Naglt1 (Na+ dependent glucose transporter 1) - Rat Genome Database

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Pathways
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Gene: Naglt1 (Na+ dependent glucose transporter 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Naglt1
Name: Na+ dependent glucose transporter 1
RGD ID: 631438
Description: Enables glucose transmembrane transporter activity. Predicted to be involved in glucose transmembrane transport and sodium ion transport. Predicted to be located in apical plasma membrane. Orthologous to human MFSD4B (major facilitator superfamily domain containing 4B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-nitrofluorene; 3,3',5-triiodo-L-thyronine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: major facilitator superfamily domain-containing protein 4B; Mfsd4b; MGC112591; rNaGLT1; sodium-dependent glucose transporter 1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82044,965,951 - 44,978,400 (-)NCBIGRCr8
mRatBN7.22043,411,550 - 43,423,873 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2043,394,843 - 43,423,873 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2045,160,541 - 45,172,841 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02044,819,750 - 44,832,046 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02045,569,736 - 45,582,176 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02045,095,232 - 45,107,532 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2045,094,791 - 45,107,555 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02046,815,193 - 46,827,493 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42044,164,008 - 44,176,308 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12044,187,018 - 44,199,319 (-)NCBI
Celera2044,125,073 - 44,137,373 (-)NCBICelera
Cytogenetic Map20q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Cloning and characterization of a novel Na+-dependent glucose transporter (NaGLT1) in rat kidney. Horiba N, etal., J Biol Chem 2003 Apr 25;278(17):14669-76.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12832054   PMID:16627065  


Genomics

Variants

.
Variants in Naglt1
107 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:69
Count of miRNA genes:57
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000057218
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
70158Bp60Blood pressure QTL 603arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)203161428444396023Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 25
Low 3 17 49 33 19 33 8 10 71 10 41 11 8
Below cutoff 26 8 8 8 1 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000057218   ⟹   ENSRNOP00000054044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2043,411,550 - 43,423,873 (-)Ensembl
Rnor_6.0 Ensembl2045,094,791 - 45,107,555 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097726   ⟹   ENSRNOP00000087398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2043,394,843 - 43,423,873 (-)Ensembl
RefSeq Acc Id: NM_176080   ⟹   NP_788269
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82044,966,102 - 44,978,400 (-)NCBI
mRatBN7.22043,411,550 - 43,423,873 (-)NCBI
Rnor_6.02045,095,232 - 45,107,532 (-)NCBI
Rnor_5.02046,815,193 - 46,827,493 (-)NCBI
RGSC_v3.42044,164,008 - 44,176,308 (-)RGD
Celera2044,125,073 - 44,137,373 (-)RGD
Sequence:
RefSeq Acc Id: XM_063279191   ⟹   XP_063135261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82044,965,951 - 44,975,745 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_788269   ⟸   NM_176080
- UniProtKB: Q4KMB5 (UniProtKB/Swiss-Prot),   Q80T22 (UniProtKB/Swiss-Prot),   A0A0G2JSX3 (UniProtKB/TrEMBL),   A6KIH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000054044   ⟸   ENSRNOT00000057218
RefSeq Acc Id: ENSRNOP00000087398   ⟸   ENSRNOT00000097726
RefSeq Acc Id: XP_063135261   ⟸   XM_063279191
- Peptide Label: isoform X1
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80T22-F1-model_v2 AlphaFold Q80T22 1-484 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701654
Promoter ID:EPDNEW_R12178
Type:initiation region
Name:Naglt1_1
Description:Na+ dependent glucose transporter 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02045,107,537 - 45,107,597EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631438 AgrOrtholog
BioCyc Gene G2FUF-3454 BioCyc
Ensembl Genes ENSRNOG00000000590 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057218 ENTREZGENE
  ENSRNOT00000057218.4 UniProtKB/TrEMBL
  ENSRNOT00000097726.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7130354 IMAGE-MGC_LOAD
InterPro MFS_dom UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:337920 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112591 IMAGE-MGC_LOAD
NCBI Gene 337920 ENTREZGENE
PANTHER MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING 4B5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SODIUM-DEPENDENT GLUCOSE TRANSPORTER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Naglt1 PhenoGen
PROSITE MFS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000590 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSX3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A760_RAT UniProtKB/TrEMBL
  A6KIH7_RAT UniProtKB/TrEMBL
  A6KIH8 ENTREZGENE, UniProtKB/TrEMBL
  MFS4B_RAT UniProtKB/Swiss-Prot
  Q4KMB5 ENTREZGENE
  Q80T22 ENTREZGENE
UniProt Secondary Q4KMB5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-09-30 Naglt1        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 484-amino acid protein 633369