SCN8A (sodium voltage-gated channel alpha subunit 8) - Rat Genome Database

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Gene: SCN8A (sodium voltage-gated channel alpha subunit 8) Chlorocebus sabaeus
Analyze
Symbol: SCN8A
Name: sodium voltage-gated channel alpha subunit 8
RGD ID: 18443617
Description: ENCODES a protein that exhibits voltage-gated sodium channel activity (ortholog); INVOLVED IN adult walking behavior (ortholog); locomotory behavior (ortholog); muscle organ development (ortholog); ASSOCIATED WITH Ataxia (ortholog); autistic disorder (ortholog); benign familial infantile seizures 5 (ortholog); FOUND IN axon initial segment (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sodium channel protein type 8 subunit alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11147,770,513 - 47,983,843 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1147,838,358 - 47,978,399 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037198,106,707 - 198,322,669 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SCN8A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11147,770,513 - 47,983,843 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1147,838,358 - 47,978,399 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037198,106,707 - 198,322,669 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SCN8A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381251,591,233 - 51,812,864 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1251,590,266 - 51,812,864 (+)Ensemblhg38GRCh38
GRCh371251,985,017 - 52,206,648 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361250,271,287 - 50,488,574 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341250,271,286 - 50,488,365NCBI
Celera1250,787,152 - 51,004,408 (+)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1249,089,349 - 49,239,456 (+)NCBIHuRef
CHM1_11251,951,468 - 52,173,106 (+)NCBICHM1_1
T2T-CHM13v2.01251,554,795 - 51,776,384 (+)NCBIT2T-CHM13v2.0
Scn8a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915100,766,600 - 100,943,819 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15100,767,739 - 100,943,819 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3815100,869,863 - 101,045,938 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15100,869,858 - 101,045,938 (+)Ensemblmm10GRCm38
MGSCv3715100,701,114 - 100,876,360 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3615100,764,359 - 100,868,722 (+)NCBIMGSCv36mm8
Celera15103,017,992 - 103,192,774 (+)NCBICelera
Cytogenetic Map15F1NCBI
cM Map1556.39NCBI
Scn8a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87133,860,901 - 134,034,809 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7133,861,227 - 134,030,026 (+)EnsemblGRCr8
mRatBN7.27131,982,152 - 132,156,075 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7131,982,480 - 132,151,292 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7133,784,484 - 133,952,871 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,014,006 - 136,182,387 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07135,924,362 - 136,093,194 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd7135,944,097 - 136,112,444 (+)NCBIDahl_SR_JrHsd
Lyon_Normotensive7136,896,450 - 137,064,826 (+)NCBILyon_Normotensive
Lyon_Hypertensive7137,023,054 - 137,191,398 (+)NCBILyon_Hypertensive
F344_StmMcwi7135,467,214 - 135,634,994 (+)NCBIF344_StmMcwi
Rnor_6.07142,575,629 - 142,683,659 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7142,575,672 - 142,684,114 (+)Ensemblrn6Rnor6.0
Rnor_5.07140,377,038 - 140,485,139 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47139,686,180 - 139,794,282 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7128,450,559 - 128,618,862 (+)NCBICelera
RGSC_v3.17139,762,616 - 139,870,727 (+)NCBI
Cytogenetic Map7q36NCBI
Scn8a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555472,086,178 - 2,195,971 (+)Ensembl
ChiLan1.0NW_0049555472,086,215 - 2,201,300 (+)NCBIChiLan1.0ChiLan1.0
SCN8A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21042,385,627 - 42,604,490 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11242,382,391 - 42,601,856 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01236,950,057 - 37,172,235 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11237,725,471 - 38,057,190 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1237,730,900 - 37,876,357 (-)EnsemblpanPan2panpan1.1
SCN8A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1273,174,257 - 3,348,349 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl273,176,013 - 3,296,482 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2742,959,130 - 43,080,423 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0273,170,259 - 3,346,792 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl273,172,854 - 3,345,743 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1273,189,615 - 3,363,479 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0273,173,058 - 3,350,013 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02743,304,862 - 43,478,762 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Scn8a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494563,880,790 - 64,000,520 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365129,164,262 - 9,279,688 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365129,164,310 - 9,281,795 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCN8A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl516,977,700 - 17,169,543 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1516,977,468 - 17,173,831 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2517,560,130 - 17,767,953 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Scn8a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624816499,179 - 631,936 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624816498,737 - 631,850 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Scn8a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11262,051,839 - 262,226,374 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in SCN8A
