Mroh3 (maestro heat-like repeat family member 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Mroh3 (maestro heat-like repeat family member 3) Rattus norvegicus
Analyze
Symbol: Mroh3
Name: maestro heat-like repeat family member 3
RGD ID: 1562634
Description: Predicted to be active in cytoplasm; INTERACTS WITH bisphenol A; 15-acetyldeoxynivalenol (ortholog); amosite asbestos (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC498236; LOC498236; LRRGT00186; uncharacterized protein LOC498236
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81350,181,713 - 50,217,164 (-)NCBIGRCr8
mRatBN7.21347,630,004 - 47,665,461 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1347,630,003 - 47,665,394 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1350,238,214 - 50,272,338 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01351,526,310 - 51,560,424 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01348,793,876 - 48,827,469 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01353,030,596 - 53,087,386 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1353,030,768 - 53,086,231 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01358,084,603 - 58,094,279 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01358,122,656 - 58,138,209 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41349,210,518 - 49,247,039 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1347,942,731 - 47,976,610 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.

Genomics

Comparative Map Data
Mroh3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81350,181,713 - 50,217,164 (-)NCBIGRCr8
mRatBN7.21347,630,004 - 47,665,461 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1347,630,003 - 47,665,394 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1350,238,214 - 50,272,338 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01351,526,310 - 51,560,424 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01348,793,876 - 48,827,469 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01353,030,596 - 53,087,386 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1353,030,768 - 53,086,231 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01358,084,603 - 58,094,279 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01358,122,656 - 58,138,209 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41349,210,518 - 49,247,039 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1347,942,731 - 47,976,610 (-)NCBICelera
Cytogenetic Map13q13NCBI
MROH3P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381200,928,944 - 200,966,668 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1200,917,460 - 200,966,536 (+)EnsemblGRCh38hg38GRCh38
GRCh371200,898,072 - 200,935,796 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361199,151,855 - 199,202,415 (+)NCBINCBI36Build 36hg18NCBI36
Celera1174,010,634 - 174,059,831 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1172,064,907 - 172,102,608 (+)NCBIHuRef
CHM1_11202,320,760 - 202,358,462 (+)NCBICHM1_1
T2T-CHM13v2.01200,185,906 - 200,223,614 (+)NCBIT2T-CHM13v2.0
Mroh3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391136,109,398 - 136,141,178 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1136,109,390 - 136,140,566 (-)EnsemblGRCm39 Ensembl
GRCm381136,181,660 - 136,212,820 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1136,181,652 - 136,212,828 (-)EnsemblGRCm38mm10GRCm38
MGSCv371138,078,227 - 138,107,953 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361137,998,061 - 138,016,886 (-)NCBIMGSCv36mm8
Celera1138,816,859 - 138,845,432 (-)NCBICelera
Cytogenetic Map1E4NCBI
cM Map159.61NCBI

Variants

.
Variants in Mroh3
278 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:101
Count of miRNA genes:88
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000036094
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
4145117Mcs27Mammary carcinoma susceptibility QTL 270.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)134343790447841255Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
12879472Bp399Blood pressure QTL 399arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134522835847841255Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat

Markers in Region
RH128048  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21347,644,336 - 47,644,553 (+)MAPPERmRatBN7.2
Rnor_6.01353,067,703 - 53,067,919NCBIRnor6.0
Rnor_5.01358,118,922 - 58,119,138UniSTSRnor5.0
RGSC_v3.41349,225,551 - 49,225,767UniSTSRGSC3.4
Celera1347,956,822 - 47,957,038UniSTS
Cytogenetic Map13q13UniSTS
Cytogenetic Map7q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 2 30 53 31 38 12 16 12 6 89 56 41 11 53 26

