529 ⟹ ENSCLAP00000005432

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955520	3,550,677 - 3,606,697 (+)	Ensembl

RefSeq Acc Id:

XM_005409277 ⟹ XP_005409334

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955520	3,550,558 - 3,606,015 (+)	NCBI

Sequence:

show sequence

GGCCGCGGGGCGGGGCGAGGGCTGCGGCGACGGCGTCGGGACGGCGCACACGTTGCATCTCTGG
CTTGCGGCGCTGGGCGACGCGGCGGGCAGAGTGGGGAGACCAGCGGCCAGCGCGGATGGCGACG
CTCTGTCTCACGGTGAACGCGGGAGCCCCGCCCCTGGAAGCCTTGCTGGCGGCAGAGCATGTGA
AAGGAGATGTCAGCATTTCTGTGGAAGAAGGGAAGGAGAATGTTCTTCGTGTTTCTGACAATGT
GGTGTTCACGGACGTTAATTCCATACTTCGCTACCTGGCTAGAGTTGCAACTACAGCCGGGCTG
TATGGCGCTAACCTGATGGAACATGCCGAGATTGATCACTGGCTGGAGTTTAGTGCTACAAAAT
TGTCTTCCTGTGATTTGTTTACTTCTGCAATCAACGACCTTAATCATTGCCTGTCTCTGAGAAC
ATTCTTAGTTGGGAACTCCTTGACCTTAGCAGATTTTTGTGTCTGGGCCACCCTAAAAGGAAAT
GCTGCGTGGCTGGAAGAGTCAAAGCAAAGCAAAGGCCCGGTGCACGTGAAGCGCTGGTTCGGCT
TTCTCGAAGCCCAGCGGGTCTTCCAGTCAGTCAGTGCCAAGTGGGGCGTCGTGGCCAGCCAGGC
CAGGGGGGCACCTGAGAAGAAACAAGACGTGGGGAAGTTTGTGGAGCTTCCAGGCGCAGAGATG
GGCAAGGTCACCGTGAGGTTTCCCCCGGAGGCGAGTGGTTACTTACACATTGGGCATGCAAAGG
CTGCTCTCCTGAACCAGCACTACCAGGTTAACTTTAAAGGGAAACTGATCATGAGATTTGATGA
CACAAATCCTGAGAAAGAAAAGGAAGATTTTGAGAAGGTCATCTTGGAAGACGTTGCAATGTTA
CATATCAAACCAGATCAGTTTACTTATACCTCAGATCACTTTGAAACTATCATGAAATATGCAG
AGAAACTAATTAAAGAAGGGAAGGCCTATGTGGACGATACTCCTGCGGAACAGATGAAAGCAGA
ACGTGAACAGAGGGTGGAGTCCCGACATAGGAACAACTCTGTTGAGAAGAACCTACAGATGTGG
GAAGAAATGAAAAAAGGGAGCCAGTTCGGTCAGTCCTGTTGTTTGAGAGCAAAAATTGACATGA
GTAGTAACAACGGGTGTATGAGGGACCCCACCCTTTACCGCTGCAAAATTCAGCCGCACCCAAG
AACCAGGAGCAGATACAATGTTTACCCAACGTACGATTTTGCCTGCCCCATAGTTGACAGCATC
GAGGGTGTCACGCATGCCCTGAGAACCACGGAGTACCATGACCGAGACGAGCAGTTCTACTGGA
TTATTGAAGCTTTAGGCATAAGAAAGCCATATATCTGGGAATATAGTCGGCTGAATCTCAACAA
CACAGTGCTATCGAAGAGAAAACTCACGTGGTTTGTGGATGAAGGGCTGGTAGATGGCTGGGAC
