Nlkl1 (Nlk like 1) - Rat Genome Database

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Gene: Nlkl1 (Nlk like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Nlkl1 (Ensembl: RGD1561440)
Name: Nlk like 1 (Ensembl:similar to nemo like kinase)
RGD ID: 1561440
Description: Predicted to enable ATP binding activity and MAP kinase activity. Predicted to be involved in MAPK cascade and protein phosphorylation. Predicted to be located in cytoplasm; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; rotenone.
Type: pseudo (Ensembl: protein-coding)
RefSeq Status: INFERRED
Previously known as: LOC363942; RGD1561440; serine/threonine-protein kinase NLK-like; similar to nemo like kinase
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Related Functional Gene: Nlk  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81316,449,503 - 16,454,029 (-)NCBIGRCr8
mRatBN7.21315,934,550 - 15,939,076 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1315,934,543 - 15,937,979 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1316,295,561 - 16,300,087 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01317,580,237 - 17,584,763 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01316,282,357 - 16,286,883 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01319,211,596 - 19,215,319 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01324,416,614 - 24,418,560 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4135,490,860 - 5,492,338 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1315,964,144 - 15,967,867 (-)NCBICelera
Cytogenetic Map13p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
MAPK cascade  (IEA)

Cellular Component
cytoplasm  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Nlkl1
30 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317027Aia22Adjuvant induced arthritis QTL 222.29joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)13134266636Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317034Aia9Adjuvant induced arthritis QTL 94.62joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131176653532331607Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
631672Iddm12Insulin dependent diabetes mellitus QTL 122.20.0032blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)13599466834535351Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2303031Bp326Blood pressure QTL 326arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131176653523001904Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317044Aia23Adjuvant induced arthritis QTL 232.3joint integrity trait (VT:0010548)ankle joint diameter (CMO:0002148)131176653532331607Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat

Markers in Region
Nlk-ps1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21315,936,679 - 15,937,327 (+)MAPPERmRatBN7.2
Rnor_6.01319,213,740 - 19,214,387NCBIRnor6.0
Rnor_5.01324,416,981 - 24,417,628UniSTSRnor5.0
RGSC_v3.4135,491,101 - 5,491,748UniSTSRGSC3.4
Celera1315,966,288 - 15,966,935UniSTS
Cytogenetic Map10q25UniSTS
Cytogenetic Map13p13UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000097973   ⟹   ENSRNOP00000093293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1315,934,543 - 15,937,979 (-)Ensembl
RefSeq Acc Id: XM_039091221   ⟹   XP_038947149
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21315,934,536 - 15,938,158 (-)NCBI
RefSeq Acc Id: XM_039091222   ⟹   XP_038947150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21315,934,536 - 15,938,158 (-)NCBI
Protein Sequences
Ensembl Protein ENSRNOP00000093293.1
RefSeq Acc Id: XP_038947150   ⟸   XM_039091222
RefSeq Acc Id: XP_038947149   ⟸   XM_039091221
Ensembl Acc Id: ENSRNOP00000093293   ⟸   ENSRNOT00000097973
Protein Domains
Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
BioCyc Gene G2FUF-18658 BioCyc
Ensembl Genes ENSRNOG00000066175 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000097973.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  MAP_kinase UniProtKB/TrEMBL
  MAP_kinase_CS UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene 363942 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/TrEMBL
  SIMILAR TO NEMO-LIKE KINASE UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Nlkl1 PhenoGen
PROSITE MAPK UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000066175 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8I6AJX5_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Nlkl1  Nlk like 1  RGD1561440  similar to nemo like kinase  Symbol and Name Changed 1299863 APPROVED
2022-06-02 RGD1561440  similar to nemo like kinase  RGD1561440  similar to nemo like kinase  Data merged from RGD:149736373 737654 PROVISIONAL
2021-08-09 RGD1561440  similar to nemo like kinase      Symbol and Name status set to provisional 45752 PROVISIONAL
2008-04-30 RGD1561440  similar to nemo like kinase   RGD1561440_predicted  similar to nemo like kinase (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1561440_predicted  similar to nemo like kinase (predicted)  LOC363942  similar to nemo like kinase  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC363942  similar to nemo like kinase      Symbol and Name status set to provisional 70820 PROVISIONAL