SKIC8 (SKI8 subunit of superkiller complex) - Rat Genome Database

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Gene: SKIC8 (SKI8 subunit of superkiller complex) Chlorocebus sabaeus
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Symbol: SKIC8
Name: SKI8 subunit of superkiller complex
RGD ID: 18551462
Description: INVOLVED IN negative regulation of myeloid cell differentiation (inferred); nuclear-transcribed mRNA catabolic process (inferred); nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay (inferred); PARTICIPATES IN RNA polymerase I transcription pathway; RNA polymerase II transcription elongation pathway; FOUND IN Cdc73/Paf1 complex (inferred); cytoplasm (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: superkiller complex protein 8; WD repeat domain 61; WD repeat-containing protein 61; WDR61
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1265,037,386 - 5,062,578 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl265,037,443 - 5,053,707 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048136,733,490 - 136,759,046 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SKIC8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1265,037,386 - 5,062,578 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl265,037,443 - 5,053,707 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666048136,733,490 - 136,759,046 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SKIC8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381578,283,235 - 78,299,609 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1578,274,515 - 78,299,703 (-)Ensemblhg38GRCh38
GRCh371578,575,577 - 78,591,951 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361576,362,632 - 76,378,995 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1555,512,089 - 55,528,455 (-)NCBICelera
Cytogenetic Map15q25.1NCBI
HuRef1555,333,673 - 55,350,040 (-)NCBIHuRef
CHM1_11578,693,544 - 78,709,912 (-)NCBICHM1_1
T2T-CHM13v2.01576,145,807 - 76,162,185 (-)NCBIT2T-CHM13v2.0
Skic8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39954,624,437 - 54,641,833 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl954,622,019 - 54,641,803 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38954,717,153 - 54,734,549 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl954,714,735 - 54,734,519 (-)Ensemblmm10GRCm38
MGSCv37954,564,962 - 54,582,335 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36954,515,292 - 54,532,665 (-)NCBIMGSCv36mm8
Celera951,961,542 - 51,978,914 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map929.73NCBI
Skic8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8863,999,669 - 64,016,959 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl863,999,671 - 64,016,846 (-)EnsemblGRCr8
mRatBN7.2855,103,542 - 55,120,837 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl855,103,545 - 55,120,813 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx860,637,147 - 60,654,389 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0858,916,139 - 58,933,381 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0856,780,385 - 56,797,627 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd864,808,877 - 64,826,116 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive867,001,438 - 67,018,677 (-)NCBILyon_Normotensive
Lyon_Hypertensive865,440,602 - 65,457,779 (-)NCBILyon_Hypertensive
F344_StmMcwi856,888,714 - 56,905,884 (-)NCBIF344_StmMcwi
Rnor_6.0859,296,339 - 59,313,663 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl859,296,346 - 59,313,574 (-)Ensemblrn6Rnor6.0
Rnor_5.0857,877,391 - 57,894,650 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4858,268,875 - 58,286,551 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera854,591,114 - 54,608,291 (-)NCBICelera
RGSC_v3.1858,287,928 - 58,305,605 (-)NCBI
Cytogenetic Map8q24NCBI
Skic8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955450770,750 - 789,485 (-)Ensembl
ChiLan1.0NW_004955450771,646 - 788,895 (-)NCBIChiLan1.0ChiLan1.0
SKIC8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21667,487,391 - 67,513,537 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11571,653,905 - 71,679,266 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01557,204,199 - 57,229,052 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11576,177,132 - 76,193,618 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1576,175,131 - 76,194,368 (-)EnsemblpanPan2panpan1.1
SKIC8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1358,403,146 - 58,418,782 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl358,403,146 - 58,418,782 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha361,094,456 - 61,111,977 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0358,871,007 - 58,888,533 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl358,871,007 - 58,888,490 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1358,367,396 - 58,384,922 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0358,575,244 - 58,592,754 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0358,924,483 - 58,942,009 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Skic8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640118,856,155 - 118,875,612 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647136,704,160 - 36,723,669 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647136,704,236 - 36,723,675 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SKIC8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl747,641,162 - 47,659,866 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1747,641,103 - 47,661,353 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2753,195,064 - 53,213,364 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Skic8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248942,575,916 - 2,592,666 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248942,575,870 - 2,592,667 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Skic8
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1848,784,879 - 48,803,731 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in SKIC8
570 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000012981   ⟹   ENSCSAP00000010996
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl265,037,443 - 5,053,707 (+)Ensembl
RefSeq Acc Id: XM_008015723   ⟹   XP_008013914
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1265,037,386 - 5,061,361 (+)NCBI
Vero_WHO_p1.0NW_023666048136,734,849 - 136,759,046 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008015724   ⟹   XP_008013915
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1265,037,387 - 5,062,578 (+)NCBI
Vero_WHO_p1.0NW_023666048136,733,490 - 136,759,046 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008015726   ⟹   XP_008013917
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1265,037,391 - 5,053,909 (+)NCBI
Vero_WHO_p1.0NW_023666048136,742,194 - 136,759,046 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008013915 (Get FASTA)   NCBI Sequence Viewer  
  XP_008013917 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000010996
  ENSCSAP00000010996.1
RefSeq Acc Id: XP_008013914   ⟸   XM_008015723
- Peptide Label: isoform X1
RefSeq Acc Id: XP_008013915   ⟸   XM_008015724
- Peptide Label: isoform X2
RefSeq Acc Id: XP_008013917   ⟸   XM_008015726
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RQV7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000010996   ⟸   ENSCSAT00000012981


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000014890 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000012981.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro G-protein_beta_WD-40_rep UniProtKB/TrEMBL
  SKI8 UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene WDR61 ENTREZGENE
PANTHER WD REPEAT-CONTAINING PROTEIN 61 UniProtKB/TrEMBL
  WD REPEAT-CONTAINING PROTEIN 61 UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
PRINTS GPROTEINBRPT UniProtKB/TrEMBL
PROSITE WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/TrEMBL
UniProt A0A0D9RQV7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-21 SKIC8  SKI8 subunit of superkiller complex  WDR61  WD repeat domain 61  Symbol and/or name change 5135510 APPROVED