GACCCGAGATTCCCCACGGTGCGCGGCGTGCTTCGGAGAGGGATGACGGTGGAGGGGCTGAAGC
AGTTCATTGCCGCCCAGGGCTCCTCACGTTCAGTGGTGAACATGGAATGGGACAAAATCTGGGC
ATTTAACAAAAAGGTCATCGACCCCGTGGCCCCAAGGTACGTGGCACTGCTGAAGAAGGAAGTG
ATCCCCGTGAACATTCCTGAGGCACAGGAGGAGATGAAGGAGGTGGCCAAACACCCGAAGAACC
CCGAGGTGGGCCTGAAGCCCGTGTGGTACGGCTCCAGGGTGCTCATCGAAGGGGCCGACGCGCA
GACGCTCGCAGAGGGGGAGATGGTGACCTTTATCAACTGGGGCAACATCAACATCACTAACATC
CACAAAAATGCAGATGGAAAAATTGTATCTCTTGATGGAAAATTGAATTTGGAGAATAAAGACT
ATAAGAAAACCACTAAGATCACTTGGCTGGCAGAGACCGCACGGGCTCTTCCTATCCCAGCCGT
CTGTGTCACTTACGAGCACTTGATCACAAAGCCGGTGCTGGGGAAGGACGAGGACTTCAAGCAG
TACGTCAACAAGAACAGCAAGCGTGAAGAACTGATGCTGGGGGATCCCTGCCTTAAGGACTTGA
AGAAAGGAGACATTATCCAGCTCCAGAGGAGAGGCTTCTTCATCTGTGACCAGCCGTACGAGCC
TGTTAGCCCATATAGTTGCAAGGAAGCCCCGTGCATTTTGATATATATTCCTGACGGACATACA
AAGGAAATGCCAACATCTGGGTCAAAGGAAAAGACCAAAGGAGAAGCCACAAAAACCGAGGTGA
TTCCTGCTCCTAAGGAAAGAGCAGCACCTCCTGTGAATAAATCTTGTGCTACGTCTGAGGCTTC
CCTCGTCCTTCACAACAGAGTGGCTGCCCAAGGGGACGTGGTGCGTGAATTGAAGGCCAGAAAG
GCAGCCAAGGACGATATAGACGCCGCGGTGAAGCAGCTTCTGGCTTTGAAAGCCGAATACAAAG
AGAAGACTGGCCAGGAATATAAACCTGGGAACCCTCCTGCCGCAGGGGCTCTGGGTGCTTCTTC
TCAGGTGCCAGCTGCTGCCAGCATTCAGGAAAGCAGGTCTCTGTACGACAGAGTCGCCGCACAG
GGGGAGCTGGTTCGAAAGCTGAAGGCTGAGAAGGCCCTTAAGGCTAAAATAAATGAAGCTGTTG
AGTGCTTACTGTCCCTGAAAGCTGAGTACAAAGAGAAAACCGGGAAGGACTATGTGCCCGGCCA
GCCACCGTCAGCAACCCTAGAGCCCCACCCGGCCAGCAACTATGCGCCTGCTGGCCCGGAAACC
CCGGAGGCCAGGGCACTGTACGACAGAGTGGCTGCTCAAGGAGAAGTGGTTCGAAAACTTAAAG
CTGAAAAAGCTTCTACGGATCAGGTGGACCCTGCCGTGCAAGCGCTGCTGGAGCTGAAGGCACA
GTACAAGGCCCTGGTGGGAGTGGAGTACAAGCCCGTGTCTGCCACCGGGGCTGAGGACAGAGGC
AAGAAGAAGAAAGAAAAGGAGAACAAATCTGAAAAGCAAAACAAGCCTCAGACACCAGACGACG
GCCATGGGAAGGACCCTGCTAAAAGCCAGGGGAGCGGGCTGGCGCCCAGCGGCGCAGGGGAGGG
GCAGGGCCCCAAGAAGCAGACGCGGTTGGGTCTTGAGGCAAGAAAAGAAGAAAATCTTGCTGAT
TGGTATTCTCAGGTCATCACGAAGTCCGAGATGATCGAGTACTACGATGTGAGCGGCTGCTACA
