Get1 (guided entry of tail-anchored proteins factor 1) - Rat Genome Database

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Gene: Get1 (guided entry of tail-anchored proteins factor 1) Rattus norvegicus
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Symbol: Get1
Name: guided entry of tail-anchored proteins factor 1
RGD ID: 735104
Description: Predicted to enable protein-membrane adaptor activity. Involved in tail-anchored membrane protein insertion into ER membrane. Part of GET complex. Orthologous to human GET1 (guided entry of tail-anchored proteins factor 1); INTERACTS WITH 1-naphthyl isothiocyanate; 4,4'-diaminodiphenylmethane; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: tail-anchored protein insertion receptor WRB; tryptophan rich basic protein; tryptophan-rich basic protein; tryptophan-rich protein; Wrb
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81148,915,298 - 48,929,235 (+)NCBIGRCr8
mRatBN7.21135,438,555 - 35,460,156 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1135,445,815 - 35,459,973 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1144,103,011 - 44,116,953 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01136,774,391 - 36,788,333 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01135,920,216 - 35,934,148 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01136,497,513 - 36,511,445 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1136,497,509 - 36,511,535 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01140,028,142 - 40,042,074 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,453,285 - 36,467,217 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11136,510,873 - 36,524,805 (+)NCBI
Celera1133,012,406 - 33,026,338 (-)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
6. Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells. Yamamoto Y and Sakisaka T, Mol Cell. 2012 Nov 9;48(3):387-97. doi: 10.1016/j.molcel.2012.08.028. Epub 2012 Oct 4.
Additional References at PubMed
PMID:15489334   PMID:27458190  


Genomics

Comparative Map Data
Get1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81148,915,298 - 48,929,235 (+)NCBIGRCr8
mRatBN7.21135,438,555 - 35,460,156 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1135,445,815 - 35,459,973 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1144,103,011 - 44,116,953 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01136,774,391 - 36,788,333 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01135,920,216 - 35,934,148 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01136,497,513 - 36,511,445 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1136,497,509 - 36,511,535 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01140,028,142 - 40,042,074 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,453,285 - 36,467,217 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11136,510,873 - 36,524,805 (+)NCBI
Celera1133,012,406 - 33,026,338 (-)NCBICelera
Cytogenetic Map11q11NCBI
GET1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382139,380,326 - 39,428,528 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2139,377,698 - 39,428,528 (+)EnsemblGRCh38hg38GRCh38
GRCh372140,752,252 - 40,800,454 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362139,674,140 - 39,691,496 (+)NCBINCBI36Build 36hg18NCBI36
Build 342139,674,139 - 39,691,486NCBI
Celera2125,949,901 - 25,967,508 (+)NCBICelera
Cytogenetic Map21q22.2NCBI
HuRef2126,220,985 - 26,238,560 (+)NCBIHuRef
CHM1_12140,313,371 - 40,330,979 (+)NCBICHM1_1
T2T-CHM13v2.02137,764,912 - 37,813,128 (+)NCBIT2T-CHM13v2.0
Get1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391695,946,600 - 95,959,052 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1695,946,607 - 95,959,052 (+)EnsemblGRCm39 Ensembl
GRCm381696,145,400 - 96,157,852 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1696,145,407 - 96,157,852 (+)EnsemblGRCm38mm10GRCm38
MGSCv371696,367,026 - 96,379,459 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361696,250,329 - 96,262,762 (+)NCBIMGSCv36mm8
Celera1697,220,073 - 97,232,510 (+)NCBICelera
Cytogenetic Map16C4NCBI
cM Map1656.84NCBI
Get1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540738,160,218 - 38,168,808 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540738,160,951 - 38,168,808 (+)NCBIChiLan1.0ChiLan1.0
GET1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22235,478,596 - 35,496,578 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12130,334,471 - 30,352,451 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02125,734,722 - 25,752,196 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12139,072,103 - 39,088,937 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2139,072,103 - 39,088,928 (+)Ensemblpanpan1.1panPan2
GET1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13134,282,650 - 34,299,916 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3133,396,185 - 33,433,643 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03133,630,745 - 33,667,483 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3133,650,809 - 33,674,732 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13133,502,811 - 33,539,864 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03133,508,008 - 33,544,636 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03133,998,996 - 34,035,703 (+)NCBIUU_Cfam_GSD_1.0
GET1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13202,962,664 - 202,979,902 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113202,962,652 - 202,978,390 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213213,126,901 - 213,142,261 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Get1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474524,627,526 - 24,635,159 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474524,625,206 - 24,635,129 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Get1
135 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:886
Count of miRNA genes:322
Interacting mature miRNAs:438
Transcripts:ENSRNOT00000002222
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat

