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Gene: NKX1-1 (NK1 homeobox 1) Sus scrofa

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Symbol:

NKX1-1

Name:

NK1 homeobox 1

RGD ID:

13862142

Description:

ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN lipid metabolic process (ortholog); nervous system process (ortholog); regulation of generation of precursor metabolites and energy (ortholog); FOUND IN nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

NK1 transcription factor-related protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NKX1-1 (NK1 homeobox 1)	HGNC	Ensembl, NCBI, OrthoDB
Mus musculus (house mouse):	Nkx1-1 (NK1 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Nkx1-1 (NK1 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nkx1-1 (NK1 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NKX1-1 (NK1 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NKX1-1 (NK1 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nkx1-1 (NK1 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NKX1-1 (NK1 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nkx1-1 (NK1 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Nkx1-1 (NK1 homeobox 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Sscrofa11.1 - Pig Sscrofa11.1 Assembly

Position:

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	608,098 - 611,859 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	8	608,327 - 611,859 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IBA)

lipid metabolic process (ISO)

nervous system process (ISO)

regulation of DNA-templated transcription (IEA)

regulation of generation of precursor metabolites and energy (ISO)

regulation of glucose metabolic process (ISO)

regulation of transcription by RNA polymerase II (IBA,IEA)

Cellular Component

nucleus (IBA,IEA)

Molecular Function

DNA binding (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA,IEA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

NKX1-1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	608,098 - 611,859 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	8	608,327 - 611,859 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

NKX1-1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	1,402,932 - 1,406,442 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	1,402,932 - 1,406,442 (-)	Ensembl			hg38	GRCh38
GRCh37	4	1,396,720 - 1,400,230 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	1,380,072 - 1,392,453 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	4	1,324,669 - 1,339,840 (-)	NCBI		Celera
Cytogenetic Map	4	p16.3	NCBI
HuRef	4	1,366,669 - 1,377,571 (-)	NCBI		HuRef
CHM1_1	4	1,396,490 - 1,400,000 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	1,401,206 - 1,404,716 (-)	NCBI		T2T-CHM13v2.0

Nkx1-1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	33,588,078 - 33,591,434 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	33,588,078 - 33,591,320 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	33,430,734 - 33,434,090 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	33,430,734 - 33,433,976 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	33,773,383 - 33,776,625 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	33,773,383 - 33,776,625 (-)	NCBI		MGSCv36	mm8
Celera	5	30,909,910 - 30,913,492 (-)	NCBI		Celera
Cytogenetic Map	5	B1	NCBI
cM Map	5	17.65	NCBI

Nkx1-1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	81,521,206 - 81,524,788 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	81,521,220 - 81,524,566 (+)	Ensembl				GRCr8
mRatBN7.2	14	77,296,676 - 77,300,575 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	77,296,796 - 77,300,036 (+)	Ensembl				mRatBN7.2
Rnor_6.0	14	82,603,538 - 82,607,031 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	82,603,671 - 82,607,031 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	83,287,754 - 83,291,039 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	83,216,329 - 83,219,569 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	76,215,871 - 76,219,364 (+)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

Nkx1-1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955514	763,160 - 781,635 (-)	Ensembl
ChiLan1.0	NW_004955514	763,160 - 781,635 (-)	NCBI	ChiLan1.0	ChiLan1.0

NKX1-1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	1,736,687 - 1,740,204 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	1,703,817 - 1,707,333 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	1,547,939 - 1,551,457 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	1,423,117 - 1,430,833 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2

NKX1-1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	62,634,654 - 62,638,111 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	62,634,783 - 62,638,111 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	65,150,929 - 65,154,386 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	63,109,511 - 63,112,971 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	63,109,640 - 63,112,971 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	62,601,641 - 62,605,099 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	62,805,130 - 62,808,591 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	63,164,504 - 63,167,959 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Nkx1-1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	68,207,850 - 68,209,154 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936477	21,909,542 - 21,910,599 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NKX1-1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	47,358,966 - 47,362,488 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	47,359,087 - 47,362,476 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023667306	14,442 - 17,435 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nkx1-1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624755	25,897,061 - 25,899,884 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624755	25,896,953 - 25,900,096 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Nkx1-1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	11	71,415,773 - 71,419,123 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in NKX1-1
17 total Variants

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021100889	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AEMK02000062	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSSCT00000061424 ⟹ ENSSSCP00000040796

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1 Ensembl	8	608,098 - 611,859 (-)	Ensembl

RefSeq Acc Id:

XM_021100889 ⟹ XP_020956548

Type:

CODING

Position:

Pig Assembly	Chr	Position (strand)	Source
Sscrofa11.1	8	608,327 - 611,859 (-)	NCBI

Sequence:

show sequence

ATGAGCGCGAGCGGCCCGGCGGCTCCGGGGGACGGCCCCGCGCTGCCGCTGCCGCCGCCTGGGC
CCGGCCCGGGGCCCGCACCGCCCGCGCCCGCCGCCGCCGCCGCCGCCGCCCGGGACGCCATGGA
CGGGCGCGCCGAGCTGCCCGCCTTCCCCCGCGCCGGAGCCCCGCCGCTCGCCGCCAGCGACACT
GTGCCCGCTGCACCCGAGGGGGCTGGGGCGGCCCGGCCCGGCCCGCCGCCGCGCCCCACCTCCT
TCTCGGTGCTGGACATCCTGGACCCCAACAAGTTCAACAGCAGAAGACGCCGCTGTGTGCTGCT
GGGCCCCGTGGCGCCCGCGGCGTGCGCCCCGGCCCCGTGCGCCCCGGCCCCCGCTGCCCCGGGA
CGCCCGCCGCGCTCGGAGGAGCTGGAGCGCCGCGCCCTCGCCGCCGCTGGAGGAGCTGGAGCCG
GCCCCGGAGCTGAGCCGCCGCACGCCGGCGACCCCTGCAAGGCTGACGAGGCCGAGGCCAACGG
CTACAGCAGCGGCGGCGGCCGCAGCCCGAGCGCGGACAGCGGGGACGAGGCACCAGACGACGAC
GACGACGACGAGGCGCCCGAGGCGGGGGCGGCGCGAGGCGCGGAGGCGCGAGGAGGCGGCAGCG
GCCTCGGGGCCCGCGGGTCGGGCAGCCAGGGCGAGGCCGAGGCGCCCCCCGGCGCCGTCGACGA
GACGGCGGCCCCCGGCCCCCGCGGGAACTCTCCCGGAGCCTCGGGCCCGCCGGGGGTCGTGGCG
GCGGCGGCAGTGGCGCCGGCGGGCGGGGGGACCACCCCGCAGGGGGCGGCGGCGGCGACCAAGC
CCAAGCGGAAGCGCACGGGCTCCGACTCCAAGTCCGGGAAGCCTCGGCGCGCGCGCACCGCCTT
CACCTACGAGCAGCTCGTGGCGCTGGAGAACAAGTTCAAGGCGACGCGCTACCTGTCGGTTTGC
GAGCGCCTCAACCTGGCGCTGTCGCTGAGCCTCACCGAGACGCAGGTGAAGATCTGGTTCCAGA
ACCGCCGCACCAAGTGGAAGAAGCAGAACCCCGGCGCCGACACGAGCGCGCCGACCGGCGGCGG
CGGAGGGCCGGGGCCGGGCGCGGGGCCGGGCGCGGGGCTGCCCGGCGGCCTCAGCCCGCTCAGC
CCGTCGCCGCCCATGGGCGCGCCGCTCGCCATGCACGGCCCGGCCGGGTACCCGGCGCACGGCC
CCGGCGGCCTGGTGTGCGCCGCACAGCTGCCCTTCCTGTCGAGCCCCGCGGTGCTGTCGCCCTT
TGTGCTGGGCTCGCAGACCTACGGCGCGCCCGCCTTCTACGCGCCGCACCTCTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_020956548	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSSCP00000040796
	ENSSSCP00000040796.2
	ENSSSCP00025032373.1
	ENSSSCP00030034815.1
	ENSSSCP00035045247.1
	ENSSSCP00040045003.1
	ENSSSCP00045014943.1
	ENSSSCP00050002263.1
	ENSSSCP00055016707.1
	ENSSSCP00060032395.1
	ENSSSCP00065041487.1
	ENSSSCP00070009051.1