TCCTCCGGCCCTGGGCATACTCCATCTGGGAGTCCATCCAGGCCTTCTTCAACGCTGAGATCAA
GAAGCTGGGTGTCGAGAACTGCTACTTCCCCATCTTCGTGTCTCAGAGCGCGCTGGAGAAGGAG
AAGACGCACATTGCCGACTTTGCCCCTGAGGTGGCTTGGGTTACGAGGTCTGGGAAGACGGAGC
TGGCAGAGCCGATCGCCATCCGCCCCACCAGTGAGACAGTCATGTACCCCACGTATGCAAAGTG
GGTGCAGTCCCACAGAGACCTGCCCATCCGGCTCAACCAGTGGTGCAATGTGGTGCGCTGGGAG
TTCAAGCACCCGCAGCCTTTCCTGCGCACCCGGGAGTTCCTCTGGCAGGAGGGGCACAGTGCTT
TCGCCACCTTTGAGGAAGCAGCAGAAGAGGTCCTGCAGATCCTCGAGTTATACGCACGGGTGTA
CGAGGAGCTCCTGGCCATCCCTGTGGTCAAGGGCAGGAAGACGGAGAAGGAGAAGTTTGCGGGC
GGAGACTACACGACGACGGTGGAGGCCTTCATATCCGCCAGCGGCAGAGCCATCCAGGGAGCAA
CATCACATCATCTAGGCCAGAACTTTTCTAAAATGTGTGAAATCGTTTTTGAAGACCCCAAGAA
ACCAGGAGAGAAGCAGTTTGCTTACCAGTGCTCCTGGGGCCTGACCACGCGCACCATCGGCGTG
ATGATCATGGTGCACGGGGACAACATGGGCTTGGTCTTGCCGCCCCGGGTGGCCTCTGTCCAGG
TGGTGGTCATTCCTTGTGGCATCACGAACGCGCTGTCTGAGGAAGACAAGGAGGCCCTGATGGC
CAAGTGCAATGATTACCGCACGCGGCTGCTCAGTGCCAACATCCGCGCCCGTGTCGACTTGCGA
GATAACTATTCTCCAGGGTGGAAGTTCAATCACTGGGAGCTCAAGGGAGTTCCCATTCGACTTG
AAGTTGGGCCCCGCGACATGAAGAGCTGTCAGTTTGTCGCTGTCCGGCGGGACACTGGAGAAAA
GCTGACGGTGGCTGAGAGTGAGGCCGAGGCGAAACTGGAGGCTATGTTGGAAGAGATCCACGCT
AACCTCTTCCAAAGGGCTTCTGAAGACCTTAAGACCCACATGGTAGTGGCAGATACAATGGAAG
ACCTTCAGAAGACGCTTGACTCTGGGAAGATCGCACAGATCCCGTTCTGTGGGGAAATTGAGTG
CGAGGACTGGATCAAGAAGACCACCGCCAGGGACCAGGACCTGGAGCCTGGGGCCCCCTCCATG
GGCGCAAAGAGCCTCTGCATCCCCTTCCAGCCGCTGCGGGAGCTGCCGCCCGGGGCCGTGTGCG
TGTGCGGCAGGAGCCCCGCCAAGTTCTACACCCTGTTCGGCCGGAGCTACTGAGGACAGTGCGG
AGCTCTCCTTCCTCGCTTTTTAAAGAATCGACACCAATGTCTTCTCAGATACAGTTTTATGATT
TTTTTAAAAATAAAACTTGTAAAAGGAGGTCATGTGAGACAGCTCTTCTTACACCTGACTTCAC
GTTGGAGAAGACTTTCCTGTAAACTACCCGGCAATAAATACTATGAGTTAATACCGCT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005409334	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000005431
	ENSCLAP00000005431.1
	ENSCLAP00000005432.1

