Zfp59 (zinc finger protein 59) - Rat Genome Database

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Gene: Zfp59 (zinc finger protein 59) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Zfp59
Name: zinc finger protein 59
RGD ID: 1591403
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus; INTERACTS WITH Soman.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: AABR07002784.1; LOC685610; similar to zinc finger protein 59; zinc finger protein 60-like
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,435,484 - 92,457,703 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl192,436,923 - 92,476,637 (-)EnsemblGRCr8
mRatBN7.2183,307,916 - 83,330,139 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,309,355 - 83,330,251 (-)EnsemblmRatBN7.2
Rnor_6.0184,937,006 - 84,960,094 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl184,937,034 - 84,950,210 (-)NCBIrn6Rnor6.0
Rnor_5.0186,155,478 - 86,176,404 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4183,062,521 - 83,124,896 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera177,707,634 - 77,730,729 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Soman  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Zfp59
208 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:37
Interacting mature miRNAs:38
Transcripts:ENSRNOT00000025586, ENSRNOT00000066529
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat

Markers in Region
D1Rat338  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8192,449,801 - 92,449,938 (+)Marker Load Pipeline
mRatBN7.2183,322,233 - 83,322,370 (+)MAPPERmRatBN7.2
Rnor_6.0184,951,324 - 84,951,460NCBIRnor6.0
Rnor_5.0186,168,520 - 86,168,656UniSTSRnor5.0
RGSC_v3.4183,123,793 - 83,123,930RGDRGSC3.4
RGSC_v3.4183,123,794 - 83,123,930UniSTSRGSC3.4
Celera177,721,952 - 77,722,088UniSTS
RGSC_v3.1183,201,842 - 83,202,292RGD
FHH x ACI Map142.2599UniSTS
FHH x ACI Map142.2599RGD
Cytogenetic Map1q21UniSTS
D1S2862  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2183,212,361 - 83,212,636 (+)MAPPERmRatBN7.2
mRatBN7.2946,294,637 - 46,296,180 (+)MAPPERmRatBN7.2
Rnor_6.0950,910,736 - 50,912,277NCBIRnor6.0
Rnor_6.0184,728,205 - 84,728,479NCBIRnor6.0
Rnor_5.0950,577,697 - 50,579,238UniSTSRnor5.0
Rnor_5.0185,958,228 - 85,958,502UniSTSRnor5.0
RGSC_v3.4183,010,606 - 83,010,880UniSTSRGSC3.4
RGSC_v3.4943,233,350 - 43,234,891UniSTSRGSC3.4
Celera943,997,869 - 43,999,414UniSTS
Celera177,612,118 - 77,612,392UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map9q22UniSTS
RH130320  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2183,247,132 - 83,247,313 (+)MAPPERmRatBN7.2
Rnor_6.0184,878,246 - 84,878,426NCBIRnor6.0
Rnor_5.0186,095,496 - 86,095,676UniSTSRnor5.0
RGSC_v3.4183,046,822 - 83,047,002UniSTSRGSC3.4
Celera177,646,880 - 77,647,060UniSTS
RH 3.4 Map1827.1UniSTS
Cytogenetic Map1q21UniSTS
RH132003  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2183,203,915 - 83,204,102 (+)MAPPERmRatBN7.2
Rnor_6.0184,720,011 - 84,720,197NCBIRnor6.0
Rnor_5.0185,950,034 - 85,950,220UniSTSRnor5.0
RGSC_v3.4183,002,160 - 83,002,346UniSTSRGSC3.4
Celera177,603,672 - 77,603,858UniSTS
RH 3.4 Map1826.7UniSTS
Cytogenetic Map1q21UniSTS
BE098751  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2183,272,790 - 83,272,940 (+)MAPPERmRatBN7.2
Rnor_6.0184,903,901 - 84,904,050NCBIRnor6.0
Rnor_5.0186,121,151 - 86,121,300UniSTSRnor5.0
RGSC_v3.4183,072,477 - 83,072,626UniSTSRGSC3.4
Celera177,672,517 - 77,672,666UniSTS
RH 3.4 Map1828.9UniSTS
Cytogenetic Map1q21UniSTS
AU047492  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8192,399,423 - 92,399,579 (+)Marker Load Pipeline
mRatBN7.2183,271,851 - 83,272,007 (+)MAPPERmRatBN7.2
Rnor_6.0184,902,962 - 84,903,117NCBIRnor6.0
Rnor_5.0186,120,212 - 86,120,367UniSTSRnor5.0
RGSC_v3.4183,071,538 - 83,071,693UniSTSRGSC3.4
Celera177,671,578 - 77,671,733UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 52 61 125 89 11 51 29 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000083050   ⟹   ENSRNOP00000069477
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl192,436,923 - 92,476,637 (-)Ensembl
mRatBN7.2 Ensembl183,309,355 - 83,330,251 (-)Ensembl
RefSeq Acc Id: XM_008759213   ⟹   XP_008757435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8192,435,484 - 92,457,171 (-)NCBI
mRatBN7.2183,307,916 - 83,330,138 (-)NCBI
Rnor_6.0184,937,006 - 84,960,093 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008759214   ⟹   XP_008757436
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8192,435,484 - 92,457,702 (-)NCBI
mRatBN7.2183,307,916 - 83,330,138 (-)NCBI
Rnor_6.0184,937,006 - 84,960,093 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063277717   ⟹   XP_063133787
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8192,435,484 - 92,457,702 (-)NCBI
RefSeq Acc Id: XM_063277719   ⟹   XP_063133789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8192,435,484 - 92,457,703 (-)NCBI
RefSeq Acc Id: XM_063277722   ⟹   XP_063133792
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8192,435,484 - 92,457,703 (-)NCBI
RefSeq Acc Id: XP_008757436   ⟸   XM_008759214
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008757435   ⟸   XM_008759213
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000069477   ⟸   ENSRNOT00000083050
RefSeq Acc Id: XP_063133789   ⟸   XM_063277719
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063133792   ⟸   XM_063277722
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063133787   ⟸   XM_063277717
- Peptide Label: isoform X1
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JVG6-F1-model_v2 AlphaFold A0A0G2JVG6 1-612 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1591403 AgrOrtholog
BioCyc Gene G2FUF-60270 BioCyc
Ensembl Genes ENSRNOG00000053366 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000083050 ENTREZGENE
  ENSRNOT00000083050.3 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro Ikaros_C2H2-ZF UniProtKB/TrEMBL
  KRAB UniProtKB/TrEMBL
  KRAB_dom_sf UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene 685610 ENTREZGENE
PANTHER ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 501 UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp59 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000053366 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF109640 UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A0G2JVG6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Zfp59  zinc finger protein 59  AABR07002784.1    Data merged from RGD:15007859 737654 PROVISIONAL
2019-11-08 AABR07002784.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2008-03-05 Zfp59  zinc finger protein 59  LOC685610  similar to zinc finger protein 59  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC685610  similar to zinc finger protein 59      Symbol and Name status set to provisional 70820 PROVISIONAL