Lilrb1 (leukocyte immunoglobulin like receptor B1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Lilrb1 (leukocyte immunoglobulin like receptor B1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Lilrb1
Name: leukocyte immunoglobulin like receptor B1
RGD ID: 6487069
Description: Predicted to enable inhibitory MHC class I receptor activity. Predicted to be involved in cytokine-mediated signaling pathway and immune response-regulating signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leukocyte immunoglobulin-like receptor subfamily B member 3-like; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1; LOC100912456; LOC690948; similar to paired-Ig-like receptor A11
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8174,372,772 - 74,379,871 (+)NCBIGRCr8
mRatBN7.2165,457,264 - 65,464,523 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl165,457,534 - 65,464,520 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0163,883,684 - 63,891,697 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl163,964,155 - 63,967,366 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0162,876,160 - 62,883,184 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4163,770,484 - 63,777,186 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera163,183,573 - 63,212,699 (+)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000078512   ⟹   ENSRNOP00000075528
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl163,964,155 - 63,967,366 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080799   ⟹   ENSRNOP00000070789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl165,457,534 - 65,464,295 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113262   ⟹   ENSRNOP00000094182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl165,457,534 - 65,464,520 (+)Ensembl
RefSeq Acc Id: XM_003748711   ⟹   XP_003748759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,372,772 - 74,379,871 (+)NCBI
mRatBN7.2165,457,404 - 65,464,523 (+)NCBI
Rnor_6.0163,883,901 - 63,891,061 (+)NCBI
Rnor_5.0162,876,160 - 62,883,184 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006228039   ⟹   XP_006228101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,372,772 - 74,379,871 (+)NCBI
mRatBN7.2165,457,403 - 65,464,523 (+)NCBI
Rnor_6.0163,883,901 - 63,891,062 (+)NCBI
Rnor_5.0162,876,160 - 62,883,184 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006228040   ⟹   XP_006228102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,372,772 - 74,379,871 (+)NCBI
mRatBN7.2165,457,403 - 65,464,259 (+)NCBI
Rnor_6.0163,883,901 - 63,890,542 (+)NCBI
Rnor_5.0162,876,160 - 62,883,184 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006228042   ⟹   XP_006228104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,372,772 - 74,379,871 (+)NCBI
mRatBN7.2165,457,403 - 65,464,523 (+)NCBI
Rnor_6.0163,883,894 - 63,891,067 (+)NCBI
Rnor_5.0162,876,160 - 62,883,184 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039100379   ⟹   XP_038956307
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,372,772 - 74,376,675 (+)NCBI
mRatBN7.2165,457,403 - 65,461,312 (+)NCBI
RefSeq Acc Id: XM_063280906   ⟹   XP_063136976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,372,773 - 74,379,871 (+)NCBI
RefSeq Acc Id: XR_010062963
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,372,772 - 74,379,679 (+)NCBI
RefSeq Acc Id: XP_003748759   ⟸   XM_003748711
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JYU1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228104   ⟸   XM_006228042
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006228101   ⟸   XM_006228039
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AZE5 (UniProtKB/TrEMBL),   A0A0G2KAU3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006228102   ⟸   XM_006228040
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_038956307   ⟸   XM_039100379
- Peptide Label: isoform X6
Ensembl Acc Id: ENSRNOP00000075528   ⟸   ENSRNOT00000078512
Ensembl Acc Id: ENSRNOP00000070789   ⟸   ENSRNOT00000080799
Ensembl Acc Id: ENSRNOP00000094182   ⟸   ENSRNOT00000113262
RefSeq Acc Id: XP_063136976   ⟸   XM_063280906
- Peptide Label: isoform X5
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2KAU3-F1-model_v2 AlphaFold A0A0G2KAU3 1-399 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-61047 BioCyc
Ensembl Genes ENSRNOG00000058538 Ensembl
  ENSRNOG00000062358 UniProtKB/TrEMBL
  ENSRNOG00000066254 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078512.2 UniProtKB/TrEMBL
  ENSRNOT00000080799.2 UniProtKB/TrEMBL
  ENSRNOT00000113262.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig-like_Receptors_ImmuneReg UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/TrEMBL
KEGG Report rno:100912456 UniProtKB/TrEMBL
NCBI Gene LOC100912456 ENTREZGENE
PANTHER LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY B MEMBER 3-RELATED UniProtKB/TrEMBL
  LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY B MEMBER 4 UniProtKB/TrEMBL
  MHC CLASS I NK CELL RECEPTOR UniProtKB/TrEMBL
Pfam Ig_2 UniProtKB/TrEMBL
  PF00047 UniProtKB/TrEMBL
PhenoGen Lilrb1 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000058538 RatGTEx
  ENSRNOG00000062358 RatGTEx
  ENSRNOG00000066254 RatGTEx
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A0G2JYU1 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2KAU3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AZE5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Lilrb1  leukocyte immunoglobulin like receptor B1  Lilrb1  leukocyte immunoglobulin like receptor B1  Data merged from RGD:149736366 737654 PROVISIONAL
2021-08-09 Lilrb1  leukocyte immunoglobulin like receptor B1      Symbol and Name status set to provisional 45752 PROVISIONAL
2021-03-09 Lilrb1  leukocyte immunoglobulin like receptor B1  LOC690948  similar to paired-Ig-like receptor A11  Data merged from RGD:1589833 737654 PROVISIONAL
2016-01-20 Lilrb1  leukocyte immunoglobulin like receptor B1  Lilrb1  leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-06-30 Lilrb1  leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1  LOC100912456  leukocyte immunoglobulin-like receptor subfamily B member 3-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100912456  leukocyte immunoglobulin-like receptor subfamily B member 3-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC690948  similar to paired-Ig-like receptor A11      Symbol and Name status set to provisional 70820 PROVISIONAL