CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: alanine
Accession: CHEBI:16449
browse the term
Definition: An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.
Synonyms: related_synonym: 2-Aminopropanoic acid; 2-Aminopropionic acid; A; ALA; Alanin; Formula=C3H7NO2; InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6); InChIKey=QNAYBMKLOCPYGJ-UHFFFAOYSA-N; SMILES=CC(N)C(O)=O; alanina
alt_id: CHEBI:13748; CHEBI:22277; CHEBI:2539
xref: Beilstein:635807; CAS:302-72-7; Drug_Central:4306; Gmelin:2449; KEGG:C01401; PMID:17439666; PMID:22264337; Reaxys:635807; Wikipedia:Alanine
cyclic_relationship: is_conjugate_acid_of CHEBI:32439; is_conjugate_base_of CHEBI:32440; is_tautomer_of CHEBI:66916
G
Gria3
glutamate ionotropic receptor AMPA type subunit 3
affects response to substance
ISO
GRIA3 protein affects the susceptibility to 5-fluorowillardiine
CTD
PMID:15264227
NCBI chr X:127,561,843...127,829,763
Ensembl chr X:127,562,660...127,829,753
G
Cacna1h
calcium voltage-gated channel subunit alpha1 H
multiple interactions
ISO
3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of CACNA1H protein]
CTD
PMID:29129814
NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617
G
Egr1
early growth response 1
multiple interactions
ISO
3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of EGR1 protein]
CTD
PMID:29129814
NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
G
Usp5
ubiquitin specific peptidase 5
multiple interactions
ISO
3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of USP5 protein]
CTD
PMID:29129814
NCBI chr 4:157,332,735...157,347,803
Ensembl chr 4:157,332,740...157,347,803
G
Ctsd
cathepsin D
multiple interactions
EXP
alliin affects the reaction [Isoproterenol affects the activity of CTSD protein]
CTD
PMID:17623887
NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
G
Fasn
fatty acid synthase
multiple interactions
ISO
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN protein]
CTD
PMID:29305303
NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
G
Fgf2
fibroblast growth factor 2
decreases secretion multiple interactions
ISO
alliin results in decreased secretion of FGF2 protein alliin promotes the reaction [FGF2 protein results in increased expression of TP53 protein]
CTD
PMID:16351512
NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
multiple interactions
EXP ISO
alliin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein] alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR protein]
CTD
PMID:16640830 PMID:29305303
NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
G
Lcat
lecithin cholesterol acyltransferase
multiple interactions
EXP
alliin inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]
CTD
PMID:16640830
NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813
G
Srebf1
sterol regulatory element binding transcription factor 1
multiple interactions
ISO
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 protein]
CTD
PMID:29305303
NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
G
Srebf2
sterol regulatory element binding transcription factor 2
multiple interactions
ISO
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 protein]
CTD
PMID:29305303
NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
G
Tp53
tumor protein p53
multiple interactions
ISO
alliin promotes the reaction [FGF2 protein results in increased expression of TP53 protein]
CTD
PMID:16351512
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
G
Vegfa
vascular endothelial growth factor A
decreases secretion
ISO
alliin results in decreased secretion of VEGFA protein
CTD
PMID:16351512
NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
G
Ddit3
DNA-damage inducible transcript 3
multiple interactions
ISO
2-(methylamino)isobutyric acid inhibits the reaction [arsenite results in increased expression of DDIT3 mRNA]
CTD
PMID:22215663
NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
G
Hspa5
heat shock protein family A (Hsp70) member 5
multiple interactions
ISO
2-(methylamino)isobutyric acid inhibits the reaction [arsenite results in increased expression of HSPA5 mRNA]
CTD
PMID:22215663
NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
G
Igf1
insulin-like growth factor 1
increases uptake multiple interactions
EXP