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001412863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769566 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598883 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272539 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010056928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010056929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY539937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000036094   ⟹   ENSRNOP00000033535
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1347,630,003 - 47,665,394 (-)Ensembl
Rnor_6.0 Ensembl1353,030,768 - 53,086,231 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096849   ⟹   ENSRNOP00000085156
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1347,630,003 - 47,665,394 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115491   ⟹   ENSRNOP00000089648
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1347,630,003 - 47,665,394 (-)Ensembl
RefSeq Acc Id: NM_001412863   ⟹   NP_001399792
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81350,181,713 - 50,217,164 (-)NCBI
mRatBN7.21347,630,004 - 47,665,461 (-)NCBI
RefSeq Acc Id: XM_063272535   ⟹   XP_063128605
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81350,181,713 - 50,217,066 (-)NCBI
RefSeq Acc Id: XM_063272536   ⟹   XP_063128606
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81350,181,713 - 50,217,139 (-)NCBI
RefSeq Acc Id: XM_063272537   ⟹   XP_063128607
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81350,184,129 - 50,217,058 (-)NCBI
RefSeq Acc Id: XM_063272538   ⟹   XP_063128608
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81350,181,713 - 50,213,100 (-)NCBI
RefSeq Acc Id: XM_063272539   ⟹   XP_063128609
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81350,181,713 - 50,206,849 (-)NCBI
RefSeq Acc Id: XR_010056928
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81350,183,260 - 50,217,058 (-)NCBI
RefSeq Acc Id: XR_010056929
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81350,190,433 - 50,217,058 (-)NCBI
Ensembl Acc Id: ENSRNOP00000033535   ⟸   ENSRNOT00000036094
Ensembl Acc Id: ENSRNOP00000085156   ⟸   ENSRNOT00000096849
Ensembl Acc Id: ENSRNOP00000089648   ⟸   ENSRNOT00000115491
RefSeq Acc Id: NP_001399792   ⟸   NM_001412863
- UniProtKB: A0A8I6GCI5 (UniProtKB/TrEMBL),   Q6QI22 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128606   ⟸   XM_063272536
- Peptide Label: isoform X1
- UniProtKB: Q6QI22 (UniProtKB/TrEMBL),   A0A8I6GCI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128605   ⟸   XM_063272535
- Peptide Label: isoform X1
- UniProtKB: Q6QI22 (UniProtKB/TrEMBL),   A0A8I6GCI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128608   ⟸   XM_063272538
- Peptide Label: isoform X3
- UniProtKB: Q6QI22 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128609   ⟸   XM_063272539
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063128607   ⟸   XM_063272537
- Peptide Label: isoform X2
- UniProtKB: Q6QI22 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6QI22-F1-model_v2 AlphaFold Q6QI22 1-925 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562634 AgrOrtholog
BioCyc Gene G2FUF-18182 BioCyc
Ensembl Genes ENSRNOG00000025987 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036094.3 UniProtKB/TrEMBL
  ENSRNOT00000096849.1 UniProtKB/TrEMBL
  ENSRNOT00000115491.1 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  Maestro_heat-like_prot UniProtKB/TrEMBL
  Maestro_HEAT_rpt UniProtKB/TrEMBL
NCBI Gene 498236 ENTREZGENE
PANTHER MAESTRO HEAT-LIKE REPEAT FAMILY MEMBER 3 UniProtKB/TrEMBL
  PTHR23120 UniProtKB/TrEMBL
Pfam Maestro_HEAT UniProtKB/TrEMBL
PhenoGen Mroh3 PhenoGen
RatGTEx ENSRNOG00000025987 RatGTEx
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
UniProt A0A8I6AC69_RAT UniProtKB/TrEMBL
  A0A8I6GCI5 ENTREZGENE, UniProtKB/TrEMBL
  Q6QI22 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-09-06 Mroh3  maestro heat-like repeat family member 3  LOC498236  LRRGT00186  Name and Symbol changed 629549 APPROVED
2006-02-09 LOC498236  LRRGT00186      Symbol and Name status set to provisional 70820 PROVISIONAL