3926 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008003292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008003293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008003294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008003295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008003296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008003297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008003298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008003299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037997093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037997094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037997095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037997096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037997097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_073020750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_073020751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_073020752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_073020753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_073020754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_073020755 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_073020756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_073020757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JBLKOC010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCSAT00000003872   ⟹   ENSCSAP00000002142
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1147,838,358 - 47,978,399 (+)Ensembl
RefSeq Acc Id: XM_008003292   ⟹   XP_008001483
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11147,771,382 - 47,982,451 (+)NCBI
Vero_WHO_p1.0NW_023666037198,112,147 - 198,321,689 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008003293   ⟹   XP_008001484
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11147,770,513 - 47,982,451 (+)NCBI
Vero_WHO_p1.0NW_023666037198,112,147 - 198,322,669 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008003294   ⟹   XP_008001485
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11147,817,473 - 47,982,451 (+)NCBI
Vero_WHO_p1.0NW_023666037198,112,147 - 198,275,607 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008003295   ⟹   XP_008001486
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11147,771,381 - 47,982,451 (+)NCBI
Vero_WHO_p1.0NW_023666037198,106,707 - 198,321,689 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008003296   ⟹   XP_008001487
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11147,771,382 - 47,982,451 (+)NCBI
Vero_WHO_p1.0NW_023666037198,107,061 - 198,321,665 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008003297   ⟹   XP_008001488
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11147,771,382 - 47,983,843 (+)NCBI
Vero_WHO_p1.0NW_023666037198,107,061 - 198,321,665 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008003299   ⟹   XP_008001490
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11147,771,382 - 47,983,843 (+)NCBI
Vero_WHO_p1.0NW_023666037198,107,061 - 198,321,665 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037997093   ⟹   XP_037853021
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037198,112,147 - 198,322,062 (-)NCBI
RefSeq Acc Id: XM_037997094   ⟹   XP_037853022
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037198,106,707 - 198,254,289 (-)NCBI
RefSeq Acc Id: XM_037997095   ⟹   XP_037853023
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037198,106,707 - 198,254,289 (-)NCBI
RefSeq Acc Id: XM_037997096   ⟹   XP_037853024
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037198,107,061 - 198,321,665 (-)NCBI
RefSeq Acc Id: XM_037997097   ⟹   XP_037853025
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666037198,106,707 - 198,233,846 (-)NCBI
RefSeq Acc Id: XP_008001484   ⟸   XM_008003293
- Peptide Label: isoform X1
RefSeq Acc Id: XP_008001486   ⟸   XM_008003295
- Peptide Label: isoform X2
RefSeq Acc Id: XP_008001488   ⟸   XM_008003297
- Peptide Label: isoform X4
RefSeq Acc Id: XP_008001490   ⟸   XM_008003299
- Peptide Label: isoform X7
RefSeq Acc Id: XP_008001483   ⟸   XM_008003292
- Peptide Label: isoform X1
RefSeq Acc Id: XP_008001487   ⟸   XM_008003296
- Peptide Label: isoform X3
RefSeq Acc Id: XP_008001485   ⟸   XM_008003294
- Peptide Label: isoform X1
Ensembl Acc Id: ENSCSAP00000002142   ⟸   ENSCSAT00000003872
RefSeq Acc Id: XP_037853023   ⟸   XM_037997095
- Peptide Label: isoform X5
RefSeq Acc Id: XP_037853022   ⟸   XM_037997094
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037853025   ⟸   XM_037997097
- Peptide Label: isoform X8
RefSeq Acc Id: XP_037853024   ⟸   XM_037997096
- Peptide Label: isoform X6
RefSeq Acc Id: XP_037853021   ⟸   XM_037997093
- Peptide Label: isoform X1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000005859 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000003872.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
  iswi atpase UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/TrEMBL
  IQ_motif_EF-hand-BS UniProtKB/TrEMBL
  Na_channel_a8su UniProtKB/TrEMBL
  Na_channel_asu UniProtKB/TrEMBL
  Na_chnl_inactivation_gate UniProtKB/TrEMBL
  Na_trans_assoc UniProtKB/TrEMBL
  Na_trans_cytopl UniProtKB/TrEMBL
  VGCC_Ca_Na UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/TrEMBL
NCBI Gene SCN8A ENTREZGENE
PANTHER PTHR10037 UniProtKB/TrEMBL
  SODIUM CHANNEL PROTEIN TYPE 8 SUBUNIT ALPHA UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/TrEMBL
  IQ_SCN5A_C UniProtKB/TrEMBL
  Na_trans_assoc UniProtKB/TrEMBL
  Na_trans_cytopl UniProtKB/TrEMBL
PRINTS NACHANNEL UniProtKB/TrEMBL
  NACHANNEL8 UniProtKB/TrEMBL
PROSITE PS50096 UniProtKB/TrEMBL
SMART SM00015 UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A0D9R0K3 ENTREZGENE, UniProtKB/TrEMBL