Aars1 (alanyl-tRNA synthetase 1) - Rat Genome Database

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Gene: Aars1 (alanyl-tRNA synthetase 1) Heterocephalus glaber
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Symbol: Aars1 (Ensembl: AARS)
Name: alanyl-tRNA synthetase 1
RGD ID: 18933609
Description: ENCODES a protein that exhibits alanine-tRNA ligase activity (ortholog); amino acid binding (ortholog); ATP binding (ortholog); INVOLVED IN alanyl-tRNA aminoacylation (ortholog); cerebellar Purkinje cell layer development (ortholog); negative regulation of neuron apoptotic process (ortholog); PARTICIPATES IN alanine metabolic pathway; lactic acidosis pathway; primary hyperoxaluria type 1 pathway; ASSOCIATED WITH adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ortholog); Charcot-Marie-Tooth disease (ortholog); Charcot-Marie-Tooth disease axonal type 2N (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Aars; alanine--tRNA ligase, cytoplasmic
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474612,540,633 - 12,567,376 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474612,540,969 - 12,566,989 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
mitochondrion  (IEA)
nucleus  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Aars1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474612,540,633 - 12,567,376 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474612,540,969 - 12,566,989 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
AARS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381670,252,298 - 70,289,506 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1670,251,983 - 70,289,707 (-)Ensemblhg38GRCh38
GRCh371670,286,201 - 70,323,409 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361668,843,798 - 68,880,913 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341668,843,797 - 68,880,913NCBI
Celera1655,204,771 - 55,241,876 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1656,119,458 - 56,156,083 (-)NCBIHuRef
CHM1_11671,693,759 - 71,730,869 (-)NCBICHM1_1
T2T-CHM13v2.01676,063,291 - 76,100,495 (-)NCBIT2T-CHM13v2.0
Aars1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398111,759,781 - 111,784,237 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8111,759,776 - 111,784,296 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm388111,027,778 - 111,055,569 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8111,033,144 - 111,057,664 (+)Ensemblmm10GRCm38
MGSCv378113,557,867 - 113,580,770 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368113,920,642 - 113,943,545 (+)NCBIMGSCv36mm8
Celera8115,257,943 - 115,280,837 (+)NCBICelera
Cytogenetic Map8E1NCBI
cM Map857.9NCBI
Aars1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81955,906,694 - 55,930,499 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1955,906,702 - 55,930,497 (+)EnsemblGRCr8
mRatBN7.21938,999,130 - 39,021,152 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1938,999,163 - 39,021,147 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1945,803,476 - 45,825,481 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01946,456,819 - 46,478,824 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01948,767,870 - 48,789,877 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1949,684,963 - 49,706,913 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive1947,808,459 - 47,830,411 (+)NCBILyon_Normotensive
Lyon_Hypertensive1949,683,220 - 49,705,170 (+)NCBILyon_Hypertensive
F344_StmMcwi1947,439,297 - 47,461,265 (+)NCBIF344_StmMcwi
Rnor_6.01943,193,264 - 43,215,281 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1943,193,257 - 43,215,281 (-)Ensemblrn6Rnor6.0
Rnor_5.01954,018,025 - 54,040,573 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41940,952,408 - 40,974,425 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1938,390,301 - 38,412,318 (+)NCBICelera
RGSC_v3.11940,957,348 - 40,979,299 (+)NCBI
Cytogenetic Map19q12NCBI
Aars1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554843,089,235 - 3,115,230 (-)Ensembl
ChiLan1.0NW_0049554843,090,678 - 3,115,224 (-)NCBIChiLan1.0ChiLan1.0
AARS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21883,876,270 - 83,912,138 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11689,807,117 - 89,843,061 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01654,727,601 - 54,763,458 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11670,086,735 - 70,121,902 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1670,086,735 - 70,121,902 (-)EnsemblpanPan2panpan1.1