RefSeq Acc Id:

XP_005409334 ⟸ XM_005409277

- UniProtKB:

A0A8C2UT66 (UniProtKB/TrEMBL), A0A8C2UT40 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MATLCLTVNAGAPPLEALLAAEHVKGDVSISVEEGKENVLRVSDNVVFTDVNSILRYLARVATT
AGLYGANLMEHAEIDHWLEFSATKLSSCDLFTSAINDLNHCLSLRTFLVGNSLTLADFCVWATL
KGNAAWLEESKQSKGPVHVKRWFGFLEAQRVFQSVSAKWGVVASQARGAPEKKQDVGKFVELPG
AEMGKVTVRFPPEASGYLHIGHAKAALLNQHYQVNFKGKLIMRFDDTNPEKEKEDFEKVILEDV
AMLHIKPDQFTYTSDHFETIMKYAEKLIKEGKAYVDDTPAEQMKAEREQRVESRHRNNSVEKNL
QMWEEMKKGSQFGQSCCLRAKIDMSSNNGCMRDPTLYRCKIQPHPRTRSRYNVYPTYDFACPIV
DSIEGVTHALRTTEYHDRDEQFYWIIEALGIRKPYIWEYSRLNLNNTVLSKRKLTWFVDEGLVD
GWDDPRFPTVRGVLRRGMTVEGLKQFIAAQGSSRSVVNMEWDKIWAFNKKVIDPVAPRYVALLK
KEVIPVNIPEAQEEMKEVAKHPKNPEVGLKPVWYGSRVLIEGADAQTLAEGEMVTFINWGNINI
TNIHKNADGKIVSLDGKLNLENKDYKKTTKITWLAETARALPIPAVCVTYEHLITKPVLGKDED
FKQYVNKNSKREELMLGDPCLKDLKKGDIIQLQRRGFFICDQPYEPVSPYSCKEAPCILIYIPD
GHTKEMPTSGSKEKTKGEATKTEVIPAPKERAAPPVNKSCATSEASLVLHNRVAAQGDVVRELK
ARKAAKDDIDAAVKQLLALKAEYKEKTGQEYKPGNPPAAGALGASSQVPAAASIQESRSLYDRV
AAQGELVRKLKAEKALKAKINEAVECLLSLKAEYKEKTGKDYVPGQPPSATLEPHPASNYAPAG
PETPEARALYDRVAAQGEVVRKLKAEKASTDQVDPAVQALLELKAQYKALVGVEYKPVSATGAE
DRGKKKKEKENKSEKQNKPQTPDDGHGKDPAKSQGSGLAPSGAGEGQGPKKQTRLGLEARKEEN
LADWYSQVITKSEMIEYYDVSGCYILRPWAYSIWESIQAFFNAEIKKLGVENCYFPIFVSQSAL
EKEKTHIADFAPEVAWVTRSGKTELAEPIAIRPTSETVMYPTYAKWVQSHRDLPIRLNQWCNVV
RWEFKHPQPFLRTREFLWQEGHSAFATFEEAAEEVLQILELYARVYEELLAIPVVKGRKTEKEK
FAGGDYTTTVEAFISASGRAIQGATSHHLGQNFSKMCEIVFEDPKKPGEKQFAYQCSWGLTTRT
IGVMIMVHGDNMGLVLPPRVASVQVVVIPCGITNALSEEDKEALMAKCNDYRTRLLSANIRARV
DLRDNYSPGWKFNHWELKGVPIRLEVGPRDMKSCQFVAVRRDTGEKLTVAESEAEAKLEAMLEE
IHANLFQRASEDLKTHMVVADTMEDLQKTLDSGKIAQIPFCGEIECEDWIKKTTARDQDLEPGA
PSMGAKSLCIPFQPLRELPPGAVCVCGRSPAKFYTLFGRSY

hide sequence

Ensembl Acc Id:

ENSCLAP00000005432 ⟸ ENSCLAT00000005529

Ensembl Acc Id:

