Slc12a3 (solute carrier family 12 member 3) - Rat Genome Database

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Gene: Slc12a3 (solute carrier family 12 member 3) Heterocephalus glaber
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Symbol: Slc12a3
Name: solute carrier family 12 member 3
RGD ID: 18929300
Description: ENCODES a protein that exhibits enzyme binding (ortholog); protein serine/threonine kinase binding (ortholog); sodium ion transmembrane transporter activity (ortholog); INVOLVED IN chloride transport (ortholog); renal sodium ion absorption (ortholog); response to aldosterone (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH aortic disease (ortholog); Bartter disease (ortholog); essential hypertension (ortholog); FOUND IN apical plasma membrane (ortholog); cytosol (ortholog); extracellular exosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: solute carrier family 12 (sodium/chloride transporters), member 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474629,098,254 - 29,132,752 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474629,087,867 - 29,132,793 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Slc12a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474629,098,254 - 29,132,752 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474629,087,867 - 29,132,793 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
SLC12A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381656,865,207 - 56,915,850 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1656,865,207 - 56,915,850 (+)Ensemblhg38GRCh38
GRCh371656,899,119 - 56,949,762 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,456,643 - 55,504,850 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341655,456,642 - 55,504,850NCBI
Celera1641,398,377 - 41,450,052 (+)NCBICelera
Cytogenetic Map16q13NCBI
HuRef1642,768,662 - 42,819,218 (+)NCBIHuRef
CHM1_11658,307,135 - 58,357,791 (+)NCBICHM1_1
T2T-CHM13v2.01662,661,526 - 62,712,168 (+)NCBIT2T-CHM13v2.0
Slc12a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39895,055,737 - 95,092,850 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl895,055,829 - 95,092,842 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38894,329,109 - 94,366,222 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,329,201 - 94,366,214 (+)Ensemblmm10GRCm38
MGSCv37896,853,108 - 96,890,122 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36897,218,355 - 97,255,092 (+)NCBIMGSCv36mm8
Celera898,660,930 - 98,697,944 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.46NCBI
Slc12a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,636,594 - 10,690,008 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1910,636,596 - 10,675,050 (-)EnsemblGRCr8
mRatBN7.21910,630,651 - 10,679,250 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,631,393 - 10,669,091 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1910,594,046 - 10,632,542 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,360,884 - 11,399,380 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,647,871 - 10,686,368 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1910,626,269 - 10,664,788 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive1914,436,935 - 14,475,330 (-)NCBILyon_Normotensive
Lyon_Hypertensive1914,929,827 - 14,968,223 (-)NCBILyon_Hypertensive
F344_StmMcwi1910,478,303 - 10,516,826 (-)NCBIF344_StmMcwi
Rnor_6.01911,106,033 - 11,144,674 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,106,033 - 11,144,641 (-)Ensemblrn6Rnor6.0
Rnor_5.01911,084,193 - 11,122,657 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41911,070,329 - 11,109,634 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1910,518,752 - 10,557,092 (-)NCBICelera
RGSC_v3.11911,075,156 - 11,114,460 (-)NCBI
Cytogenetic Map19p13-p12NCBI
Slc12a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543314,553,758 - 14,587,602 (+)Ensembl
ChiLan1.0NW_00495543314,553,752 - 14,588,317 (+)NCBIChiLan1.0ChiLan1.0
SLC12A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21866,316,962 - 66,386,655 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11672,237,646 - 72,307,205 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01637,142,797 - 37,193,713 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11656,276,026 - 56,326,973 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1656,276,049 - 56,324,528 (+)EnsemblpanPan2panpan1.1
SLC12A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,413,737 - 59,449,129 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,413,828 - 59,449,081 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha256,042,573 - 56,077,948 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0259,952,797 - 59,988,344 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl259,952,888 - 59,988,297 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1256,783,974 - 56,819,378 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,791,053 - 57,826,469 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,685,512 - 58,720,937 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc12a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934950,512,705 - 50,545,228 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364759,044,106 - 9,076,307 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364759,044,099 - 9,076,301 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC12A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl618,844,600 - 18,885,476 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1618,844,752 - 18,885,497 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SLC12A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1542,808,773 - 42,877,714 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl542,811,597 - 42,862,002 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604733,488,318 - 33,536,531 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc12a3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1171,236,697 - 1,272,974 (+)NCBIRrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000015755   ⟹   ENSHGLP00000015591
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474629,098,254 - 29,132,752 (-)Ensembl
RefSeq Acc Id: XM_004843194   ⟹   XP_004843251
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474629,097,478 - 29,132,793 (-)NCBI
RefSeq Acc Id: XM_004843195   ⟹   XP_004843252
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474629,097,478 - 29,132,793 (-)NCBI
RefSeq Acc Id: XM_013071623   ⟹   XP_012927077
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474629,103,927 - 29,132,793 (-)NCBI
RefSeq Acc Id: XM_013071624   ⟹   XP_012927078
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474629,103,927 - 29,132,793 (-)NCBI
RefSeq Acc Id: XM_013071625   ⟹   XP_012927079
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474629,099,877 - 29,132,793 (-)NCBI
RefSeq Acc Id: XM_013071626   ⟹   XP_012927080
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474629,103,927 - 29,132,793 (-)NCBI
RefSeq Acc Id: XM_013071627   ⟹   XP_012927081
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474629,087,867 - 29,132,793 (-)NCBI
RefSeq Acc Id: XR_002394372
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474629,097,478 - 29,132,793 (-)NCBI
RefSeq Acc Id: XR_002394374
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474629,106,119 - 29,132,793 (-)NCBI
RefSeq Acc Id: XP_012927081   ⟸   XM_013071627
- Peptide Label: isoform X7
- UniProtKB: A0AAX6QVE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004843252   ⟸   XM_004843195
- Peptide Label: isoform X4
- UniProtKB: A0A0P6JW96 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004843251   ⟸   XM_004843194
- Peptide Label: isoform X3
- UniProtKB: G5BR76 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012927079   ⟸   XM_013071625
- Peptide Label: isoform X5
- UniProtKB: A0AAX6QUM5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012927078   ⟸   XM_013071624
- Peptide Label: isoform X2
- UniProtKB: A0AAX6QTU8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012927080   ⟸   XM_013071626
- Peptide Label: isoform X6
- UniProtKB: A0AAX6QUQ7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012927077   ⟸   XM_013071623
- Peptide Label: isoform X1
- UniProtKB: A0AAX6QSY7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000015591   ⟸   ENSHGLT00000015755


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000011157 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000015755 ENTREZGENE
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/TrEMBL
InterPro AA-permease/SLC12A_dom UniProtKB/TrEMBL
  AA_permease_N UniProtKB/TrEMBL
  SLC12_C UniProtKB/TrEMBL
  SLC12A3 UniProtKB/TrEMBL
  SLC12A_fam UniProtKB/TrEMBL
KEGG Report hgl:101704301 UniProtKB/TrEMBL
NCBI Gene Slc12a3 ENTREZGENE
PANTHER PTHR11827 UniProtKB/TrEMBL
  PTHR11827:SF9 UniProtKB/TrEMBL
Pfam AA_permease UniProtKB/TrEMBL
  AA_permease_N UniProtKB/TrEMBL
  SLC12 UniProtKB/TrEMBL
PRINTS NACLTRNSPORT UniProtKB/TrEMBL
UniProt A0A0P6JW96 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QSY7 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QTU8 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QUM5 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QUQ7 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QVE2 ENTREZGENE, UniProtKB/TrEMBL
  G5BR76 ENTREZGENE, UniProtKB/TrEMBL