Markers in Region
BI275060  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21135,459,417 - 35,459,567 (+)MAPPERmRatBN7.2
Rnor_6.01136,511,114 - 36,511,263NCBIRnor6.0
Rnor_5.01140,041,743 - 40,041,892UniSTSRnor5.0
RGSC_v3.41136,466,886 - 36,467,035UniSTSRGSC3.4
Celera1133,012,588 - 33,012,737UniSTS
RH 3.4 Map11265.0UniSTS
Cytogenetic Map11q11UniSTS
BI276795  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21135,459,461 - 35,459,618 (+)MAPPERmRatBN7.2
Rnor_6.01136,511,158 - 36,511,314NCBIRnor6.0
Rnor_5.01140,041,787 - 40,041,943UniSTSRnor5.0
RGSC_v3.41136,466,930 - 36,467,086UniSTSRGSC3.4
Celera1133,012,537 - 33,012,693UniSTS
RH 3.4 Map11262.7UniSTS
Cytogenetic Map11q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000002222   ⟹   ENSRNOP00000002222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1135,445,838 - 35,459,973 (+)Ensembl
Rnor_6.0 Ensembl1136,497,509 - 36,511,535 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095254   ⟹   ENSRNOP00000078941
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1135,445,815 - 35,457,937 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098902   ⟹   ENSRNOP00000079459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1135,445,884 - 35,459,733 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112143   ⟹   ENSRNOP00000089517
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1135,445,838 - 35,459,973 (+)Ensembl
RefSeq Acc Id: NM_199373   ⟹   NP_955405
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81148,915,298 - 48,929,230 (+)NCBI
mRatBN7.21135,445,815 - 35,459,749 (+)NCBI
Rnor_6.01136,497,513 - 36,511,445 (+)NCBI
Rnor_5.01140,028,142 - 40,042,074 (+)NCBI
RGSC_v3.41136,453,285 - 36,467,217 (+)RGD
Celera1133,012,406 - 33,026,338 (-)RGD
Sequence:
RefSeq Acc Id: XM_039088204   ⟹   XP_038944132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81148,915,451 - 48,929,235 (+)NCBI
mRatBN7.21135,445,847 - 35,460,156 (+)NCBI
RefSeq Acc Id: XM_039088205   ⟹   XP_038944133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81148,915,426 - 48,929,235 (+)NCBI
mRatBN7.21135,445,837 - 35,460,156 (+)NCBI
RefSeq Acc Id: XM_039088208   ⟹   XP_038944136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81148,919,931 - 48,929,235 (+)NCBI
mRatBN7.21135,449,901 - 35,460,156 (+)NCBI
RefSeq Acc Id: NP_955405   ⟸   NM_199373
- UniProtKB: Q6P6S5 (UniProtKB/Swiss-Prot),   A6KPR9 (UniProtKB/TrEMBL),   A6KPS0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002222   ⟸   ENSRNOT00000002222
RefSeq Acc Id: XP_038944133   ⟸   XM_039088205
- Peptide Label: isoform X1
- UniProtKB: A6KPS1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944132   ⟸   XM_039088204
- Peptide Label: isoform X1
- UniProtKB: A6KPS1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944136   ⟸   XM_039088208
- Peptide Label: isoform X1
- UniProtKB: A6KPS1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079459   ⟸   ENSRNOT00000098902
Ensembl Acc Id: ENSRNOP00000089517   ⟸   ENSRNOT00000112143
Ensembl Acc Id: ENSRNOP00000078941   ⟸   ENSRNOT00000095254

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P6S5-F1-model_v2 AlphaFold Q6P6S5 1-174 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698088
Promoter ID:EPDNEW_R8612
Type:initiation region
Name:Wrb_1
Description:tryptophan rich basic protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01136,497,505 - 36,497,565EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:735104 AgrOrtholog
BioCyc Gene G2FUF-21712 BioCyc
Ensembl Genes ENSRNOG00000001629 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055016718 UniProtKB/Swiss-Prot
  ENSRNOG00060020812 UniProtKB/Swiss-Prot
  ENSRNOG00065013811 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002222.6 UniProtKB/Swiss-Prot
  ENSRNOT00000095254.1 UniProtKB/TrEMBL
  ENSRNOT00000098902.1 UniProtKB/TrEMBL
  ENSRNOT00000112143.1 UniProtKB/TrEMBL
  ENSRNOT00055028429 UniProtKB/Swiss-Prot
  ENSRNOT00060036222 UniProtKB/Swiss-Prot
  ENSRNOT00065022736 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.660 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598163 IMAGE-MGC_LOAD
InterPro Get1 UniProtKB/TrEMBL
  Helix_hairpin_bin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WRB/Get1 UniProtKB/Swiss-Prot
KEGG Report rno:288233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72575 IMAGE-MGC_LOAD
NCBI Gene 288233 ENTREZGENE
PANTHER GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CHD5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Get1 PhenoGen
RatGTEx ENSRNOG00000001629 RatGTEx
  ENSRNOG00055016718 RatGTEx
  ENSRNOG00060020812 RatGTEx
  ENSRNOG00065013811 RatGTEx
UniProt A0A8I5ZLZ4_RAT UniProtKB/TrEMBL
  A0A8I5ZMV3_RAT UniProtKB/TrEMBL
  A0A8I6AAH3_RAT UniProtKB/TrEMBL
  A6KPR9 ENTREZGENE, UniProtKB/TrEMBL
  A6KPS0 ENTREZGENE, UniProtKB/TrEMBL
  A6KPS1 ENTREZGENE, UniProtKB/TrEMBL
  Q6P6S5 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-05 Get1  guided entry of tail-anchored proteins factor 1  Wrb  tryptophan rich basic protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Wrb  tryptophan rich basic protein      Symbol and Name status set to approved 1299863 APPROVED