IGF1 protein results in increased uptake of 2-(methylamino)isobutyric acid oxophenylarsine inhibits the reaction [IGF1 protein results in increased uptake of 2-(methylamino)isobutyric acid]
CTD
PMID:1928324
NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
G
Rps6kb1
ribosomal protein S6 kinase B1
multiple interactions
ISO
2-(methylamino)isobutyric acid inhibits the reaction [arsenite results in increased phosphorylation of RPS6KB1 protein]
CTD
PMID:22215663
NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
G
Slc38a2
solute carrier family 38, member 2
multiple interactions
ISO
SLC38A2 mutant form inhibits the reaction [arsenite results in increased transport of 2-(methylamino)isobutyric acid]
CTD
PMID:22215663
NCBI chr 7:138,088,654...138,100,869
Ensembl chr 7:138,088,649...138,100,841
G
Dek
DEK proto-oncogene
multiple interactions
ISO
DEK protein results in increased chemical synthesis of and results in increased secretion of Alanine
CTD
PMID:28558019
NCBI chr17:17,965,872...17,987,836
Ensembl chr17:17,965,881...17,987,834
G
Idh2
isocitrate dehydrogenase (NADP(+)) 2
decreases abundance multiple interactions
ISO
IDH2 protein mutant form results in decreased abundance of Alanine Triazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of Alanine]
CTD
PMID:27469509
NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
G
Alad
aminolevulinate dehydratase
decreases activity
EXP
Selenocysteine analog results in decreased activity of ALAD protein
CTD
PMID:14630126
NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
Selenocysteine inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of FOS protein]; Selenocysteine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of FOS protein]
CTD
PMID:14572605
NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
G
Gsta2
glutathione S-transferase alpha 2
increases expression
EXP
Selenocysteine results in increased expression of GSTA2 mRNA
CTD
PMID:12034368
NCBI chr 8:85,640,081...85,645,621
G
Gsta3
glutathione S-transferase alpha 3
increases expression
EXP
Selenocysteine results in increased expression of GSTA3 mRNA
CTD
PMID:12034368
NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
G
Gsta5
glutathione S-transferase alpha 5
increases expression
EXP
Selenocysteine results in increased expression of GSTA5 mRNA
CTD
PMID:12034368
NCBI chr 8:85,553,659...85,564,914
Ensembl chr 8:85,553,734...85,565,179
G
Gstp1
glutathione S-transferase pi 1
increases expression
EXP
Selenocysteine results in increased expression of GSTP1 mRNA
CTD
PMID:12034368
NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
Selenocysteine inhibits the reaction [Lipopolysaccharides affects the localization of and affects the activity of RELA protein]; Selenocysteine inhibits the reaction [Peroxynitrous Acid affects the localization of and affects the activity of RELA protein]
CTD
PMID:14572605
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
G
Kyat1
kynurenine aminotransferase 1
increases amination
ISO
KYAT1 protein results in increased amination of lanthionine
CTD
PMID:22093698
NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
G
Cyp2c6v1
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
decreases expression
ISO
metalaxyl results in decreased expression of CYP2C19 protein
CTD
PMID:32194361
NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
G
Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression
ISO
metalaxyl results in decreased expression of CYP7A1 protein
CTD
PMID:32194361
NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
G
Ncoa2
nuclear receptor coactivator 2
multiple interactions
ISO
N-benzoylalanine promotes the reaction [THRA protein binds to NCOA2 protein]; N-benzoylalanine promotes the reaction [THRB protein binds to NCOA2 protein]
CTD
PMID:31566444
NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
G
Thra
thyroid hormone receptor alpha
multiple interactions
ISO
N-benzoylalanine promotes the reaction [THRA protein binds to NCOA2 protein]
CTD
PMID:31566444
NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
G
Thrb
thyroid hormone receptor beta
multiple interactions affects binding
ISO
N-benzoylalanine promotes the reaction [THRB protein binds to NCOA2 protein] N-benzoylalanine binds to THRB protein
CTD
PMID:31566444
NCBI chr15:8,890,578...9,239,815
Ensembl chr15:8,890,578...9,086,282
G
Abcc1
ATP binding cassette subfamily C member 1
multiple interactions
ISO