AARS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1576,288,780 - 76,343,262 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl576,288,782 - 76,343,207 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha576,250,625 - 76,276,397 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0576,725,260 - 76,750,984 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl576,725,265 - 76,748,174 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1576,547,302 - 76,573,204 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0576,370,741 - 76,396,505 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0576,862,531 - 76,888,314 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Aars1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934936,294,883 - 36,320,498 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647523,268,491 - 23,294,496 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647523,268,613 - 23,294,236 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AARS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl613,298,330 - 13,321,383 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1613,298,336 - 13,321,423 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2613,363,115 - 13,385,168 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AARS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1553,399,717 - 53,433,472 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl553,395,638 - 53,433,461 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604716,186,832 - 16,220,663 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aars1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11730,728,728 - 30,750,176 (+)NCBIRrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000016578   ⟹   ENSHGLP00000016409
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474612,540,633 - 12,567,376 (-)Ensembl
RefSeq Acc Id: XM_004842866   ⟹   XP_004842923
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474612,540,969 - 12,566,960 (-)NCBI
RefSeq Acc Id: XM_013071491   ⟹   XP_012926945
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474612,540,969 - 12,566,989 (-)NCBI
RefSeq Acc Id: XM_021256708   ⟹   XP_021112367
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474612,540,969 - 12,566,717 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004842923 (Get FASTA)   NCBI Sequence Viewer  
  XP_012926945 (Get FASTA)   NCBI Sequence Viewer  
  XP_021112367 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000016409
GenBank Protein JAN99108 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_012926945   ⟸   XM_013071491
- UniProtKB: A0A0P6JV39 (UniProtKB/TrEMBL),   G5B5W3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004842923   ⟸   XM_004842866
- UniProtKB: A0A0P6JV39 (UniProtKB/TrEMBL),   G5B5W3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021112367   ⟸   XM_021256708
- UniProtKB: A0A0P6JV39 (UniProtKB/TrEMBL),   G5B5W3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000016409   ⟸   ENSHGLT00000016578


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000011756 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000016578 ENTREZGENE
Gene3D-CATH 2.40.30.130 UniProtKB/TrEMBL
  3.10.310.40 UniProtKB/TrEMBL
  Bira Bifunctional Protein, Domain 2 UniProtKB/TrEMBL
  Threonyl-trna Synthetase, Chain A, domain 2 UniProtKB/TrEMBL
InterPro aa-tRNA-synth_II/BPL/LPL UniProtKB/TrEMBL
  Ala-tRNA-lgiase_IIc UniProtKB/TrEMBL
  Ala-tRNA-ligase_IIc_anticod-bd UniProtKB/TrEMBL
  Ala-tRNA-synth_IIc_core UniProtKB/TrEMBL
  Ala-tRNA-synth_IIc_N UniProtKB/TrEMBL
  Ala-tRNA_ligase UniProtKB/TrEMBL
  Ala_tRNA_ligase_euk/bac UniProtKB/TrEMBL
  DHHA1_dom UniProtKB/TrEMBL
  Thr/Ala-tRNA-synth_IIc_edit UniProtKB/TrEMBL
  Transl_B-barrel_sf UniProtKB/TrEMBL
  tRNA_SAD UniProtKB/TrEMBL
KEGG Report hgl:101717838 UniProtKB/TrEMBL
NCBI Gene Aars1 ENTREZGENE
PANTHER ALANINE--TRNA LIGASE, CYTOPLASMIC UniProtKB/TrEMBL
  ALANYL-TRNA SYNTHETASE UniProtKB/TrEMBL
Pfam DHHA1 UniProtKB/TrEMBL
  tRNA-synt_2c UniProtKB/TrEMBL
  tRNA_SAD UniProtKB/TrEMBL
PRINTS TRNASYNTHALA UniProtKB/TrEMBL
PROSITE AA_TRNA_LIGASE_II_ALA UniProtKB/TrEMBL
SMART tRNA_SAD UniProtKB/TrEMBL
Superfamily-SCOP SSF101353 UniProtKB/TrEMBL
  SSF50447 UniProtKB/TrEMBL
  SSF55186 UniProtKB/TrEMBL
  SSF55681 UniProtKB/TrEMBL
UniProt A0A0P6JV39 ENTREZGENE, UniProtKB/TrEMBL
  G5B5W3 ENTREZGENE, UniProtKB/TrEMBL