Naa80 (N(alpha)-acetyltransferase 80, NatH catalytic subunit) - Rat Genome Database

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Gene: Naa80 (N(alpha)-acetyltransferase 80, NatH catalytic subunit) Rattus norvegicus
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Symbol: Naa80
Name: N(alpha)-acetyltransferase 80, NatH catalytic subunit
RGD ID: 6496422
Description: Predicted to enable acetyl-CoA binding activity and peptide alpha-N-acetyltransferase activity. Predicted to be involved in regulation of actin polymerization or depolymerization. Predicted to be located in cytosol. Orthologous to human NAA80 (N-alpha-acetyltransferase 80, NatH catalytic subunit); INTERACTS WITH aflatoxin B1; glyphosate; 1,2-dimethylhydrazine (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100910872; N-acetyltransferase 6; N-acetyltransferase 6 (GCN5-related); N-acetyltransferase 6-like; N-alpha-acetyltransferase 80; Nat6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,132,957 - 117,136,207 (+)NCBIGRCr8
mRatBN7.28108,254,314 - 108,257,564 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,253,302 - 108,257,563 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8113,881,134 - 113,884,384 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,080,291 - 112,083,541 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,923,073 - 109,926,323 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,336,441 - 116,339,691 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,336,441 - 116,339,690 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08115,692,701 - 115,695,951 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8107,560,892 - 107,564,142 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
cytosol  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10644992   PMID:12477932   PMID:29581253   PMID:29581307   PMID:30028079  


Genomics

Comparative Map Data
Naa80
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,132,957 - 117,136,207 (+)NCBIGRCr8
mRatBN7.28108,254,314 - 108,257,564 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,253,302 - 108,257,563 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8113,881,134 - 113,884,384 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,080,291 - 112,083,541 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,923,073 - 109,926,323 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,336,441 - 116,339,691 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,336,441 - 116,339,690 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08115,692,701 - 115,695,951 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8107,560,892 - 107,564,142 (+)NCBICelera
Cytogenetic Map8q32NCBI
NAA80
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38350,296,402 - 50,299,405 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl350,296,402 - 50,299,416 (-)EnsemblGRCh38hg38GRCh38
GRCh37350,333,833 - 50,336,836 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,308,837 - 50,311,716 (-)NCBINCBI36Build 36hg18NCBI36
Build 34350,308,837 - 50,311,716NCBI
Celera350,306,664 - 50,309,543 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef350,389,576 - 50,392,595 (-)NCBIHuRef
CHM1_1350,286,139 - 50,289,158 (-)NCBICHM1_1
T2T-CHM13v2.0350,325,758 - 50,328,761 (-)NCBIT2T-CHM13v2.0
Naa80
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,457,868 - 107,461,247 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9107,456,086 - 107,461,249 (+)EnsemblGRCm39 Ensembl
GRCm389107,580,669 - 107,584,048 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,578,887 - 107,584,050 (+)EnsemblGRCm38mm10GRCm38
MGSCv379107,482,501 - 107,486,379 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369107,438,269 - 107,442,149 (+)NCBIMGSCv36mm8
Celera9107,188,942 - 107,192,827 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map958.18NCBI
Naa80
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,110,133 - 2,110,744 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555322,109,595 - 2,112,013 (-)NCBIChiLan1.0ChiLan1.0
NAA80
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2250,279,455 - 50,282,405 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1350,284,230 - 50,287,180 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0350,225,000 - 50,228,015 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1351,459,748 - 51,462,764 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,459,748 - 51,462,764 (-)Ensemblpanpan1.1panPan2
NAA80
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,042,078 - 39,044,894 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2038,963,106 - 38,965,918 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02039,398,104 - 39,400,916 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12038,765,927 - 38,768,739 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02039,169,437 - 39,172,249 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02039,449,507 - 39,452,319 (+)NCBIUU_Cfam_GSD_1.0
Naa80
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560265,073,811 - 65,076,824 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365291,834,349 - 1,837,182 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365291,834,308 - 1,837,248 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HYAL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,793,572 - 32,794,700 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11332,793,784 - 32,794,650 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,972,319 - 35,973,185 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap13q21NCBI
NAA80
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_023666041155,299,070 - 155,302,419 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Naa80
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247304,157,714 - 4,159,927 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Naa80
6 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8102370617108923645Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat

Markers in Region
RH139126  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,254,313 - 108,254,497 (+)MAPPERmRatBN7.2
Rnor_6.08116,336,441 - 116,336,624NCBIRnor6.0
Rnor_5.08115,692,701 - 115,692,884UniSTSRnor5.0
RGSC_v3.48112,828,079 - 112,828,262UniSTSRGSC3.4
Celera8107,560,892 - 107,561,075UniSTS
RH 3.4 Map81116.6UniSTS
Cytogenetic Map8q32UniSTS
BF387601  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28108,253,956 - 108,254,130 (+)MAPPERmRatBN7.2
Rnor_6.08116,336,084 - 116,336,257NCBIRnor6.0
Rnor_5.08115,692,344 - 115,692,517UniSTSRnor5.0
RGSC_v3.48112,827,722 - 112,827,895UniSTSRGSC3.4
Celera8107,560,535 - 107,560,708UniSTS
RH 3.4 Map81120.8UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000090123   ⟹   ENSRNOP00000069333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8108,253,302 - 108,257,563 (+)Ensembl
Rnor_6.0 Ensembl8116,336,441 - 116,339,690 (+)Ensembl
RefSeq Acc Id: NM_001304776   ⟹   NP_001291705
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88117,132,957 - 117,136,207 (+)NCBI
mRatBN7.28108,254,314 - 108,257,564 (+)NCBI
Rnor_6.08116,336,441 - 116,339,691 (+)NCBI
Celera8107,560,892 - 107,564,142 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001291705 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI05846 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069333.1
RefSeq Acc Id: NP_001291705   ⟸   NM_001304776
- UniProtKB: A0A0G2JV35 (UniProtKB/TrEMBL),   A6I2Y5 (UniProtKB/TrEMBL),   Q3KR83 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069333   ⟸   ENSRNOT00000090123
Protein Domains
N-acetyltransferase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696275
Promoter ID:EPDNEW_R6800
Type:initiation region
Name:Nat6_1
Description:N-acetyltransferase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08116,336,380 - 116,336,440EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:6496422 AgrOrtholog
BioCyc Gene G2FUF-29189 BioCyc
Ensembl Genes ENSRNOG00000054063 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000090123.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.630.30 UniProtKB/TrEMBL
InterPro Acyl_CoA_acyltransferase UniProtKB/TrEMBL
  GNAT_dom UniProtKB/TrEMBL
  NAT6 UniProtKB/TrEMBL
KEGG Report rno:100910872 UniProtKB/TrEMBL
NCBI Gene LOC100910872 ENTREZGENE
PANTHER N-ALPHA-ACETYLTRANSFERASE 80 UniProtKB/TrEMBL
  PTHR13538 UniProtKB/TrEMBL
Pfam Acetyltransf_1 UniProtKB/TrEMBL
PhenoGen Naa80 PhenoGen
PROSITE GNAT UniProtKB/TrEMBL
RatGTEx ENSRNOG00000054063 RatGTEx
Superfamily-SCOP SSF55729 UniProtKB/TrEMBL
UniProt A0A0G2JV35 ENTREZGENE, UniProtKB/TrEMBL
  A6I2Y5 ENTREZGENE, UniProtKB/TrEMBL
  Q3KR83 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-04-27 Naa80  N(alpha)-acetyltransferase 80, NatH catalytic subunit  Nat6  N-acetyltransferase 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-17 Nat6  N-acetyltransferase 6  Nat6  N-acetyltransferase 6 (GCN5-related)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-06-12 Nat6  N-acetyltransferase 6 (GCN5-related)  LOC100910872  N-acetyltransferase 6-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100910872  N-acetyltransferase 6-like      Symbol and Name status set to provisional 70820 PROVISIONAL