[selenomethylselenocysteine co-treated with irinotecan] results in decreased expression of ABCC1
CTD
PMID:15897249
NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
G
Abcc4
ATP binding cassette subfamily C member 4
multiple interactions decreases expression
EXP
Isoflavones promotes the reaction [selenomethylselenocysteine results in decreased expression of ABCC4 mRNA]
CTD
PMID:19025659
NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
G
Apaf1
apoptotic peptidase activating factor 1
increases expression
ISO
selenomethylselenocysteine metabolite results in increased expression of APAF1 mRNA
CTD
PMID:25321483
NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
G
Ar
androgen receptor
decreases expression
ISO EXP
selenomethylselenocysteine results in decreased expression of AR protein selenomethylselenocysteine results in decreased expression of AR mRNA
CTD
PMID:16637076 PMID:19025659
NCBI chr X:67,656,253...67,828,998
Ensembl chr X:67,656,253...67,829,026
G
Arntl
aryl hydrocarbon receptor nuclear translocator-like
decreases expression
EXP
selenomethylselenocysteine results in decreased expression of ARNTL mRNA
CTD
PMID:19122877
NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465
G
Bak1
BCL2-antagonist/killer 1
increases expression
ISO
selenomethylselenocysteine metabolite results in increased expression of BAK1 mRNA
CTD
PMID:25321483
NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
G
Banp
Btg3 associated nuclear protein
increases expression
ISO
selenomethylselenocysteine results in increased expression of BANP mRNA
CTD
PMID:18514395
NCBI chr19:54,766,441...54,843,795
Ensembl chr19:54,766,589...54,840,569
G
Bcl2
BCL2, apoptosis regulator
decreases expression multiple interactions
ISO EXP
selenomethylselenocysteine results in decreased expression of BCL2 mRNA selenomethylselenocysteine results in decreased expression of BCL2 protein [selenomethylselenocysteine results in decreased expression of BCL2 mRNA] which results in increased activity of TNFSF10 protein
CTD
PMID:11396176 PMID:19360359
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
G
Bcl2l1
Bcl2-like 1
decreases expression
ISO
selenomethylselenocysteine metabolite results in decreased expression of BCL2L1 mRNA
CTD
PMID:25321483
NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
G
Bcl2l11
BCL2 like 11
increases expression
ISO
selenomethylselenocysteine metabolite results in increased expression of BCL2L11 mRNA
CTD
PMID:25321483
NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
G
Bmf
Bcl2 modifying factor
multiple interactions increases expression
ISO
BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP3 protein modified form]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP6 protein modified form]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP9 protein modified form]; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of PARP1 protein modified form]; C646 compound inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]; HDAC8 inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]; selenomethylselenocysteine metabolite inhibits the reaction [HDAC8 protein binds to BMF promoter]; selenomethylselenocysteine metabolite inhibits the reaction [STAT3 protein binds to BMF promoter]; selenomethylselenocysteine metabolite promotes the reaction [EP300 protein binds to BMF promoter]; selenomethylselenocysteine metabolite promotes the reaction [SP3 protein binds to BMF promoter]; STAT3 protein inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA] selenomethylselenocysteine metabolite results in increased expression of BMF protein selenomethylselenocysteine metabolite results in increased expression of BMF mRNA; selenomethylselenocysteine metabolite results in increased expression of BMF protein
CTD
PMID:25321483
NCBI chr 3:110,303,515...110,324,125
Ensembl chr 3:110,306,067...110,324,084
G
Casp3
caspase 3
increases activity increases expression multiple interactions
ISO
selenomethylselenocysteine results in increased activity of CASP3 protein selenomethylselenocysteine metabolite results in increased expression of CASP3 protein modified form BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP3 protein modified form]
CTD
PMID:15318939 PMID:25321483
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
G
Casp6
caspase 6
increases expression multiple interactions