ENSCLAP00000005431 ⟸ ENSCLAT00000005528

Protein Domains

Aminoacyl-transfer RNA synthetases class-II family WHEP-TRS

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000003851	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000005528	ENTREZGENE
	ENSCLAT00000005528.1	UniProtKB/TrEMBL
	ENSCLAT00000005529.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1050.130	UniProtKB/TrEMBL
	3.30.110.30	UniProtKB/TrEMBL
	3.40.50.620	UniProtKB/TrEMBL
	3.40.50.800	UniProtKB/TrEMBL
	Bira Bifunctional Protein, Domain 2	UniProtKB/TrEMBL
	Glutamyl-trna Synthetase, Domain 2	UniProtKB/TrEMBL
	Glutamyl-tRNA Synthetase, Domain 3	UniProtKB/TrEMBL
	Ribosomal Protein L25, Chain P	UniProtKB/TrEMBL
	S15/NS1, RNA-binding	UniProtKB/TrEMBL
InterPro	aa-tRNA-synt_IIb	UniProtKB/TrEMBL
	aa-tRNA-synth_I_CS	UniProtKB/TrEMBL
	aa-tRNA-synth_II	UniProtKB/TrEMBL
	aa-tRNA-synth_II/BPL/LPL	UniProtKB/TrEMBL
	Anticodon-bd	UniProtKB/TrEMBL
	Anticodon-bd_dom_sf	UniProtKB/TrEMBL
	Glu-tRNA-synth_arc/euk	UniProtKB/TrEMBL
	Glu/Gln-tRNA-synth	UniProtKB/TrEMBL
	Glu/Gln-tRNA-synth_Ib_cat-dom	UniProtKB/TrEMBL
	Glu/Gln-tRNA-synth_Ib_codon-bd	UniProtKB/TrEMBL
	Glu_tRNA_lig_a-bdl	UniProtKB/TrEMBL
	Glutathione-S-Trfase_C_sf	UniProtKB/TrEMBL
	Pro-tRNA-ligase_IIa_arc-type	UniProtKB/TrEMBL
	Pro-tRNA_ligase_II_C	UniProtKB/TrEMBL
	Pro-tRNA_synth_II	UniProtKB/TrEMBL
	ProRS_core_arch_euk	UniProtKB/TrEMBL
	Rbsml_L25/Gln-tRNA_synth_N	UniProtKB/TrEMBL
	Ribosomal_L25/Gln-tRNA_synth	UniProtKB/TrEMBL
	Rossmann-like_a/b/a_fold	UniProtKB/TrEMBL
	S15_NS1_RNA-bd	UniProtKB/TrEMBL
	tRNA-synt_1c_C2	UniProtKB/TrEMBL
	WHEP-TRS_dom	UniProtKB/TrEMBL
NCBI Gene	Eprs	ENTREZGENE
PANTHER	BIFUNCTIONAL GLUTAMATE/PROLINE--TRNA LIGASE	UniProtKB/TrEMBL
	PTHR43382	UniProtKB/TrEMBL
Pfam	HGTP_anticodon	UniProtKB/TrEMBL
	ProRS-C_1	UniProtKB/TrEMBL
	tRNA-synt_1c	UniProtKB/TrEMBL
	tRNA-synt_1c_C	UniProtKB/TrEMBL
	tRNA-synt_1c_C2	UniProtKB/TrEMBL
	tRNA-synt_2b	UniProtKB/TrEMBL
	WHEP-TRS	UniProtKB/TrEMBL
PRINTS	TRNASYNTHGLU	UniProtKB/TrEMBL
PROSITE	AA_TRNA_LIGASE_I	UniProtKB/TrEMBL
	AA_TRNA_LIGASE_II	UniProtKB/TrEMBL
	WHEP_TRS_1	UniProtKB/TrEMBL
	WHEP_TRS_2	UniProtKB/TrEMBL
SMART	ProRS-C_1	UniProtKB/TrEMBL
	WHEP-TRS	UniProtKB/TrEMBL
Superfamily-SCOP	Class II aaRS ABD-related	UniProtKB/TrEMBL
	Nucleotidylyl transferase	UniProtKB/TrEMBL
	SSF47060	UniProtKB/TrEMBL
	SSF47616	UniProtKB/TrEMBL
	SSF50715	UniProtKB/TrEMBL
	SSF55681	UniProtKB/TrEMBL
	SSF64586	UniProtKB/TrEMBL
UniProt	A0A8C2UT40	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2UT66	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-08-20	Eprs1	glutamyl-prolyl-tRNA synthetase 1	Eprs	glutamyl-prolyl-tRNA synthetase	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB