Saxol1 (stabilizer of axonemal microtubules like 1) - Rat Genome Database

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Gene: Saxol1 (stabilizer of axonemal microtubules like 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Saxol1
Name: stabilizer of axonemal microtubules like 1
RGD ID: 1549779
Description: Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including cold acclimation; positive regulation of cilium assembly; and protein stabilization. Predicted to be located in motile cilium. Predicted to be active in microtubule cytoskeleton and sperm flagellum. Orthologous to human SAXO1 (stabilizer of axonemal microtubules 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Fam154a; hypothetical protein LOC317471; LOC317471; Saxo1; similar to hypothetical protein MGC35182; stabilizer of axonemal microtubules 1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X31,605,096 - 31,607,253 (+)NCBIGRCr8
mRatBN7.2X27,973,442 - 27,975,599 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_UtxX29,007,712 - 29,009,869 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X32,443,119 - 32,445,276 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X28,622,353 - 28,624,510 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X29,520,263 - 29,522,420 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX29,520,263 - 29,522,420 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X29,913,311 - 29,915,334 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X48,658,495 - 48,660,513 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX28,345,521 - 28,347,678 (+)NCBICelera
Cytogenetic MapXq13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334  


Genomics

Variants

.
Variants in Saxol1
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:14
Count of miRNA genes:13
Interacting mature miRNAs:13
Transcripts:ENSRNOT00000037047
Prediction methods:Microtar, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598873Memor2Memory QTL 22.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)X2099094741052531Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
2290375Gluco34Glucose level QTL 342.75blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X2099094741203591Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat
71116Niddm16Non-insulin dependent diabetes mellitus QTL 167.81blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X1529780260297802Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
2 3 2 28 20 15 4 8 4 3 40 20 20 12 37 11

Sequence


Ensembl Acc Id: ENSRNOT00000037047   ⟹   ENSRNOP00000055963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX29,520,263 - 29,522,420 (+)Ensembl
RefSeq Acc Id: NM_001014112   ⟹   NP_001014134
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X31,605,096 - 31,607,253 (+)NCBI
mRatBN7.2X27,973,442 - 27,975,599 (+)NCBI
Rnor_6.0X29,520,263 - 29,522,420 (+)NCBI
Rnor_5.0X29,913,311 - 29,915,334 (+)NCBI
RGSC_v3.4X48,658,495 - 48,660,513 (+)RGD
CeleraX28,345,521 - 28,347,678 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001014134 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH78965 (Get FASTA)   NCBI Sequence Viewer  
  EDL90555 (Get FASTA)   NCBI Sequence Viewer  
  Q6AYP6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001014134   ⟸   NM_001014112
- UniProtKB: Q6AYP6 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000055963   ⟸   ENSRNOT00000037047

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYP6-F1-model_v2 AlphaFold Q6AYP6 1-462 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1549779 AgrOrtholog
BioCyc Gene G2FUF-2610 BioCyc
Ensembl Genes ENSRNOG00000025637 Ensembl
IMAGE_CLONE IMAGE:7111432 IMAGE-MGC_LOAD
InterPro SAXO1/2 UniProtKB/Swiss-Prot
KEGG Report rno:317471 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93843 IMAGE-MGC_LOAD
NCBI Gene 317471 ENTREZGENE
PANTHER PTHR31516 UniProtKB/Swiss-Prot
  STABILIZER OF AXONEMAL MICROTUBULES 1 UniProtKB/Swiss-Prot
Pfam SAXO1-2 UniProtKB/Swiss-Prot
PhenoGen Saxol1 PhenoGen
RatGTEx ENSRNOG00000025637 RatGTEx
UniProt Q6AYP6 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-10 Saxol1  stabilizer of axonemal microtubules like 1  Saxo1  stabilizer of axonemal microtubules 1  Name and Symbol changed 629549 APPROVED
2015-04-17 Saxo1  stabilizer of axonemal microtubules 1  LOC317471  similar to hypothetical protein MGC35182  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-15 LOC317471  similar to hypothetical protein MGC35182      Symbol and Name status set to provisional 70820 PROVISIONAL