ISO
selenomethylselenocysteine metabolite results in increased expression of CASP6 protein modified form BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP6 protein modified form]
CTD
PMID:25321483
NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967 Ensembl chr 2:235,341,365...235,353,967
G
Casp8
caspase 8
increases expression
ISO
selenomethylselenocysteine metabolite results in increased expression of CASP8 protein modified form
CTD
PMID:25321483
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
G
Casp9
caspase 9
multiple interactions increases expression
ISO
BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of CASP9 protein modified form]
CTD
PMID:25321483
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
G
Ccna2
cyclin A2
decreases expression
EXP
selenomethylselenocysteine results in decreased expression of CCNA2 protein
CTD
PMID:11396176
NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
G
Ccnd1
cyclin D1
decreases expression multiple interactions
ISO EXP
selenomethylselenocysteine results in decreased expression of CCND1 protein selenomethylselenocysteine results in decreased expression of CCND1 mRNA; selenomethylselenocysteine results in decreased expression of CCND1 protein [selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of CCND1 protein
CTD
PMID:11396176 PMID:18855134 PMID:19276161
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
G
Cdk2
cyclin dependent kinase 2
multiple interactions
ISO
selenomethylselenocysteine results in decreased phosphorylation of and results in decreased activity of CDK2 protein
CTD
PMID:10656618
NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression multiple interactions
ISO
selenomethylselenocysteine metabolite results in increased expression of CDKN1A protein [Aminooxyacetic Acid results in decreased metabolism of selenomethylselenocysteine] which results in decreased expression of CDKN1A protein
CTD
PMID:25321483
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
G
Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases expression
EXP
selenomethylselenocysteine results in increased expression of CDKN1B protein
CTD
PMID:11396176 PMID:19276161
NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
G
Ces1d
carboxylesterase 1D
increases expression
ISO
selenomethylselenocysteine results in increased expression of CES1
CTD
PMID:15897249
NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
G
Chmp1a
charged multivesicular body protein 1A
increases expression
ISO
selenomethylselenocysteine results in increased expression of CHMP1A mRNA
CTD
PMID:18514395
NCBI chr19:56,001,724...56,010,004
Ensembl chr19:56,001,724...56,010,004
G
Col1a1
collagen type I alpha 1 chain
decreases expression
ISO
selenomethylselenocysteine results in decreased expression of COL1A1 mRNA; selenomethylselenocysteine results in decreased expression of COL1A1 protein
CTD
PMID:18514395
NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
G
Col1a2
collagen type I alpha 2 chain
decreases expression
ISO
selenomethylselenocysteine results in decreased expression of COL1A2 mRNA; selenomethylselenocysteine results in decreased expression of COL1A2 protein
CTD
PMID:18514395
NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
G
Col4a5
collagen type IV alpha 5 chain
increases expression
ISO
selenomethylselenocysteine results in increased expression of COL4A5 mRNA
CTD
PMID:18514395
NCBI chr X:112,769,595...112,983,720
Ensembl chr X:112,769,645...112,983,685
G
Col6a1
collagen type VI alpha 1 chain
increases expression
ISO
selenomethylselenocysteine results in increased expression of COL6A1 mRNA
CTD
PMID:18514395
NCBI chr20:12,657,913...12,676,370
Ensembl chr20:12,658,065...12,675,561
G
Col7a1
collagen type VII alpha 1 chain
decreases expression
ISO
selenomethylselenocysteine results in decreased expression of COL7A1 mRNA
CTD
PMID:18514395
NCBI chr 8:117,694,441...117,726,844
Ensembl chr 8:117,694,605...117,726,844
G
Cry2
cryptochrome circadian regulator 2
increases expression
EXP
selenomethylselenocysteine results in increased expression of CRY2 mRNA
CTD
PMID:19122877
NCBI chr 3:81,314,151...81,344,143
Ensembl chr 3:81,314,149...81,344,110
G
Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
multiple interactions
ISO
[selenomethylselenocysteine co-treated with irinotecan] results in increased expression of CYP3A5
CTD
PMID:15897249
NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
G
Dbp
D-box binding PAR bZIP transcription factor
increases expression
EXP
selenomethylselenocysteine results in increased expression of DBP mRNA
CTD
PMID:19122877
NCBI chr 1:101,687,896...101,692,845
Ensembl chr 1:101,687,855...101,692,846
G
Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
selenomethylselenocysteine results in increased expression of DDIT3 mRNA
CTD
PMID:10656618
NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
G
Dhcr24
24-dehydrocholesterol reductase
decreases expression
EXP
selenomethylselenocysteine results in decreased expression of DHCR24 mRNA
CTD
PMID:19025659
NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206
G
Drg1
developmentally regulated GTP binding protein 1
multiple interactions
ISO
[selenomethylselenocysteine co-treated with irinotecan] results in decreased expression of DRG1
CTD
PMID:15897249
NCBI chr14:83,460,540...83,476,568
Ensembl chr14:83,460,540...83,476,568
G
Ep300
E1A binding protein p300
multiple interactions
ISO
selenomethylselenocysteine metabolite promotes the reaction [EP300 protein binds to BMF promoter]
CTD
PMID:25321483
NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
G
Esr1
estrogen receptor 1
decreases expression multiple interactions
ISO
selenomethylselenocysteine results in decreased expression of ESR1 protein [selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of ESR1 protein
CTD
PMID:18855134
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
G
Faslg
Fas ligand
multiple interactions
ISO
[selenomethylselenocysteine co-treated with irinotecan] results in increased expression of FASLG
CTD
PMID:15897249
NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
G
Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
ISO
selenomethylselenocysteine results in increased expression of GADD45A mRNA
CTD
PMID:10656618
NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
G
Gpx1
glutathione peroxidase 1
increases activity increases expression
ISO
selenomethylselenocysteine results in increased activity of GPX1 protein selenomethylselenocysteine results in increased expression of GPX1 mRNA; selenomethylselenocysteine results in increased expression of GPX1 protein
CTD
PMID:18514395 PMID:19033020
NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
G
Gpx4
glutathione peroxidase 4
increases expression
ISO
selenomethylselenocysteine results in increased expression of GPX4 mRNA
CTD
PMID:18514395
NCBI chr 7:12,516,357...12,519,154
Ensembl chr 7:12,516,352...12,519,154
G
Grik1
glutamate ionotropic receptor kainate type subunit 1
increases expression
ISO
selenomethylselenocysteine results in increased expression of GRIK1 mRNA
CTD
PMID:18514395
NCBI chr11:27,811,954...28,213,940
Ensembl chr11:27,811,957...27,971,359
G
Grik3
glutamate ionotropic receptor kainate type subunit 3
increases expression
ISO
selenomethylselenocysteine results in increased expression of GRIK3 mRNA
CTD
PMID:18514395
NCBI chr 5:143,500,441...143,715,546
Ensembl chr 5:143,500,441...143,715,546
G
Hdac8
histone deacetylase 8
multiple interactions
ISO
HDAC8 inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]; selenomethylselenocysteine metabolite inhibits the reaction [HDAC8 protein binds to BMF promoter]
CTD
PMID:25321483
NCBI chr X:72,163,777...72,370,058
Ensembl chr X:72,163,777...72,370,044
G
Igf1r
insulin-like growth factor 1 receptor
increases expression
ISO
selenomethylselenocysteine results in increased expression of IGF1R mRNA
CTD
PMID:18514395
NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases phosphorylation
EXP
selenomethylselenocysteine results in increased phosphorylation of JUN protein
CTD
PMID:19276161
NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
G
Klk1
kallikrein 1
decreases expression
ISO
selenomethylselenocysteine results in decreased expression of KLK3 protein
CTD
PMID:16637076
NCBI chr 1:100,131,562...100,135,556
Ensembl chr 1:100,059,967...100,203,329 Ensembl chr 1:100,059,967...100,203,329 Ensembl chr 1:100,059,967...100,203,329
G
Mki67
marker of proliferation Ki-67
multiple interactions decreases expression
ISO
[selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of MKI67 protein selenomethylselenocysteine results in decreased expression of MKI67 protein
CTD
PMID:18855134
NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
G
Msrb1
methionine sulfoxide reductase B1
increases expression
ISO
selenomethylselenocysteine results in increased expression of MSRB1 mRNA
CTD
PMID:18514395
NCBI chr10:14,105,750...14,111,463
Ensembl chr10:14,105,750...14,111,463
G
Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased localization of NFKB1 protein]
CTD
PMID:21213327
NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
G
Nos2
nitric oxide synthase 2
multiple interactions
ISO
selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD
PMID:21213327
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
G
P4ha1
prolyl 4-hydroxylase subunit alpha 1
increases expression
ISO
selenomethylselenocysteine results in increased expression of P4HA1 mRNA
CTD
PMID:18514395
NCBI chr20:28,920,616...28,972,576
Ensembl chr20:28,920,616...28,971,966
G
Parp1
poly (ADP-ribose) polymerase 1
multiple interactions increases expression
ISO
[Aminooxyacetic Acid results in decreased metabolism of selenomethylselenocysteine] which results in decreased expression of PARP1 protein modified form; BMF protein promotes the reaction [selenomethylselenocysteine metabolite results in increased expression of PARP1 protein modified form]
CTD
PMID:25321483
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
G
Per2
period circadian regulator 2
increases expression
EXP
selenomethylselenocysteine results in increased expression of PER2 mRNA
CTD
PMID:19122877
NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359
G
Per3
period circadian regulator 3
increases expression
EXP
selenomethylselenocysteine results in increased expression of PER3 mRNA
CTD
PMID:19122877
NCBI chr 5:168,088,126...168,123,482
Ensembl chr 5:168,086,998...168,123,395
G
Pgr
progesterone receptor
decreases expression multiple interactions
ISO
selenomethylselenocysteine results in decreased expression of PGR protein [selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of PGR protein
CTD
PMID:18855134
NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
G
Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
increases expression
ISO
selenomethylselenocysteine results in increased expression of PPP1R15A mRNA
CTD
PMID:10656618
NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
G
Prkce
protein kinase C, epsilon
decreases expression
ISO
selenomethylselenocysteine results in decreased expression of PRKCE protein
CTD
PMID:10656618
NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
G
Prkcz
protein kinase C, zeta
decreases expression
ISO
selenomethylselenocysteine results in decreased expression of PRKCZ protein
CTD
PMID:10656618
NCBI chr 5:172,658,071...172,769,492
Ensembl chr 5:172,658,748...172,769,421
G
Rab3b
RAB3B, member RAS oncogene family
increases expression
ISO
selenomethylselenocysteine results in increased expression of RAB3B mRNA
CTD
PMID:18514395
NCBI chr 5:128,501,789...128,568,170
Ensembl chr 5:128,501,847...128,568,188
G
Rab4a
RAB4A, member RAS oncogene family
increases expression
ISO
selenomethylselenocysteine results in increased expression of RAB4A mRNA
CTD
PMID:18514395
NCBI chr19:56,585,598...56,613,078
Ensembl chr19:56,585,767...56,613,075
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
selenomethylselenocysteine inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]
CTD
PMID:21213327
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
G
Scarb1
scavenger receptor class B, member 1
increases expression
ISO
selenomethylselenocysteine results in increased expression of SCARB1 mRNA
CTD
PMID:18514395
NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
G
Selenof
selenoprotein F
increases expression
ISO
selenomethylselenocysteine results in increased expression of SELENOF mRNA
CTD
PMID:18514395
NCBI chr 2:250,600,823...250,633,903
Ensembl chr 2:250,600,823...250,633,897
G
Selenop
selenoprotein P
increases expression
ISO
selenomethylselenocysteine results in increased expression of SELENOP mRNA
CTD
PMID:18514395
NCBI chr 2:53,105,912...53,116,198
Ensembl chr 2:53,109,684...53,114,858
G
Selenow
selenoprotein W
increases expression
ISO
selenomethylselenocysteine results in increased expression of SELENOW mRNA
CTD
PMID:18514395
NCBI chr 1:77,530,692...77,535,765
Ensembl chr 1:77,533,148...77,535,681 Ensembl chr 1:77,533,148...77,535,681