RefSeq Acc Id:

XP_020956548 ⟸ XM_021100889

- UniProtKB:

A0A287AA71 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSASGPAAPGDGPALPLPPPGPGPGPAPPAPAAAAAAARDAMDGRAELPAFPRAGAPPLAASDT
VPAAPEGAGAARPGPPPRPTSFSVLDILDPNKFNSRRRRCVLLGPVAPAACAPAPCAPAPAAPG
RPPRSEELERRALAAAGGAGAGPGAEPPHAGDPCKADEAEANGYSSGGGRSPSADSGDEAPDDD
DDDEAPEAGAARGAEARGGGSGLGARGSGSQGEAEAPPGAVDETAAPGPRGNSPGASGPPGVVA
AAAVAPAGGGTTPQGAAAATKPKRKRTGSDSKSGKPRRARTAFTYEQLVALENKFKATRYLSVC
ERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGADTSAPTGGGGGPGPGAGPGAGLPGGLSPLS
PSPPMGAPLAMHGPAGYPAHGPGGLVCAAQLPFLSSPAVLSPFVLGSQTYGAPAFYAPHL

hide sequence

Ensembl Acc Id:

ENSSSCP00000040796 ⟸ ENSSSCT00000061424

Protein Domains

Homeobox

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSSCG00000038573	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSSSCG00025054616	UniProtKB/TrEMBL
	ENSSSCG00030054737	UniProtKB/TrEMBL
	ENSSSCG00035077387	UniProtKB/TrEMBL
	ENSSSCG00040072733	UniProtKB/TrEMBL
	ENSSSCG00045012752	UniProtKB/TrEMBL
	ENSSSCG00050004009	UniProtKB/TrEMBL
	ENSSSCG00055010770	UniProtKB/TrEMBL
	ENSSSCG00060055069	UniProtKB/TrEMBL
	ENSSSCG00065069105	UniProtKB/TrEMBL
	ENSSSCG00070005794	UniProtKB/TrEMBL
Ensembl Transcript	ENSSSCT00000061424	ENTREZGENE
	ENSSSCT00000061424.2	UniProtKB/TrEMBL
	ENSSSCT00025074701.1	UniProtKB/TrEMBL
	ENSSSCT00030076242.1	UniProtKB/TrEMBL
	ENSSSCT00035105384.1	UniProtKB/TrEMBL
	ENSSSCT00040100215.1	UniProtKB/TrEMBL
	ENSSSCT00045021714.1	UniProtKB/TrEMBL
	ENSSSCT00050005440.1	UniProtKB/TrEMBL
	ENSSSCT00055021120.1	UniProtKB/TrEMBL
	ENSSSCT00060075006.1	UniProtKB/TrEMBL
	ENSSSCT00065094861.1	UniProtKB/TrEMBL
	ENSSSCT00070010990.1	UniProtKB/TrEMBL
Gene3D-CATH	Homeodomain-like	UniProtKB/TrEMBL
InterPro	Homeobox-like_sf	UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/TrEMBL
	Homeobox_dom	UniProtKB/TrEMBL
	Homeobox_metazoa	UniProtKB/TrEMBL
	Homeobox_NK-like	UniProtKB/TrEMBL
NCBI Gene	NKX1-1	ENTREZGENE
PANTHER	HOMEOBOX PROTEIN NKX	UniProtKB/TrEMBL
	NK1 TRANSCRIPTION FACTOR-RELATED PROTEIN 1	UniProtKB/TrEMBL
Pfam	Homeodomain	UniProtKB/TrEMBL
PRINTS	HOMEOBOX	UniProtKB/TrEMBL
PROSITE	HOMEOBOX_1	UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/TrEMBL
SMART	HOX	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/TrEMBL
UniProt	A0A287AA71	ENTREZGENE, UniProtKB/TrEMBL
	A0A4X1T242_PIG	UniProtKB/TrEMBL
	A0A8D1G1P2_PIG	UniProtKB/TrEMBL
	A0A8D1K0A0_PIG	UniProtKB/TrEMBL
	A0A8D1QES7_PIG	UniProtKB/TrEMBL
	A0A8D1ZY15_PIG	UniProtKB/TrEMBL
VGNC ID	VGNC:90765	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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