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Gene: NKX1-1 (NK1 homeobox 1) Homo sapiens
Symbol: NKX1-1
Name: NK1 homeobox 1
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to localize to nuclear chromatin.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: homeobox protein 153; homeobox protein SAX-2; HPX-153 homeobox; HSPX153; NK1 transcription factor related, locus 1; NK1 transcription factor-related protein 1; NKX-1.1; SAX2
Mus musculus (house mouse) : Nkx1-1 (NK1 homeobox 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nkx1-1 (NK1 homeobox 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nkx1-1 (NK1 homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NKX1-1 (NK1 homeobox 1)
Canis lupus familiaris (dog) : NKX1-1 (NK1 homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nkx1-1 (NK1 homeobox 1)
Sus scrofa (pig) : NKX1-1 (NK1 homeobox 1)
Heterocephalus glaber (naked mole-rat) : Nkx1-1 (NK1 homeobox 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl41,402,932 - 1,406,331 (-)EnsemblGRCh38hg38GRCh38
GRCh3841,402,932 - 1,406,442 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3741,396,720 - 1,400,119 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3641,380,072 - 1,392,453 (-)NCBINCBI36hg18NCBI36
Celera41,324,669 - 1,339,840 (-)NCBI
Cytogenetic Map4p16.3NCBI
HuRef41,366,669 - 1,377,571 (-)NCBIHuRef
CHM1_141,396,490 - 1,400,000 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on NKX1-1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1603306
Created: 2007-04-28
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.