G
Slc3a1
solute carrier family 3 member 1
increases uptake
ISO
SLC3A1 protein results in increased uptake of selenomethylselenocysteine
CTD
PMID:18845132
NCBI chr 6:8,284,937...8,318,649
Ensembl chr 6:8,284,878...8,318,674
G
Slc6a19
solute carrier family 6 member 19
increases uptake
ISO
SLC6A19 protein results in increased uptake of selenomethylselenocysteine
CTD
PMID:18845132
NCBI chr 1:32,199,869...32,218,628
Ensembl chr 1:32,199,810...32,220,045
G
Snap23
synaptosome associated protein 23
decreases expression
ISO
selenomethylselenocysteine results in decreased expression of SNAP23 mRNA
CTD
PMID:18514395
NCBI chr 3:112,333,972...112,362,960
G
Sort1
sortilin 1
increases expression
ISO
selenomethylselenocysteine results in increased expression of SORT1 mRNA
CTD
PMID:18514395
NCBI chr 2:211,078,092...211,156,312
Ensembl chr 2:211,078,334...211,156,312
G
Sp3
Sp3 transcription factor
multiple interactions
ISO
selenomethylselenocysteine metabolite promotes the reaction [SP3 protein binds to BMF promoter]
CTD
PMID:25321483
NCBI chr 3:59,644,579...59,689,011
Ensembl chr 3:59,646,015...59,688,692
G
Spp1
secreted phosphoprotein 1
decreases expression
ISO
selenomethylselenocysteine results in decreased expression of SPP1 protein
CTD
PMID:15318939
NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
G
Srd5a1
steroid 5 alpha-reductase 1
multiple interactions
EXP
[selenomethylselenocysteine co-treated with Isoflavones] results in decreased activity of SRD5A1 protein
CTD
PMID:19025659
NCBI chr 1:36,320,504...36,354,694
Ensembl chr 1:36,320,461...36,354,756
G
Stat3
signal transducer and activator of transcription 3
multiple interactions
ISO
selenomethylselenocysteine metabolite inhibits the reaction [STAT3 protein binds to BMF promoter]; STAT3 protein inhibits the reaction [selenomethylselenocysteine metabolite results in increased expression of BMF mRNA]
CTD
PMID:25321483
NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
G
Tnfsf10
TNF superfamily member 10
multiple interactions
ISO
[selenomethylselenocysteine results in decreased expression of BCL2 mRNA] which results in increased activity of TNFSF10 protein
CTD
PMID:19360359
NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
G
Trnau1ap
tRNA selenocysteine 1 associated protein 1
increases expression
ISO
selenomethylselenocysteine results in increased expression of TRNAU1AP mRNA
CTD
PMID:18514395
NCBI chr 5:150,463,797...150,506,803
Ensembl chr 5:150,492,587...150,506,871
G
Xpa
XPA, DNA damage recognition and repair factor
multiple interactions
ISO
selenomethylselenocysteine inhibits the reaction [Zinc binds to XPA protein]
CTD
PMID:15265038
NCBI chr 5:61,749,767...61,793,641
Ensembl chr 5:61,749,767...61,792,928
G
Klrc1
killer cell lectin like receptor C1
decreases expression
ISO
sofosbuvir co-treated with ledipasvir decreased expression of NCR1 protein in natural killer cells
RGD
PMID:31218578
RGD:40400920
NCBI chr 4:163,453,435...163,463,718
Ensembl chr 4:163,458,528...163,463,718
G
Ncr1
natural cytotoxicity triggering receptor 1
affects expression
ISO
sofosbuvir co-treated with ledipasvir affects expression of NCR1 protein in natural killer cells
RGD
PMID:31218578
RGD:40400920
NCBI chr 1:73,178,917...73,226,504
Ensembl chr 1:73,179,013...73,226,777
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
CHEBI ontology
19841
role
19792
biological role
19792
biochemical role
19328
metabolite
19308
fundamental metabolite
12655
alanine
108
D-alanine +
2
L-alanine +
100
L-alanine-2,3,3,3-d4
0
alanine derivative +
106
alanine residue +
0
alanine-2,3,3,3-d4
0
alanine-d7
0
alanino group +
0
alanyl group +
0
Path 2
CHEBI ontology
19841
subatomic particle
19839
composite particle
19839
hadron
19839
baryon
19839
nucleon
19839
atomic nucleus
19839
atom
19839
main group element atom
19732
p-block element atom
19732
carbon group element atom
19636
carbon atom
19625
organic molecular entity
19625
organic group
18537
organic divalent group
18528
organodiyl group
18528
carbonyl group
18436
carbonyl compound
18436
carboxylic acid
18113
monocarboxylic acid
17483
fatty acid
16001
saturated fatty acid
15974
propionic acid
3673
alanine
108
D-alanine +
2
L-alanine +
100
L-alanine-2,3,3,3-d4
0
alanine derivative +
106
alanine residue +
0
alanine-2,3,3,3-d4
0
alanine-d7
0
alanino group +
0
alanyl group +
0