Cdrt15l2 (CMT1A duplicated region transcript 15 like 2) - Rat Genome Database

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Gene: Cdrt15l2 (CMT1A duplicated region transcript 15 like 2) Rattus norvegicus
Analyze
Symbol: Cdrt15l2 (Ensembl: RGD1559804)
Name: CMT1A duplicated region transcript 15 like 2 (Ensembl:ral guanine nucleotide dissociation stimulator-like)
RGD ID: 1559804
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Orthologous to human CDRT15L2 (CMT1A duplicated region transcript 15 like 2); INTERACTS WITH acrylamide; copper atom; copper(0).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC498591; LOC100910243; LOC498591; ral guanine nucleotide dissociation stimulator-like; RGD1559804; similar to hypothetical protein 4930474N05; uncharacterized protein LOC498591
RGD Orthologs
Human
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81611,232,244 - 11,238,199 (-)NCBIGRCr8
mRatBN7.21611,226,012 - 11,231,967 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1611,122,718 - 11,158,623 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1611,148,955 - 11,154,902 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01612,293,700 - 12,299,647 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01611,156,894 - 11,276,617 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01612,190,742 - 12,196,263 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1612,191,697 - 12,194,118 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01610,516,168 - 10,518,927 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41611,610,676 - 11,613,098 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1612,007,086 - 12,009,278 (+)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Cdrt15l2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81611,232,244 - 11,238,199 (-)NCBIGRCr8
mRatBN7.21611,226,012 - 11,231,967 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1611,122,718 - 11,158,623 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1611,148,955 - 11,154,902 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01612,293,700 - 12,299,647 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01611,156,894 - 11,276,617 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01612,190,742 - 12,196,263 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1612,191,697 - 12,194,118 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01610,516,168 - 10,518,927 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41611,610,676 - 11,613,098 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1612,007,086 - 12,009,278 (+)NCBICelera
Cytogenetic Map16p14NCBI
CDRT15L2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381720,579,724 - 20,580,911 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1720,579,724 - 20,580,911 (+)EnsemblGRCh38hg38GRCh38
GRCh371720,483,037 - 20,484,224 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361720,422,589 - 20,424,816 (+)NCBINCBI36Build 36hg18NCBI36
Cytogenetic Map17p11.2NCBI
HuRef1719,685,439 - 19,686,319 (+)NCBIHuRef
CHM1_11720,491,737 - 20,492,924 (+)NCBICHM1_1
T2T-CHM13v2.01720,528,374 - 20,529,561 (+)NCBIT2T-CHM13v2.0
LOC100984246
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21956,848,650 - 56,849,902 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11761,851,695 - 61,854,053 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01734,687,352 - 34,689,552 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11742,060,430 - 42,062,503 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1742,060,430 - 42,062,500 (+)Ensemblpanpan1.1panPan2

Variants

.
Variants in Cdrt15l2
142 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:353
Count of miRNA genes:189
Interacting mature miRNAs:206
Transcripts:ENSRNOT00000066957, ENSRNOT00000071517
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat

Markers in Region
AU049625  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1611,356,313 - 11,356,575UniSTS
Celera1612,005,568 - 12,005,835UniSTS
Cytogenetic Map16p15UniSTS


Expression

RNA-SEQ Expression

ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 9 9 8 1 8 12 1 7 3 23 1

Sequence


Ensembl Acc Id: ENSRNOT00000071517   ⟹   ENSRNOP00000067413
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1612,191,697 - 12,194,118 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000072045   ⟹   ENSRNOP00000067521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1611,122,718 - 11,125,181 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106098   ⟹   ENSRNOP00000084126
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1611,122,877 - 11,125,181 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118287   ⟹   ENSRNOP00000094680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1611,122,877 - 11,158,623 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119610   ⟹   ENSRNOP00000090903
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1611,156,464 - 11,158,623 (-)Ensembl
RefSeq Acc Id: NM_001394798   ⟹   NP_001381727
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81611,232,244 - 11,238,199 (-)NCBI
mRatBN7.21611,226,012 - 11,231,967 (-)NCBI
RefSeq Acc Id: NR_172208
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81611,232,244 - 11,238,199 (-)NCBI
mRatBN7.21611,226,012 - 11,231,967 (-)NCBI
RefSeq Acc Id: XM_063275631   ⟹   XP_063131701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81611,232,332 - 11,234,762 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001381727 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131701 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI58777 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067521.2
  ENSRNOP00000094680.1
Ensembl Acc Id: ENSRNOP00000067413   ⟸   ENSRNOT00000071517
Ensembl Acc Id: ENSRNOP00000084126   ⟸   ENSRNOT00000106098
Ensembl Acc Id: ENSRNOP00000094680   ⟸   ENSRNOT00000118287
Ensembl Acc Id: ENSRNOP00000067521   ⟸   ENSRNOT00000072045
Ensembl Acc Id: ENSRNOP00000090903   ⟸   ENSRNOT00000119610
RefSeq Acc Id: NP_001381727   ⟸   NM_001394798
- UniProtKB: A0A8I6AS40 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063131701   ⟸   XM_063275631
- Peptide Label: isoform X1
Protein Domains
N-terminal Ras-GEF

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B0BND3-F1-model_v2 AlphaFold B0BND3 1-158 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559804 AgrOrtholog
BioCyc Gene G2FUF-12037 BioCyc
Ensembl Genes ENSRNOG00000045563 Ensembl
  ENSRNOG00000069329 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072045.3 UniProtKB/TrEMBL
  ENSRNOT00000118287.1 UniProtKB/TrEMBL
Gene3D-CATH Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7133601 IMAGE-MGC_LOAD
InterPro Ras-like_Gua-exchang_fac_N UniProtKB/TrEMBL
  Ras_GEF_dom UniProtKB/TrEMBL
MGC_CLONE MGC:188101 IMAGE-MGC_LOAD
NCBI Gene 498591 ENTREZGENE
PANTHER 1700018F24RIK PROTEIN-RELATED UniProtKB/TrEMBL
  1700018F24RIK PROTEIN-RELATED-RELATED UniProtKB/TrEMBL
PhenoGen Cdrt15l2 PhenoGen
PROSITE RASGEF_NTER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000045563 RatGTEx
  ENSRNOG00000069329 RatGTEx
Superfamily-SCOP Ras_GEF UniProtKB/TrEMBL
UniProt A0A8I6AS40 ENTREZGENE, UniProtKB/TrEMBL
  D3ZPG3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Cdrt15l2  CMT1A duplicated region transcript 15 like 2  RGD1559804  similar to hypothetical protein 4930474N05  Symbol and Name Changed 1299863 APPROVED
2021-03-09 RGD1559804  similar to hypothetical protein 4930474N05  LOC100910243  ral guanine nucleotide dissociation stimulator-like  Data merged from RGD:6499543 737654 PROVISIONAL
2013-05-24 RGD1559804  similar to hypothetical protein 4930474N05  LOC683196  hypothetical protein LOC683196  Data merged from RGD:1590370 1643240 APPROVED
2012-07-05 LOC100910243  ral guanine nucleotide dissociation stimulator-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 RGD1559804  similar to hypothetical protein 4930474N05   RGD1559804_predicted  similar to hypothetical protein 4930474N05 (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-20 LOC683196  hypothetical protein LOC683196      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1559804_predicted  similar to hypothetical protein 4930474N05 (predicted)  LOC498591  similar to hypothetical protein 4930474N05  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498591  similar to hypothetical protein 4930474N05      Symbol and Name status set to provisional 70820 PROVISIONAL